tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Jordan ML et al. | Tacrolimus for rescue of refractory renal allograft rejection. | 1998 | Transplant. Proc. | pmid:9636511 |
| Undre NA and Schäfer A | Factors affecting the pharmacokinetics of tacrolimus in the first year after renal transplantation. European Tacrolimus Multicentre Renal Study Group. | 1998 | Transplant. Proc. | pmid:9636512 |
| Gołębiewska J et al. | Tako-tsubo cardiomyopathy on the first day after renal transplantation - case report and literature review. | 2014 | Transplant. Proc. | pmid:25380951 |
| Neuhaus PJ | Optimised first-line FK506-based protocols in liver transplantation: experience from the University Hospital Rudolf Virchow, Berlin. | 1994 | Transplant. Proc. | pmid:7527961 |
| Wang XH et al. | Tacrolimus vs CyA Neoral in combination with MMF and steroids after cadaveric renal transplantation. | 2000 | Transplant. Proc. | pmid:11119899 |
| Jordan ML et al. | FK 506 salvage of renal allografts with ongoing rejection failing cyclosporine immunosuppression. | 1993 | Transplant. Proc. | pmid:7679827 |
| Youhua Z et al. | Clinical study of FK 506 in renal transplant recipients. | 2000 | Transplant. Proc. | pmid:11119900 |
| TuÄŸcu M et al. | Tacrolimus-Induced Diabetic Ketoacidosis and Effect of Switching to Everolimus: A Case Report. | 2015 | Transplant. Proc. | pmid:26093759 |
| Jusko WJ and D'Ambrosio R | Monitoring FK 506 concentrations in plasma and whole blood. | 1991 | Transplant. Proc. | pmid:1721260 |
| Millis JM et al. | Treatment of steroid-resistant rejection with tacrolimus prior to OKT3 in liver transplant recipients. | 1996 | Transplant. Proc. | pmid:8623213 |
| Staschak S et al. | A cost comparison of liver transplantation with FK 506 or CyA as the primary immunosuppressive agent. | 1990 | Transplant. Proc. | pmid:1689896 |
| Aravot D et al. | A new immunosuppressive protocol for lung transplantation: early promising results. | 2003 | Transplant. Proc. | pmid:12644072 |
| Brook NR et al. | Prograf produces a molecular environment favoring antifibrosis, an effect reversed by the addition of rapamune. | 2005 Jan-Feb | Transplant. Proc. | pmid:15808577 |
| Shitrit D et al. | Tacrolimus-induced hemolytic uremic syndrome case presentation in a lung transplant recipient. | 2003 | Transplant. Proc. | pmid:12644073 |
| Mollevà DG et al. | Late xenograft rejection: comparison between liver and heart xenografts under low-dose tacrolimus. | 2002 | Transplant. Proc. | pmid:11959212 |
| Crespo-Leiro MG et al. | Replacement of cyclosporine by tacrolimus for immunosuppression in heart transplant patients: safety and efficacy. | 2002 | Transplant. Proc. | pmid:11959213 |
| Cai TH et al. | Improved immunosuppression with combination tacrolimus (FK506) and mycophenolic acid in orthotopic liver transplantation. | 1998 | Transplant. Proc. | pmid:9636572 |
| Ringe B et al. | Tacrolimus and mycophenolate mofetil in clinical liver transplantation: experience with a steroid-sparing concept. | 1998 | Transplant. Proc. | pmid:9636573 |
| Santos T et al. | New Recipes With Known Ingredients: Combined Therapy of Everolimus and Low-dose Tacrolimus in De Novo Renal Allograft Recipients. | 2015 | Transplant. Proc. | pmid:26036483 |
| Mazali FC et al. | Posttransplant diabetes mellitus: incidence and risk factors. | 2008 | Transplant. Proc. | pmid:18455010 |
| Moriuchi H et al. | Mechanisms of immunosuppressive effects of FK 506 in light of apoptosis of hepatocytes and infiltrating lymphocytes in rat allografted livers. | 2000 | Transplant. Proc. | pmid:11120182 |
| Oliveira DB and Chang R | Report of the first 118 tacrolimus-treated patients at St George's Hospital, London. | 1999 | Transplant. Proc. | pmid:10576047 |
| Asano T et al. | Increased tacrolimus trough levels in association with severe diarrhea, a case report. | 2004 | Transplant. Proc. | pmid:15518758 |
| Schreiber SL et al. | Immunophilin-ligand complexes as probes of intracellular signaling pathways. | 1991 | Transplant. Proc. | pmid:1721293 |
| Butt TR et al. | Molecular basis of immunosuppressive drug action: regulation of steroid receptor-mediated transcription by FK 506. | 1996 | Transplant. Proc. | pmid:8623486 |
| Merli M et al. | Conversion from twice-daily to once-daily tacrolimus administration in liver transplant patient. | 2010 | Transplant. Proc. | pmid:20534292 |
| Gerber DA et al. | Immunosuppressive agents: recent developments in molecular action and clinical application. | 1998 | Transplant. Proc. | pmid:9636637 |
| Burg M et al. | Enteric-coated mycophenolate sodium reduces gastrointestinal symptoms in renal transplant patients. | 2009 | Transplant. Proc. | pmid:20005359 |
| Fan Y et al. | Tacrolimus versus cyclosporine for adult lung transplant recipients: a meta-analysis. | 2009 | Transplant. Proc. | pmid:19545736 |
| Yamazaki R et al. | Interindividual variation of maximal blood levels of tacrolimus after its oral administration in hematopoietic cell transplant recipients. | 2009 | Transplant. Proc. | pmid:19545738 |
| Xu M et al. | Effect of peritransplant FTY720 alone or in combination with posttransplant FK 506 in a rat model of cardiac allotransplantation. | 1997 | Transplant. Proc. | pmid:9365631 |
| Spada M et al. | Monitoring of intestinal myoelectrical activity after isolated small bowel transplantation in FK 506 immunosuppressed pigs. | 1994 | Transplant. Proc. | pmid:7518141 |
| Ziolkowski J et al. | Renal function after liver transplantation: calcineurin inhibitor nephrotoxicity. | 2003 | Transplant. Proc. | pmid:14529923 |
| Foroncewicz B et al. | Anti-CD25 and tacrolimus therapy may not prevent early primary biliary cirrhosis recurrence after liver transplantation: two case reports. | 2003 | Transplant. Proc. | pmid:14529924 |
| Reggiani P et al. | A "steroid-free" tacrolimus and low-dose mycophenolate mofetil primary immunosuppression does not prevent early acute rejection after liver transplantation. | 2005 | Transplant. Proc. | pmid:15919435 |
| Yasunami Y et al. | Induction of donor-specific unresponsiveness in rat islet allografts by FK 506. | 1992 | Transplant. Proc. | pmid:1376510 |
| Martinez OM et al. | Molecular markers of Epstein-Barr virus infection in the circulation of transplant recipients. | 1995 | Transplant. Proc. | pmid:7533372 |
| Moreno Gonzales M et al. | Sublingual Tacrolimus in Liver Transplantation: A Valid Option? | Transplant. Proc. | pmid:27569953 | |
| Kai N et al. | A study on the timing of immunologic priming in autoimmune insulitis in NOD mice. | 1992 | Transplant. Proc. | pmid:1376511 |
| Kim SW et al. | Decreased formation of nitric oxide in rats treated with FK506. | 2003 | Transplant. Proc. | pmid:12591357 |
| Motta I et al. | FK 506 favors the generation of memory T cells in vitro. | 1991 | Transplant. Proc. | pmid:1721324 |
| Isai H et al. | FK 506 and orthotopic liver transplantation in the rat. | 1990 | Transplant. Proc. | pmid:1699329 |
| Nakata S et al. | Immunosuppressive effect of FK 506 on cytotoxic T lymphocytes and delayed-type hypersensitivity in rats. | 1991 | Transplant. Proc. | pmid:1721325 |
| Ennaifer R et al. | Nodular hyperplasia of the gastrointestinal tract after liver transplantation: role of immunosuppressive therapy? A case report. | 2015 | Transplant. Proc. | pmid:25891739 |
| Jonas S et al. | Cyclosporine-based quadruple induction therapy versus tacrolimus-based dual immunosuppression after liver transplantation: ten-year follow-up. | 2002 | Transplant. Proc. | pmid:12176459 |
| Tsuchida Y et al. | Vascularized bone marrow allotransplantation in rats prolongs a simultaneous skin allograft. | 1997 | Transplant. Proc. | pmid:9142252 |
| Wasiak D et al. | Delayed, Uncommon Recurrence of Hepatocellular Carcinoma After Liver Transplantation: A Case Report. | 2016 | Transplant. Proc. | pmid:27496507 |
| Orlandi V et al. | Tacrolimus-associated myositis: a case report in a renal transplant patient. | 2004 | Transplant. Proc. | pmid:15110639 |
| Pohanka E et al. | Improved attainment of NKF classified lipid target levels after conversion from cyclosporine to tacrolimus in renal graft recipients. | 2005 | Transplant. Proc. | pmid:15919490 |
| Woodside KJ et al. | Conversion from cyclosporine to tacrolimus results in improved creatinine but does not alter lipid profile. | 2005 | Transplant. Proc. | pmid:15919491 |
| Shapiro R et al. | A prospective, randomized trial of FK 506/prednisone vs FK 506/azathioprine/prednisone in renal transplant patients. | 1995 | Transplant. Proc. | pmid:7533432 |
| Winkler M et al. | Comparison of plasma vs whole blood as matrix for FK 506 drug level monitoring. | 1995 | Transplant. Proc. | pmid:7533433 |
| Whiteside TL et al. | Serial monitoring of immunologic function and phenotype of lymphocytes in the blood of transplanted patients randomized to cyclosporine or FK 506. | 1991 | Transplant. Proc. | pmid:1721356 |
| Fischereder M et al. | Gynaecomastia following solid organ transplantation. | 2002 | Transplant. Proc. | pmid:12270376 |
| Budde K et al. | Five year outcome of tacrolimus rescue therapy in late rejection after renal transplantation. | 2002 | Transplant. Proc. | pmid:12176499 |
| Takahara S et al. | Excellent results following 3 years of tacrolimus immunosuppression in kidney transplantation recipients in Japan: overall analysis of more than 1000 patients. | 2002 | Transplant. Proc. | pmid:12176500 |
| Shu KH et al. | A multicenter trial of FK506 as rescue therapy for renal transplant recipients in Taiwan. | 1998 | Transplant. Proc. | pmid:9838570 |
| Lo CM et al. | Use of FK506 as primary or rescue therapy after liver transplantation in Hong Kong. | 1998 | Transplant. Proc. | pmid:9838571 |
| Bennett WM | Renal complications after heart transplantation. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083019 |
| Reichenspurner H et al. | Tacrolimus-based immunosuppressive protocols in lung transplantation. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083062 |
| Ko S et al. | Predominant role of local immunosuppressive effect in enhanced efficacy of liposomal FK506 in organ transplantation. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123117 |
| Khanna A et al. | Cardiac changes at autopsy in adult liver transplant recipients under tacrolimus. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123118 |
| Rao AS et al. | Augmentation of natural chimerism with donor bone marrow in orthotopic liver recipients. | 1996 | Transplant. Proc. | pmid:8908140 |
| Alper G and Small SL | Cerebrospinal fluid after organ transplantation. | 1996 | Transplant. Proc. | pmid:8908142 |
| Kim YI et al. | FK 506 prevents critical warm ischemia damage to the pig liver and improves hepatic microcirculation. | 1994 | Transplant. Proc. | pmid:7520636 |
| Sanghvi A et al. | Increased cyclosporine uptake by cells pretreated with FK506 and evidence for binding of both drugs to a common intracellular protein. | 1989 | Transplant. Proc. | pmid:2468204 |
| Winkler M et al. | Association of elevated FK 506 plasma levels with nephrotoxicity in liver-grafted patients. | 1991 | Transplant. Proc. | pmid:1721389 |
| Takagishi K et al. | Effects of FK-506 on collagen arthritis in mice. | 1989 | Transplant. Proc. | pmid:2468205 |
| Schmidt RJ et al. | Hemolytic-uremic syndrome in a renal transplant recipient on FK 506 immunosuppression. | 1991 | Transplant. Proc. | pmid:1721390 |
| Paul LC | Overview of side effects of immunosuppressive therapy. | 2001 | Transplant. Proc. | pmid:11377462 |
| Rodrigo E et al. | Histopathological findings according to Banff-97 classification system comparing tacrolimus versus cyclosporine. | 2002 | Transplant. Proc. | pmid:12176550 |
| Jordán de Luna C et al. | Pharmacogenetic study of ABCB1 and CYP3A5 genes during the first year following heart transplantation regarding tacrolimus or cyclosporine levels. | 2011 Jul-Aug | Transplant. Proc. | pmid:21839244 |
| Elinav H et al. | Plasma oxidizability and plasma carbonyls, markers of oxidative stress, in liver transplant patients. | 2001 | Transplant. Proc. | pmid:11543789 |
| Opelz G | Immunosuppression with FK 506 does not improve kidney graft survival. Collaborative Transplant Study. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083513 |
| Troppmann C et al. | FK 506 versus cyclosporine A for steroid-free synergistic combination therapy with rapamycin in a discordant large animal donor xenoislet transplant model. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123585 |
| Braun N et al. | Impairment of renal function following liver transplantation. | 2003 | Transplant. Proc. | pmid:12826191 |
| Meloni F et al. | Monocyte chemoattractant protein-1 levels in bronchoalveolar lavage fluid of lung-transplanted patients treated with tacrolimus as rescue treatment for refractory acute rejection. | 2003 | Transplant. Proc. | pmid:12826211 |
| Cooper MH et al. | The induction of pseudo-graft-versus-host disease following syngeneic bone marrow transplantation using FK 506. | 1991 | Transplant. Proc. | pmid:1721419 |
| Yagura K et al. | Pharmacokinetic characteristics of two types of liposomal FK 506. | 1996 | Transplant. Proc. | pmid:8658708 |
| Taber DJ et al. | Drug-drug interaction between chloramphenicol and tacrolimus in a liver transplant recipient. | 2000 | Transplant. Proc. | pmid:10812156 |
| Soran A et al. | Renal retransplantation in elderly recipients under tacrolimus-based immunosuppression. | 2000 | Transplant. Proc. | pmid:10812157 |
| El-Sabrout R et al. | Sirolimus in combination with tacrolimus or mycophenolate mofetil for minimizing acute rejection risk in renal transplant recipients--a single center experience. | 2003 | Transplant. Proc. | pmid:12742474 |
| Formica RN et al. | Sirolimus-based immunosuppression with reduce dose cyclosporine or tacrolimus after renal transplantation. | 2003 | Transplant. Proc. | pmid:12742475 |
| Baran DA et al. | Can initial tacrolimus trough levels be predicted from clinical variables? | 2004 | Transplant. Proc. | pmid:15621157 |
| Filler G et al. | One-year glomerular filtration rate predicts graft survival in pediatric renal recipients: a randomized trial of tacrolimus vs cyclosporine microemulsion. | 2002 | Transplant. Proc. | pmid:12176634 |
| Hasegawa A et al. | Optimal use of tacrolimus in living donor renal transplantation in children. | 2002 | Transplant. Proc. | pmid:12176635 |
| Glanemann M et al. | Mycophenolate mofetil is superior in combination with tacrolimus compared to cyclosporine for immunosuppressive therapy after liver transplantation. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267194 |
| van den Berg AP et al. | Prediction of the inhibition of IL-2 production by calcineurin inhibitors. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267197 |
| Otto C et al. | Selective immunosuppression with FK 506, anti-IL-2R, and anti-ICAM-1 monoclonal antibodies: contrasting effects after liver and small bowel transplantation in rats. | 1998 | Transplant. Proc. | pmid:9723426 |
| Chen H et al. | Combined effect of rapamycin and FK 506 in prolongation of small bowel graft survival in the mouse. | 1998 | Transplant. Proc. | pmid:9745497 |
| Matevossian E et al. | Nitric oxide inhibition and consecutive Aspisol application show a prolonged survival of orthotopic transplanted livers in a rat model. | 2008 | Transplant. Proc. | pmid:18555092 |
| Neff GW et al. | Sirolimus therapy in orthotopic liver transplant recipients with calcineurin inhibitor related chronic renal insufficiency. | 2003 | Transplant. Proc. | pmid:14697970 |
| Thomson AW et al. | Influence of FK 506 on T lymphocytes, Langerhans' cells and the expression of cytokine receptors and adhesion molecules in psoriatic skin lesions: a preliminary study. | 1991 | Transplant. Proc. | pmid:1721452 |
| Mohsin N et al. | Low tacrolimus dose requirements in renal transplant recipients in the omani population: implications for pharmacogenetics? | 2005 | Transplant. Proc. | pmid:16213259 |
| Todo S et al. | Effect of FK506 in experimental organ transplantation. | 1988 | Transplant. Proc. | pmid:2450416 |
| Mehra MR et al. | Racial differences in clinical outcome using tacrolimus and mycophenolate mofetil immunosuppression in heart transplantation. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267442 |
| Yura H et al. | Development of a macromolecular prodrug of FK 506: II: In vitro study for FK 506-dextran conjugate. | 1998 | Transplant. Proc. | pmid:9636416 |
| Wu J et al. | Comparative immunoregulatory effects of rapamycin, FK 506 and cyclosporine on mitogen-induced cytokine production and lymphoproliferation. | 1991 | Transplant. Proc. | pmid:1703683 |
| Yoshimura R et al. | A comparative study between cyclosporine and FK 506 effects on renal microsomal P-450. | 1991 | Transplant. Proc. | pmid:1703686 |
| Hartwig T et al. | Low-dose sirolimus and tacrolimus in kidney transplantation: first results of a single-center experience. | 2001 Nov-Dec | Transplant. Proc. | pmid:11750383 |