tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Alak AM et al. | An HPLC/MS/MS assay for tacrolimus in patient blood samples. Correlation with results of an ELISA assay. | 1997 | J Pharm Biomed Anal | pmid:9447546 |
| Butcher SP et al. | Neuroprotective actions of FK506 in experimental stroke: in vivo evidence against an antiexcitotoxic mechanism. | 1997 | J. Neurosci. | pmid:9278529 |
| Singh N et al. | Predictors and outcome of early- versus late-onset major bacterial infections in liver transplant recipients receiving tacrolimus (FK506) as primary immunosuppression. | 1997 | Eur. J. Clin. Microbiol. Infect. Dis. | pmid:9447904 |
| Hohage H et al. | Effects of cyclosporin A and FK 506 on lipid metabolism and fibrinogen in kidney transplant recipients. | 1997 | Clin Transplant | pmid:9193847 |
| Gold BG et al. | A nonimmunosuppressant FKBP-12 ligand increases nerve regeneration. | 1997 | Exp. Neurol. | pmid:9344552 |
| Katari SR et al. | Clinical features of acute reversible tacrolimus (FK 506) nephrotoxicity in kidney transplant recipients. | 1997 | Clin Transplant | pmid:9193849 |
| Ciancio G et al. | Post-transplant lymphoproliferative disease in kidney transplant patients in the new immunosuppressive era. | 1997 | Clin Transplant | pmid:9193850 |
| Jindal RM | Post-transplant hyperlipidaemia. | 1997 | Postgrad Med J | pmid:9497947 |
| Koneru B et al. | Blood transfusions in liver recipients: a conundrum or a clear benefit in the cyclosporine/tacrolimus era? | 1997 | Transplantation | pmid:9197350 |
| Cameron AM et al. | FKBP12 binds the inositol 1,4,5-trisphosphate receptor at leucine-proline (1400-1401) and anchors calcineurin to this FK506-like domain. | 1997 | J. Biol. Chem. | pmid:9346894 |
| Sugitani A et al. | En bloc pancreas and kidney transplantation in a patient with limited vascular access. | 1997 | Transplantation | pmid:9197366 |
| Hosoi R et al. | Isoform-specific up-regulation by ouabain of Na+,K+-ATPase in cultured rat astrocytes. | 1997 | J. Neurochem. | pmid:9349566 |
| Guerini D | Calcineurin: not just a simple protein phosphatase. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9199180 |
| Krüger M et al. | Inhibition of CREB- and cAMP response element-mediated gene transcription by the immunosuppressive drugs cyclosporin A and FK506 in T cells. | 1997 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:9349628 |
| Rouviere N et al. | Immunosuppressor binding to the immunophilin FKBP59 affects the local structural dynamics of a surface beta-strand: time-resolved fluorescence study. | 1997 | Biochemistry | pmid:9200682 |
| Prokisch H et al. | Impairment of calcineurin function in Neurospora crassa reveals its essential role in hyphal growth, morphology and maintenance of the apical Ca2+ gradient. | 1997 | Mol. Gen. Genet. | pmid:9349701 |
| Alak AM | Measurement of tacrolimus (FK506) and its metabolites: a review of assay development and application in therapeutic drug monitoring and pharmacokinetic studies. | 1997 | Ther Drug Monit | pmid:9200777 |
| Saitoh O et al. | Cyclosporine A inhibits interleukin-8 production in a human colon epithelial cell line (HT-29). | 1997 | J. Gastroenterol. | pmid:9349985 |
| Kageyama M et al. | FK506-binding proteins regulate smooth muscle contractility by altering neurotransmitter release. | 1997 | Eur. J. Pharmacol. | pmid:9314039 |
| de Paulis A et al. | Human synovial mast cells. II. Heterogeneity of the pharmacologic effects of antiinflammatory and immunosuppressive drugs. | 1997 | Arthritis Rheum. | pmid:9082935 |
| Yasutomi M et al. | Evaluation of tetrahydropyranyladriamycin as an immunosuppressant in concordant xenotransplantation. | 1997 | J. Heart Lung Transplant. | pmid:9087871 |
| Kitagaki K et al. | Facilitation of apoptosis by cyclosporins A and H, but not FK506 in mouse bronchial eosinophils. | 1997 | Eur. J. Pharmacol. | pmid:9430427 |
| Morrissey PE et al. | Correlation of clinical outcomes after tacrolimus conversion for resistant kidney rejection or cyclosporine toxicity with pathologic staging by the Banff criteria. | 1997 | Transplantation | pmid:9089224 |
| Midtvedt K et al. | Successful pregnancies in a combined pancreas and renal allograft recipient and in a renal graft recipient on tacrolimus treatment. | 1997 | Nephrol. Dial. Transplant. | pmid:9430893 |
| Kiuchi T et al. | A hepatic graft tuberculosis transmitted from a living-related donor. | 1997 | Transplantation | pmid:9089234 |
| Paterson DL and Singh N | Interactions between tacrolimus and antimicrobial agents. | 1997 | Clin. Infect. Dis. | pmid:9431391 |
| Krämer BK and Schweda F | Differing proteinuria control with cyclosporin and tacrolimus. | 1997 | Lancet | pmid:9093272 |
| Openshaw H | Peripheral neuropathy after bone marrow transplantation. | 1997 | Biol. Blood Marrow Transplant. | pmid:9360782 |
| Maurer M et al. | Hair growth modulation by topical immunophilin ligands: induction of anagen, inhibition of massive catagen development, and relative protection from chemotherapy-induced alopecia. | 1997 | Am. J. Pathol. | pmid:9094998 |
| Rinaldi M et al. | FK506 effectiveness in reducing acute rejection after heart transplantation: a prospective randomized study. | 1997 | J. Heart Lung Transplant. | pmid:9361242 |
| Steiner JP et al. | Neurotrophic actions of nonimmunosuppressive analogues of immunosuppressive drugs FK506, rapamycin and cyclosporin A. | 1997 | Nat. Med. | pmid:9095176 |
| Nakai A et al. | The immunosuppressant drug FK506 ameliorates secondary mitochondrial dysfunction following transient focal cerebral ischemia in the rat. | 1997 | Neurobiol. Dis. | pmid:9361306 |
| Reyes J et al. | Graft-versus-host disease after liver and small bowel transplantation in a child. | 1997 | Clin Transplant | pmid:9361921 |
| Blau CA et al. | A proliferation switch for genetically modified cells. | 1997 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9096348 |
| Neu AM et al. | Evaluation of neurotoxicity in pediatric renal transplant recipients treated with tacrolimus (FK506). | 1997 | Clin Transplant | pmid:9361932 |
| Garcia-Morales R et al. | The effects of chimeric cells following donor bone marrow infusions as detected by PCR-flow assays in kidney transplant recipients. | 1997 | J. Clin. Invest. | pmid:9062371 |
| Xenos EX et al. | The use of tacrolimus as induction and maintenance immunosuppression in renal cadaveric transplant recipients over the age of 60. | 1997 | Clin Transplant | pmid:9361949 |
| Göthel SF et al. | An internal FK506-binding domain is the catalytic core of the prolyl isomerase activity associated with the Bacillus subtilis trigger factor. | 1997 | Eur. J. Biochem. | pmid:9063446 |
| Karlsson H and Nässberger L | FK506 suppresses the mitogen-induced increase in lymphocyte adhesiveness to endothelial cells, but does not affect endothelial cell activation in response to inflammatory stimuli. | 1997 | Transplantation | pmid:9355847 |
| Ishida H et al. | Cataract development induced by repeated oral dosing with FK506 (tacrolimus) in adult rats. | 1997 | Toxicology | pmid:9355935 |
| Wang JH and Kelly PT | Attenuation of paired-pulse facilitation associated with synaptic potentiation mediated by postsynaptic mechanisms. | 1997 | J. Neurophysiol. | pmid:9356420 |
| Lee JW et al. | Tacrolimus (FK506): validation of a sensitive enzyme-linked immunosorbent assay kit for and application to a clinical pharmacokinetic study. | 1997 | Ther Drug Monit | pmid:9108651 |
| Thyagarajan GK et al. | FK506-induced fulminant leukoencephalopathy after single-lung transplantation. | 1997 | Ann. Thorac. Surg. | pmid:9386723 |
| Holt DW and Johnston A | Tacrolimus quality assessment. | 1997 | Ther Drug Monit | pmid:9108659 |
| Wang MS et al. | Comparative dose-dependence study of FK506 and cyclosporin A on the rate of axonal regeneration in the rat sciatic nerve. | 1997 | J. Pharmacol. Exp. Ther. | pmid:9262378 |
| McElwee KJ et al. | Topical FK506: a potent immunotherapy for alopecia areata? Studies using the Dundee experimental bald rat model. | 1997 | Br. J. Dermatol. | pmid:9390322 |
| Pirsch JD et al. | A comparison of tacrolimus (FK506) and cyclosporine for immunosuppression after cadaveric renal transplantation. FK506 Kidney Transplant Study Group. | 1997 | Transplantation | pmid:9112351 |
| Zhang Q et al. | A specific method for the measurement of tacrolimus in human whole blood by liquid chromatography/tandem mass spectrometry. | 1997 | Ther Drug Monit | pmid:9263391 |
| Huang J and Schreiber SL | A yeast genetic system for selecting small molecule inhibitors of protein-protein interactions in nanodroplets. | 1997 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9391035 |
| Hikita N et al. | Use of topical FK506 in a corneal graft rejection model in Lewis rats. | 1997 | Invest. Ophthalmol. Vis. Sci. | pmid:9112986 |
| Hickman PE et al. | Clinical chemistry and post-liver-transplant monitoring. | 1997 | Clin. Chem. | pmid:9265907 |
| Nyanguile O et al. | A nonnatural transcriptional coactivator. | 1997 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9391036 |
| Aicher L et al. | Decrease in kidney calbindin-D 28kDa as a possible mechanism mediating cyclosporine A- and FK-506-induced calciuria and tubular mineralization. | 1997 | Biochem. Pharmacol. | pmid:9113092 |
| Paterson DL et al. | Could a herpesvirus mimic tacrolimus-induced leukoencephalopathy? | 1997 | Ann. Neurol. | pmid:9266742 |
| Kageyama S et al. | Augmentation of natural killer cell activity induced by cytomegalovirus infection in mice treated with FK506. | 1997 | Acta Virol. | pmid:9391652 |
| Ahsan N et al. | Successful reversal of acute vascular rejection in a renal allograft with combined mycophenolate mofetil and tacrolimus as primary immunotherapy. | 1997 | Clin Transplant | pmid:9113443 |
| Yoshimoto T et al. | [Leukoencephalopathy probably caused by tacrolimus hydrate after stem cell transplantation in a girl with MDS 7 monosomy]. | 1997 | Rinsho Ketsueki | pmid:9267167 |
| Sokal EM et al. | Early signs and risk factors for the increased incidence of Epstein-Barr virus-related posttransplant lymphoproliferative diseases in pediatric liver transplant recipients treated with tacrolimus. | 1997 | Transplantation | pmid:9392308 |
| Singh N et al. | Invasive fungal infections in liver transplant recipients receiving tacrolimus as the primary immunosuppressive agent. | 1997 | Clin. Infect. Dis. | pmid:9114144 |
| Alessiani M et al. | [Flexibility of the surgical model of intestinal transplantation in swine]. | 1997 | Minerva Chir | pmid:9432575 |
| Ito E and Tanaka Y | Influences of immunosuppressive agents, FK506 and cyclosporin on systemic Candida albicans infection in mice. | 1997 | Mycopathologia | pmid:9433807 |
| Boucek MM et al. | The Registry of the International Society of Heart and Lung Transplantation: first official pediatric report--1997. | 1997 | J. Heart Lung Transplant. | pmid:9436131 |
| Hossain MA et al. | Immunosuppression in auxiliary partial liver transplantation with FK506 in rats. | 1997 | Transplant. Proc. | pmid:9414861 |
| Weber M et al. | Decreased rejection episodes in African-American renal transplant recipients receiving mycophenolate mofetil/tacrolimus therapy. | 1997 | Transplant. Proc. | pmid:9414883 |
| Scantlebury VP et al. | Outcome of kidney transplantation in African-Americans using tacrolimus. | 1997 | Transplant. Proc. | pmid:9414906 |
| Gruessner RW et al. | Solitary pancreas transplantation for nonuremic patients with labile insulin-dependent diabetes mellitus. | 1997 | Transplantation | pmid:9415558 |
| Lang T et al. | Cholic acid synthesis is reduced in pediatric liver recipients during graft dysfunction due to ischemic injury and allograft rejection. | 1997 | Transplantation | pmid:9415561 |
| Marienfeld R et al. | Cyclosporin A interferes with the inducible degradation of NF-kappa B inhibitors, but not with the processing of p105/NF-kappa B1 in T cells. | 1997 | Eur. J. Immunol. | pmid:9247567 |
| Massicot F et al. | Modulation of energy status and cytotoxicity induced by FK506 and cyclosporin A in a renal epithelial cell line. | 1997 | Arch. Toxicol. | pmid:9248632 |
| Talbot D et al. | Alopecia as a consequence of tacrolimus therapy in renal transplantation? | 1997 | Transplantation | pmid:9415574 |
| Newstead CG | Tacrolimus in renal transplantation. | 1997 | Nephrol. Dial. Transplant. | pmid:9249761 |
| Neuhaus P et al. | Tacrolimus-based immunosuppression after liver transplantation: a randomised study comparing dual versus triple low-dose oral regimens. | 1997 | Transpl. Int. | pmid:9249934 |
| Dhawan A et al. | Tacrolimus (FK506) malabsorption: management with fluconazole coadministration. | 1997 | Transpl. Int. | pmid:9249946 |
| Nagai H et al. | FK-506 and cyclosporin A potentiate the IgE antibody production by contact sensitization with hapten in mice. | 1997 | J. Pharmacol. Exp. Ther. | pmid:9336339 |
| Seifeldin RA et al. | Nifedipine interaction with tacrolimus in liver transplant recipients. | 1997 | Ann Pharmacother | pmid:9161650 |
| Ballantyne CM et al. | Pathophysiology and treatment of lipid perturbation after cardiac transplantation. | 1997 | Curr. Opin. Cardiol. | pmid:9192484 |
| Gruessner RW and Sharp HL | Living-related intestinal transplantation: first report of a standardized surgical technique. | 1997 | Transplantation | pmid:9415566 |
| Holt DW and Johnston A | Monitoring new immunosuppressive agents. Are the methods adequate? | 1997 | Drug Metabol Drug Interact | pmid:9713574 |
| Shapiro R et al. | Reversibility of tacrolimus-induced posttransplant diabetes: an illustrative case and review of the literature. | 1997 | Transplant. Proc. | pmid:9290809 |
| Shaw LM | Mycophenolate mofetil: pharmacokinetic strategies for optimizing immunosuppression. | 1997 | Drug Metabol Drug Interact | pmid:9713576 |
| Ilan Y et al. | Transient immunosuppression with FK506 permits long-term expression of therapeutic genes introduced into the liver using recombinant adenoviruses in the rat. | 1997 | Hepatology | pmid:9328318 |
| Vella JP and Sayegh MH | Maintenance pharmacological immunosuppressive strategies in renal transplantation. | 1997 | Postgrad Med J | pmid:9338020 |
| Gruessner AC and Sutherland DE | Pancreas transplants for United States (US) and non-US cases as reported to the International Pancreas Transplant Registry (IPTR) and to the United Network for Organ Sharing (UNOS). | 1997 | Clin Transpl | pmid:9919390 |
| Ericzon BG et al. | Secretion and composition of bile after human liver transplantation: studies on the effects of cyclosporine and tacrolimus. | 1997 | Transplantation | pmid:9000664 |
| Odorico JS et al. | Advances in pancreas transplantation: the University of Wisconsin experience. | 1997 | Clin Transpl | pmid:9919400 |
| Kelly PA et al. | Ciprofloxacin does not block the antiproliferative effect of tacrolimus. | 1997 | Transplantation | pmid:9000686 |
| Nair SC et al. | Molecular cloning of human FKBP51 and comparisons of immunophilin interactions with Hsp90 and progesterone receptor. | 1997 | Mol. Cell. Biol. | pmid:9001212 |
| Pirenne J et al. | Donor-specific unmodified bone marrow transfusion does not facilitate intestinal engraftment after bowel transplantation in a porcine model. | 1997 | Surgery | pmid:9001555 |
| Felldin M et al. | Rescue therapy with tacrolimus (FK 506) in renal transplant recipients--a Scandinavian multicenter analysis. | 1997 | Transpl. Int. | pmid:9002146 |
| Steiner JP et al. | Neurotrophic immunophilin ligands stimulate structural and functional recovery in neurodegenerative animal models. | 1997 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9050897 |
| Seidel ER and Ragan VL | Inhibition by rapamycin of ornithine decarboxylase and epithelial cell proliferation in intestinal IEC-6 cells in culture. | 1997 | Br. J. Pharmacol. | pmid:9051292 |
| Aoki Y and Kao PN | Cyclosporin A-sensitive calcium signaling represses NFkappaB activation in human bronchial epithelial cells and enhances NFkappaB activation in Jurkat T-cells. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9177287 |
| Prasad NV et al. | Metabolism of tacrolimus (FK 506) in rat liver microsomes. Effect of rifampin and dexamethasone. | 1997 | Res. Commun. Mol. Pathol. Pharmacol. | pmid:9178371 |
| Alak AM and Moy S | Biological activity of tacrolimus (FK506) and its metabolites from whole blood of kidney transplant patients. | 1997 | Transplant. Proc. | pmid:9270821 |
| Scholler G et al. | Comparison of cyclosporine A and FK506 with regard to complaints and psychosocial characteristics before and after liver transplantation. | 1997 | Transplant. Proc. | pmid:9270822 |
| Pichlmayr R et al. | Three-year follow-up of the European Multicenter Tacrolimus (FK506) Liver Study. | 1997 | Transplant. Proc. | pmid:9270825 |
| Rolfe FG et al. | Cyclosporin A and FK506 reduce interleukin-5 mRNA abundance by inhibiting gene transcription. | 1997 | Am. J. Respir. Cell Mol. Biol. | pmid:9271313 |
| ten Berge RJ and Schellekens PT | [Immunology in clinical practice. VI. Current immunosuppressive drugs]. | 1997 | Ned Tijdschr Geneeskd | pmid:9550813 |
| Mayer AD et al. | Multicenter randomized trial comparing tacrolimus (FK506) and cyclosporine in the prevention of renal allograft rejection: a report of the European Tacrolimus Multicenter Renal Study Group. | 1997 | Transplantation | pmid:9275110 |
| Guérette B et al. | Prevention by anti-LFA-1 of acute myoblast death following transplantation. | 1997 | J. Immunol. | pmid:9278346 |