tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Slocum AMY | A surgeon's nightmare: pyoderma gangrenosum with pathergy effect mimicking necrotising fasciitis. | 2017 | BMJ Case Rep | pmid:29269363 |
| Wiebe C et al. | Class II Eplet Mismatch Modulates Tacrolimus Trough Levels Required to Prevent Donor-Specific Antibody Development. | 2017 | J. Am. Soc. Nephrol. | pmid:28729289 |
| Tolkachjov SN et al. | Frontal fibrosing alopecia among men: AÂ clinicopathologic study of 7 cases. | 2017 | J. Am. Acad. Dermatol. | pmid:28716436 |
| Ahn SW et al. | A multicenter prospective observational study on the safety and efficacy of tacrolimus in patients with myasthenia gravis. | 2017 | J. Neurol. Sci. | pmid:28716258 |
| Savić V et al. | Tacrolimus loaded biocompatible lecithin-based microemulsions with improved skin penetration: Structure characterization and in vitro/in vivo performances. | 2017 | Int J Pharm | pmid:28711641 |
| Montenovo MI et al. | Superior Patient and Graft Survival in Adult Liver Transplant with Rabbit Antithymocyte Globulin Induction: Experience with 595 Patients. | 2017 | Exp Clin Transplant | pmid:27309029 |
| Berisa Prado S et al. | Topical Tacrolimus for Corneal Subepithelial Infiltrates Secondary to Adenoviral Keratoconjunctivitis. | 2017 | Cornea | pmid:28704319 |
| Lloberas N et al. | The combination of CYP3A4*22 and CYP3A5*3 single-nucleotide polymorphisms determines tacrolimus dose requirement after kidney transplantation. | 2017 | Pharmacogenet. Genomics | pmid:28704257 |
| Groll AH et al. | Pharmacokinetic Assessment of Drug-Drug Interactions of Isavuconazole With the Immunosuppressants Cyclosporine, Mycophenolic Acid, Prednisolone, Sirolimus, and Tacrolimus in Healthy Adults. | 2017 | Clin Pharmacol Drug Dev | pmid:27273343 |
| Hirai T et al. | The effectiveness of new triple combination therapy using synthetic disease-modifying anti-rheumatic drugs with different pharmacological function against rheumatoid arthritis: the verification by an in vitro and clinical study. | 2017 | Clin. Rheumatol. | pmid:27783236 |
| Solmaz S et al. | Tacrolimus-Induced Diabetic Ketoacidosis After Allogeneic Bone Marrow Transplant. | 2017 | Exp Clin Transplant | pmid:26643544 |
| Wei L et al. | Therapeutic Effects of FK506 on IgA Nephropathy Rat. | 2017 | Kidney Blood Press. Res. | pmid:29179182 |
| Fox BD et al. | Tacrolimus Levels Are Not Associated with Risk of Malignancy in Lung Transplant Recipients. | 2017 | Ann. Transplant. | pmid:29133776 |
| Das B et al. | Alemtuzumab (Campath-1H) therapy for refractory rejections in pediatric heart transplant recipients. | 2017 | Pediatr Transplant | pmid:27862703 |
| Kita K and Mano Y | Application of volumetric absorptive microsampling device for quantification of tacrolimus in human blood as a model drug of high blood cell partition. | 2017 | J Pharm Biomed Anal | pmid:28601765 |
| Abongwa C et al. | Successful treatment of tacrolimus-related pure red cell aplasia and autoimmune hemolytic anemia with rituximab in a pediatric cardiac transplant patient. | 2017 | Pediatr Blood Cancer | pmid:28598573 |
| Wu Z et al. | FOXP3 rs3761548 polymorphism is associated with tacrolimus-induced acute nephrotoxicity in renal transplant patients. | 2017 | Eur. J. Clin. Pharmacol. | pmid:27747372 |
| Tamashiro EY et al. | Influence of CYP3A4 and CYP3A5 polymorphisms on tacrolimus and sirolimus exposure in stable kidney transplant recipients. | 2017 | Drug Metab Pers Ther | pmid:28593920 |
| Srinivas NR | Letter: sublingual dosing of tacrolimus in transplant patients-interesting concept to overcome first pass effects. | 2017 | Aliment. Pharmacol. Ther. | pmid:28589592 |
| BenÃtez C et al. | Letter: sublingual dosing of tacrolimus in transplant patients-interesting concept to overcome first pass effects. Authors' reply. | 2017 | Aliment. Pharmacol. Ther. | pmid:28589580 |
| Weidinger S et al. | A 5-year randomized trial on the safety and efficacy of pimecrolimus in atopic dermatitis: a critical appraisal. | 2017 | Br. J. Dermatol. | pmid:28868633 |
| Sharma N et al. | Myositis-associated Interstitial Lung Disease: Predictors of Failure of Conventional Treatment and Response to Tacrolimus in a US Cohort. | 2017 | J. Rheumatol. | pmid:28864644 |
| Charman C | A 5-year randomized trial on the safety and efficacy of pimecrolimus in atopic dermatitis: a critical appraisal - comment. | 2017 | Br. J. Dermatol. | pmid:28858382 |
| Yu Y et al. | Tacrolimus downregulates inflammation by regulating pro‑/anti‑inflammatory responses in LPS‑induced keratitis. | 2017 | Mol Med Rep | pmid:28849181 |
| Shahidi M | Thrombosis and von Willebrand Factor. | 2017 | Adv. Exp. Med. Biol. | pmid:27628010 |
| Gerlach UA et al. | Intragraft and Systemic Immune Parameters Discriminating Between Rejection and Long-Term Graft Function in a Preclinical Model of Intestinal Transplantation. | 2017 | Transplantation | pmid:27607529 |
| Miller AK et al. | Transmission of Donor-Derived Breast Carcinoma as a Recurrent Mass in a Keratolimbal Allograft. | 2017 | Cornea | pmid:28476053 |
| Nakagawa K et al. | Immunosuppressive treatment using tacrolimus promotes pregnancy outcome in infertile women with repeated implantation failures. | 2017 | Am. J. Reprod. Immunol. | pmid:28466977 |
| Ramirez R et al. | Posterior Reversible Encephalopathy Syndrome After Orthotopic Heart Transplantation: A Case Report. | 2017 | Am J Case Rep | pmid:28465499 |
| Aguiar D et al. | Real-World Multicenter Experience of Immunosuppression Minimization Among 661 Liver Transplant Recipients. | 2017 | Ann. Transplant. | pmid:28461684 |
| Justice JA et al. | Disruption of K2.1 somato-dendritic clusters prevents the apoptogenic increase of potassium currents. | 2017 | Neuroscience | pmid:28461216 |
| Henderson CN et al. | Continuous Abdominal Irrigation for Treatment of Tertiary Peritonitis in the Immunosuppressed Patient after Solid Organ Transplant: A Novel Approach. | 2017 | Am Surg | pmid:28424115 |
| Chen B et al. | Efficacy and safety of tacrolimus treatment for neuromyelitis optica spectrum disorder. | 2017 | Sci Rep | pmid:28400553 |
| Woillard JB et al. | Population Pharmacokinetics and Bayesian Estimators for Refined Dose Adjustment of a New Tacrolimus Formulation in Kidney and Liver Transplant Patients. | 2017 | Clin Pharmacokinet | pmid:28389935 |
| Koguchi-Yoshioka H et al. | Intravenous immunoglobulin contributes to the control of antimelanoma differentiation-associated protein 5 antibody-associated dermatomyositis with palmar violaceous macules/papules. | 2017 | Br. J. Dermatol. | pmid:28346662 |
| Lu XF et al. | Use of a semi-physiological pharmacokinetic model to investigate the influence of itraconazole on tacrolimus absorption, distribution and metabolism in mice. | 2017 | Xenobiotica | pmid:27533047 |
| Zhang L et al. | Characterization of calcineurin from Cryptococcus humicola and the application of calcineurin in aluminum tolerance. | 2017 | BMC Biotechnol. | pmid:28356086 |
| O'Leary JG | Editorial: tacrolimus-how low can you go? | 2017 | Aliment. Pharmacol. Ther. | pmid:28589579 |
| Song K et al. | Engineering of the LysR family transcriptional regulator FkbR1 and its target gene to improve ascomycin production. | 2017 | Appl. Microbiol. Biotechnol. | pmid:28349163 |
| Chiasson VL et al. | Regulatory T-Cell Augmentation or Interleukin-17 Inhibition Prevents Calcineurin Inhibitor-Induced Hypertension in Mice. | 2017 | Hypertension | pmid:28584011 |
| Kodama S et al. | Tacrolimus-Induced Reversible Cerebral Vasoconstriction Syndrome with Delayed Multi-Segmental Vasoconstriction. | 2017 | J Stroke Cerebrovasc Dis | pmid:28342655 |
| Lichtenberg S et al. | The incidence of post-transplant cancer among kidney transplant recipients is associated with the level of tacrolimus exposure during the first year after transplantation. | 2017 | Eur. J. Clin. Pharmacol. | pmid:28342067 |
| Shoda W et al. | Calcineurin inhibitors block sodium-chloride cotransporter dephosphorylation in response to high potassium intake. | 2017 | Kidney Int. | pmid:28341239 |
| Wan T et al. | Effects of nanoparticles with hydrotropic nicotinamide on tacrolimus: permeability through psoriatic skin and antipsoriatic and antiproliferative activities. | 2017 | Int J Nanomedicine | pmid:28260894 |
| Bellon H et al. | The Effect of Immunosuppression on Airway Integrity. | 2017 | Transplantation | pmid:28471870 |
| Zhu J et al. | Granzyme B producing B-cells in renal transplant patients. | 2017 | Clin. Immunol. | pmid:28461110 |
| Marini BL et al. | Risk of graft-versus-host disease with rituximab-containing conditioning regimens in allogeneic hematopoietic stem cell transplant. | 2017 | J Oncol Pharm Pract | pmid:26970572 |
| Stojanovic J et al. | Immune Desensitization Allows Pediatric Blood Group Incompatible Kidney Transplantation. | 2017 | Transplantation | pmid:27463537 |
| Ferjani H et al. | Beneficial effects of mycophenolate mofetil on cardiotoxicity induced by tacrolimus in wistar rats. | 2017 | Exp. Biol. Med. (Maywood) | pmid:26582055 |
| Monaghan P et al. | The antimalarial action of FK506 and rapamycin: evidence for a direct effect on FK506-binding protein PfFKBP35. | 2017 | Parasitology | pmid:28274284 |
| Solari S et al. | Sublingual tacrolimus administration provides similar drug exposure to per-oral route employing lower doses in liver transplantation: a pilot study. | 2017 | Aliment. Pharmacol. Ther. | pmid:28261844 |
| Moes AD et al. | Chlorthalidone Versus Amlodipine for Hypertension in Kidney Transplant Recipients Treated With Tacrolimus: A Randomized Crossover Trial. | 2017 | Am. J. Kidney Dis. | pmid:28259499 |
| Terada Y et al. | Tacrolimus Triggers Transient Receptor Potential Vanilloid-1-Dependent Relapse of Pancreatitis-Related Pain in Mice. | 2017 | Pharmacology | pmid:28253495 |
| Basu B et al. | Long-term efficacy and safety of common steroid-sparing agents in idiopathic nephrotic children. | 2017 | Clin. Exp. Nephrol. | pmid:27108294 |
| Moiseev IS et al. | Pharmacokinetic comparison of cyclosporin A and tacrolimus in graft-versus-host disease prophylaxis. | 2017 | Ann. Hematol. | pmid:28343273 |
| Cui W et al. | Therapy of tacrolimus combined with corticosteroids in idiopathic membranous nephropathy. | 2017 | Braz. J. Med. Biol. Res. | pmid:28355356 |
| Tremblay S et al. | A Steady-State Head-to-Head Pharmacokinetic Comparison of All FK-506 (Tacrolimus) Formulations (ASTCOFF): An Open-Label, Prospective, Randomized, Two-Arm, Three-Period Crossover Study. | 2017 | Am. J. Transplant. | pmid:27340950 |
| Chakfe N | Commentary on "Tacrolimus Eluting Suture Inhibits Neointimal Hyperplasia: An Experimental In Vivo Study in Rats". | 2017 | Eur J Vasc Endovasc Surg | pmid:28169106 |
| Siponen M et al. | Topical tacrolimus, triamcinolone acetonide, and placebo in oral lichen planus: a pilot randomized controlled trial. | 2017 | Oral Dis | pmid:28168769 |
| Vanhove T et al. | Response to: 'Bodyweight-adjustments introduce significant correlations between CYP3A metrics and tacrolimus clearance'. | 2017 | Br J Clin Pharmacol | pmid:28168728 |
| Dobbels F et al. | Efficacy of a medication adherence enhancing intervention in transplantation: The MAESTRO-Tx trial. | 2017 | J. Heart Lung Transplant. | pmid:28162931 |
| Gao L et al. | Low incidence of acute graft-versus-host disease with short-term tacrolimus in haploidentical hematopoietic stem cell transplantation. | 2017 | Leuk. Res. | pmid:28273549 |
| Grant CR et al. | Immunosuppressive drugs affect interferon (IFN)-γ and programmed cell death 1 (PD-1) kinetics in patients with newly diagnosed autoimmune hepatitis. | 2017 | Clin. Exp. Immunol. | pmid:28257599 |
| Kaneshiro S et al. | The efficacy and safety of additional administration of tacrolimus in patients with rheumatoid arthritis who showed an inadequate response to tocilizumab. | 2017 | Mod Rheumatol | pmid:27181115 |
| Qiao M et al. | The Natural Course of Atopic Dermatitis and the Association with Asthma. | 2017 | Inflammation | pmid:28063089 |
| Aschauer C et al. | Positioning of Tacrolimus for the Treatment of Diabetic Nephropathy Based on Computational Network Analysis. | 2017 | PLoS ONE | pmid:28060893 |
| Qin HZ et al. | Evaluating tacrolimus treatment in idiopathic membranous nephropathy in a cohort of 408 patients. | 2017 | BMC Nephrol | pmid:28056860 |
| Kim D et al. | FK506, an Immunosuppressive Drug, Induces Autophagy by Binding to the V-ATPase Catalytic Subunit A in Neuronal Cells. | 2017 | J. Proteome Res. | pmid:28056508 |
| Dong Y et al. | Risk Factors, Clinical Features, and Treatment Outcomes of Recurrent Mooren Ulcers in China. | 2017 | Cornea | pmid:28060068 |
| de Oliveira JTP et al. | Variability index of tacrolimus serum levels in pediatric liver transplant recipients younger than 12Â years: Non-adherence or risk of non-adherence? | 2017 | Pediatr Transplant | pmid:29034612 |
| Kim YK et al. | New tablet formulation of tacrolimus with smaller interindividual variability may become a better treatment option than the conventional capsule formulation in organ transplant patients. | 2017 | Drug Des Devel Ther | pmid:29033547 |
| Noda K et al. | Tacrolimus-induced hypertrophic cardiomyopathy in a patient with dermatomyositis. | 2017 | Rheumatology (Oxford) | pmid:28977571 |
| Wang J et al. | Metabolic network model guided engineering ethylmalonyl-CoA pathway to improve ascomycin production in Streptomyces hygroscopicus var. ascomyceticus. | 2017 | Microb. Cell Fact. | pmid:28974216 |
| Ordóñez-Robles M et al. | Analysis of the Pho regulon in Streptomyces tsukubaensis. | 2017 | Microbiol. Res. | pmid:28942849 |
| Maneechote C et al. | Roles of mitochondrial dynamics modulators in cardiac ischaemia/reperfusion injury. | 2017 | J. Cell. Mol. Med. | pmid:28941171 |
| Jia Y et al. | Estimation of Mycophenolic Acid Area Under the Curve With Limited-Sampling Strategy in Chinese Renal Transplant Recipients Receiving Enteric-Coated Mycophenolate Sodium. | 2017 | Ther Drug Monit | pmid:27941535 |
| Cohen JB et al. | Belatacept Compared With Tacrolimus for Kidney Transplantation: A Propensity Score Matched Cohort Study. | 2017 | Transplantation | pmid:27941427 |
| Reese PP et al. | Automated Reminders and Physician Notification to Promote Immunosuppression Adherence Among Kidney Transplant Recipients: A Randomized Trial. | 2017 | Am. J. Kidney Dis. | pmid:27940063 |
| Shrestha BM | Two Decades of Tacrolimus in Renal Transplant: Basic Science and Clinical Evidences. | 2017 | Exp Clin Transplant | pmid:27938316 |
| Dutta D et al. | Recruitment of calcineurin to the TCR positively regulates T cell activation. | 2017 | Nat. Immunol. | pmid:27941787 |
| Triñanes J et al. | Deciphering Tacrolimus-Induced Toxicity in Pancreatic β Cells. | 2017 | Am. J. Transplant. | pmid:28432716 |
| Terakura S et al. | Exploratory research for optimal GvHD prophylaxis after single unit CBT in adults: short-term methotrexate reduced the incidence of severe GvHD more than mycophenolate mofetil. | 2017 | Bone Marrow Transplant. | pmid:27941766 |
| Gonzalez-Andrades M et al. | Sterile Corneal Infiltrates Secondary to Psoriasis Exacerbations: Topical Tacrolimus as an Alternative Treatment Option. | 2017 | Eye Contact Lens | pmid:26222098 |
| Perez LE et al. | Visilizumab with tacrolimus and methotrexate for GvHD prevention after allogeneic hematopoietic cell transplantation from mismatched unrelated donors. | 2017 | Bone Marrow Transplant. | pmid:27991896 |
| Lee SM et al. | Inhibition of acute lethal pulmonary inflammation by the IDO-AhR pathway. | 2017 | Proc. Natl. Acad. Sci. U.S.A. | pmid:28673995 |
| Naicker D et al. | Nationwide conversion to generic tacrolimus in pediatric kidney transplant recipients. | 2017 | Pediatr. Nephrol. | pmid:28660366 |
| Wood LA et al. | New tools for "hot-wiring" clathrin-mediated endocytosis with temporal and spatial precision. | 2017 | J. Cell Biol. | pmid:28954824 |
| Kannegieter NM et al. | Pharmacodynamic Monitoring of Tacrolimus-Based Immunosuppression in CD14+ Monocytes After Kidney Transplantation. | 2017 | Ther Drug Monit | pmid:28640063 |
| Sigurgeirsson B and Luger T | A 5-year randomized trial on the safety and efficacy of pimecrolimus in atopic dermatitis: a critical appraisal - author response. | 2017 | Br. J. Dermatol. | pmid:28940181 |
| Andrade LM et al. | Improved tacrolimus skin permeation by co-encapsulation with clobetasol in lipid nanoparticles: Study of drug effects in lipid matrix by electron paramagnetic resonance. | 2017 | Eur J Pharm Biopharm | pmid:28627400 |
| Wojciechowski D et al. | Mycophenolate Mofetil Withdrawal With Conversion to Everolimus to Treat BK Virus Infection in Kidney Transplant Recipients. | 2017 | Transplant. Proc. | pmid:28923623 |
| Baas M et al. | Unique clinical conditions associated with different acinar regions of fibrosis in long-term surviving pediatric liver grafts. | 2017 | Pediatr Transplant | pmid:28627016 |
| Nanmoku K et al. | Effective and Safe Reduction of Conventional Immunosuppressants Using Everolimus in Maintenance Kidney Transplant Recipients. | 2017 | Transplant. Proc. | pmid:28923615 |
| Božina N et al. | Steady-state pharmacokinetics of mycophenolic acid in renal transplant patients: exploratory analysis of the effects of cyclosporine, recipients' and donors' ABCC2 gene variants, and their interactions. | 2017 | Eur. J. Clin. Pharmacol. | pmid:28624888 |
| Sakassegawa-Naves FE et al. | Tacrolimus Ointment for Refractory Posterior Blepharitis. | 2017 | Curr. Eye Res. | pmid:28922018 |
| Pathak S et al. | Single synchronous delivery of FK506-loaded polymeric microspheres with pancreatic islets for the successful treatment of streptozocin-induced diabetes in mice. | 2017 | Drug Deliv | pmid:28911248 |
| Qi H et al. | Integration of parallel C-labeling experiments and in silico pathway analysis for enhanced production of ascomycin. | 2017 | Biotechnol. Bioeng. | pmid:27869289 |
| Gatault P et al. | Reduction of Extended-Release Tacrolimus Dose in Low-Immunological-Risk Kidney Transplant Recipients Increases Risk of Rejection and Appearance of Donor-Specific Antibodies: A Randomized Study. | 2017 | Am. J. Transplant. | pmid:27862923 |
| Vanhove T et al. | Effect of the Direct Oral Anticoagulants Rivaroxaban and Apixaban on the Disposition of Calcineurin Inhibitors in Transplant Recipients. | 2017 | Ther Drug Monit | pmid:27861314 |
| Yagi S et al. | New-onset diabetes mellitus after living-donor liver transplantation: association with graft synthetic function. | 2017 | Surg. Today | pmid:27837276 |