Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with tacrolimus
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Shirai T et al. | Successful treatment with tacrolimus in TAFRO syndrome: two case reports and literature review. | 2018 | Medicine (Baltimore) | pmid:29879072 |
Liu L et al. | New insights of subfertility among transplanted women: Immunosuppressive drug FK506 leads to calcium leak and oocyte activation before fertilization. | 2018 | J. Cell. Biochem. | pmid:29131377 |
Pham TT et al. | Tissue adhesive FK506-loaded polymeric nanoparticles for multi-layered nano-shielding of pancreatic islets to enhance xenograft survival in a diabetic mouse model. | 2018 | Biomaterials | pmid:29128846 |
Kamanamool N et al. | Comparison of disease activity between tacrolimus and mycophenolate mofetil in lupus nephritis: a randomized controlled trial. | 2018 | Lupus | pmid:29105558 |
Fu J et al. | Transcriptomic analysis uncovers novel synergistic mechanisms in combination therapy for lupus nephritis. | 2018 | Kidney Int. | pmid:29102373 |
Bond MMK et al. | Cyclosporine Versus Tacrolimus: Which Calcineurin Inhibitor Has Influence on Cytomegalovirus Infection in Cardiac Transplantation? | 2018 | Transplant. Proc. | pmid:29661443 |
Lee WS et al. | Tacrolimus regulates endoplasmic reticulum stress-mediated osteoclastogenesis and inflammation: In vitro and collagen-induced arthritis mouse model. | 2018 | Cell Biol. Int. | pmid:28833755 |
Quintero J et al. | Conversion from twice-daily to once-daily tacrolimus formulation in pediatric liver transplant recipients - a long-term prospective study. | 2018 | Transpl. Int. | pmid:28833714 |
Zeng K et al. | Dissolution Test of Tacrolimus Capsule: Effects of Filtration and Glass Adsorption. | 2018 | AAPS PharmSciTech | pmid:28828626 |
Kim JP et al. | The effect of full dose composite tissue allotransplantation immunosuppression on allograft motor nerve regeneration in a rat sciatic nerve model. | 2018 | Microsurgery | pmid:28792625 |
Koppelstaetter C et al. | Effect of cyclosporine, tacrolimus and sirolimus on cellular senescence in renal epithelial cells. | 2018 | Toxicol In Vitro | pmid:29309803 |
Jiang JW et al. | Optimal immunosuppressor induces stable gut microbiota after liver transplantation. | 2018 | World J. Gastroenterol. | pmid:30228781 |
Harada N et al. | Serum Asunaprevir and Daclatasvir Concentrations and Outcomes in Patients with Recurrent Hepatitis C Who Have Undergone Living Donor Liver Transplantation. | 2018 | Anticancer Res. | pmid:30194210 |
Sahu S et al. | Active natural oil-based nanoemulsion containing tacrolimus for synergistic antipsoriatic efficacy. | 2018 | Nanomedicine (Lond) | pmid:30188761 |
Min S et al. | A randomized clinical trial of age and genotype-guided tacrolimus dosing after pediatric solid organ transplantation. | 2018 | Pediatr Transplant | pmid:30178515 |
Zegarska J et al. | Evaluation of the Relationship Between Concentrations of Tacrolimus Metabolites, 13-O-Demethyl Tacrolimus and 15-O-Demethyl Tacrolimus, and Clinical and Biochemical Parameters in Kidney Transplant Recipients. | 2018 | Transplant. Proc. | pmid:30177142 |
Lee H et al. | Thymoglobulin Versus Basiliximab Induction Therapy in Low-Risk Kidney Transplant Recipients: A Single-Center Experience. | 2018 | Transplant. Proc. | pmid:29880348 |
La Maestra S et al. | Brain microglia activation induced by intracranial administration of oligonucleotides and its pharmacological modulation. | 2018 | Drug Deliv Transl Res | pmid:29869293 |
Marquet P et al. | Pharmacokinetic Therapeutic Drug Monitoring of Advagraf in More Than 500 Adult Renal Transplant Patients, Using an Expert System Online. | 2018 | Ther Drug Monit | pmid:29505493 |
Liang TT et al. | Modeling Analysis of Potential Target of Dolastatin 16 by Computational Virtual Screening. | 2018 | Chem. Pharm. Bull. | pmid:29863061 |
Chen J et al. | Controlled dimerization of insulin-like growth factor-1 and insulin receptors reveals shared and distinct activities of holo and hybrid receptors. | 2018 | J. Biol. Chem. | pmid:29330302 |
Marquet P et al. | Comparative clinical trial of the variability factors of the exposure indices used for the drug monitoring of two tacrolimus formulations in kidney transplant recipients. | 2018 | Pharmacol. Res. | pmid:29229354 |
Zhang T et al. | Association of donor small ubiquitin-like modifier 4 rs237025 genetic variant with tacrolimus elimination in the early period after liver transplantation. | 2018 | Liver Int. | pmid:28941036 |
Ishikawa S et al. | Management of Juvenile Idiopathic Arthritis in ABO-incompatible Kidney Transplantation: A Case Report. | 2018 | Transplant. Proc. | pmid:29661455 |
Moura Neto A et al. | Frequency of Thyroid Dysfunction in Patients With Diabetes Mellitus Before and After Liver Transplantation. | 2018 | Transplant. Proc. | pmid:29661439 |
Moura Neto A et al. | Clinical Profile of Patients With Diabetes Mellitus and Liver Transplantation: Results After a Multidisciplinary Team Intervention. | 2018 | Transplant. Proc. | pmid:29661438 |
Crouse L et al. | Pyoderma gangrenosum in an infant: A case report and review of the literature. | 2018 | Pediatr Dermatol | pmid:29656404 |
Stanton BZ et al. | Chemically induced proximity in biology and medicine. | 2018 | Science | pmid:29590011 |
Foroutan A et al. | Successful treatment of allergic conjunctival granuloma by topical tacrolimus: A clinicopathologic case report. | 2018 | Indian J Ophthalmol | pmid:29582827 |
Efe C et al. | Tacrolimus and Mycophenolate Mofetil as Second-Line Therapies for Pediatric Patients with Autoimmune Hepatitis. | 2018 | Dig. Dis. Sci. | pmid:29569003 |
Bittersohl H et al. | A simple and highly sensitive on-line column extraction liquid chromatography-tandem mass spectrometry method for the determination of protein-unbound tacrolimus in human plasma samples. | 2018 | J Chromatogr A | pmid:29544893 |
Solomentsev G et al. | Conformational Entropy of FK506 Binding to FKBP12 Determined by Nuclear Magnetic Resonance Relaxation and Molecular Dynamics Simulations. | 2018 | Biochemistry | pmid:29412644 |
Sano H et al. | T-cell-replete haploidentical stem cell transplantation using low-dose antithymocyte globulin in children with relapsed or refractory acute leukemia. | 2018 | Int. J. Hematol. | pmid:29508228 |
Kociszewska-Najman B et al. | Low Transfer of Tacrolimus and Its Metabolites into Colostrum of Graft Recipient Mothers. | 2018 | Nutrients | pmid:29495430 |
Ghadimi M et al. | Tacrolimus interaction with oral oestrogen in kidney transplant recipients: A case-control study. | 2018 | J Clin Pharm Ther | pmid:29492991 |
Li X et al. | Association of the PPARγ/PI3K/Akt pathway with the cardioprotective effects of tacrolimus in myocardial ischemic/reperfusion injury. | 2018 | Mol Med Rep | pmid:29488613 |
Yeh CT et al. | Seroclearance of hepatitis B surface antigen following hepatitis E exacerbation on chronic hepatitis E and B dual infection in a renal transplant recipient: a case report. | 2018 | J Med Case Rep | pmid:29486803 |
Takeuchi T et al. | Post-marketing surveillance study of the long-term use of mizoribine for the treatment of lupus nephritis: 2-Year results. | 2018 | Mod Rheumatol | pmid:28722500 |
Takeuchi T et al. | Safety and effectiveness of tacrolimus add-on therapy for rheumatoid arthritis patients without an adequate response to biological disease-modifying anti-rheumatic drugs (DMARDs): Post-marketing surveillance in Japan. | 2018 | Mod Rheumatol | pmid:28649878 |
Rayar M et al. | High Intrapatient Variability of Tacrolimus Exposure in the Early Period After Liver Transplantation Is Associated With Poorer Outcomes. | 2018 | Transplantation | pmid:29315140 |
Naniwa T et al. | Long-term efficacy and safety of add-on tacrolimus for persistent, active rheumatoid arthritis despite treatment with methotrexate and tumor necrosis factor inhibitors. | 2018 | Int J Rheum Dis | pmid:29314738 |
Li YM et al. | Soluble Tim-3 and Gal-9 are associated with renal allograft dysfunction in kidney transplant recipients: A cross-sectional study. | 2018 | Int. Immunopharmacol. | pmid:29310109 |
Saliba F et al. | Efficacy and Safety of Everolimus and Mycophenolic Acid With Early Tacrolimus Withdrawal After Liver Transplantation: A Multicenter Randomized Trial. | 2017 | Am. J. Transplant. | pmid:28133906 |
Gu K et al. | Atypical pneumonia due to human bocavirus in an immunocompromised patient. | 2017 | CMAJ | pmid:28507089 |
Undre N and Dickinson J | Relative bioavailability of single doses of prolonged-release tacrolimus administered as a suspension, orally or via a nasogastric tube, compared with intact capsules: a phase 1 study in healthy participants. | 2017 | BMJ Open | pmid:28377389 |
Smolders EJ et al. | Decreased tacrolimus plasma concentrations during HCV therapy: a drug-drug interaction or is there an alternative explanation? | 2017 | Int. J. Antimicrob. Agents | pmid:28185946 |
Nishiya Y et al. | A new efficient method of generating photoaffinity beads for drug target identification. | 2017 | Bioorg. Med. Chem. Lett. | pmid:28108248 |
MartÃn-Fernández M et al. | Effects of Cyclosporine, Tacrolimus, and Rapamycin on Osteoblasts. | 2017 | Transplant. Proc. | pmid:29149986 |
Nakamura K et al. | AS2553627, a novel JAK inhibitor, prevents chronic rejection in rat cardiac allografts. | 2017 | Eur. J. Pharmacol. | pmid:27993641 |
Zhang W et al. | Isoglycyrrhizinate Magnesium Enhances Hepatoprotective Effect of FK506 on Ischemia-Reperfusion Injury Through HMGB1 Inhibition in a Rat Model of Liver Transplantation. | 2017 | Transplantation | pmid:28885495 |