Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with tacrolimus
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Abu Zaid M et al. | Plasma biomarkers of risk for death in a multicenter phase 3 trial with uniform transplant characteristics post-allogeneic HCT. | 2017 | Blood | pmid:27827824 |
Slocum AMY | A surgeon's nightmare: pyoderma gangrenosum with pathergy effect mimicking necrotising fasciitis. | 2017 | BMJ Case Rep | pmid:29269363 |
Berisa Prado S et al. | Topical Tacrolimus for Corneal Subepithelial Infiltrates Secondary to Adenoviral Keratoconjunctivitis. | 2017 | Cornea | pmid:28704319 |
Lloberas N et al. | The combination of CYP3A4*22 and CYP3A5*3 single-nucleotide polymorphisms determines tacrolimus dose requirement after kidney transplantation. | 2017 | Pharmacogenet. Genomics | pmid:28704257 |
Saito R et al. | Two cases of eczematous drug eruption caused by oral tacrolimus administration. | 2017 | Contact Derm. | pmid:28703346 |
Hirai T et al. | The effectiveness of new triple combination therapy using synthetic disease-modifying anti-rheumatic drugs with different pharmacological function against rheumatoid arthritis: the verification by an in vitro and clinical study. | 2017 | Clin. Rheumatol. | pmid:27783236 |
Fox BD et al. | Tacrolimus Levels Are Not Associated with Risk of Malignancy in Lung Transplant Recipients. | 2017 | Ann. Transplant. | pmid:29133776 |
Lombardi A et al. | Impaired mitochondrial calcium uptake caused by tacrolimus underlies beta-cell failure. | 2017 | Cell Commun. Signal | pmid:29132395 |
Lee JE et al. | A Case of Rheumatoid Vasculitis Involving Hepatic Artery in Early Rheumatoid Arthritis. | 2017 | J. Korean Med. Sci. | pmid:28581281 |
Riva N et al. | Pharmacoepidemiology of tacrolimus in pediatric liver transplantation. | 2017 | Pediatr Transplant | pmid:28574195 |
Wu H et al. | Novel self-assembled tacrolimus nanoparticles cross-linking thermosensitive hydrogels for local rheumatoid arthritis therapy. | 2017 | Colloids Surf B Biointerfaces | pmid:27736727 |
Damon C et al. | Predictive Modeling of Tacrolimus Dose Requirement Based on High-Throughput Genetic Screening. | 2017 | Am. J. Transplant. | pmid:27597269 |
Gooptu M and Koreth J | Better acute graft--host disease outcomes for allogeneic transplant recipients in the modern era: a tacrolimus effect? | 2017 | Haematologica | pmid:28458253 |
Costa JS et al. | Polyomavirus Nephropathy: Ten-Year Experience. | 2017 | Transplant. Proc. | pmid:28457399 |
Ren S et al. | Comparative effectiveness and tolerance of immunosuppressive treatments for idiopathic membranous nephropathy: A network meta-analysis. | 2017 | PLoS ONE | pmid:28898290 |
Shemesh E et al. | The Medication Level Variability Index (MLVI) Predicts Poor Liver Transplant Outcomes: A Prospective Multi-Site Study. | 2017 | Am. J. Transplant. | pmid:28321975 |
Karchin JM et al. | Small Molecule-Induced Domain Swapping as a Mechanism for Controlling Protein Function and Assembly. | 2017 | Sci Rep | pmid:28287617 |
Mizuno H et al. | Extranodal NK/T cell lymphoma in a living donor liver transplant recipient. | 2017 | Ann. Hematol. | pmid:28280996 |
Chiasson VL et al. | Regulatory T-Cell Augmentation or Interleukin-17 Inhibition Prevents Calcineurin Inhibitor-Induced Hypertension in Mice. | 2017 | Hypertension | pmid:28584011 |
Lichtenberg S et al. | The incidence of post-transplant cancer among kidney transplant recipients is associated with the level of tacrolimus exposure during the first year after transplantation. | 2017 | Eur. J. Clin. Pharmacol. | pmid:28342067 |
Shoda W et al. | Calcineurin inhibitors block sodium-chloride cotransporter dephosphorylation in response to high potassium intake. | 2017 | Kidney Int. | pmid:28341239 |
Cakir U et al. | Role of Everolimus on Cardiac Functions in Kidney Transplant Recipients. | 2017 | Transplant. Proc. | pmid:28340820 |
Zhu J et al. | Granzyme B producing B-cells in renal transplant patients. | 2017 | Clin. Immunol. | pmid:28461110 |
Stojanovic J et al. | Immune Desensitization Allows Pediatric Blood Group Incompatible Kidney Transplantation. | 2017 | Transplantation | pmid:27463537 |
Terada Y et al. | Tacrolimus Triggers Transient Receptor Potential Vanilloid-1-Dependent Relapse of Pancreatitis-Related Pain in Mice. | 2017 | Pharmacology | pmid:28253495 |
Zhang X et al. | Influence of IL-18 and IL-10 Polymorphisms on Tacrolimus Elimination in Chinese Lung Transplant Patients. | 2017 | Dis. Markers | pmid:28246425 |
Mashayekhi S et al. | The treatment of vulval lichen sclerosus in prepubertal girls: a critically appraised topic. | 2017 | Br. J. Dermatol. | pmid:28244087 |
Guttman-Yassky E et al. | Molecular signatures order the potency of topically applied anti-inflammatory drugs in patients with atopic dermatitis. | 2017 | J. Allergy Clin. Immunol. | pmid:28238742 |
Kanai T et al. | Adequate tacrolimus concentration for myasthenia gravis treatment. | 2017 | Eur. J. Neurol. | pmid:28102047 |
Sarier M et al. | HPV type 45-positive condyloma acuminata of the bladder in a renal transplant recipient. | 2017 | Transpl Infect Dis | pmid:28100036 |
Fan B et al. | Prograf produces more benefits for CYP3A5 low expression patients in early stage after kidney transplantation. | 2017 | Biomed. Pharmacother. | pmid:28157649 |
Juvvadi PR et al. | Calcineurin in fungal virulence and drug resistance: Prospects for harnessing targeted inhibition of calcineurin for an antifungal therapeutic approach. | 2017 | Virulence | pmid:27325145 |
D'Avola D et al. | Cardiovascular morbidity and mortality after liver transplantation: The protective role of mycophenolate mofetil. | 2017 | Liver Transpl. | pmid:28160394 |
Kaneshiro S et al. | The efficacy and safety of additional administration of tacrolimus in patients with rheumatoid arthritis who showed an inadequate response to tocilizumab. | 2017 | Mod Rheumatol | pmid:27181115 |
Andreu F et al. | A New CYP3A5*3 and CYP3A4*22 Cluster Influencing Tacrolimus Target Concentrations: A Population Approach. | 2017 | Clin Pharmacokinet | pmid:28050888 |
Shimizu K | Development of New Liposome Targeting Strategies for Application of Disease Therapies. | 2017 | Yakugaku Zasshi | pmid:28049894 |
Ordóñez-Robles M et al. | Analysis of the Pho regulon in Streptomyces tsukubaensis. | 2017 | Microbiol. Res. | pmid:28942849 |
Maneechote C et al. | Roles of mitochondrial dynamics modulators in cardiac ischaemia/reperfusion injury. | 2017 | J. Cell. Mol. Med. | pmid:28941171 |
Baskiran A et al. | Pregnancy After Liver Transplantation: Risks and Outcomes. | 2017 | Transplant. Proc. | pmid:28923640 |
Shi G et al. | Variation of CD4CD25Foxp3 Regulatory T Cells and Th17 Cells in the Peripheral Blood of Human Liver Allograft Patients With Long-term Survival. | 2017 | Transplant. Proc. | pmid:28923634 |
Reese PP et al. | Automated Reminders and Physician Notification to Promote Immunosuppression Adherence Among Kidney Transplant Recipients: A Randomized Trial. | 2017 | Am. J. Kidney Dis. | pmid:27940063 |
Shrestha BM | Two Decades of Tacrolimus in Renal Transplant: Basic Science and Clinical Evidences. | 2017 | Exp Clin Transplant | pmid:27938316 |
Weininger U et al. | Dynamics of Aromatic Side Chains in the Active Site of FKBP12. | 2017 | Biochemistry | pmid:27936610 |
Gonzalez-Andrades M et al. | Sterile Corneal Infiltrates Secondary to Psoriasis Exacerbations: Topical Tacrolimus as an Alternative Treatment Option. | 2017 | Eye Contact Lens | pmid:26222098 |
Božina N et al. | Steady-state pharmacokinetics of mycophenolic acid in renal transplant patients: exploratory analysis of the effects of cyclosporine, recipients' and donors' ABCC2 gene variants, and their interactions. | 2017 | Eur. J. Clin. Pharmacol. | pmid:28624888 |
Olmedo MartÃn RV et al. | Medium to long-term efficacy and safety of oral tacrolimus in moderate to severe steroid refractory ulcerative colitis. | 2017 | Rev Esp Enferm Dig | pmid:28617029 |
Pathak S et al. | Single synchronous delivery of FK506-loaded polymeric microspheres with pancreatic islets for the successful treatment of streptozocin-induced diabetes in mice. | 2017 | Drug Deliv | pmid:28911248 |
Maldonado AQ et al. | Prevalence of CYP3A5 Genomic Variances and Their Impact on Tacrolimus Dosing Requirements among Kidney Transplant Recipients in Eastern North Carolina. | 2017 | Pharmacotherapy | pmid:28605053 |
Chucair-Elliott AJ et al. | Colony Stimulating Factor-1 Receptor Expressing Cells Infiltrating the Cornea Control Corneal Nerve Degeneration in Response to HSV-1 Infection. | 2017 | Invest. Ophthalmol. Vis. Sci. | pmid:28903153 |
Pietrosi G and Chinnici C | Report on Liver Cell Transplantation Using Human Fetal Liver Cells. | 2017 | Methods Mol. Biol. | pmid:27830561 |