Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with tacrolimus
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Ofri R et al. | Clinical evaluation of pimecrolimus eye drops for treatment of canine keratoconjunctivitis sicca: a comparison with cyclosporine A. | 2009 | Vet. J. | pmid:17950639 |
Sestak K et al. | Tacrolimus-FK506 induced immunosuppression in gnotobiotic piglets. | 2000 | Vet. Immunol. Immunopathol. | pmid:11137126 |
Mauldin EA et al. | Proliferative and necrotizing otitis externa in four cats. | 2007 | Vet. Dermatol. | pmid:17845627 |
Banovic F et al. | Tacrolimus therapy for dermal arteritis of the nasal philtrum refractory to surgery and anti-inflammatory therapy (doxycycline/niacinamide and topical fluocinolone) in a dog. | 2018 | Vet. Dermatol. | pmid:28990239 |
Marsella R and Nicklin CF | Investigation on the use of 0.3% tacrolimus lotion for canine atopic dermatitis: a pilot study. | 2002 | Vet. Dermatol. | pmid:12174182 |
Olivry T et al. | Treatment of canine atopic dermatitis: 2010 clinical practice guidelines from the International Task Force on Canine Atopic Dermatitis. | 2010 | Vet. Dermatol. | pmid:20456716 |
Marsella R et al. | Investigation on the effects of topical therapy with 0.1% tacrolimus ointment (Protopic) on intradermal skin test reactivity in atopic dogs. | 2004 | Vet. Dermatol. | pmid:15305928 |
Lehner GM and Linek M | A case of vesicular cutaneous lupus erythematosus in a Border collie successfully treated with topical tacrolimus and nicotinamide-tetracycline. | 2013 | Vet. Dermatol. | pmid:24118370 |
Bensignor E and Olivry T | Treatment of localized lesions of canine atopic dermatitis with tacrolimus ointment: a blinded randomized controlled trial. | 2005 | Vet. Dermatol. | pmid:15725106 |
Scholz FM et al. | Focal metatarsal fistulae syndrome affecting a greyhound dog successfully treated with topical 0.1% tacrolimus ointment. | 2015 | Vet. Dermatol. | pmid:26216245 |