tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| Hersperger R et al. | Preparation and immunosuppressive activity of 32-(O)-acylated and 32-(O)-thioacylated analogues of ascomycin. | 1999 | Bioorg. Med. Chem. Lett. | pmid:10021934 |
| Praghakaran K et al. | Rational management of posttransplant lymphoproliferative disorder in pediatric recipients. | 1999 | J. Pediatr. Surg. | pmid:10022154 |
| Reynolds PD et al. | Glucocorticoid resistance in the squirrel monkey is associated with overexpression of the immunophilin FKBP51. | 1999 | J. Clin. Endocrinol. Metab. | pmid:10022435 |
| Powers JF et al. | Discordant effects of rapamycin on proliferation and p70S6 kinase phosphorylation in normal and neoplastic rat chromaffin cells. | 1999 | Neurosci. Lett. | pmid:10025577 |
| Scholz C et al. | R73A and H144Q mutants of the yeast mitochondrial cyclophilin Cpr3 exhibit a low prolyl isomerase activity in both peptide and protein-folding assays. | 1999 | FEBS Lett. | pmid:10025965 |
| Clemann N and Bechter R | Effects of rapamycin and FK 506 on rat Sertoli cells in vitro. | 1998 | Adv. Exp. Med. Biol. | pmid:10026935 |
| Atta MG et al. | Tyrosine kinase inhibitors and immunosuppressants perturb the myo-inositol but not the betaine cotransporter in isotonic and hypertonic MDCK cells. | 1999 | Kidney Int. | pmid:10027932 |
| McDiarmid SV et al. | Factors affecting growth after pediatric liver transplantation. | 1999 | Transplantation | pmid:10030286 |
| Shapiro R et al. | A prospective, randomized trial of tacrolimus/prednisone versus tacrolimus/prednisone/mycophenolate mofetil in renal transplant recipients. | 1999 | Transplantation | pmid:10030287 |
| Dell'Antonio G and Randhawa PS | "Striped" pattern of medullary ray fibrosis in allograft biopsies from kidney transplant recipients maintained on tacrolimus. | 1999 | Transplantation | pmid:10030300 |
| Vyas S et al. | Outcome of twin pregnancy in a renal transplant recipient treated with tacrolimus. | 1999 | Transplantation | pmid:10030303 |
| Johnson CE et al. | Stability of tacrolimus with morphine sulfate, hydromorphone hydrochloride, and ceftazidime during simulated intravenous coadministration. | 1999 | Am J Health Syst Pharm | pmid:10030533 |
| Dolinski KJ and Heitman J | Hmo1p, a high mobility group 1/2 homolog, genetically and physically interacts with the yeast FKBP12 prolyl isomerase. | 1999 | Genetics | pmid:10049913 |
| Regazzi MB et al. | Clinical pharmacokinetics of tacrolimus in heart transplant recipients. | 1999 | Ther Drug Monit | pmid:10051048 |
| Zucker K et al. | Evidence that tacrolimus augments the bioavailability of mycophenolate mofetil through the inhibition of mycophenolic acid glucuronidation. | 1999 | Ther Drug Monit | pmid:10051052 |
| Chen HY et al. | Prediction of tacrolimus blood levels by using the neural network with genetic algorithm in liver transplantation patients. | 1999 | Ther Drug Monit | pmid:10051054 |
| Yamaguchi Y et al. | Peroxynitrite formation during rat hepatic allograft rejection. | 1999 | Hepatology | pmid:10051479 |
| Clardy J | Borrowing to make ends meet. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10051553 |
| Briesewitz R et al. | Affinity modulation of small-molecule ligands by borrowing endogenous protein surfaces. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10051576 |
| Chambraud B et al. | Immunophilins, Refsum disease, and lupus nephritis: the peroxisomal enzyme phytanoyl-COA alpha-hydroxylase is a new FKBP-associated protein. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10051602 |
| Maesaki S et al. | Synergic effects of tactolimus and azole antifungal agents against azole-resistant Candida albican strains. | 1998 | J. Antimicrob. Chemother. | pmid:10052898 |
| Haas RJ et al. | Non-Hodgkin lymphoma after heart-lung transplantation: response to chemotherapy. | 1999 | Med. Pediatr. Oncol. | pmid:10064195 |
| Mortola E et al. | The use of two immunosuppressive drugs, cyclosporin A and tacrolimus, to inhibit virus replication and apoptosis in cells infected with feline immunodeficiency virus. | 1998 | Vet. Res. Commun. | pmid:10066129 |
| Inui A et al. | Food allergy and tacrolimus. | 1999 | J. Pediatr. Gastroenterol. Nutr. | pmid:10067752 |
| Herzig K and Johnson DW | Marked elevation of blood cyclosporin and tacrolimus levels due to concurrent metronidazole therapy. | 1999 | Nephrol. Dial. Transplant. | pmid:10069238 |
| Tarumi K et al. | CTLA4IgG treatment induces long-term acceptance of rat small bowel allografts. | 1999 | Transplantation | pmid:10071020 |
| Trimarchi HM et al. | FK506-associated thrombotic microangiopathy: report of two cases and review of the literature. | 1999 | Transplantation | pmid:10071024 |
| Kaufman DB et al. | Mycophenolate mofetil and tacrolimus as primary maintenance immunosuppression in simultaneous pancreas-kidney transplantation: initial experience in 50 consecutive cases. | 1999 | Transplantation | pmid:10071032 |
| Khanna A et al. | Tacrolimus induces increased expression of transforming growth factor-beta1 in mammalian lymphoid as well as nonlymphoid cells. | 1999 | Transplantation | pmid:10071036 |
| Kessler M et al. | A renal allograft recipient with late recurrence of focal and segmental glomerulosclerosis after switching from cyclosporine to tacrolimus. | 1999 | Transplantation | pmid:10071045 |
| Jain AB et al. | Effect of t-tube clamping on the pharmacokinetics of mycophenolic acid in liver transplant patients on oral therapy of mycophenolate mofetil. | 1999 | Liver Transpl Surg | pmid:10071348 |
| Jain AB et al. | Primary adult liver transplantation under tacrolimus: more than 90 months actual follow-up survival and adverse events. | 1999 | Liver Transpl Surg | pmid:10071354 |
| Mitsumoto Y et al. | FK506 with portal decompression exerts beneficial effects following extended hepatectomy in dogs. | 1999 | Eur Surg Res | pmid:10072610 |
| Jain A et al. | Immunosuppressive therapy. | 1999 | Surg. Clin. North Am. | pmid:10073182 |
| Reyes J and Mazariegos GV | Pediatric transplantation. | 1999 | Surg. Clin. North Am. | pmid:10073188 |
| Sigalet DL et al. | Effect of combined immunosuppressive drug therapy on small intestinal nutrient transport in the rat. | 1999 | Clin. Biochem. | pmid:10074892 |
| Trajković V et al. | Cyclosporin A suppresses the induction of nitric oxide synthesis in interferon-gamma-treated L929 fibroblasts. | 1999 | Scand. J. Immunol. | pmid:10075015 |
| Jordan ML et al. | Long-term results of pancreas transplantation under tacrolius immunosuppression. | 1999 | Transplantation | pmid:10075592 |
| Shapiro R et al. | Pediatric renal transplantation under tacrolimus-based immunosuppression. | 1999 | Transplantation | pmid:10075598 |
| Kaplan B et al. | Low bioavailability of cyclosporine microemulsion and tacrolimus in a small bowel transplant recipient: possible relationship to intestinal P-glycoprotein activity. | 1999 | Transplantation | pmid:10075604 |
| Takada S et al. | Effect of hepatocyte growth factor on tacrolimus-induced nephrotoxicity in spontaneously hypertensive rats. | 1999 | Transpl. Int. | pmid:10080403 |
| Kleindienst R et al. | Bronchiolitis obliterans organizing pneumonia associated with Pneumocystis carinii infection in a liver transplant patient receiving tacrolimus. | 1999 | Clin Transplant | pmid:10081638 |
| Ghasemian SR et al. | Tacrolimus vs Neoral in renal and renal/pancreas transplantation. | 1999 | Clin Transplant | pmid:10081648 |
| Scott JS et al. | Tacrolimus: a cause of hypertrophic cardiomyopathy in pediatric heart transplant recipients? | 1999 Feb-Mar | Transplant. Proc. | pmid:10083017 |
| Meiser BM et al. | The efficacy of the combination of tacrolimus and mycophenolate mofetil for prevention of acute myocardial rejection is dependent on routine monitoring of mycophenolic acid trough acid levels. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083018 |
| Bennett WM | Renal complications after heart transplantation. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083019 |
| Reichenspurner H et al. | Tacrolimus-based immunosuppressive protocols in lung transplantation. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083062 |
| Miller J | Tacrolimus and mycophenolate mofetil in renal transplant recipients: one year results of a multicenter, randomized dose ranging trial. FK506/MMF Dose-Ranging Kidney Transplant Study Group. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083106 |
| Undre NA et al. | Low systemic exposure to tacrolimus correlates with acute rejection. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083114 |