tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Brazis PW et al. | A case of bilateral optic neuropathy in a patient on tacrolimus (FK506) therapy after liver transplantation. | 2000 | Am. J. Ophthalmol. | pmid:10764869 |
| Gordjani N et al. | Cyclosporin-A-induced effects on the free Ca2+ concentration in LLC-PK1-cells and their mechanisms. | 2000 | Pflugers Arch. | pmid:10764223 |
| Nevins TE | Overview of new immunosuppressive therapies. | 2000 | Curr. Opin. Pediatr. | pmid:10763765 |
| Thorp M et al. | The effect of conversion from cyclosporine to tacrolimus on gingival hyperplasia, hirsutism and cholesterol. | 2000 | Transplantation | pmid:10762229 |
| Tchah H and Lim B | Effect of FK 506 on the cornea: use of topical FK 506 in corneal transplantation in a guinea pig-rat model. | 1999 | Korean J Ophthalmol | pmid:10761401 |
| Minervini MI et al. | Acute renal allograft rejection with severe tubulitis (Banff 1997 grade IB). | 2000 | Am. J. Surg. Pathol. | pmid:10757402 |
| Yamamoto K et al. | Immune response to adenovirus-delivered antigens upregulates utrophin and results in mitigation of muscle pathology in mdx mice. | 2000 | Hum. Gene Ther. | pmid:10757347 |
| Takahashi N | [Macrolide compounds as inhibitors of the intracellular signal transmission pathway: the mechanism of actions of rapamycin and FK506]. | 2000 | Jpn J Antibiot | pmid:10756454 |
| Kano S et al. | [Role of FK506-binding protein (FKBP) in Ca+ oscillation in bronchial epithelial cells]. | 2000 | Jpn J Antibiot | pmid:10756444 |
| Mohamed MA et al. | TGF-beta expression in renal transplant biopsies: a comparative study between cyclosporin-A and tacrolimus. | 2000 | Transplantation | pmid:10755567 |
| Miller J et al. | Safety and efficacy of tacrolimus in combination with mycophenolate mofetil (MMF) in cadaveric renal transplant recipients. FK506/MMF Dose-Ranging Kidney Transplant Study Group. | 2000 | Transplantation | pmid:10755543 |
| Johnson C et al. | Randomized trial of tacrolimus (Prograf) in combination with azathioprine or mycophenolate mofetil versus cyclosporine (Neoral) with mycophenolate mofetil after cadaveric kidney transplantation. | 2000 | Transplantation | pmid:10755536 |
| Harmon JD et al. | Stuttering priapism in a liver transplant patient with toxic levels of fk506. | 1999 | Urology | pmid:10754131 |
| Freeman EE and Grosskreutz CL | The effects of FK506 on retinal ganglion cells after optic nerve crush. | 2000 | Invest. Ophthalmol. Vis. Sci. | pmid:10752948 |
| Davis DL et al. | Biochemical characterization of the minor immunophilins. | 2000 | Clin. Biochem. | pmid:10751584 |
| Wang MS and Gold BG | FK506 increases the regeneration of spinal cord axons in a predegenerated peripheral nerve autograft. | 1999 | J Spinal Cord Med | pmid:10751133 |
| Shimizu T et al. | Clinical and histological analysis of acute tacrolimus (TAC) nephrotoxicity in renal allografts. | 1999 | Clin Transplant | pmid:10751057 |
| Chiou WL et al. | Apparent lack of effect of P-glycoprotein on the gastrointestinal absorption of a substrate, tacrolimus, in normal mice. | 2000 | Pharm. Res. | pmid:10751036 |
| Minematsu T et al. | Pharmacokinetic/pharmacodynamic analysis of tacrolimus-induced QT prolongation in guinea pigs. | 1999 | Biol. Pharm. Bull. | pmid:10746167 |
| Gaziev D et al. | Chronic graft-versus-host disease: is there an alternative to the conventional treatment? | 2000 | Bone Marrow Transplant. | pmid:10745252 |
| Skuk D et al. | Myoblast transplantation in whole muscle of nonhuman primates. | 2000 | J. Neuropathol. Exp. Neurol. | pmid:10744058 |
| Emre S et al. | Treatment of tacrolimus-related adverse effects by conversion to cyclosporine in liver transplant recipients. | 2000 | Transpl. Int. | pmid:10743694 |
| Yoshida EM et al. | Post-transplant diabetic ketoacidosis--a possible consequence of immunosuppression with calcineurin inhibiting agents: a case series. | 2000 | Transpl. Int. | pmid:10743693 |
| Weidelt T and Isenberg G | Augmentation of SR Ca(2+) release by rapamycin and FK506 causes K(+)-channel activation and membrane hyperpolarization in bladder smooth muscle. | 2000 | Br. J. Pharmacol. | pmid:10742283 |
| Dubowchik GM et al. | Fluoresceinated FKBP12 ligands for a high-throughput fluorescence polarization assay. | 2000 | Bioorg. Med. Chem. Lett. | pmid:10741553 |
| Li ST et al. | High Ca(2+)/low Mg(2+) solution induces long-term depression in rat CA1 pyramidal neurons. | 2000 | Neurosci. Lett. | pmid:10739895 |
| Böhmig GA et al. | Role of humoral immune reactions as target for antirejection therapy in recipients of a spousal-donor kidney graft. | 2000 | Am. J. Kidney Dis. | pmid:10739788 |
| Wong KM et al. | Abbreviated tacrolimus area-under-the-curve monitoring for renal transplant recipients. | 2000 | Am. J. Kidney Dis. | pmid:10739787 |
| Kawai T et al. | FK506-induced autoimmune diabetes. | 2000 | Ann. Intern. Med. | pmid:10733461 |
| Adalsteinsson H and Bruice TC | Generation and evaluation of putative neuroregenerative drugs. Part 1: virtual point mutations to the polyketide rapamycin. | 2000 | Bioorg. Med. Chem. | pmid:10732978 |
| Prima V et al. | Alteration of the glucocorticoid receptor subcellular localization by non steroidal compounds. | 2000 Jan-Feb | J. Steroid Biochem. Mol. Biol. | pmid:10731632 |
| Squadrito F et al. | Tacrolimus limits polymorphonuclear leucocyte accumulation and protects against myocardial ischaemia- reperfusion injury. | 2000 | J. Mol. Cell. Cardiol. | pmid:10731442 |
| Eades SK et al. | Increased tacrolimus levels in a pediatric renal transplant patient attributed to chronic diarrhea. | 2000 | Pediatr Transplant | pmid:10731062 |
| Pappas PA et al. | Sirolimus in pediatric gastrointestinal transplantation: the use of sirolimus for pediatric transplant patients with tacrolimus-related cardiomyopathy. | 2000 | Pediatr Transplant | pmid:10731058 |
| Sigalet DL et al. | Impact of FK506 and steroids on adaptation after intestinal resection or segmental transplantation. | 2000 | Pediatr Transplant | pmid:10731053 |
| Ierardi E et al. | Oral tacrolimus (FK 506) in Crohn's disease complicated by fistulae of the perineum. | 2000 | J. Clin. Gastroenterol. | pmid:10730928 |
| Bargalló N et al. | Cortical laminar necrosis caused by immunosuppressive therapy and chemotherapy. | 2000 | AJNR Am J Neuroradiol | pmid:10730638 |
| Plosker GL and Foster RH | Tacrolimus: a further update of its pharmacology and therapeutic use in the management of organ transplantation. | 2000 | Drugs | pmid:10730553 |
| Fukuda H et al. | Differences between lymphocyte subsets, after allogeneic bone marrow transplantation, in patients who received tacrolimus and patients who received cyclosporin A. | 2000 | Int. J. Hematol. | pmid:10729997 |
| Konrad T et al. | Evidence for impaired glucose effectiveness in cirrhotic patients after liver transplantation. | 2000 | Metab. Clin. Exp. | pmid:10726916 |
| Inomata Y et al. | [Weaning of immunosuppression in living-related liver transplantation]. | 1999 | Nihon Rinsho Meneki Gakkai Kaishi | pmid:10726480 |
| Hale GA et al. | Blood tacrolimus concentrations in bone marrow transplant patients undergoing plasmapheresis. | 2000 | Bone Marrow Transplant. | pmid:10723590 |
| Carr DB et al. | Maternal hemodynamics and pregnancy outcome in women with prior orthotopic liver transplantation. | 2000 | Liver Transpl. | pmid:10719023 |
| Lee M et al. | FK506 promotes functional recovery in crushed rat sciatic nerve. | 2000 | Muscle Nerve | pmid:10716776 |
| Smythe GM et al. | Enhanced migration and fusion of donor myoblasts in dystrophic and normal host muscle. | 2000 | Muscle Nerve | pmid:10716768 |
| Campbell G et al. | Spontaneous axonal regeneration after optic nerve injury in adult rat. | 1999 | Neuroreport | pmid:10716240 |
| Sugawara T et al. | Immunosuppressants promote adult dorsal root regeneration into the spinal cord. | 1999 | Neuroreport | pmid:10716239 |
| Dunnett SB | The failure of axon regeneration in the CNS is not absolute. | 1999 | Neuroreport | pmid:10716198 |
| Vela CG et al. | Prospective study of lipid disorders in FK506-versus cyclosporine-treated renal transplant patients. | 2000 | Transplant. Proc. | pmid:10715453 |
| Morita H et al. | Acceptance of skin xenografts (from guinea pig to mice) by portal venous and intravenous injections of donor hematolymphoid cells. | 2000 | Transplant. Proc. | pmid:10715422 |
| Takada Y et al. | Improvement of allograft viability with organs procured from non-heart-beating donors in porcine liver transplantation. | 2000 | Transplant. Proc. | pmid:10715416 |
| Mamane Y et al. | Posttranslational regulation of IRF-4 activity by the immunophilin FKBP52. | 2000 | Immunity | pmid:10714679 |
| Egner R et al. | The transmembrane domain 10 of the yeast Pdr5p ABC antifungal efflux pump determines both substrate specificity and inhibitor susceptibility. | 2000 | Mol. Microbiol. | pmid:10712705 |
| DuBell WH et al. | K(+) currents responsible for repolarization in mouse ventricle and their modulation by FK-506 and rapamycin. | 2000 | Am. J. Physiol. Heart Circ. Physiol. | pmid:10710358 |
| Kitabayashi H et al. | FTY720 prevents development of experimental autoimmune myocarditis through reduction of circulating lymphocytes. | 2000 | J. Cardiovasc. Pharmacol. | pmid:10710126 |
| Kuriyama S et al. | Immunomodulation with FK506 around the time of intravenous re-administration of an adenoviral vector facilitates gene transfer into primed rat liver. | 2000 | Int. J. Cancer | pmid:10709105 |
| Singh N et al. | Immunosuppressive-associated leukoencephalopathy in organ transplant recipients. | 2000 | Transplantation | pmid:10708096 |
| Lapa e Silva JR et al. | Prevention of antigen-induced bronchial hyperreactivity and airway inflammation in sensitized guinea-pigs by tacrolimus. | 1999 | Mediators Inflamm. | pmid:10704085 |
| James JA et al. | Reduction in gingival overgrowth associated with conversion from cyclosporin A to tacrolimus. | 2000 | J. Clin. Periodontol. | pmid:10703661 |
| Bartucci MR | Issues in cyclosporine drug substitution: implications for patient management. | 1999 | J Transpl Coord | pmid:10703396 |
| Ulsh PJ et al. | New strategies using 'low-dose' mycophenolate mofetil to reduce acute rejection in patients following kidney transplantation. | 1999 | J Transpl Coord | pmid:10703393 |
| Soran A et al. | Outcome of kidney transplantation under tacrolimus-based immunosuppression in elderly patients. | 1999 | J Transpl Coord | pmid:10703390 |
| Dumont FJ | FK506, an immunosuppressant targeting calcineurin function. | 2000 | Curr. Med. Chem. | pmid:10702636 |
| Rovira P et al. | The impact of immunosuppressive drugs on the analysis of T cell activation. | 2000 | Curr. Med. Chem. | pmid:10702633 |
| Migita K et al. | FK506 augments glucocorticoid-mediated cyclooxygenase-2 down-regulation in human rheumatoid synovial fibroblasts. | 2000 | Lab. Invest. | pmid:10701683 |
| Williams ST et al. | Preliminary analysis of a randomized trial comparing microemulsion cyclosporine and tacrolimus for recipients of renal transplants from non-heart-beating donors. | 2000 | Transplant. Proc. | pmid:10701022 |
| White SA et al. | Influence of delayed graft function in renal transplants from cadaveric or non-heart-beating donors. | 2000 | Transplant. Proc. | pmid:10701018 |
| Braun F et al. | Living-related versus living-unrelated kidney transplantation using tacrolimus initial immunosuppression. | 2000 | Transplant. Proc. | pmid:10700989 |
| White SA et al. | Effect of acute rejection on expression of fibrosis associated genes in renal transplant recipients. | 2000 | Transplant. Proc. | pmid:10700949 |
| Aronowski J et al. | Interplay between the gamma isoform of PKC and calcineurin in regulation of vulnerability to focal cerebral ischemia. | 2000 | J. Cereb. Blood Flow Metab. | pmid:10698072 |
| Bader A et al. | Primary porcine enterocyte and hepatocyte cultures to study drug oxidation reactions. | 2000 | Br. J. Pharmacol. | pmid:10694240 |
| Davis DL et al. | Minor immunophilin binding of tacrolimus and sirolimus metabolites. | 2000 | Clin. Biochem. | pmid:10693980 |
| LaPres JJ et al. | ARA9 modifies agonist signaling through an increase in cytosolic aryl hydrocarbon receptor. | 2000 | J. Biol. Chem. | pmid:10692406 |
| Suga Y et al. | A case of ichthyosis linearis circumflexa successfully treated with topical tacrolimus. | 2000 | J. Am. Acad. Dermatol. | pmid:10688732 |
| Glynne R et al. | How self-tolerance and the immunosuppressive drug FK506 prevent B-cell mitogenesis. | 2000 | Nature | pmid:10688206 |
| Oppenheimer F | Steroid withdrawal in renal transplant recipients. | 2000 | Transplant. Proc. | pmid:10686314 |
| Li XC and Strom TB | Blocking T-cell costimulation in transplantation: opportunities and challenges. | 2000 | Transfusion | pmid:10685997 |
| Sengoku T et al. | FK506 inhibition of histamine release and cytokine production by mast cells and basophils. | 2000 | Int. J. Immunopharmacol. | pmid:10685002 |
| Filler G et al. | Pharmacokinetics of mycophenolate mofetil are influenced by concomitant immunosuppression. | 2000 | Pediatr. Nephrol. | pmid:10684356 |
| Del Poeta M et al. | Synergistic antifungal activities of bafilomycin A(1), fluconazole, and the pneumocandin MK-0991/caspofungin acetate (L-743,873) with calcineurin inhibitors FK506 and L-685,818 against Cryptococcus neoformans. | 2000 | Antimicrob. Agents Chemother. | pmid:10681348 |
| Skuk D and Tremblay JP | Progress in myoblast transplantation: a potential treatment of dystrophies. | 2000 Feb 1-15 | Microsc. Res. Tech. | pmid:10679968 |
| Tisdale JF et al. | Cyclophosphamide and other new agents for the treatment of severe aplastic anemia. | 2000 | Semin. Hematol. | pmid:10676915 |
| de Mattos AM et al. | Nephrotoxicity of immunosuppressive drugs: long-term consequences and challenges for the future. | 2000 | Am. J. Kidney Dis. | pmid:10676738 |
| Misawa A et al. | FK506-induced intractable leukoencephalopathy following allogeneic bone marrow transplantation. | 2000 | Bone Marrow Transplant. | pmid:10673708 |
| Sayo Y et al. | Transforming growth factor beta induction of insulin gene expression is mediated by pancreatic and duodenal homeobox gene-1 in rat insulinoma cells. | 2000 | Eur. J. Biochem. | pmid:10672004 |
| Hirose R et al. | Experience with daclizumab in liver transplantation: renal transplant dosing without calcineurin inhibitors is insufficient to prevent acute rejection in liver transplantation. | 2000 | Transplantation | pmid:10670644 |
| Jordan ML et al. | Results of pancreas transplantation after steroid withdrawal under tacrolimus immunosuppression. | 2000 | Transplantation | pmid:10670637 |
| Furukawa H et al. | Prolongation of canine liver allograft survival by a novel immunosuppressant, FTY720: effect of monotherapy and combined treatment with conventional drugs. | 2000 | Transplantation | pmid:10670633 |
| Winter C et al. | The immunophilin ligand FK506, but not GPI-1046, protects against neuronal death and inhibits c-Jun expression in the substantia nigra pars compacta following transection of the rat medial forebrain bundle. | 2000 | Neuroscience | pmid:10670442 |
| Tyagi MG and Thomas M | Enhanced cardiovascular reactivity to desmopressin in water-restricted rats: facilitatory role of immunosuppression. | 1999 | Methods Find Exp Clin Pharmacol | pmid:10669908 |
| Chenhsu RY et al. | Renal allograft dysfunction associated with rifampin-tacrolimus interaction. | 2000 | Ann Pharmacother | pmid:10669182 |
| McAlister VC et al. | Sirolimus-tacrolimus combination immunosuppression. | 2000 | Lancet | pmid:10665560 |
| Schuppe H et al. | Topical tacrolimus for recalcitrant leg ulcer in rheumatoid arthritis. | 2000 | Rheumatology (Oxford) | pmid:10662882 |
| Tamura A et al. | Immunosuppressive therapy using FTY720 combined with tacrolimus in rat liver transplantation. | 2000 | Surgery | pmid:10660758 |
| Tamura J et al. | [The role of protein kinases and phosphatases in erythroid colony formation of elderly]. | 1999 | Nihon Ronen Igakkai Zasshi | pmid:10655734 |
| Novelli M et al. | Oral absorption of tacrolimus in children with intestinal failure due to short or absent small bowel. | 1999 | Transpl. Int. | pmid:10654359 |
| Wu GS et al. | Deoxyspergualin delays xenograft rejection in the guinea pig-to-C6-deficient rat heart transplantation model. | 1999 | Transpl. Int. | pmid:10654352 |
| Jain A et al. | Conversion to neoral for neurotoxicity after primary adult liver transplantation under tacrolimus. | 2000 | Transplantation | pmid:10653398 |
| Reddy KS et al. | Simultaneous kidney-pancreas transplantation without antilymphocyte induction. | 2000 | Transplantation | pmid:10653379 |
| Schrama YC et al. | Concealed by veils. | 2000 | Nephrol. Dial. Transplant. | pmid:10648679 |