tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Qin J et al. | Radiological and clinical findings of 25 patients with invasive pulmonary aspergillosis: retrospective analysis of 2150 liver transplantation cases. | 2012 | Br J Radiol | pmid:22496071 |
| Anoopkumar-Dukie S et al. | Mitochondrial modulation of oxygen-dependent radiosensitivity in some human tumour cell lines. | 2009 | Br J Radiol | pmid:19366737 |
| Murphy GJ et al. | Randomized clinical trial of the effect of microemulsion cyclosporin and tacrolimus on renal allograft fibrosis. | 2003 | Br J Surg | pmid:12808614 |
| Middleton SJ et al. | Adult small intestinal transplantation in England and Wales. | 2003 | Br J Surg | pmid:12808622 |
| Morris-Stiff GJ et al. | Sequential changes in plasma selenium concentration after cadaveric renal transplantation. | 2004 | Br J Surg | pmid:14991636 |
| Wilson CH et al. | Randomized clinical trial of daclizumab induction and delayed introduction of tacrolimus for recipients of non-heart-beating kidney transplants. | 2005 | Br J Surg | pmid:15856479 |
| Waller JR et al. | Effects of the combination of rapamycin with tacrolimus or cyclosporin on experimental intimal hyperplasia. | 2002 | Br J Surg | pmid:12390379 |
| Brook NR et al. | Fibrosis-associated gene expression in renal transplant glomeruli after acute renal allograft rejection. | 2003 | Br J Surg | pmid:12905557 |
| Jain S et al. | Tacrolimus has less fibrogenic potential than cyclosporin A in a model of renal ischaemia-reperfusion injury. | 2000 | Br J Surg | pmid:11091246 |
| Bicknell GR et al. | Differential effects of cyclosporin and tacrolimus on the expression of fibrosis-associated genes in isolated glomeruli from renal transplants. | 2000 | Br J Surg | pmid:11091247 |
| White DJ | Immunosuppression for heart transplantation. | 1993 | Br. J. Biomed. Sci. | pmid:7694717 |
| Reichert TE et al. | The role of endogenous interleukin-2 in proliferation of human carcinoma cell lines. | 1999 | Br. J. Cancer | pmid:10555752 |
| Andersson Y et al. | Synergistic anti-cancer effects of immunotoxin and cyclosporin in vitro and in vivo. | 2009 | Br. J. Cancer | pmid:19773757 |
| Chambers CA | Topical tacrolimus for cutaneous lupus erythematosus. | 2003 | Br. J. Dermatol. | pmid:12752154 |
| Ludwig E et al. | New treatment modalities for granuloma faciale. | 2003 | Br. J. Dermatol. | pmid:14511001 |
| Vecchietti G et al. | Topical tacrolimus (FK506) for relapsing erosive stomatitis in paraneoplastic pemphigus. | 2003 | Br. J. Dermatol. | pmid:12752158 |
| Bens G et al. | Topical treatment of Netherton's syndrome with tacrolimus ointment without significant systemic absorption. | 2003 | Br. J. Dermatol. | pmid:12890237 |
| Reich K et al. | Topical tacrolimus for pyoderma gangrenosum. | 1998 | Br. J. Dermatol. | pmid:9892935 |
| Danby SG and Cork MJ | The effects of pimecrolimus on the innate immune response in atopic dermatitis. | 2013 | Br. J. Dermatol. | pmid:23362967 |
| Murrell DF et al. | A randomized controlled trial of pimecrolimus cream 1% in adolescents and adults with head and neck atopic dermatitis and intolerant of, or dependent on, topical corticosteroids. | 2007 | Br. J. Dermatol. | pmid:17935515 |
| Schmitt J et al. | Efficacy and tolerability of proactive treatment with topical corticosteroids and calcineurin inhibitors for atopic eczema: systematic review and meta-analysis of randomized controlled trials. | 2011 | Br. J. Dermatol. | pmid:20819086 |
| Liao YH et al. | Comparison of cutaneous tolerance and efficacy of calcitriol 3 microg g(-1) ointment and tacrolimus 0.3 mg g(-1) ointment in chronic plaque psoriasis involving facial or genitofemoral areas: a double-blind, randomized controlled trial. | 2007 | Br. J. Dermatol. | pmid:17935517 |
| Schauber J et al. | Topical treatment of perianal eczema with tacrolimus 0.1%. | 2009 | Br. J. Dermatol. | pmid:19575757 |
| Rustin MH | The safety of tacrolimus ointment for the treatment of atopic dermatitis: a review. | 2007 | Br. J. Dermatol. | pmid:17854353 |
| Bunker CB | Male genital lichen sclerosus and tacrolimus. | 2007 | Br. J. Dermatol. | pmid:17854373 |
| Wu CS et al. | FK506 inhibits the enhancing effects of transforming growth factor (TGF)-β1 on collagen expression and TGF-β/Smad signalling in keloid fibroblasts: implication for new therapeutic approach. | 2012 | Br. J. Dermatol. | pmid:22540338 |
| Tennis P et al. | Evaluation of cancer risk related to atopic dermatitis and use of topical calcineurin inhibitors. | 2011 | Br. J. Dermatol. | pmid:21466537 |
| Braza TJ et al. | Tacrolimus 0.1% ointment for seborrhoeic dermatitis: an open-label pilot study. | 2003 | Br. J. Dermatol. | pmid:12828755 |
| Vidal D and Alomar A | Successful treatment of periostomal pyoderma gangrenosum using topical tacrolimus. | 2004 | Br. J. Dermatol. | pmid:14996128 |
| Lan CC et al. | FK506 (tacrolimus) and endothelin combined treatment induces mobility of melanoblasts: new insights into follicular vitiligo repigmentation induced by topical tacrolimus on sun-exposed skin. | 2011 | Br. J. Dermatol. | pmid:21039414 |
| Carroll CL et al. | Better medication adherence results in greater improvement in severity of psoriasis. | 2004 | Br. J. Dermatol. | pmid:15491434 |
| Wenzel J et al. | Successful treatment of recalcitrant Wegener's granulomatosis of the skin with tacrolimus (Prograf). | 2004 | Br. J. Dermatol. | pmid:15491443 |
| Chung BY et al. | The proactive treatment of atopic dermatitis with tacrolimus ointment in Korean patients: a comparative study between once-weekly and thrice-weekly applications. | 2013 | Br. J. Dermatol. | pmid:23110605 |
| Kabashima K et al. | Treatment of eosinophilic pustular folliculitis (Ofuji's disease) with tacrolimus ointment. | 2004 | Br. J. Dermatol. | pmid:15491457 |
| Esquivel-Pedraza L et al. | Treatment of oral lichen planus with topical pimecrolimus 1% cream. | 2004 | Br. J. Dermatol. | pmid:15099380 |
| Aguilar-Bernier M et al. | Successful treatment of pruritus with topical tacrolimus in a patient with primary biliary cirrhosis. | 2005 | Br. J. Dermatol. | pmid:15840123 |
| Sorgentini C et al. | Lichen striatus in an adult: successful treatment with tacrolimus. | 2004 | Br. J. Dermatol. | pmid:15099383 |
| Dissemond J et al. | Pimecrolimus in an adhesive ointment as a new treatment option for oral lichen planus. | 2004 | Br. J. Dermatol. | pmid:15099387 |
| Harth W and Linse R | Topical tacrolimus in granuloma annulare and necrobiosis lipoidica. | 2004 | Br. J. Dermatol. | pmid:15099394 |
| Higgins E and Collins P | Recurrent bullous erythema multiforme treated with topical tacrolimus 0·1% ointment. | 2011 | Br. J. Dermatol. | pmid:21114481 |
| Kanekura T et al. | Efficacy of topical tacrolimus for treating the malar rash of systemic lupus erythematosus. | 2003 | Br. J. Dermatol. | pmid:12588393 |
| Vente C et al. | Erosive mucosal lichen planus: response to topical treatment with tacrolimus. | 1999 | Br. J. Dermatol. | pmid:10233234 |
| Lyon CC et al. | Recalcitrant pyoderma gangrenosum treated with systemic tacrolimus. | 1999 | Br. J. Dermatol. | pmid:10233300 |
| Jolles S et al. | Combination oral and topical tacrolimus in therapy-resistant pyoderma gangrenosum. | 1999 | Br. J. Dermatol. | pmid:10233301 |
| Walker SL et al. | The effect of topical tacrolimus on severe recalcitrant chronic discoid lupus erythematosus. | 2002 | Br. J. Dermatol. | pmid:12174136 |
| Mrowietz U et al. | The novel ascomycin derivative SDZ ASM 981 is effective for psoriasis when used topically under occlusion. | 1998 | Br. J. Dermatol. | pmid:9990361 |
| Anstey A | Therapeutic advances and shift in disease paradigm for atopic dermatitis. | 2008 | Br. J. Dermatol. | pmid:19036027 |
| McElwee KJ et al. | Topical FK506: a potent immunotherapy for alopecia areata? Studies using the Dundee experimental bald rat model. | 1997 | Br. J. Dermatol. | pmid:9390322 |
| Hoeger PH et al. | The treatment of facial atopic dermatitis in children who are intolerant of, or dependent on, topical corticosteroids: a randomized, controlled clinical trial. | 2009 | Br. J. Dermatol. | pmid:19067708 |
| Fujimoto N et al. | Facial lichen striatus: successful treatment with tacrolimus ointment. | 2003 | Br. J. Dermatol. | pmid:12653755 |
| Ueda M et al. | Successful treatment of amyopathic dermatomyositis with topical tacrolimus. | 2003 | Br. J. Dermatol. | pmid:12653761 |
| Lan CC et al. | FK506 independently upregulates transforming growth factor beta and downregulates inducible nitric oxide synthase in cultured human keratinocytes: possible mechanisms of how tacrolimus ointment interacts with atopic skin. | 2004 | Br. J. Dermatol. | pmid:15377358 |
| Piram M et al. | Short- and long-term outcome of linear morphoea in children. | 2013 | Br. J. Dermatol. | pmid:24032480 |
| Reitamo S et al. | 0.03% Tacrolimus ointment applied once or twice daily is more efficacious than 1% hydrocortisone acetate in children with moderate to severe atopic dermatitis: results of a randomized double-blind controlled trial. | 2004 | Br. J. Dermatol. | pmid:15030341 |
| Chuh AA | The application of topical tacrolimus in vesicular pemphigoid. | 2004 | Br. J. Dermatol. | pmid:15030368 |
| Gollnick H et al. | Pimecrolimus cream 1% in the long-term management of adult atopic dermatitis: prevention of flare progression. A randomized controlled trial. | 2008 | Br. J. Dermatol. | pmid:18341665 |
| Hjelmgren J et al. | Cost-effectiveness of tacrolimus ointment vs. standard treatment in patients with moderate and severe atopic dermatitis: a health-economic model simulation based on a patient survey and clinical trial data. | 2007 | Br. J. Dermatol. | pmid:17263826 |
| Volz T et al. | Pimecrolimus cream 1% in erosive oral lichen planus--a prospective randomized double-blind vehicle-controlled study. | 2008 | Br. J. Dermatol. | pmid:18647310 |
| Nissi R et al. | Altered p53 and Bcl-2 expression in keratinocytes of vulvar lichen sclerosus during pimecrolimus treatment. | 2009 | Br. J. Dermatol. | pmid:19659469 |
| Lan CC et al. | FK506 promotes melanocyte and melanoblast growth and creates a favourable milieu for cell migration via keratinocytes: possible mechanisms of how tacrolimus ointment induces repigmentation in patients with vitiligo. | 2005 | Br. J. Dermatol. | pmid:16120133 |
| Ständer S et al. | Topical pimecrolimus and tacrolimus transiently induce neuropeptide release and mast cell degranulation in murine skin. | 2007 | Br. J. Dermatol. | pmid:17388925 |
| Rigopoulos D et al. | Efficacy and safety of tacrolimus ointment 0.1% vs. betamethasone 17-valerate 0.1% in the treatment of chronic paronychia: an unblinded randomized study. | 2009 | Br. J. Dermatol. | pmid:19120329 |
| Oranje AP et al. | Wet-wrap treatment using dilutions of tacrolimus ointment and fluticasone propionate cream in human APOC1 (+/+) mice with atopic dermatitis. | 2009 | Br. J. Dermatol. | pmid:18795918 |
| Wataya-Kaneda M et al. | A topical combination of rapamycin and tacrolimus for the treatment of angiofibroma due to tuberous sclerosis complex (TSC): a pilot study of nine Japanese patients with TSC of different disease severity. | 2011 | Br. J. Dermatol. | pmid:21692771 |
| Spergel JM et al. | Addition of topical pimecrolimus to once-daily mid-potent steroid confers no short-term therapeutic benefit in the treatment of severe atopic dermatitis; a randomized controlled trial. | 2007 | Br. J. Dermatol. | pmid:17573885 |
| Taher ZA et al. | Analysis of interleukin-10 levels in lesions of vitiligo following treatment with topical tacrolimus. | 2009 | Br. J. Dermatol. | pmid:19438859 |
| Undre NA et al. | Skin and systemic pharmacokinetics of tacrolimus following topical application of tacrolimus ointment in adults with moderate to severe atopic dermatitis. | 2009 | Br. J. Dermatol. | pmid:19076975 |
| Caproni M et al. | The comparative effects of tacrolimus and hydrocortisone in adult atopic dermatitis: an immunohistochemical study. | 2007 | Br. J. Dermatol. | pmid:17223872 |
| Bilenchi R et al. | Human papillomavirus reactivation following topical tacrolimus therapy of anogenital lichen sclerosus. | 2007 | Br. J. Dermatol. | pmid:17223903 |
| Niwa Y et al. | Topical application of the immunosuppressant tacrolimus accelerates carcinogenesis in mouse skin. | 2003 | Br. J. Dermatol. | pmid:14632799 |
| Mashiko M et al. | A case of angiolymphoid hyperplasia with eosinophilia successfully treated with tacrolimus ointment. | 2006 | Br. J. Dermatol. | pmid:16536847 |
| Ko MJ and Chu CY | Topical tacrolimus therapy for localized bullous pemphigoid. | 2003 | Br. J. Dermatol. | pmid:14632824 |
| Böhm M et al. | Resolution of lichen aureus in a 10-year-old child after topical pimecrolimus. | 2004 | Br. J. Dermatol. | pmid:15327576 |
| Kreuter A et al. | Pimecrolimus 1% cream for perianal atopic dermatitis. | 2005 | Br. J. Dermatol. | pmid:15656832 |
| Fiorentino DF et al. | The direct cellular target of topically applied pimecrolimus may not be infiltrating lymphocytes. | 2011 | Br. J. Dermatol. | pmid:21166661 |
| Lewis FM and Neill SM | Safety of calcineurin inhibitors in the management of lichen sclerosis. | 2007 | Br. J. Dermatol. | pmid:17535239 |
| Neckermann G et al. | Atopic dermatitis-like symptoms in hypomagnesaemic hairless rats are prevented and inhibited by systemic or topical SDZ ASM 981. | 2000 | Br. J. Dermatol. | pmid:10792216 |
| Ramsay HM and Harden PN | Cyclosporin-induced flushing in a renal transplant recipient resolving after substitution with tacrolimus. | 2000 | Br. J. Dermatol. | pmid:10792253 |
| Ellis C et al. | International Consensus Conference on Atopic Dermatitis II (ICCAD II): clinical update and current treatment strategies. | 2003 | Br. J. Dermatol. | pmid:12694268 |
| Hengge UR et al. | Multicentre, phase II trial on the safety and efficacy of topical tacrolimus ointment for the treatment of lichen sclerosus. | 2006 | Br. J. Dermatol. | pmid:17034535 |
| Kang HY and Choi YM | FK506 increases pigmentation and migration of human melanocytes. | 2006 | Br. J. Dermatol. | pmid:17034537 |
| Lübbe J and Sorg O | Tacrolimus ointment and skin carcinogenesis in the DMBA/TPA model in mice. | 2004 | Br. J. Dermatol. | pmid:15606530 |
| Burkhart CG and Burkhart CN | Tacrolimus and topical steroids: which is more effective? | 2004 | Br. J. Dermatol. | pmid:15606537 |
| Tzung TY et al. | Tacrolimus vs. clobetasol propionate in the treatment of facial cutaneous lupus erythematosus: a randomized, double-blind, bilateral comparison study. | 2007 | Br. J. Dermatol. | pmid:17199600 |
| Lee DH et al. | Pimecrolimus 1% cream for the treatment of steroid-induced rosacea: an 8-week split-face clinical trial. | 2008 | Br. J. Dermatol. | pmid:18363758 |
| Moreno-Arias GA et al. | Plasma cell balanitis treated with tacrolimus 0.1%. | 2005 | Br. J. Dermatol. | pmid:16307659 |
| Lonowski S et al. | Vitiligo: a potential autoimmune sequela of DRESS syndrome. | 2016 | Br. J. Dermatol. | pmid:27038429 |
| Bhol KC and Schechter PJ | Topical nanocrystalline silver cream suppresses inflammatory cytokines and induces apoptosis of inflammatory cells in a murine model of allergic contact dermatitis. | 2005 | Br. J. Dermatol. | pmid:15948987 |
| Reitamo S et al. | A multicentre, randomized, double-blind, controlled study of long-term treatment with 0.1% tacrolimus ointment in adults with moderate to severe atopic dermatitis. | 2005 | Br. J. Dermatol. | pmid:15948994 |
| Bos JD | Topical tacrolimus and pimecrolimus are not associated with skin atrophy. | 2002 | Br. J. Dermatol. | pmid:11903264 |
| Wolff K et al. | Efficacy and tolerability of three different doses of oral pimecrolimus in the treatment of moderate to severe atopic dermatitis: a randomized controlled trial. | 2005 | Br. J. Dermatol. | pmid:15948996 |
| Rigopoulos D et al. | Pimecrolimus 1% cream in the treatment of disseminated granuloma annulare. | 2005 | Br. J. Dermatol. | pmid:15949015 |
| Kirtschig G et al. | Successful treatment of erosive vulvovaginal lichen planus with topical tacrolimus. | 2002 | Br. J. Dermatol. | pmid:12207624 |
| Pereira U et al. | Mechanisms of the sensory effects of tacrolimus on the skin. | 2010 | Br. J. Dermatol. | pmid:20302583 |
| Grassberger M et al. | A novel anti-inflammatory drug, SDZ ASM 981, for the treatment of skin diseases: in vitro pharmacology. | 1999 | Br. J. Dermatol. | pmid:10468798 |
| Ho N et al. | A double-blind, randomized, placebo-controlled trial of topical tacrolimus 0·1% vs. clobetasol propionate 0·05% in childhood vitiligo. | 2011 | Br. J. Dermatol. | pmid:21457214 |
| Rigopoulos D et al. | Tacrolimus ointment 0.1% in pityriasis alba: an open-label, randomized, placebo-controlled study. | 2006 | Br. J. Dermatol. | pmid:16792767 |
| Weissenbacher S et al. | Pimecrolimus cream 1% for papulopustular rosacea: a randomized vehicle-controlled double-blind trial. | 2007 | Br. J. Dermatol. | pmid:17493072 |
| Williams HC | Preventing eczema flares with topical corticosteroids or tacrolimus: which is best? | 2011 | Br. J. Dermatol. | pmid:21271989 |
| Takeuchi S et al. | Pruritus of patients with atopic dermatitis in daily life and their experience of therapeutic effects: results of a web-based questionnaire survey. | 2015 | Br. J. Dermatol. | pmid:25421804 |