tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Nishimoto M et al. | Drug interactions and safety profiles with concomitant use of caspofungin and calcineurin inhibitors in allogeneic haematopoietic cell transplantation. | 2017 | Br J Clin Pharmacol | pmid:28407449 |
| Moura Penteado LA et al. | Evaluation of the effect of tacrolimus on periodontitis induced in rats. | 2017 | Arch. Oral Biol. | pmid:28399470 |
| Desai VCA et al. | Comparative Effectiveness of Tacrolimus-Based Steroid Sparing versus Steroid Maintenance Regimens in Kidney Transplantation: Results from Discrete Event Simulation. | 2017 | Med Decis Making | pmid:28384413 |
| Panackal AA et al. | Spinal Arachnoiditis as a Complication of Cryptococcal Meningoencephalitis in Non-HIV Previously Healthy Adults. | 2017 | Clin. Infect. Dis. | pmid:28011613 |
| Sato K et al. | Early post-transplant hyperbilirubinemia is a possible predictive factor for developing neurological complications in pediatric living donor liver transplant patients receiving tacrolimus. | 2017 | Pediatr Transplant | pmid:27804185 |
| Chakkera HA et al. | Calcineurin Inhibitors: Pharmacologic Mechanisms Impacting Both Insulin Resistance and Insulin Secretion Leading to Glucose Dysregulation and Diabetes Mellitus. | 2017 | Clin. Pharmacol. Ther. | pmid:27804122 |
| Fox BD et al. | Tacrolimus Levels Are Not Associated with Risk of Malignancy in Lung Transplant Recipients. | 2017 | Ann. Transplant. | pmid:29133776 |
| Lombardi A et al. | Impaired mitochondrial calcium uptake caused by tacrolimus underlies beta-cell failure. | 2017 | Cell Commun. Signal | pmid:29132395 |
| Cong M et al. | Novel oleyl amine-modified polymannuronic acid micelle loading tacrolimus for therapy of allergic conjunctivitis. | 2017 | Int. J. Biol. Macromol. | pmid:28655660 |
| Suda M et al. | Effectiveness of multi-target therapy in anti-melanoma differentiation-associated gene 5 antibody-positive dermatomyositis with early-stage interstitial lung disease. | 2017 | Scand. J. Rheumatol. | pmid:28649889 |
| Gouvêa ALF et al. | BK polyomavirus nephropathy in two kidney transplant patients with distinct diagnostic strategies for BK virus and similar clinical outcomes: two case reports. | 2017 | J Med Case Rep | pmid:28535782 |
| DaSilva I et al. | Rituximab for Steroid-Dependent or Frequently Relapsing Idiopathic Nephrotic Syndrome in Adults: A Retrospective, Multicenter Study in Spain. | 2017 | BioDrugs | pmid:28534103 |
| Baron PW et al. | Post-Transplant Diabetes Mellitus After Kidney Transplant in Hispanics and Caucasians Treated with Tacrolimus-Based Immunosuppression. | 2017 | Ann. Transplant. | pmid:28533501 |
| Dorr CR et al. | CRISPR/Cas9 Genetic Modification of in HuH-7 Human Hepatocyte Cell Line Leads to Cell Lines with Increased Midazolam and Tacrolimus Metabolism. | 2017 | Drug Metab. Dispos. | pmid:28533324 |
| Liu G et al. | FK506 Attenuates the Inflammation in Rat Spinal Cord Injury by Inhibiting the Activation of NF-κB in Microglia Cells. | 2017 | Cell. Mol. Neurobiol. | pmid:27572744 |
| Koguchi-Yoshioka H et al. | Intravenous immunoglobulin contributes to the control of antimelanoma differentiation-associated protein 5 antibody-associated dermatomyositis with palmar violaceous macules/papules. | 2017 | Br. J. Dermatol. | pmid:28346662 |
| Shemesh E et al. | The Medication Level Variability Index (MLVI) Predicts Poor Liver Transplant Outcomes: A Prospective Multi-Site Study. | 2017 | Am. J. Transplant. | pmid:28321975 |
| Nambu M et al. | A calcineurin antifungal strategy with analogs of FK506. | 2017 | Bioorg. Med. Chem. Lett. | pmid:28412204 |
| Karchin JM et al. | Small Molecule-Induced Domain Swapping as a Mechanism for Controlling Protein Function and Assembly. | 2017 | Sci Rep | pmid:28287617 |
| Kawamura H et al. | Rapid Induction Therapy with Oral Tacrolimus in Elderly Patients with Refractory Ulcerative Colitis Can Easily Lead to Elevated Tacrolimus Concentrations in Blood: A Report of 5 Cases. | 2017 | Am J Case Rep | pmid:28411286 |
| Sadati MS et al. | Recalcitrant cases of pyoderma gangrenosum, responding dramatically to systemic tacrolimus. | 2017 | G Ital Dermatol Venereol | pmid:28409579 |
| de Graav GN et al. | A Randomized Controlled Clinical Trial Comparing Belatacept With Tacrolimus After De Novo Kidney Transplantation. | 2017 | Transplantation | pmid:28403127 |
| Sinha A et al. | Mycophenolate mofetil is inferior to tacrolimus in sustaining remission in children with idiopathic steroid-resistant nephrotic syndrome. | 2017 | Kidney Int. | pmid:28318625 |
| Genvigir FDV et al. | Influence of ABCC2, CYP2C8, and CYP2J2 Polymorphisms on Tacrolimus and Mycophenolate Sodium-Based Treatment in Brazilian Kidney Transplant Recipients. | 2017 | Pharmacotherapy | pmid:28316087 |
| Mertens JS et al. | Morphea and Eosinophilic Fasciitis: An Update. | 2017 | Am J Clin Dermatol | pmid:28303481 |
| Saeki K et al. | Endobronchial Lesions of Mycobacterium abscessus Infection in an Immunocompromised Patient. | 2017 | Am. J. Respir. Crit. Care Med. | pmid:28199133 |
| Manocha GD et al. | Defining the contribution of neuroinflammation to Parkinson's disease in humanized immune system mice. | 2017 | Mol Neurodegener | pmid:28196514 |
| Pengcheng W et al. | Validation of Donor-Specific Tolerance of Intestinal Transplant by a Secondary Heart Transplantation Model. | 2017 | Exp Clin Transplant | pmid:28122485 |
| Kannegieter NM et al. | The Effect of Tacrolimus and Mycophenolic Acid on CD14+ Monocyte Activation and Function. | 2017 | PLoS ONE | pmid:28122021 |
| Unadkat JV et al. | Single Implantable FK506 Disk Prevents Rejection in Vascularized Composite Allotransplantation. | 2017 | Plast. Reconstr. Surg. | pmid:28121868 |
| Sukma Dewi I et al. | Association of Serum MiR-142-3p and MiR-101-3p Levels with Acute Cellular Rejection after Heart Transplantation. | 2017 | PLoS ONE | pmid:28125729 |
| TruneÄka P | Once-daily tacrolimus in liver transplantation: a 'me-too drug', or a therapeutic advantage. | 2017 | Curr Opin Organ Transplant | pmid:28079558 |
| Riva N et al. | Adequate exposure to tacrolimus with sublingual administration in pediatric liver transplant patients. | 2017 | Int J Clin Pharmacol Ther | pmid:28079516 |
| Zhao YT et al. | Sensitized signalling between L-type Ca2+ channels and ryanodine receptors in the absence or inhibition of FKBP12.6 in cardiomyocytes. | 2017 | Cardiovasc. Res. | pmid:28077437 |
| Ericson JE et al. | A Systematic Literature Review Approach to Estimate the Therapeutic Index of Selected Immunosuppressant Drugs After Renal Transplantation. | 2017 | Ther Drug Monit | pmid:28081041 |
| Rozen-Zvi B et al. | Association of the combination of time-weighted variability of tacrolimus blood level and exposure to low drug levels with graft survival after kidney transplantation. | 2017 | Nephrol. Dial. Transplant. | pmid:28025383 |
| Miyazaki D et al. | Steroid-Sparing Effect of 0.1% Tacrolimus Eye Drop for Treatment of Shield Ulcer and Corneal Epitheliopathy in Refractory Allergic Ocular Diseases. | 2017 | Ophthalmology | pmid:28017421 |
| Müller F et al. | Rhamnolipids form drug-loaded nanoparticles for dermal drug delivery. | 2017 | Eur J Pharm Biopharm | pmid:28012989 |
| Kitazawa F et al. | Pharmacokinetic Interaction Between Tacrolimus and Fentanyl in Patients Receiving Allogeneic Hematopoietic Stem Cell Transplantation. | 2017 | Ann. Transplant. | pmid:28947731 |
| De Majumdar S et al. | A Low Concentration of Tacrolimus/Semifluorinated Alkane (SFA) Eyedrop Suppresses Intraocular Inflammation in Experimental Models of Uveitis. | 2017 | Curr. Mol. Med. | pmid:28782485 |
| Kim MJ et al. | The Anti-Inflammatory Effects of Oral-Formulated Tacrolimus in Mice with Experimental Autoimmune Encephalomyelitis. | 2017 | J. Korean Med. Sci. | pmid:28776347 |
| Mussin N et al. | Sirolimus and Metformin Synergistically Inhibits Colon Cancer In Vitro and In Vivo. | 2017 | J. Korean Med. Sci. | pmid:28776332 |
| Kalam MA and Alshamsan A | Poly (d, l-lactide-co-glycolide) nanoparticles for sustained release of tacrolimus in rabbit eyes. | 2017 | Biomed. Pharmacother. | pmid:28772219 |
| Singh AR et al. | Efficacy of steroidal vs non-steroidal agents in oral lichen planus: a randomised, open-label study. | 2017 | J Laryngol Otol | pmid:27917729 |
| Veenhof H et al. | Clinical Validation of Simultaneous Analysis of Tacrolimus, Cyclosporine A, and Creatinine in Dried Blood Spots in Kidney Transplant Patients. | 2017 | Transplantation | pmid:27906832 |
| Sigurgeirsson B and Luger T | A 5-year randomized trial on the safety and efficacy of pimecrolimus in atopic dermatitis: a critical appraisal - author response. | 2017 | Br. J. Dermatol. | pmid:28940181 |
| Wojciechowski D et al. | Mycophenolate Mofetil Withdrawal With Conversion to Everolimus to Treat BK Virus Infection in Kidney Transplant Recipients. | 2017 | Transplant. Proc. | pmid:28923623 |
| Nanmoku K et al. | Effective and Safe Reduction of Conventional Immunosuppressants Using Everolimus in Maintenance Kidney Transplant Recipients. | 2017 | Transplant. Proc. | pmid:28923615 |
| Tourret J et al. | Immunosuppressive Treatment Alters Secretion of Ileal Antimicrobial Peptides and Gut Microbiota, and Favors Subsequent Colonization by Uropathogenic Escherichia coli. | 2017 | Transplantation | pmid:27681266 |
| Larche M and McGonagle D | A case of resistant spondyloarthritis (SpA) that responded to tacrolimus and mycophenolate treatment initiated at the time of renal transplantation for unrelated renal failure. | 2017 | Scand. J. Rheumatol. | pmid:26971928 |