tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Borro JM et al. | Conversion from cyclosporine to tacrolimus stabilizes the course of lung function in lung transplant recipients with bronchiolitis obliterans syndrome. | 2007 | Transplant. Proc. | pmid:17889206 |
| Tolba RH et al. | Conversion to Neoral for tacrolimus-related adverse effects in liver transplant recipients and improvement in quality of life. | 2001 Nov-Dec | Transplant. Proc. | pmid:11750475 |
| Rostaing L et al. | Influence of early FK 506 trough levels on glomerular hemodynamics at 3 months in kidney transplant recipients. | 1998 | Transplant. Proc. | pmid:9636520 |
| Cherala G et al. | Tacrolimus pharmacokinetics in Hispanic children after kidney transplantation. | 2011 | Transplant. Proc. | pmid:22172831 |
| Crespo M et al. | De novo kidney transplant recipients need higher doses of Advagraf compared with Prograf to get therapeutic levels. | 2009 Jul-Aug | Transplant. Proc. | pmid:19715848 |
| Sancho Calabuig A et al. | Very low-grade proteinuria at 3 months posttransplantation is an earlier marker of graft survival. | 2009 Jul-Aug | Transplant. Proc. | pmid:19715850 |
| Corry RJ et al. | Pancreas transplantation without antibody therapy. | 1998 | Transplant. Proc. | pmid:9532050 |
| Reggiani P et al. | Conversion to rescue therapy with FK 506: data from eight liver transplant patients. | 1994 | Transplant. Proc. | pmid:7527982 |
| Lemmens HP et al. | Outcome following orthotopic liver transplantation in HBsAg-positive patients using short- or long-term immunoprophylaxis. | 1994 | Transplant. Proc. | pmid:7527983 |
| Goto Y et al. | Outcome of tacrolimus-treated renal transplantation from elderly donors. | 2000 | Transplant. Proc. | pmid:11119908 |
| Shapiro R et al. | Randomized trial of FK 506/prednisone vs FK 506/azathioprine/prednisone after renal transplantation: preliminary report. | 1993 | Transplant. Proc. | pmid:7679836 |
| Propper DJ et al. | Effects of the immunosuppressive macrolides rapamycin and FK 506 in high responder rats presensitized to major histocompatibility complex antigens. | 1993 | Transplant. Proc. | pmid:7679837 |
| Kay JE et al. | Uptake of FK 506 by lymphocytes and erythrocytes. | 1991 | Transplant. Proc. | pmid:1721269 |
| Matsuura T et al. | Blockade of interleukin-2 production from cloned T cells by cyclosporine and FK 506 assessed by proliferation assays in vitro. | 1992 | Transplant. Proc. | pmid:1371623 |
| Jain AB et al. | Comparative study of cyclosporine and FK 506 dosage requirements in adult and pediatric orthotopic liver transplant patients. | 1991 | Transplant. Proc. | pmid:1721270 |
| Okamura N et al. | Enhanced liver regeneration by FK 506 can be blocked by interleukin-1 alpha and interleukin-2. | 1992 | Transplant. Proc. | pmid:1371624 |
| Nakai T et al. | Immunosuppressive mechanism and immune tolerance of FK 506 in rat small bowel transplantation. | 1996 | Transplant. Proc. | pmid:8623237 |
| Jin MB et al. | Protective effect of FK 506 on hepatic energy metabolism in warm ischemic canine livers induced by total hepatic vascular exclusion. | 1996 | Transplant. Proc. | pmid:8623243 |
| Ericzon BG et al. | Pancreaticoduodenal allotransplantation with FK 506 in the cynomolgus monkey. | 1990 | Transplant. Proc. | pmid:1689905 |
| Murase N et al. | Induction of liver, heart, and multivisceral graft acceptance with a short course of FK 506. | 1990 | Transplant. Proc. | pmid:1689906 |
| Burkhalter F et al. | High incidence of rejection episodes and poor tolerance of sirolimus in a protocol with early steroid withdrawal and calcineurin inhibitor-free maintenance therapy in renal transplantation: experiences of a randomized prospective single-center study. | 2012 | Transplant. Proc. | pmid:23195006 |
| Bora F et al. | Drug interaction between tacrolimus and ertapenem in renal transplantation recipients. | 2012 | Transplant. Proc. | pmid:23195020 |
| Liu WT et al. | In vitro generation of tacrolimus metabolites and their detection in whole blood. | 1998 | Transplant. Proc. | pmid:9636590 |
| Jiang H and Kobayashi M | Differences between cyclosporin A and tacrolimus in organ transplantation. | 1999 | Transplant. Proc. | pmid:10455942 |
| Watanabe K et al. | Donor bone marrow cell infusion is effective in inducing tolerance in dogs treated with fractionated lymphoid irradiation and FK506. | 2000 | Transplant. Proc. | pmid:11120286 |
| Woodle ES et al. | Role of protocol biopsies in the treatment of refractory renal allograft rejection with FK 506. | 1996 | Transplant. Proc. | pmid:8623495 |
| Rao P et al. | Effect of FK 506 on FK-binding protein and transforming growth factor beta gene expression. | 1991 | Transplant. Proc. | pmid:1721301 |
| Watanabe Y et al. | The expression of nonmuscle myosin heavy chain in rat renal transplantation. | 1999 | Transplant. Proc. | pmid:10578260 |
| Takara T et al. | Intraportal donor-specific transfusion given 24 hours before small bowel transplantation with cyclosporine and FK 506. | 1994 | Transplant. Proc. | pmid:7518150 |
| Kusne S et al. | Infectious complications after small bowel transplantation in adults. | 1994 | Transplant. Proc. | pmid:7518153 |
| Iwahori T et al. | Pharmacokinetic differences between morning and evening administration of cyclosporine and tacrolimus therapy. | 2005 | Transplant. Proc. | pmid:15919450 |
| Masutani H et al. | Suppression of the histologic changes of GVHD by FK 506 in rat small bowel transplantation. | 1992 | Transplant. Proc. | pmid:1376519 |
| Wennberg L et al. | Efficacy of various immunosuppressive drugs in preventing pig-to-rat islet xenograft rejection. | 1995 | Transplant. Proc. | pmid:7533391 |
| Mizuta K et al. | Increase of bile acid production by tacrolimus in the rat liver. | 2003 | Transplant. Proc. | pmid:12591477 |
| van Hooff JP and Christiaans MH | Use of tacrolimus in renal transplantation. | 1999 | Transplant. Proc. | pmid:10616483 |
| Fung J et al. | A randomized trial of primary liver transplantation under immunosuppression with FK 506 vs cyclosporine. | 1991 | Transplant. Proc. | pmid:1721333 |
| Serrano J et al. | Tacrolimus is effective in both dual and triple regimens after liver transplantation. | 2002 | Transplant. Proc. | pmid:12176469 |
| du Toit DF et al. | Tacrolimus (FK506) monotherapy provides potent and significant suppression of allogeneic foetal rat pancreatic allograft rejection. | 1998 | Transplant. Proc. | pmid:9865300 |
| Jacques F et al. | Comparison of cyclosporine and tacrolimus in combination with rabbit antithymocyte immunoglobulins as induction therapy in cardiac transplantation. | 2009 | Transplant. Proc. | pmid:19857745 |
| Cardinal H et al. | The evolution of kidney function after lung transplantation: a retrospective cohort study. | 2009 | Transplant. Proc. | pmid:19857746 |
| Hansen LJ et al. | Early pharmacokinetic profiles of enteral tacrolimus after multivisceral transplantation. | 1997 | Transplant. Proc. | pmid:9142303 |
| Deniz H et al. | Inhibition of the renin angiotensin system decreases fibrogenic cytokine expression in tacrolimus nephrotoxicity in rats. | 2006 | Transplant. Proc. | pmid:16549154 |
| Fisniku O et al. | Protective effects of PG490-88 on chronic allograft rejection by changing intragraft gene expression profiles. | 2005 | Transplant. Proc. | pmid:15919518 |
| Tze WJ et al. | FK 506: an effective immunosuppressant for islet xenotransplantation. | 1992 | Transplant. Proc. | pmid:1281577 |
| Kamei T et al. | Established intraportal islet allograft is rejected despite the acceptance of donor-specific second cardiac allograft. | 1992 | Transplant. Proc. | pmid:1281579 |
| Jordan ML et al. | FK 506 conversion of renal allografts failing cyclosporine immunosuppression. | 1991 | Transplant. Proc. | pmid:1721365 |
| Solà R et al. | Tacrolimus in induction immunosuppressive treatment in renal transplantation: comparison with cyclosporine. | 2003 | Transplant. Proc. | pmid:12962763 |
| Alessiani M et al. | Infections in adult liver transplant patients under FK 506 immunosuppression. | 1991 | Transplant. Proc. | pmid:1703345 |
| Offner G et al. | FK 506 in a 14-year-old renal allograft recipient with cyclosporine-related liver nephrotoxicity: 1-year follow-up. | 1991 | Transplant. Proc. | pmid:1721366 |
| Pascual J et al. | Comparison between a two-drug regimen with tacrolimus and steroids and a triple one with azathioprine in kidney transplantation: results of a European trial with 3-year follow up. | 2003 | Transplant. Proc. | pmid:12962764 |
| Imai K et al. | Histopathological study of canine pancreaticoduodenal allotransplantation with FK506, cyclosporine, and triple regimen immunosuppression. | 1991 | Transplant. Proc. | pmid:1703347 |
| Charpentier B | A three arm study comparing immediate tacrolimus therapy with ATG induction therapy followed by either tacrolimus or cyclosporine in adult renal transplant recipients. | 2002 | Transplant. Proc. | pmid:12176511 |
| Choi JY and Kwon OJ | Post-transplant diabetes mellitus: is it associated with poor allograft outcomes in renal transplants? | 2013 | Transplant. Proc. | pmid:24156999 |
| Watanabe K et al. | Prolongation effect of FK506 on the survival of 3-day preserved kidney allografts in dogs. | 1998 | Transplant. Proc. | pmid:9838579 |
| Molmenti E et al. | Noncompliance after pediatric liver transplantation. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083164 |
| Shimizu T et al. | Clinical and histological analysis of chronic tacrolimus nephrotoxicity in renal allografts. | 2008 | Transplant. Proc. | pmid:18790237 |
| Li W et al. | High-dose cellular IL-10 exacerbates rejection and reverses effects of cyclosporine and tacrolimus in Mouse cardiac transplantation. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123209 |
| Schumacher G et al. | Neurologic symptoms improve in patients with Wilson's disease despite immunosuppression. | 1996 | Transplant. Proc. | pmid:8962200 |
| Masaki Y et al. | Cellular basis of acquired immunologic tolerance following total bowel transplantation in rats. I. Relation between donor lymphocyte chimerism and host-cell-mediated immunity. | 1995 | Transplant. Proc. | pmid:7536971 |
| Watanabe K et al. | Prolongation effect of a small dose of FK506, cyclosporine, or azathioprine on renal allografts in dogs treated with fractionated lymphoid irradiation and donor bone marrow cell infusion. | 1989 | Transplant. Proc. | pmid:2468213 |
| Eidelman BH et al. | Neurologic complications of FK 506. | 1991 | Transplant. Proc. | pmid:1721398 |
| McGrath JS and Shehata M | Chronic allograft nephropathy: prospective randomised trial of cyclosporin withdrawal and mycophenolate mofetil or tacrolimus substitution. | 2001 | Transplant. Proc. | pmid:11377500 |
| Baid S et al. | Tacrolimus-associated posttransplant diabetes mellitus in renal transplant recipients: role of hepatitis C infection. | 2002 | Transplant. Proc. | pmid:12176569 |
| Nakao A et al. | Changes of allo-intestinal graft survival and intragraft cytokine expression by bone marrow augmentation with tacrolimus treatment in rats. | 2001 Feb-Mar | Transplant. Proc. | pmid:11266851 |
| Janezic AL et al. | Alternatively spliced variants of IL-2 mRNA in sequential transplant kidney core needle biopsies. | 2001 Feb-Mar | Transplant. Proc. | pmid:11266873 |
| Hoshino Y et al. | FTY720, a novel immunosuppressant, shows a synergistic effect in combination with FK 506 in rat allograft models. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083547 |
| Chiba K et al. | FTY720, a novel immunosuppressant, induces sequestration of circulating lymphocytes by acceleration of lymphocyte homing. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083549 |
| Keown PA and Primmett DR | Cyclosporine: the principal immunosuppressant for renal transplantation. | 1998 | Transplant. Proc. | pmid:9723252 |
| Armenti VT et al. | Pregnancy outcomes in female renal transplant recipients. | 1998 | Transplant. Proc. | pmid:9723259 |
| Yamada MF et al. | Myeloablative cord blood transplantation for adults with hematological malignancies using tacrolimus and short-term methotrexate for graft-versus-host disease prophylaxis: single-institution analysis. | 2008 | Transplant. Proc. | pmid:19100456 |
| Zucker MJ et al. | De novo immunosuppression with sirolimus and tacrolimus in heart transplant recipients compared with cyclosporine and mycophenolate mofetil: a one-year follow-up analysis. | 2005 | Transplant. Proc. | pmid:15964386 |
| Polanco N et al. | Everolimus-based immunosuppression therapy for BK virus nephropathy. | Transplant. Proc. | pmid:25645770 | |
| Fukuzawa M et al. | Effect of donor-specific transfusion and FK 506 on small intestine allotransplantation. | 1991 | Transplant. Proc. | pmid:1721427 |
| Park KM et al. | Bone loss after orthotopic liver transplantation: FK 506 versus cyclosporine. | 1996 | Transplant. Proc. | pmid:8658863 |
| Ogasa N et al. | Effect of FK 506 on growth of transplanted newborn rat intestine. | 1991 | Transplant. Proc. | pmid:1721428 |
| Kakefuda T et al. | Detection of nitrosylhemoglobin in liver allograft in rats by using near-infrared spectroscopy. | 1996 | Transplant. Proc. | pmid:8658885 |
| Venkataramanan R et al. | Biopharmaceutical aspects of FK-506. | 1987 | Transplant. Proc. | pmid:2445070 |
| Kawabe A et al. | Anti-adhesion (anti-ICAM-1 and anti-LFA-1) therapy in a rat pancreas transplantation model. | 1996 | Transplant. Proc. | pmid:8658893 |
| Kino T et al. | Effect of FK-506 on human mixed lymphocyte reaction in vitro. | 1987 | Transplant. Proc. | pmid:2445071 |
| Neff GW et al. | Ten years of sirolimus therapy in orthotopic liver transplant recipients. | 2003 | Transplant. Proc. | pmid:12742498 |
| Petz W et al. | Experience with the use of basiliximab in liver transplantation--use in pediatric and adult recipients in combination with cyclosporine or tacrolimus. | 2002 | Transplant. Proc. | pmid:12176648 |
| Slatinska J et al. | Long-term follow-up of stable kidney transplant recipients after conversion from tacrolimus twice daily immediate release to tacrolimus once-daily prolonged release: a large single-center experience. | 2013 | Transplant. Proc. | pmid:23726604 |
| Grabczewska Z et al. | Neither cyclosporine nor tacrolimus deteriorate endothelial function in renal transplant recipients assessed with reactive hyperernia index. | 2013 | Transplant. Proc. | pmid:23726621 |
| Del Castillo D | Analysis of primary and recurrent rejection following renal transplantation in a large, comparative, multicentre trial. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267283 |
| Pirsch JD | Mycophenolate mofetil, tacrolimus, Neoral: from clinical trials to the clinic. | 1998 | Transplant. Proc. | pmid:9723448 |
| Antoine C et al. | Vascular microthrombosis in renal transplant recipients treated with tacrolimus. | 1998 | Transplant. Proc. | pmid:9745577 |
| Ivulich S et al. | Clinical Challenges of Tacrolimus for Maintenance Immunosuppression Post-Lung Transplantation. | 2017 | Transplant. Proc. | pmid:29149976 |
| Morales J et al. | Alemtuzumab induction in kidney transplantation: clinical results and impact on T-regulatory cells. | 2008 | Transplant. Proc. | pmid:19010240 |
| Carrieri G et al. | Effect of FK 506 in the prophylaxis of autoimmune glomerulonephritis in NZB/WF1 mice. | 1991 | Transplant. Proc. | pmid:1721460 |
| Garcia CD et al. | Pediatric renal transplantation under tacrolimus or cyclosporine immunosuppression and basiliximab induction. | 2002 | Transplant. Proc. | pmid:12431513 |
| Iwata H et al. | Prolongation of xenograft survival by combining donor-specific intravenous presensitization with FK 506. | 2002 | Transplant. Proc. | pmid:12431592 |
| Itagaki F et al. | Drug interaction of tacrolimus and proton pump inhibitors in renal transplant recipients with CYP2C19 gene mutation. | 2002 | Transplant. Proc. | pmid:12431607 |
| Hashi S et al. | Assessment of four methodologies (microparticle enzyme immunoassay, chemiluminescent enzyme immunoassay, affinity column-mediated immunoassay, and flow injection assay-tandem mass spectrometry) for measuring tacrolimus blood concentration in Japanese liver transplant recipients. | 2014 | Transplant. Proc. | pmid:24767342 |
| Owen ER et al. | Peripheral nerve regeneration in human hand transplantation. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267484 |
| Molmenti EP et al. | Incidence, management, and outcome of posttransplant lymphoproliferative disease in pediatric liver transplant recipients. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267487 |
| Stempfle HU et al. | Rapid trabecular bone loss after cardiac transplantation using FK506 (tacrolimus)-based immunosuppression. | 1998 | Transplant. Proc. | pmid:9636459 |
| Wojarski J et al. | Immunosuppressive Treatment and Its Effect on the Occurrence of Pneumocystis jiroveci, Mycoplasma pneumoniae, Chlamydophila pnemoniae, and Legionella pneumophila Infections/Colonizations Among Lung Transplant Recipients. | 2018 | Transplant. Proc. | pmid:30177108 |
| Marcus N et al. | Medium-term outcome of tacrolimus immunosuppression following rejection or graft dysfunction in heart transplant patients. | 1998 | Transplant. Proc. | pmid:9636460 |
| Halim MA et al. | De novo Crohn's disease in a renal transplant recipient. | 2007 | Transplant. Proc. | pmid:17524953 |
| Kumano K et al. | FK 506-induced nephrotoxicity in rats. | 1991 | Transplant. Proc. | pmid:1703696 |