tacrolimus

Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.

Cross Reference

Introduction

To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with tacrolimus?

tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with tacrolimus

MeSH term MeSH ID Detail
Hypersensitivity D006967 22 associated lipids
Osteosarcoma D012516 50 associated lipids
Acne Vulgaris D000152 35 associated lipids
Urination Disorders D014555 9 associated lipids
Arterial Occlusive Diseases D001157 12 associated lipids
Anemia, Hemolytic D000743 4 associated lipids
Leukemia, Erythroblastic, Acute D004915 41 associated lipids
Vision Disorders D014786 10 associated lipids
Multiple Myeloma D009101 13 associated lipids
Osteochondrodysplasias D010009 3 associated lipids
Melanoma D008545 69 associated lipids
Hematologic Diseases D006402 3 associated lipids
Muscular Dystrophies D009136 10 associated lipids
Osteoporosis D010024 12 associated lipids
Anemia, Aplastic D000741 6 associated lipids
Kidney Diseases D007674 29 associated lipids
Hematuria D006417 13 associated lipids
Weight Gain D015430 101 associated lipids
Brain Diseases D001927 27 associated lipids
Cardiovascular Diseases D002318 24 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with tacrolimus

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with tacrolimus?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with tacrolimus?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with tacrolimus?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with tacrolimus?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with tacrolimus?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with tacrolimus

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Per page 10 20 50 100 | Total 15051
Authors Title Published Journal PubMed Link
Rahman S et al. Nordihydroguiaretic acid attenuates skin tumorigenesis in Swiss albino mice with the condition of topical co-administration of an immunosuppressant. 2015 Chem. Biol. Interact. pmid:25770929
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Kim D et al. Hydrogen sulfide and hypoxia-induced changes in TASK (K2P3/9) activity and intracellular Ca(2+) concentration in rat carotid body glomus cells. 2015 Respir Physiol Neurobiol pmid:25956223
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Lightman S et al. Pegylated interferon-α-2b reduces corticosteroid requirement in patients with Behçet's disease with upregulation of circulating regulatory T cells and reduction of Th17. 2015 Ann. Rheum. Dis. pmid:25269831
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Zhang XS et al. FkbN and Tcs7 are pathway-specific regulators of the FK506 biosynthetic gene cluster in Streptomyces tsukubaensis L19. 2016 J. Ind. Microbiol. Biotechnol. pmid:27757551
Martial LC et al. A preliminary study searching for the right dose of tacrolimus in very young (≤4 years) renal transplant patients. 2016 J. Pharm. Pharmacol. pmid:27669677
Gaballa S et al. Results of a 2-arm, phase 2 clinical trial using post-transplantation cyclophosphamide for the prevention of graft-versus-host disease in haploidentical donor and mismatched unrelated donor hematopoietic stem cell transplantation. 2016 Cancer pmid:27404668
Kim HY et al. Tracking protein-protein interaction and localization in living cells using a high-affinity molecular binder. 2016 Biochem. Biophys. Res. Commun. pmid:26820537
Chang KT et al. Tacrolimus suppresses atopic dermatitis-associated cytokines and chemokines in monocytes. 2016 J Microbiol Immunol Infect pmid:25315214
Brooks E et al. Population Pharmacokinetic Modelling and Bayesian Estimation of Tacrolimus Exposure: Is this Clinically Useful for Dosage Prediction Yet? 2016 Clin Pharmacokinet pmid:27138787
Zeng W et al. Hyaluronic acid-coated niosomes facilitate tacrolimus ocular delivery: Mucoadhesion, precorneal retention, aqueous humor pharmacokinetics, and transcorneal permeability. 2016 Colloids Surf B Biointerfaces pmid:26820107
Nuki Y et al. Comparison of the therapeutic efficacy and safety between tacrolimus and infliximab for moderate-to-severe ulcerative colitis: a single center experience. 2016 Scand. J. Gastroenterol. pmid:26818468
Jin H et al. Clinical study of double dose of valsartan combined with tacrolimus in treatment of diabetic nephropathy. 2016 Eur Rev Med Pharmacol Sci pmid:26813471
Joko T et al. Therapeutic Effect of 0.1% Topical Tacrolimus for Childhood Interstitial Keratitis Refractory to Cyclosporine. 2016 J Nippon Med Sch pmid:26960587
Wang N et al. Paclitaxel and Tacrolimus Coencapsulated Polymeric Micelles That Enhance the Therapeutic Effect of Drug-Resistant Ovarian Cancer. 2016 ACS Appl Mater Interfaces pmid:26809267
Malachowski SJ et al. Annular Lichenoid Dermatitis of Youth: A Chronic Case Managed Using Pimecrolimus. 2016 Pediatr Dermatol pmid:27653808
Sawada T et al. Experimental Studies on Protective Effects of FK506 Against Hepatic Ischemia-Reperfusion Injury. 2016 J. Med. Invest. pmid:27644569
Hu X et al. Chimeric Allografts Induced by Short-Term Treatment With Stem Cell-Mobilizing Agents Result in Long-Term Kidney Transplant Survival Without Immunosuppression: A Study in Rats. 2016 Am. J. Transplant. pmid:26749344
Cameron AM et al. Chimeric Allografts Induced by Short-Term Treatment With Stem Cell Mobilizing Agents Result in Long-Term Kidney Transplant Survival Without Immunosuppression: II, Study in Miniature Swine. 2016 Am. J. Transplant. pmid:26748958
Chen CA et al. Quantitative analysis of tissue inflammation and responses to treatment in immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome, and review of literature. 2016 J Microbiol Immunol Infect pmid:26748735
Karagüzel G et al. Vitamin D status and the effects of oral vitamin D treatment in children with vitiligo: A prospective study. 2016 Clin Nutr ESPEN pmid:28531780
Yoshida T et al. Oral tacrolimus oil formulations for enhanced lymphatic delivery and efficient inhibition of T-cell's interleukin-2 production. 2016 Eur J Pharm Biopharm pmid:26748381
Muñoz Gómez MM et al. [Tacrolimus-induced gynecomastia in a patient with polymyositis]. 2016 Med Clin (Barc) pmid:26678165
Ferjani H et al. Protective effect of mycophenolate mofetil against nephrotoxicity and hepatotoxicity induced by tacrolimus in Wistar rats. 2016 J. Physiol. Biochem. pmid:26746208
Vasu S et al. Granulocyte Colony-Stimulating Factor-Mobilized Allografts Contain Activated Immune Cell Subsets Associated with Risk of Acute and Chronic Graft-versus-Host Disease. 2016 Biol. Blood Marrow Transplant. pmid:26743340
Pouché L et al. A candidate gene approach of the calcineurin pathway to identify variants associated with clinical outcomes in renal transplantation. 2016 Pharmacogenomics pmid:26894651
Abdel-Kahaar E et al. Analytical Validation and Cross-Validation of an NFAT-Regulated Gene Expression Assay for Pharmacodynamic Monitoring of Therapy With Calcineurin Inhibitors. 2016 Ther Drug Monit pmid:27661400
Radziejewski K and Balicki I Comparative clinical evaluation of tacrolimus and cyclosporine eye drops for the treatment of canine keratoconjunctivitis sicca. 2016 Acta Vet. Hung. pmid:27653428
Kannegieter NM et al. Conversion to Once-Daily Tacrolimus Results in Increased p38MAPK Phosphorylation in T Lymphocytes of Kidney Transplant Recipients. 2016 Ther Drug Monit pmid:26606072
Wang Z et al. Nanocomposite microparticles (nCmP) for the delivery of tacrolimus in the treatment of pulmonary arterial hypertension. 2016 Int J Pharm pmid:27568494
Rahnama-Moghadam S et al. Vesicular eruption in a 2-year-old boy. 2016 J Fam Pract pmid:27565104
Yang EM et al. Tacrolimus for children with refractory nephrotic syndrome: a one-year prospective, multicenter, and open-label study of Tacrobell®, a generic formula. 2016 World J Pediatr pmid:26684309
Haasova M et al. Immunosuppressive therapy for kidney transplantation in children and adolescents: systematic review and economic evaluation. 2016 Health Technol Assess pmid:27557331
Ishiwata Y et al. Effects of Miconazole Oral Gel on Blood Concentrations of Tacrolimus and Cyclosporine: A Retrospective Observational Study. 2016 Ther Drug Monit pmid:27559841
Lee C et al. Treatment of bleomycin-induced pulmonary fibrosis by inhaled tacrolimus-loaded chitosan-coated poly(lactic-co-glycolic acid) nanoparticles. 2016 Biomed. Pharmacother. pmid:26898446
Zegarska J et al. Tacrolimus Metabolite M-III May Have Nephrotoxic and Myelotoxic Effects and Increase the Incidence of Infections in Kidney Transplant Recipients. 2016 Transplant. Proc. pmid:27496443
Bargnoux AS et al. Evaluation of the New Siemens Tacrolimus Assay on the Dimension EXL Integrated Chemistry System Analyzer: Comparison With an Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry Method. 2016 Ther Drug Monit pmid:27494947
Arai K et al. A Case Report of Drug-Induced Thrombocytopenia after Living Donor Liver Transplantation. 2016 Kobe J Med Sci pmid:27492209
Woolner K and Sauder M Periorbital erythema following alcohol ingestion during treatment with topical tacrolimus. 2016 CMAJ pmid:26598374
Yoshida S et al. Treatment with DHA/EPA ameliorates atopic dermatitis-like skin disease by blocking LTB4 production. 2016 J. Med. Invest. pmid:27644556
Kociszewska-Najman B et al. Congenital Infections in Neonates of Women With Liver or Kidney Transplants. 2016 Transplant. Proc. pmid:27496446
Zmonarski SC et al. Lowering of Messenger Ribonucleic Acid Toll-Like Receptors 2-4,9 in Peripheral Blood Mononuclear Cells in Kidney Allograft Recipients, Relationships With Immunosuppressive Treatment, and Delayed Graft Function Occurrence. 2016 Transplant. Proc. pmid:27496439
Ashizuka S et al. Adrenomedullin Therapy in Patients with Refractory Ulcerative Colitis: A Case Series. 2016 Dig. Dis. Sci. pmid:26470867
Saito B et al. Umbilical cord blood transplantation for adults using tacrolimus with two-day very-short-term methotrexate for graft-versus-host disease prophylaxis. 2016 Leuk. Res. pmid:27376545
Matsui K et al. Betamethasone, but Not Tacrolimus, Suppresses the Development of Th2 Cells Mediated by Langerhans Cell-Like Dendritic Cells. 2016 Biol. Pharm. Bull. pmid:27374298
Kimsa M et al. Transforming growth factor β-related genes in human retinal pigment epithelial cells after tacrolimus treatment. 2016 Pharmacol Rep pmid:27372923
García-Delgado R et al. Systemic Absorption of Topical Tacrolimus in Metastatic Crohn Disease With Skin Ulcers. 2016 Actas Dermosifiliogr pmid:27372545
Gray JM and Ameduri RK Tacrolimus-associated hemolytic uremic syndrome in a pediatric heart transplant recipient. 2016 Pediatr Transplant pmid:27371345
Watanabe R et al. Successful multi-target therapy using corticosteroid, tacrolimus, cyclophosphamide, and rituximab for rapidly progressive interstitial lung disease in a patient with clinically amyopathic dermatomyositis. 2016 Mod Rheumatol pmid:25698368
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Sharma A et al. Perioperative Desensitization Improves Outcomes Among Crossmatch Positive Recipients of Deceased Donor Renal Transplants. 2016 Prog Transplant pmid:27207404
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Menninga NJ et al. Restless Legs Syndrome Following Lung Transplantation: Prevalence and Relationship With Tacrolimus Exposure. 2016 Prog Transplant pmid:27207403
Badri PS et al. Pharmacokinetics of Tacrolimus and Cyclosporine in Liver Transplant Recipients Receiving 3 Direct-Acting Antivirals as Treatment for Hepatitis C Infection. 2016 Ther Drug Monit pmid:27310199
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Matsukawa T et al. Reduced-dose methotrexate in combination with tacrolimus was associated with rapid engraftment and recovery from oral mucositis without affecting the incidence of GVHD. 2016 Int. J. Hematol. pmid:27119977
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Castagna L et al. Tacrolimus compared with cyclosporine A after haploidentical T-cell replete transplantation with post-infusion cyclophosphamide. 2016 Bone Marrow Transplant. pmid:26595078
Wang YY et al. Characterization of Discrete Phosphopantetheinyl Transferases in Streptomyces tsukubaensis L19 Unveils a Complicate Phosphopantetheinylation Network. 2016 Sci Rep pmid:27052100
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Cai SC et al. Topical calcineurin inhibitors in eczema and cancer association: A cohort study. 2016 J Dermatolog Treat pmid:27049893
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Yamamoto T et al. Editorial: tacrolimus vs. anti-tumour necrosis factor agents for moderately to severely active ulcerative colitis--authors' reply. 2016 Aliment. Pharmacol. Ther. pmid:27040167
Imamura CK et al. Impact of cytochrome P450 2C19 polymorphisms on the pharmacokinetics of tacrolimus when coadministered with voriconazole. 2016 J Clin Pharmacol pmid:26239045
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Gu C et al. Triptolide Reduces the Required Dose of Tacrolimus by Attenuating Inflammation, Enhancing Immunosuppression, and Increasing Donor Chimerism in a Heterotopic Hindlimb Transplantation Model. 2016 Plast. Reconstr. Surg. pmid:27879593
Lee WS et al. Efficacy and safety of low-dose tacrolimus for active rheumatoid arthritis with an inadequate response to methotrexate. 2016 Korean J. Intern. Med. pmid:26961485