Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with tacrolimus
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Hao D et al. | Lymphocytic infiltration of the eyelid: two cases responding to tacrolimus and topical glucocorticoid. | 2013 | Acta Derm. Venereol. | pmid:23423497 |
Weisshaar E | Successful treatment of genital pruritus using topical immunomodulators as a single therapy in multi-morbid patients. | 2008 | Acta Derm. Venereol. | pmid:18311464 |
Inoue T et al. | Prolonged topical application of tacrolimus inhibits immediate hypersensitivity reactions by reducing degranulation of mast cells. | 2006 | Acta Derm. Venereol. | pmid:16585982 |
Ortonne JP et al. | 0.3% Tacrolimus gel and 0.5% Tacrolimus cream show efficacy in mild to moderate plaque psoriasis: Results of a randomized, open-label, observer-blinded study. | 2006 | Acta Derm. Venereol. | pmid:16585986 |
Kirsner RS et al. | Safety and efficacy of tacrolimus ointment versus pimecrolimus cream in the treatment of patients with atopic dermatitis previously treated with corticosteroids. | 2010 | Acta Derm. Venereol. | pmid:20107727 |
Ambo M | Relapsing Kaposi's varicelliform eruption and herpes simplex following facial tacrolimus treatment for atopic dermatitis. | 2002 | Acta Derm. Venereol. | pmid:12353724 |
Schreier MH | Immunophilins and immunosuppression by cyclosporins and macrolide structures. | 1994 | Acta Derm Venereol Suppl (Stockh) | pmid:7521103 |
Liang J et al. | Refined structure of the FKBP12-rapamycin-FRB ternary complex at 2.2 A resolution. | 1999 | Acta Crystallogr. D Biol. Crystallogr. | pmid:10089303 |
Bracher A et al. | Structural characterization of the PPIase domain of FKBP51, a cochaperone of human Hsp90. | 2011 | Acta Crystallogr. D Biol. Crystallogr. | pmid:21636895 |
Li P et al. | Structure of the N-terminal domain of human FKBP52. | 2003 | Acta Crystallogr. D Biol. Crystallogr. | pmid:12499534 |