tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Esposito C et al. | Sirolimus prevents short-term renal changes induced by ischemia-reperfusion injury in rats. | 2011 | Am. J. Nephrol. | pmid:21358177 |
| Ren H et al. | Tacrolimus versus cyclophosphamide in steroid-dependent or steroid-resistant focal segmental glomerulosclerosis: a randomized controlled trial. | 2013 | Am. J. Nephrol. | pmid:23343906 |
| Tsipotis E et al. | Bioavailability, Efficacy and Safety of Generic Immunosuppressive Drugs for Kidney Transplantation: A Systematic Review and Meta-Analysis. | 2016 | Am. J. Nephrol. | pmid:27576318 |
| Taber DJ et al. | Significant racial differences in the key factors associated with early graft loss in kidney transplant recipients. | 2014 | Am. J. Nephrol. | pmid:24969370 |
| Li J et al. | Evaluation of mycophenolic acid exposure using a limited sampling strategy in renal transplant recipients. | 2013 | Am. J. Nephrol. | pmid:23689735 |
| Soubhia RM et al. | Tacrolimus and nonsteroidal anti-inflammatory drugs: an association to be avoided. | 2005 Jul-Aug | Am. J. Nephrol. | pmid:15976495 |
| Weir MR et al. | Late calcineurin inhibitor withdrawal as a strategy to prevent graft loss in patients with suboptimal kidney transplant function. | 2004 Jul-Aug | Am. J. Nephrol. | pmid:15237243 |
| Bagnis C et al. | Comparative acute nephrotoxicity of FK-506 and ciclosporin in an isolated in situ autoperfused rat kidney model. | 1997 | Am. J. Nephrol. | pmid:9057948 |
| von Felbert V et al. | Squamous cell carcinoma arising from a localized vulval lesion of Hailey-Hailey disease after tacrolimus therapy. | 2010 | Am. J. Obstet. Gynecol. | pmid:20816142 |
| Kauppila S et al. | The effect of topical pimecrolimus on inflammatory infiltrate in vulvar lichen sclerosus. | 2010 | Am. J. Obstet. Gynecol. | pmid:19889396 |
| Jensen JT et al. | Patient satisfaction after the treatment of vulvovaginal erosive lichen planus with topical clobetasol and tacrolimus: a survey study. | 2004 | Am. J. Obstet. Gynecol. | pmid:15284791 |
| Marquezan MC et al. | Effect of Topical Tacrolimus in the Treatment of Thygeson's Superficial Punctate Keratitis. | 2015 | Am. J. Ophthalmol. | pmid:26133248 |
| Ciardella AP et al. | Cytomegalovirus retinitis and FK 506. | 2003 | Am. J. Ophthalmol. | pmid:12888078 |
| Goldberg NR et al. | Success with single-agent immunosuppression for multifocal choroidopathies. | 2014 | Am. J. Ophthalmol. | pmid:25194229 |
| Al-Amri AM | Long-term follow-up of tacrolimus ointment for treatment of atopic keratoconjunctivitis. | 2014 | Am. J. Ophthalmol. | pmid:24439439 |
| Rikkers SM et al. | Topical tacrolimus treatment of atopic eyelid disease. | 2003 | Am. J. Ophthalmol. | pmid:12614745 |
| Yen MT et al. | Oscillopsia and pseudonystagmus in kidney transplant patients. | 1999 | Am. J. Ophthalmol. | pmid:10612521 |
| Mochizuki M et al. | A clinical trial of FK506 in refractory uveitis. | 1993 | Am. J. Ophthalmol. | pmid:7685147 |
| Brazis PW et al. | A case of bilateral optic neuropathy in a patient on tacrolimus (FK506) therapy after liver transplantation. | 2000 | Am. J. Ophthalmol. | pmid:10764869 |
| Jung JW et al. | Long-term result of maintenance treatment with tacrolimus ointment in chronic ocular graft-versus-host disease. | 2015 | Am. J. Ophthalmol. | pmid:25498356 |
| Ishioka M et al. | FK506 treatment of noninfectious uveitis. | 1994 | Am. J. Ophthalmol. | pmid:7526689 |
| Lee YJ et al. | Application for tacrolimus ointment in treating refractory inflammatory ocular surface diseases. | 2013 | Am. J. Ophthalmol. | pmid:23394907 |
| Moriya K et al. | Tacrolimus ameliorates metabolic disturbance and oxidative stress caused by hepatitis C virus core protein: analysis using mouse model and cultured cells. | 2009 | Am. J. Pathol. | pmid:19729476 |
| Lin Y et al. | PERK activation preserves the viability and function of remyelinating oligodendrocytes in immune-mediated demyelinating diseases. | 2014 | Am. J. Pathol. | pmid:24269558 |
| Maurer M et al. | Hair growth modulation by topical immunophilin ligands: induction of anagen, inhibition of massive catagen development, and relative protection from chemotherapy-induced alopecia. | 1997 | Am. J. Pathol. | pmid:9094998 |
| Bröcker V et al. | Arteriolar lesions in renal transplant biopsies: prevalence, progression, and clinical significance. | 2012 | Am. J. Pathol. | pmid:22464889 |
| Zager RA et al. | Renal cholesterol accumulation: a durable response after acute and subacute renal insults. | 2001 | Am. J. Pathol. | pmid:11485932 |
| Lunz JG et al. | Replicative senescence of biliary epithelial cells precedes bile duct loss in chronic liver allograft rejection: increased expression of p21(WAF1/Cip1) as a disease marker and the influence of immunosuppressive drugs. | 2001 | Am. J. Pathol. | pmid:11290556 |
| Sohn HW et al. | Engagement of CD99 induces apoptosis through a calcineurin-independent pathway in Ewing's sarcoma cells. | 1998 | Am. J. Pathol. | pmid:9846983 |
| Langer A et al. | Humoral and cellular immunopathology of hepatic and cardiac hamster-into-rat xenograft rejection. Marked stimulation of IgM++bright/IgD+dull splenic B cells. | 1993 | Am. J. Pathol. | pmid:7686346 |
| Ito T et al. | Collapse and restoration of MHC class-I-dependent immune privilege: exploiting the human hair follicle as a model. | 2004 | Am. J. Pathol. | pmid:14742267 |
| Rokaw MD et al. | FK-506 and rapamycin but not cyclosporin inhibit aldosterone-stimulated sodium transport in A6 cells. | 1996 | Am. J. Physiol. | pmid:8760046 |
| Tumlin JA et al. | Expression of calcineurin activity and alpha-subunit isoforms in specific segments of the rat nephron. | 1995 | Am. J. Physiol. | pmid:7485542 |
| duBell WH et al. | Independent inhibition of calcineurin and K+ currents by the immunosuppressant FK-506 in rat ventricle. | 1998 | Am. J. Physiol. | pmid:9843803 |
| Aoki Y et al. | CsA-sensitive purine-box transcriptional regulator in bronchial epithelial cells contains NF45, NF90, and Ku. | 1998 | Am. J. Physiol. | pmid:9843854 |
| Kanoh S et al. | Effect of FK506 on ATP-induced intracellular calcium oscillations in cow tracheal epithelium. | 1999 | Am. J. Physiol. | pmid:10362712 |
| Bragado MJ et al. | p70s6k is activated by CCK in rat pancreatic acini. | 1997 | Am. J. Physiol. | pmid:9252447 |
| Shah AU et al. | Protease activation during in vivo pancreatitis is dependent on calcineurin activation. | 2009 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:20501444 |
| Yamada T et al. | Role of T cells in development of chronic pancreatitis in male Wistar Bonn/Kobori rats: effects of tacrolimus. | 2001 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:11705744 |
| Husain SZ et al. | Caerulein-induced intracellular pancreatic zymogen activation is dependent on calcineurin. | 2007 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:17332472 |
| Tashiro M et al. | Calcineurin mediates pancreatic growth in protease inhibitor-treated mice. | 2004 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:14684381 |
| Gao G et al. | Rapamycin inhibits hydrogen peroxide-induced loss of vascular contractility. | 2011 | Am. J. Physiol. Heart Circ. Physiol. | pmid:21357511 |
| DuBell WH et al. | K(+) currents responsible for repolarization in mouse ventricle and their modulation by FK-506 and rapamycin. | 2000 | Am. J. Physiol. Heart Circ. Physiol. | pmid:10710358 |
| Fauconnier J et al. | Frequency-dependent and proarrhythmogenic effects of FK-506 in rat ventricular cells. | 2005 | Am. J. Physiol. Heart Circ. Physiol. | pmid:15471978 |
| Ogino A et al. | Amlodipine inhibits granulation tissue cell apoptosis through reducing calcineurin activity to attenuate postinfarction cardiac remodeling. | 2007 | Am. J. Physiol. Heart Circ. Physiol. | pmid:17644576 |
| Balasubramaniam R et al. | Caffeine-induced arrhythmias in murine hearts parallel changes in cellular Ca(2+) homeostasis. | 2005 | Am. J. Physiol. Heart Circ. Physiol. | pmid:15923307 |
| Hafizi S et al. | ANG II activates effectors of mTOR via PI3-K signaling in human coronary smooth muscle cells. | 2004 | Am. J. Physiol. Heart Circ. Physiol. | pmid:15317677 |
| Giordano A et al. | Rapamycin antagonizes NF-kappaB nuclear translocation activated by TNF-alpha in primary vascular smooth muscle cells and enhances apoptosis. | 2006 | Am. J. Physiol. Heart Circ. Physiol. | pmid:16428340 |
| Kohno M et al. | A new cardioprotective agent, JTV519, improves defective channel gating of ryanodine receptor in heart failure. | 2003 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12433661 |
| Gómez AM et al. | FKBP12.6 overexpression decreases Ca2+ spark amplitude but enhances [Ca2+]i transient in rat cardiac myocytes. | 2004 | Am. J. Physiol. Heart Circ. Physiol. | pmid:15271664 |