tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Karanam BV et al. | Disposition of L-732,531, a potent immunosuppressant, in rats and baboons. | 1998 | Drug Metab. Dispos. | pmid:9763399 |
| Billaud EM et al. | Evidence for a pharmacokinetic interaction between itraconazole and tacrolimus in organ transplant patients. | 1998 | Br J Clin Pharmacol | pmid:9764970 |
| Wang JD et al. | Lymphotactin: a key regulator of lymphocyte trafficking during acute graft rejection. | 1998 | Immunology | pmid:9767457 |
| Hauser IA et al. | Therapeutic concentrations of cyclosporine A, but not FK506, increase P-glycoprotein expression in endothelial and renal tubule cells. | 1998 | Kidney Int. | pmid:9767529 |
| Lamb ML and Jorgensen WL | Investigations of neurotrophic inhibitors of FK506 binding protein via Monte Carlo simulations. | 1998 | J. Med. Chem. | pmid:9767630 |
| Bennett WM | The nephrotoxicity of new and old immunosuppressive drugs. | 1998 | Ren Fail | pmid:9768435 |
| Luo Z et al. | Calcineurin inhibitors and cardiac hypertrophy. | 1998 | Nat. Med. | pmid:9771723 |
| Gómez J et al. | The Bcl-2 gene is differentially regulated by IL-2 and IL-4: role of the transcription factor NF-AT. | 1998 | Oncogene | pmid:9771966 |
| Fellermann K et al. | Steroid-unresponsive acute attacks of inflammatory bowel disease: immunomodulation by tacrolimus (FK506). | 1998 | Am. J. Gastroenterol. | pmid:9772045 |
| Chelmicka-Schorr E et al. | Immunoaugmenting effect of FK 506 on experimental allergic encephalomyelitis in Lewis rats. | 1998 | J. Autoimmun. | pmid:9776710 |
| Weichert G and Sauder DN | Efficacy of tacrolimus (FK 506) in idiopathic treatment-resistant pyoderma gangrenosum. | 1998 | J. Am. Acad. Dermatol. | pmid:9777778 |
| Motamedi H and Shafiee A | The biosynthetic gene cluster for the macrolactone ring of the immunosuppressant FK506. | 1998 | Eur. J. Biochem. | pmid:9780228 |
| Maestri M et al. | [Treatment of the nephrotoxicity of immunosuppressive drugs with insulin-like growth factor-I]. | 1998 | Minerva Chir | pmid:9780630 |
| Nishida T et al. | [FK506 for the prophylaxis of graft-versus-host-disease after bone marrow transplantation from HLA-genotypically mismatched unrelated donor]. | 1998 | Rinsho Ketsueki | pmid:9785975 |
| Rayes N et al. | Pregnancies following liver transplantation--how safe are they? A report of 19 cases under cyclosporine A and tacrolimus. | 1998 | Clin Transplant | pmid:9787947 |
| Peddi VR et al. | Use of tacrolimus eliminates acute rejection as a major complication following simultaneous kidney and pancreas transplantation. | 1998 | Clin Transplant | pmid:9787948 |
| Wu A et al. | Outcome of 22 successful pregnancies after liver transplantation. | 1998 | Clin Transplant | pmid:9787957 |
| Heering P et al. | Distal tubular acidosis induced by FK506. | 1998 | Clin Transplant | pmid:9787958 |
| Masugi T and Otsuka K | [Immunosuppressive drugs and calcineurin]. | 1998 | Tanpakushitsu Kakusan Koso | pmid:9788176 |
| Bajaj-Elliott M et al. | Interactions between stromal cell--derived keratinocyte growth factor and epithelial transforming growth factor in immune-mediated crypt cell hyperplasia. | 1998 | J. Clin. Invest. | pmid:9788959 |