Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with tacrolimus
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Jain A et al. | Tacrolimus and curcumin co-loaded liposphere gel: Synergistic combination towards management of psoriasis. | 2016 | J Control Release | pmid:27725194 |
Quist SR et al. | Effects of Topical Tacrolimus and Polyunsaturated Fatty Acids on In Vivo Release of Eicosanoids in Atopic Dermatitis During Dermal Microdialysis. | 2016 | Acta Derm. Venereol. | pmid:26911315 |
Wang X et al. | Trans-11 vaccenic acid improves insulin secretion in models of type 2 diabetes in vivo and in vitro. | 2016 | Mol Nutr Food Res | pmid:27061233 |
Tang J et al. | ER Stress via CHOP Pathway is Involved in FK506-Induced Apoptosis in Rat Fibroblasts. | 2016 | Cell. Physiol. Biochem. | pmid:27771715 |
Pathak S et al. | Preparation of High-Payload, Prolonged-Release Biodegradable Poly(lactic-co-glycolic acid)-Based Tacrolimus Microspheres Using the Single-Jet Electrospray Method. | 2016 | Chem. Pharm. Bull. | pmid:26833445 |
Jannot AS et al. | A Lack of Significant Effect of POR*28 Allelic Variant on Tacrolimus Exposure in Kidney Transplant Recipients. | 2016 | Ther Drug Monit | pmid:26829596 |
Sayar E et al. | The Ineffectiveness of Tacrolimus in an Infant With a Mutation in the IL-10 Receptor. | 2016 | J. Clin. Gastroenterol. | pmid:26828243 |
Gathogo E et al. | Impact of Tacrolimus Compared With Cyclosporin on the Incidence of Acute Allograft Rejection in Human Immunodeficiency Virus-Positive Kidney Transplant Recipients. | 2016 | Transplantation | pmid:26413990 |
Sienkiewicz B et al. | The impact of CYP3A5 on the metabolism of cyclosporine A and tacrolimus in the evaluation of efficiency and safety of immunosuppressive treatment in patients after kidney transplantation. | 2016 | Pharmazie | pmid:29441922 |
Borges-Costa J et al. | Kaposi's sarcoma presenting as violaceous macules on the chest of a kidney transplanted patient. | 2016 | BMJ Case Rep | pmid:26759393 |
Cortes X et al. | Successful use of infliximab and tacrolimus combination therapy in a patient with ulcerative colitis refractory to infliximab dose intensification plus azathioprine. | 2016 | Int J Clin Pharmacol Ther | pmid:26754306 |
Vanhove T et al. | Clinical determinants of calcineurin inhibitor disposition: a mechanistic review. | 2016 | Drug Metab. Rev. | pmid:26912097 |
Tamhankar MA et al. | Tacrolimus-induced cerebral blindness in a liver transplant patient. | 2016 | Indian J Ophthalmol | pmid:23619482 |
Tsipotis E et al. | Bioavailability, Efficacy and Safety of Generic Immunosuppressive Drugs for Kidney Transplantation: A Systematic Review and Meta-Analysis. | 2016 | Am. J. Nephrol. | pmid:27576318 |
Wang J et al. | Evaluation of mycophenolate mofetil or tacrolimus in children with steroid sensitive but frequently relapsing or steroid-dependent nephrotic syndrome. | 2016 | Nephrology (Carlton) | pmid:26697959 |
Yang Y et al. | STAT3 degradation mediated by calcineurin involved in the neurotoxicity of isoflurane. | 2016 | Neuroreport | pmid:26694943 |
Åžavk E | Neurologic Itch Management. | 2016 | Curr. Probl. Dermatol. | pmid:27578080 |
Okuda K et al. | Targeted Therapy for Acute Autoimmune Myocarditis with Nano-Sized Liposomal FK506 in Rats. | 2016 | PLoS ONE | pmid:27501378 |
Liu S et al. | The POR rs1057868-rs2868177 GC-GT diplotype is associated with high tacrolimus concentrations in early post-renal transplant recipients. | 2016 | Acta Pharmacol. Sin. | pmid:27498776 |
Delli K et al. | Comment on: 'Efficacy of topical tacrolimus for oral lichen planus: real-life experience in a retrospective cohort of patients with a review of the literature' by Ribero et al. (2015). | 2016 | J Eur Acad Dermatol Venereol | pmid:26616360 |
Zhang Y et al. | Effect of FK506 on apoptosis of facial motor neurons in rats and its possible mechanism. | 2016 | Eur Arch Otorhinolaryngol | pmid:25784181 |
Ibrahim MA et al. | Study of intercurrent infection pattern in hepatitis C seropositive renal transplant recipients, relationship with T-cell function. | 2016 | Ren Fail | pmid:27418152 |
Bessa AB et al. | Prospective Randomized Trial Investigating the Influence of Pharmaceutical Care on the Intra-Individual Variability of Tacrolimus Concentrations Early After Kidney Transplant. | 2016 | Ther Drug Monit | pmid:27414973 |
Mehraj V et al. | The Dynamic Role of the IL-33/ST2 Axis in Chronic Viral-infections: Alarming and Adjuvanting the Immune Response. | 2016 | EBioMedicine | pmid:27397514 |
MacDonald C et al. | Acute kidney injury after heart transplant in young children: risk factors and outcomes. | 2016 | Pediatr. Nephrol. | pmid:26559064 |
Pastor-Clerigues A et al. | Evaluation of the Ocular Tolerance of Three Tacrolimus Topical Pharmaceutical Preparations by Bovine Corneal Opacity and Permeability Test. | 2016 | Curr. Eye Res. | pmid:26554729 |
Vanhove T et al. | Comparative performance of oral midazolam clearance and plasma 4β-hydroxycholesterol to explain interindividual variability in tacrolimus clearance. | 2016 | Br J Clin Pharmacol | pmid:27501475 |
Roblin E et al. | Lipid profile and cardiovascular risk factors in pediatric liver transplant recipients. | 2016 | Pediatr Transplant | pmid:26750745 |
Dunyak BM and Gestwicki JE | Peptidyl-Proline Isomerases (PPIases): Targets for Natural Products and Natural Product-Inspired Compounds. | 2016 | J. Med. Chem. | pmid:27409354 |
Stiehl SR et al. | Tacrolimus interaction with dexmedetomidine--a case report. | 2016 | Pediatr Transplant | pmid:26493547 |
Sun W et al. | Activation of TRPV2 negatively regulates the differentiation of mouse brown adipocytes. | 2016 | Pflugers Arch. | pmid:27318696 |
Kang SW et al. | Inhibition of senescence and promotion of the proliferation of chondrocytes from articular cartilage by CsA and FK506 involves inhibition of p38MAPK. | 2016 | Mech. Ageing Dev. | pmid:26704447 |
Yoshimura N et al. | Effectiveness of the Combination of Everolimus and Tacrolimus With High Dosage of Mizoribine for Living Donor-Related Kidney Transplantation. | 2016 | Transplant. Proc. | pmid:27234736 |
Yamanaka K et al. | Induction Immunosuppressive Therapy With Everolimus and Low-Dose Tacrolimus Extended-Release Preserves Good Renal Function at 1Â Year After Kidney Transplantation. | 2016 | Transplant. Proc. | pmid:27234735 |
Baek CH et al. | Usefulness of Tacrolimus without Basiliximab in Well-Matched Living-Donor Renal Transplant Recipients in Korea. | 2016 | Exp Clin Transplant | pmid:27228054 |
Hošková L et al. | Comparison of Cystatin C and NGAL in Early Diagnosis of Acute Kidney Injury After Heart Transplantation. | 2016 | Ann. Transplant. | pmid:27226081 |
Schmidt KJ et al. | Long-term Outcomes in Steroid-refractory Ulcerative Colitis Treated with Tacrolimus Alone or in Combination with Purine Analogues. | 2016 | J Crohns Colitis | pmid:26419459 |
Sommerer C and Giese T | Nuclear Factor of Activated T Cells-Regulated Gene Expression as Predictive Biomarker of Personal Response to Calcineurin Inhibitors. | 2016 | Ther Drug Monit | pmid:26418701 |
Prytuła AA et al. | The Effect of Weight and CYP3A5 Genotype on the Population Pharmacokinetics of Tacrolimus in Stable Paediatric Renal Transplant Recipients. | 2016 | Clin Pharmacokinet | pmid:27138785 |
Yamamoto T et al. | Letter: which patient profile for tacrolimus in ulcerative colitis? Authors' reply. | 2016 | Aliment. Pharmacol. Ther. | pmid:27137731 |
Laharie D and Poullenot F | Letter: which patient profile for tacrolimus in ulcerative colitis? | 2016 | Aliment. Pharmacol. Ther. | pmid:27137730 |
Kim MJ et al. | Effect of Immunosuppressive Drugs on the Changes of Serum Galactose-Deficient IgA1 in Patients with IgA Nephropathy. | 2016 | PLoS ONE | pmid:27930655 |
Wei Q et al. | Efficacy and Safety of a Steroid-Free Immunosuppressive Regimen after Liver Transplantation for Hepatocellular Carcinoma. | 2016 | Gut Liver | pmid:27074818 |
Wowro SJ et al. | Effects of mTOR and calcineurin inhibitors combined therapy in Epstein-Barr virus positive and negative Burkitt lymphoma cells. | 2016 | Int. Immunopharmacol. | pmid:26613512 |
Saeki H et al. | Clinical Practice Guidelines for the Management of Atopic Dermatitis 2016. | 2016 | J. Dermatol. | pmid:27076388 |
Ueda Y and Uemoto S | Decreased tacrolimus concentration following a temporal increase during interferon-free therapy with asunaprevir and daclatasvir in patients with recurrent hepatitis C after liver transplantation. | 2016 | Transpl. Int. | pmid:26270021 |
Hitzeman N and Kinnevey C | Topical Tacrolimus for Eczema. | 2016 | Am Fam Physician | pmid:27929217 |
Myers AL et al. | Stability of tacrolimus injection diluted in 0.9% sodium chloride injection and stored in Excel bags. | 2016 | Am J Health Syst Pharm | pmid:27919876 |
Fix OK et al. | Liver transplant alone without kidney transplant for fibrinogen Aα-chain (AFib) renal amyloidosis. | 2016 | Amyloid | pmid:26972447 |
Thervet É | [Applied pharmacogenetic]. | 2016 | Nephrol. Ther. | pmid:26972091 |