tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Siekierka JJ et al. | Potential roles of other FK 506-binding proteins in mediating the effects of FK 506. | 1991 | Transplant. Proc. | pmid:1721256 |
| Morris RE | In vivo immunopharmacology of the macrolides FK 506 and rapamycin: toward the era of rational immunosuppressive drug discovery, development, and use. | 1991 | Transplant. Proc. | pmid:1721257 |
| Blanc P et al. | Antiproliferative effect of FK 506 and cyclosporine on adult human hepatocytes in culture. | 1991 | Transplant. Proc. | pmid:1721288 |
| Loréal O et al. | FK 506 is less cytotoxic than cyclosporine to human and rat hepatocytes in vitro. | 1991 | Transplant. Proc. | pmid:1721289 |
| Chen-Woan M et al. | Diminished lymphocyte growth from endomyocardial biopsies from cardiac transplant patients on FK 506 immunosuppression. | 1991 | Transplant. Proc. | pmid:1721320 |
| Fukuzawa M et al. | Effect of FK 506 on CD4+ and CD8+ T-cell function in vivo. | 1991 | Transplant. Proc. | pmid:1721321 |
| Green M et al. | Infectious complications of pediatric liver transplantation under FK 506. | 1991 | Transplant. Proc. | pmid:1721352 |
| Carroll PB et al. | Effect of the immunosuppressant FK506 on glucose-induced insulin secretion from adult rat islets of Langerhans. | 1991 | Transplantation | pmid:1702911 |
| Torre-Cisneros J et al. | The spectrum of aspergillosis in liver transplant patients: comparison of FK 506 and cyclosporine immunosuppression. | 1991 | Transplant. Proc. | pmid:1721353 |
| Starzl TE et al. | Hepatotrophic effects of FK506 in dogs. | 1991 | Transplantation | pmid:1702912 |
| McCauley J et al. | Changes in renal function after liver transplantation under FK 506. | 1991 | Transplant. Proc. | pmid:1721385 |
| Tauxe WN et al. | A comparison of the renal effects (ERPF, GFR, and FF) of FK 506 and cyclosporine in patients with liver transplantation. | 1991 | Transplant. Proc. | pmid:1721386 |
| Fukuzaki T et al. | Induction of tolerance to islet allografts with preoperative donor spleen cell injection and a short course of FK 506 treatment. | 1991 | Transplant. Proc. | pmid:1721415 |
| Tzakis AG et al. | FK 506 rescue in chronic graft-versus-host-disease after bone marrow transplantation. | 1991 | Transplant. Proc. | pmid:1721416 |
| Sewing KF and Christians U | FK 506. | 1991 | Lancet | pmid:1704090 |
| Wiederrecht G et al. | FKB1 encodes a nonessential FK 506-binding protein in Saccharomyces cerevisiae and contains regions suggesting homology to the cyclophilins. | 1991 | Proc. Natl. Acad. Sci. U.S.A. | pmid:1704127 |
| Propper DJ et al. | Evidence that FK 506 may abrogate suppressor cell activity induced by blood transfusion. | 1991 | Transplant. Proc. | pmid:1721446 |
| Fabrega AJ et al. | FK 506 enhances the beneficial effects of donor-specific blood transfusion on allograft survival in rats. | 1991 | Transplant. Proc. | pmid:1721447 |
| Davies CB et al. | Effects of donor-specific transfusion, cyclosporine A and FK 506 on rat cardiac allograft survival. | 1991 | Transplant. Proc. | pmid:1721448 |
| Halloran PF and Madrenas J | The mechanism of action of cyclosporine: a perspective for the 90's. | 1991 | Clin. Biochem. | pmid:1711939 |
| Palaszynski EW et al. | Purification and characterization of cyclosporine and FK-506 binding proteins from a human T-helper cell line. | 1991 | Clin. Biochem. | pmid:1711940 |
| Shiraki K et al. | Effect of FK-506 on replication of human cytomegalovirus in vitro. | 1991 | J. Antibiot. | pmid:1712008 |
| Ochiai T et al. | [Immunosuppressive agents--advances of the developmental studies and the mode of action]. | 1991 | Nippon Rinsho | pmid:1715926 |
| Ricordi C et al. | In vivo effect of FK506 on human pancreatic islets. | 1991 | Transplantation | pmid:1716797 |
| Katz IA et al. | Comparison of the effects of FK506 and cyclosporine on bone mineral metabolism in the rat. A pilot study. | 1991 | Transplantation | pmid:1716801 |
| Morris RE | Rapamycin: FK506's fraternal twin or distant cousin? | 1991 | Immunol. Today | pmid:1715165 |
| Baumann G et al. | Cyclosporin A and FK-506 both affect DNA binding of regulatory nuclear proteins to the human interleukin-2 promoter. | 1991 | New Biol. | pmid:1715185 |
| Jordan ML et al. | Initial studies with FK506 in renal transplantation. | 1991 Sep-Oct | Cleve Clin J Med | pmid:1718631 |
| Yem AW et al. | The Hsp56 component of steroid receptor complexes binds to immobilized FK506 and shows homology to FKBP-12 and FKBP-13. | 1992 | J. Biol. Chem. | pmid:1371107 |
| Park ST et al. | PPIase catalysis by human FK506-binding protein proceeds through a conformational twist mechanism. | 1992 | J. Biol. Chem. | pmid:1371117 |
| Bishop DK and Li W | Cyclosporin A and FK506 mediate differential effects on T cell activation in vivo. | 1992 | J. Immunol. | pmid:1371128 |
| Hatfield SM and Roehm NW | Cyclosporine and FK506 inhibition of murine mast cell cytokine production. | 1992 | J. Pharmacol. Exp. Ther. | pmid:1371158 |
| Takaya S et al. | The adverse impact on liver transplantation of using positive cytotoxic crossmatch donors. | 1992 | Transplantation | pmid:1371195 |
| Francavilla A et al. | Inhibition of liver, kidney, and intestine regeneration by rapamycin. | 1992 | Transplantation | pmid:1371198 |
| Matsukawa W et al. | Effects of a new immunosuppressive agent, FK506, in rats with active Heymann nephritis. | 1992 | J. Lab. Clin. Med. | pmid:1371298 |
| Sampson BA and Gotschlich EC | Neisseria meningitidis encodes an FK506-inhibitable rotamase. | 1992 | Proc. Natl. Acad. Sci. U.S.A. | pmid:1371354 |
| Andersson J et al. | Effects of FK506 and cyclosporin A on cytokine production studied in vitro at a single-cell level. | 1992 | Immunology | pmid:1371491 |
| Strasser S et al. | Effect of FK506 on insulin secretion in normal dogs. | 1992 | Metab. Clin. Exp. | pmid:1371575 |
| Vincent SH et al. | In vitro metabolism of FK-506 in rat, rabbit, and human liver microsomes: identification of a major metabolite and of cytochrome P450 3A as the major enzymes responsible for its metabolism. | 1992 | Arch. Biochem. Biophys. | pmid:1373595 |
| Liu J et al. | Inhibition of T cell signaling by immunophilin-ligand complexes correlates with loss of calcineurin phosphatase activity. | 1992 | Biochemistry | pmid:1373650 |
| Adachi A et al. | Immunosuppressive effect of FK506 on experimental allergic neuritis in Lewis rats: change of T cell subsets. | 1992 | Intern. Med. | pmid:1373661 |
| Fruman DA et al. | Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin A. | 1992 | Proc. Natl. Acad. Sci. U.S.A. | pmid:1373887 |
| Lake JR et al. | Maintenance immunosuppression after liver transplantation. | 1992 | Semin. Liver Dis. | pmid:1373916 |
| Taormina D et al. | Stability and sorption of FK 506 in 5% dextrose injection and 0.9% sodium chloride injection in glass, polyvinyl chloride, and polyolefin containers. | 1992 | Am J Hosp Pharm | pmid:1373936 |
| Ochiai T | [Advances in the fundamentals and therapeutic use of immunosuppressive agents]. | 1992 | Arerugi | pmid:1374229 |
| Hung DT and Schreiber SL | cDNA cloning of a human 25 kDa FK506 and rapamycin binding protein. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1374240 |
| Jayaraman T et al. | FK506 binding protein associated with the calcium release channel (ryanodine receptor). | 1992 | J. Biol. Chem. | pmid:1374404 |
| Höllsberg P et al. | Characterization of HTLV-I in vivo infected T cell clones. IL-2-independent growth of nontransformed T cells. | 1992 | J. Immunol. | pmid:1374452 |
| Ericzon BG et al. | The effect of FK506 treatment on pancreaticoduodenal allotransplantation in the primate. | 1992 | Transplantation | pmid:1376501 |
| Tze WJ et al. | FK 506--an effective immunosuppressant in achieving long-term functional islet allograft survival in diabetic rats. | 1992 | Transplant. Proc. | pmid:1376509 |
| Yasunami Y et al. | Induction of donor-specific unresponsiveness in rat islet allografts by FK 506. | 1992 | Transplant. Proc. | pmid:1376510 |
| Kai N et al. | A study on the timing of immunologic priming in autoimmune insulitis in NOD mice. | 1992 | Transplant. Proc. | pmid:1376511 |
| Ricordi C et al. | Effect of FK 506 on human pancreatic islets following renal subcapsular transplantation in diabetic nude mice. | 1992 | Transplant. Proc. | pmid:1376512 |
| Hisanaga M et al. | Successful combination therapy with FK 506 and 15-deoxyspergualin in pancreatic islet xenografting. | 1992 | Transplant. Proc. | pmid:1376513 |
| Ogasa N et al. | Successful transplantation of newborn rat intestine as a free graft. | 1992 | Transplant. Proc. | pmid:1376514 |
| Graeb C et al. | Cytoimmunologic monitoring of small bowel allograft recipients. | 1992 | Transplant. Proc. | pmid:1376515 |
| Date K et al. | Effect of FK 506 on graft survival in rat small intestinal allografts. | 1992 | Transplant. Proc. | pmid:1376516 |
| Hatazawa C et al. | Effect of FK 506 on bowel transplantation in rats. | 1992 | Transplant. Proc. | pmid:1376517 |
| Akutsu I et al. | [Inhibitory effects of cyclosporin A and FK-506 on eosinophil chemotactic factor activity in culture supernatants of mononuclear cells from asthmatics]. | 1992 | Arerugi | pmid:1280086 |
| Bergstrand H and Lundquist B | Human basophil histamine release is differently affected by inhibitors of calmodulin, diacylglycerol kinase and peptidyl prolyl cis-trans isomerase in a secretagogue specific manner. | 1992 | Allergy | pmid:1280915 |
| Barry JM | Immunosuppressive drugs in renal transplantation. A review of the regimens. | 1992 | Drugs | pmid:1281071 |
| Stiff DD et al. | Metabolism of FK 506 in differentially induced rat liver microsomes. | 1992 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:1281332 |
| Foor F et al. | Calcineurin mediates inhibition by FK506 and cyclosporin of recovery from alpha-factor arrest in yeast. | 1992 | Nature | pmid:1281518 |
| Goldfeld AE et al. | Transcription of the tumor necrosis factor alpha gene is rapidly induced by anti-immunoglobulin and blocked by cyclosporin A and FK506 in human B cells. | 1992 | Proc. Natl. Acad. Sci. U.S.A. | pmid:1281550 |
| Morikawa K et al. | The distinct effects of FK506 on the activation, proliferation, and differentiation of human B lymphocytes. | 1992 | Transplantation | pmid:1281561 |
| Moutabarrik A et al. | FK506-induced kidney tubular cell injury. | 1992 | Transplantation | pmid:1281562 |
| Yagihashi A et al. | HLA matching effect in liver transplantation. | 1992 | Transplant. Proc. | pmid:1281569 |
| Kobayashi M et al. | Posttransplant donor-specific T-lymphocytotoxic antibody in liver transplant patients with a positive crossmatch. | 1992 | Transplant. Proc. | pmid:1281570 |
| Lemster B et al. | Cytokine gene expression in murine lymphocytes activated in the presence of FK 506, bredinin, mycophenolic acid, or brequinar sodium. | 1992 | Transplant. Proc. | pmid:1281576 |
| Takaori K et al. | A comparative study on immunosuppressive effects of cyclosporin A and FK 506 on peripheral blood lymphocytes in dogs. | 1992 | Biotherapy | pmid:1377926 |
| Murthy JN et al. | Radioreceptor assay for quantifying FK-506 immunosuppressant in whole blood. | 1992 | Clin. Chem. | pmid:1377995 |
| Takai K et al. | Effects of FK506 on rat thymic epithelial cells; immunohistochemical study. | 1992 | Thymus | pmid:1378235 |
| Dutz JP et al. | Effects of cognate peptides on cytolytic and proliferative activities of cloned cytotoxic T lymphocytes. | 1992 | Int. Immunol. | pmid:1378297 |
| Kenmochi T et al. | [The effect of FK506 on segmental pancreas allograft in mongrel dogs]. | 1992 | Nihon Geka Gakkai Zasshi | pmid:1378526 |
| Mouzaki A et al. | Cyclosporin A and FK506 prevent the derepression of the IL-2 gene in mitogen-induced primary T lymphocytes. | 1992 | Cytokine | pmid:1378764 |
| Ramamoorthy S et al. | Selective impairment of taurine transport by cyclosporin A in a human placental cell line. | 1992 | Pediatr. Res. | pmid:1378960 |
| Armitage JM et al. | Clinical trial of FK 506 immunosuppression in adult cardiac transplantation. | 1992 | Ann. Thorac. Surg. | pmid:1379032 |
| Thomson AW | The spectrum of action of new immunosuppressive drugs. | 1992 | Clin. Exp. Immunol. | pmid:1379130 |
| Fischer G et al. | Mip protein of Legionella pneumophila exhibits peptidyl-prolyl-cis/trans isomerase (PPlase) activity. | 1992 | Mol. Microbiol. | pmid:1379319 |
| Steiner JP et al. | High brain densities of the immunophilin FKBP colocalized with calcineurin. | 1992 | Nature | pmid:1380130 |
| Aperia A et al. | Calcineurin mediates alpha-adrenergic stimulation of Na+,K(+)-ATPase activity in renal tubule cells. | 1992 | Proc. Natl. Acad. Sci. U.S.A. | pmid:1380157 |
| Nielsen JB et al. | Yeast FKBP-13 is a membrane-associated FK506-binding protein encoded by the nonessential gene FKB2. | 1992 | Proc. Natl. Acad. Sci. U.S.A. | pmid:1380159 |
| Calvo V et al. | Interleukin 2 stimulation of p70 S6 kinase activity is inhibited by the immunosuppressant rapamycin. | 1992 | Proc. Natl. Acad. Sci. U.S.A. | pmid:1380162 |
| Price DJ et al. | Rapamycin-induced inhibition of the 70-kilodalton S6 protein kinase. | 1992 | Science | pmid:1380182 |
| Granelli-Piperno A | SRC-related proto-oncogenes and transcription factors in primary human T cells: modulation by cyclosporin A and FK506. | 1992 | J. Autoimmun. | pmid:1380242 |
| Reem GH | Molecular mode of action of cyclosporin and FK506 in human thymocytes. | 1992 | J. Autoimmun. | pmid:1380243 |
| Bach JF | Immunointervention in autoimmune diseases from cellular selectivity to autoantigen specificity. | 1992 | J. Autoimmun. | pmid:1380245 |
| Baumann G et al. | Molecular mechanisms of immunosuppression. | 1992 | J. Autoimmun. | pmid:1380246 |
| Walpoth B et al. | Assessment of new immunosuppressive drugs in a rat cardiac allograft heterotopic model. | 1992 | Eur Surg Res | pmid:1380460 |
| Wiederrecht G et al. | Characterization of high molecular weight FK-506 binding activities reveals a novel FK-506-binding protein as well as a protein complex. | 1992 | J. Biol. Chem. | pmid:1383226 |
| Morris RE | Immunopharmacology of new xenobiotic immunosuppressive molecules. | 1992 | Semin. Nephrol. | pmid:1384096 |
| Hendey B et al. | Inhibition of neutrophil chemokinesis on vitronectin by inhibitors of calcineurin. | 1992 | Science | pmid:1384129 |
| Roberti I et al. | Evidence that the systematic analysis of bile cytology permits monitoring of hepatic allograft rejection. | 1992 | Transplantation | pmid:1384182 |
| Langrehr JM et al. | Evidence that indefinite survival of small bowel allografts achieved by a brief course of cyclosporine or FK506 is not due to systemic hyporesponsiveness. | 1992 | Transplantation | pmid:1384185 |
| McCarthy SA et al. | The effects of immunosuppressive drugs on the regulation of activation-induced apoptotic cell death in thymocytes. | 1992 | Transplantation | pmid:1384186 |
| Dhar DK et al. | The salutary effect of FK506 in ischemia-reperfusion injury of the canine liver. | 1992 | Transplantation | pmid:1384188 |
| Ericzon BG et al. | FK506-induced impairment of glucose metabolism in the primate--studies in pancreatic transplant recipients and in nontransplanted animals. | 1992 | Transplantation | pmid:1384189 |
| Meiser BM et al. | Continuous infusion of angiopeptin significantly reduces accelerated graft vessel disease induced by FK 506 in a rat heart allograft model. | 1992 | Transplant. Proc. | pmid:1384201 |
| Wakabayashi H et al. | Effect of FK 506 and cyclosporine A on hepatic energy status in the rat after warm ischemia, as monitored by 31P nuclear magnetic resonance spectroscopy in vivo. | 1992 | Transplant. Proc. | pmid:1384205 |
| Griffin AD et al. | FK 506 in canine renal transplantation. | 1992 | Transplant. Proc. | pmid:1384209 |