tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Keenan RJ et al. | Immunosuppressive properties of thalidomide. Inhibition of in vitro lymphocyte proliferation alone and in combination with cyclosporine or FK506. | 1991 | Transplantation | pmid:1719668 |
| Charlton M et al. | Everolimus Is Associated With Less Weight Gain Than Tacrolimus 2 Years After Liver Transplantation: Results of a Randomized Multicenter Study. | 2017 | Transplantation | pmid:28817434 |
| Yamagami S et al. | Mechanism of concordant corneal xenograft rejection in mice: synergistic effects of anti-leukocyte function-associated antigen-1 monoclonal antibody and FK506. | 1997 | Transplantation | pmid:9233699 |
| Singh N et al. | Immunosuppressive-associated leukoencephalopathy in organ transplant recipients. | 2000 | Transplantation | pmid:10708096 |
| Gonwa T et al. | Randomized trial of tacrolimus in combination with sirolimus or mycophenolate mofetil in kidney transplantation: results at 6 months. | 2003 | Transplantation | pmid:12717205 |
| Neuhaus P et al. | Comparison of FK506- and cyclosporine-based immunosuppression in primary orthotopic liver transplantation. A single center experience. | 1995 | Transplantation | pmid:7530868 |
| Tzakis AG et al. | Preliminary experience with campath 1H (C1H) in intestinal and liver transplantation. | 2003 | Transplantation | pmid:12717207 |
| Shield CF et al. | Assessment of health-related quality of life in kidney transplant patients receiving tacrolimus (FK506)-based versus cyclosporine-based immunosuppression. FK506 Kidney Transplant Study Group. | 1997 | Transplantation | pmid:9422413 |
| Stegall MD et al. | Prednisone withdrawal 14 days after liver transplantation with mycophenolate: a prospective trial of cyclosporine and tacrolimus. | 1997 | Transplantation | pmid:9422416 |
| Bierer BE et al. | Mechanisms of immunosuppression by FK506. Preservation of T cell transmembrane signal transduction. | 1990 | Transplantation | pmid:1694317 |
| Takeguchi N et al. | Inhibition of the multidrug efflux pump in isolated hepatocyte couplets by immunosuppressants FK506 and cyclosporine. | 1993 | Transplantation | pmid:7681229 |
| Bundick RV et al. | FK506 as an agonist to induce inhibition of interleukin 2 production. | 1992 | Transplantation | pmid:1374947 |
| Kasahara M et al. | Living-related liver transplantation for type II citrullinemia using a graft from heterozygote donor. | 2001 | Transplantation | pmid:11211185 |
| Ovuworie CA et al. | Vascular endothelial function in cyclosporine and tacrolimus treated renal transplant recipients. | 2001 | Transplantation | pmid:11685108 |
| Al-Uzri A et al. | Posttransplant diabetes mellitus in pediatric renal transplant recipients: a report of the North American Pediatric Renal Transplant Cooperative Study (NAPRTCS). | 2001 | Transplantation | pmid:11579294 |
| Mourad G et al. | Induction versus noninduction in renal transplant recipients with tacrolimus-based immunosuppression. | 2001 | Transplantation | pmid:11579299 |
| Dominguez J et al. | Conversion to rapamycin immunosuppression in renal transplant recipients: report of an initial experience. | 2000 | Transplantation | pmid:11063349 |
| Conrotto D et al. | Dramatic increase of tacrolimus plasma concentration during topical treatment for oral graft-versus-host disease. | 2006 | Transplantation | pmid:17060865 |
| Esquivel CO et al. | Suggested guidelines for the use of tacrolimus in pediatric liver transplant patients. | 1996 | Transplantation | pmid:8607198 |
| Jiang H et al. | Tacrolimus and cyclosporine differ in their capacity to overcome ongoing allograft rejection as a result of their differential abilities to inhibit interleukin-10 production. | 2002 | Transplantation | pmid:12085006 |
| Shapiro R et al. | Posttransplant diabetes in pediatric recipients on tacrolimus. | 1999 | Transplantation | pmid:10096540 |
| Cooper MH et al. | Rapamycin but not FK506 inhibits the proliferation of mononuclear phagocytes induced by colony-stimulating factors. | 1994 | Transplantation | pmid:7509089 |
| Stojanovic J et al. | Immune Desensitization Allows Pediatric Blood Group Incompatible Kidney Transplantation. | 2017 | Transplantation | pmid:27463537 |
| Bechstein WO et al. | Efficacy and safety of tacrolimus compared with cyclosporine microemulsion in primary simultaneous pancreas-kidney transplantation: 1-year results of a large multicenter trial. | 2004 | Transplantation | pmid:15114089 |
| Lo A et al. | Comparison of sirolimus-based calcineurin inhibitor-sparing and calcineurin inhibitor-free regimens in cadaveric renal transplantation. | 2004 | Transplantation | pmid:15114090 |
| Shoker A et al. | Heightened CD40 ligand gene expression in peripheral CD4+ T cells from patients with kidney allograft rejection. | 2000 | Transplantation | pmid:10949194 |
| Egawa H et al. | Isolated alkaline phosphatemia following pediatric liver transplantation in the FK506 ERA. | 1995 | Transplantation | pmid:7533958 |
| Levitsky J et al. | Allospecific regulatory effects of sirolimus and tacrolimus in the human mixed lymphocyte reaction. | 2011 | Transplantation | pmid:21239962 |
| Chan K et al. | Kidney transplantation with minimized maintenance: alemtuzumab induction with tacrolimus monotherapy--an open label, randomized trial. | 2011 | Transplantation | pmid:21836540 |
| McDiarmid SV et al. | Differences in oral FK506 dose requirements between adult and pediatric liver transplant patients. | 1993 | Transplantation | pmid:7685933 |
| Borger P et al. | Cyclosporine, FK506, mycophenolate mofetil, and prednisolone differentially modulate cytokine gene expression in human airway-derived epithelial cells. | 2000 | Transplantation | pmid:10798763 |
| Kovarik JM et al. | Pharmacokinetics of sotrastaurin combined with tacrolimus or mycophenolic acid in de novo kidney transplant recipients. | 2011 | Transplantation | pmid:21157403 |
| Jugie M et al. | Study of the impact of liver transplantation on the outcome of intestinal grafts in children. | 2006 | Transplantation | pmid:16612274 |
| Song L et al. | Effects of ASKP1240 combined with tacrolimus or mycophenolate mofetil on renal allograft survival in Cynomolgus monkeys. | 2014 | Transplantation | pmid:24992357 |
| Kasahara M et al. | Role of HLA compatibility in pediatric living-related liver transplantation. | 2002 | Transplantation | pmid:12438966 |
| Xu H et al. | Simultaneous bone marrow and composite tissue transplantation in rats treated with nonmyeloablative conditioning promotes tolerance. | 2013 | Transplantation | pmid:23250336 |
| Hudnall SD | Cardiac hypertrophy postliver transplantation: a role for FK506 and cyclosporine A? | 2002 | Transplantation | pmid:12369583 |
| Mourer JS et al. | Impact of late calcineurin inhibitor withdrawal on ambulatory blood pressure and carotid intima media thickness in renal transplant recipients. | 2013 | Transplantation | pmid:23715049 |
| Cohen JB et al. | Belatacept Compared With Tacrolimus for Kidney Transplantation: A Propensity Score Matched Cohort Study. | 2017 | Transplantation | pmid:27941427 |
| Puig I Marà JM et al. | Reflex sympathetic dystrophy syndrome of the lower limbs in a renal transplant patient treated with tacrolimus. | 2000 | Transplantation | pmid:10919604 |
| Maluccio M et al. | Tacrolimus enhances transforming growth factor-beta1 expression and promotes tumor progression. | 2003 | Transplantation | pmid:12923450 |
| Chen CH et al. | Comparison of tuberculosis infection rates in a national database of renal transplant patients with data from a single center in Taiwan. | 2014 | Transplant. Proc. | pmid:24656019 |
| Risaliti A et al. | Cardiovascular and metabolic complications after liver transplantation: Neoral- versus tacrolimus-based immunosuppression. | 2001 Nov-Dec | Transplant. Proc. | pmid:11750569 |
| Vanrenterghem Y et al. | Co-administration of tacrolimus and mycophenolate mofetil in cadaveric renal transplant recipients. | 1998 | Transplant. Proc. | pmid:9636523 |
| Cadoff EM et al. | Assay of FK 506 in plasma. | 1990 | Transplant. Proc. | pmid:1689898 |
| Ichikura H et al. | Conversion of renal transplant immunosuppression from tacrolimus (FK 506) to cyclosporine: a single center experience. | 2000 | Transplant. Proc. | pmid:11119911 |
| Zhao YJ et al. | Late, severe, noninfectious diarrhea after renal transplantation: high-risk factors, therapy, and prognosis. | 2013 Jul-Aug | Transplant. Proc. | pmid:23953533 |
| Pedroso JA et al. | Elderly kidney transplant recipient with intermittent fever: a case report of leishmaniasis with acute kidney injury during liposomal amphotericin B therapy. | 2014 | Transplant. Proc. | pmid:25242789 |
| Morales JM et al. | Ten years of treatment with tacrolimus is related to an excellent renal function, allowing monotherapy in a large proportion of cases: unicentric results of the tacrolimus versus cyclosporine A European Multicentric Study in kidney transplant patients. | 2005 | Transplant. Proc. | pmid:16386523 |
| Christians U et al. | Interactions of FK 506 and cyclosporine metabolism. | 1991 | Transplant. Proc. | pmid:1721280 |
| Osako M et al. | Alloimmune response may be involved in neointimal hyperplasia in cryopreserved aortic allografts. | 2001 | Transplant. Proc. | pmid:11406250 |
| Mueller AR et al. | Does initial graft function influence the outcome after liver transplantation? | 1998 | Transplant. Proc. | pmid:9636594 |
| Takeuchi H et al. | Lymphocyte sensitivity to cyclosporine and tacrolimus in chronic renal failure patients and clinical significance in renal transplantation. | 1998 | Transplant. Proc. | pmid:9474950 |
| Barreto P et al. | Conversion From Twice-Daily to Once-Daily Tacrolimus in Stable Kidney Graft Recipients. | 2016 | Transplant. Proc. | pmid:27742278 |
| Amada N et al. | Deoxyspergualin prophylaxis with tacrolimus further improves long-term graft survival in living-related renal-transplant recipients transfused with donor-specific blood. | 2005 | Transplant. Proc. | pmid:15848577 |
| YaÄŸmurdur MC et al. | Tacrolimus conversion in kidney transplant recipients: analysis of 107 patients. | 2004 Jan-Feb | Transplant. Proc. | pmid:15013327 |
| Bäckman L et al. | Chronic nephrotoxicity of FK 506 after liver transplantation. | 1994 | Transplant. Proc. | pmid:7518159 |
| Yagihashi A et al. | Changes in cell surface markers in human small bowel transplantation with FK 506. | 1992 | Transplant. Proc. | pmid:1376522 |
| Sakimoto H et al. | Prolonged survival of hamster-to-rat pancreas xenografts by FK 506 and splenectomy. | 1995 | Transplant. Proc. | pmid:7533394 |
| Gaston RS | Potential utility of rapamycin and tacrolimus in long-term, low-toxicity regimens. | 1999 | Transplant. Proc. | pmid:10616556 |
| Sugitani A et al. | Long-term results of tacrolimus therapy for renal transplantation in patients with diabetic nephropathy in Japan. | 2005 | Transplant. Proc. | pmid:15919459 |
| Mieles LA et al. | Liver transplantation of American veterans under FK 506 immunosuppression: a preliminary report. | 1991 | Transplant. Proc. | pmid:1721344 |
| Braun F et al. | Therapeutic drug monitoring of tacrolimus early after liver transplantation. | 2002 | Transplant. Proc. | pmid:12176473 |
| Schorlemmer HU et al. | Long-term allograft survival and tolerance induction by the synergistic activity of malononitrilamides and tacrolimus. | 1998 | Transplant. Proc. | pmid:9865312 |
| Walgenbach KJ et al. | Increased presence of mast cells and interleukin-4 during chronic rejection of rat intestinal allografts. | 1996 | Transplant. Proc. | pmid:8907896 |
| Rosh JR et al. | Therapy with FK 506 in pediatric liver recipients. | 1994 | Transplant. Proc. | pmid:7509091 |
| Bartlomiejczyk I et al. | Therapeutic monitoring of tacrolimus concentrations in blood of renal and liver transplant recipients: comparison of microparticle enzyme immunoassay and enzyme multiplied immunoassay methods. | 2006 Jan-Feb | Transplant. Proc. | pmid:16504673 |
| Hernández D et al. | Cardiovascular risk profile in nondiabetic renal transplant patients: cyclosporine versus tacrolimus. | 2003 | Transplant. Proc. | pmid:12962773 |
| Craig AM et al. | A cost-effectiveness analysis of tacrolimus versus cyclosporine microemulsion following kidney transplantation. | 2002 | Transplant. Proc. | pmid:12176519 |
| Lieberman KV et al. | FK 506 is a direct glomeruloconstrictor, as determined by electrical resistance pulse sizing (ERPS). | 1991 | Transplant. Proc. | pmid:1721376 |
| Demetris AJ et al. | Histopathology of human renal allograft rejection under FK 506: a comparison with cyclosporine. | 1991 | Transplant. Proc. | pmid:1703360 |
| Takeda M et al. | Immunologic factors contributing to acute rejection in lungs xenotransplanted between primates. | 1998 | Transplant. Proc. | pmid:9838670 |
| Murase N et al. | Immunomodulation of intestinal transplant with allograft irradiation and simultaneous donor bone marrow infusion. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083238 |
| Youbin Z et al. | Tumor Necrosis Factor-α-Induced Protein 8-Like 2 Gene Overexpression Prolongs the Survival of Rat Allogeneic Heart Allografts. | 2015 | Transplant. Proc. | pmid:26518962 |
| Gassel HJ et al. | Selective immunosuppression induces tolerance after liver transplantation: an immunohistochemical and cytofluorographic analysis of the graft and recipient immune system. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123253 |
| Yamamoto T et al. | Efficacy of Eculizumab Therapy for Atypical Hemolytic Uremic Syndrome Recurrence and Antibody-Mediated Rejection Progress After Renal Transplantation With Preformed Donor-Specific Antibodies: Case Report. | Transplant. Proc. | pmid:28104125 | |
| Kliem V et al. | FK 506 in the treatment of steroid- and OKT3-resistant rejection in renal transplant recipients: reduced dosage and anti-infective prophylaxis. | 1996 | Transplant. Proc. | pmid:8962227 |
| Ito A et al. | Induction of tolerance in rat cardiac allograft model by intrathymic injection of donor bone marrow cells. | 1995 | Transplant. Proc. | pmid:7536974 |
| DiMartini A et al. | Psychiatric morbidity in liver transplant patients. | 1991 | Transplant. Proc. | pmid:1721399 |
| Moutabarrik A et al. | Effect of FK 506 and cyclosporine on the expression of IL-6 and its receptor on stimulated monocytes. | 1993 | Transplant. Proc. | pmid:7685949 |
| Jonas S et al. | Corticosteroid-free therapy after tacrolimus-based dual immunosuppression versus cyclosporine-based quadruple-induction therapy. | 2001 | Transplant. Proc. | pmid:11377511 |
| Lee KH et al. | Distribution of Anti-ABO Immunoglobulin G Subclass and C1q Antibody in ABO-incompatible Kidney Transplantation. | 2018 | Transplant. Proc. | pmid:29731066 |
| Gotoh M et al. | Tolerance induction by liver grafting and FK 506 treatment in nonhuman primates. | 1991 | Transplant. Proc. | pmid:1721431 |
| Ishikawa M et al. | Acetaminophen absorption test as a useful indicator of small intestinal rejection in rats. | 1996 | Transplant. Proc. | pmid:8658911 |
| Li Y et al. | Long-term comparison of rat model of chronic allograft rejection of orthotopic small bowel transplantation induced by cyclosporine versus tacrolimus. | 2013 | Transplant. Proc. | pmid:23769050 |
| Sindhi R et al. | Preliminary immunosuppression withdrawal strategies with sirolimus in children with liver transplants. | 2002 | Transplant. Proc. | pmid:12176651 |
| Kandaswamy R et al. | Can we maintain immunosuppression avoiding nephrotoxic agents in pancreas transplantation? | 2008 | Transplant. Proc. | pmid:18374118 |
| Kanodia KV et al. | Study of acute antibody-mediated rejection in renal allograft biopsies. | 2008 | Transplant. Proc. | pmid:18555123 |
| Makowka L et al. | The effect of FK-506 on hyperacute rejection in presensitized rats. | 1987 | Transplant. Proc. | pmid:2445082 |
| Mühlbacher F | Tacrolimus versus cyclosporin microemulsion in liver transplantation: results of a 3-month study. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267317 |
| Morales E et al. | Conversion from cyclosporine to FK 506 as rescue therapy in renal transplantation with poorly steroid-responsive acute rejection. | 1999 | Transplant. Proc. | pmid:10500562 |
| Nardo B et al. | Evidence of microchimerism after pretransplant blood transfusion and FK 506 in liver xenograft. | 2000 | Transplant. Proc. | pmid:11134771 |
| Miyata Y et al. | Development of xenogeneic microchimerism correlated with graft outcome in hamster-to-rat heart xenotransplantation. | 1998 | Transplant. Proc. | pmid:9723548 |
| McManus BM et al. | Impact of FK 506 on myocarditis in the enteroviral murine model. | 1991 | Transplant. Proc. | pmid:1721463 |
| Barten MJ et al. | Assessment of immunosuppression by lymphocyte functions in human blood. | 2002 | Transplant. Proc. | pmid:12431640 |
| Kacar S et al. | Low-dose calcineurin inhibitor regimen combined with mammalian target of rapamycin inhibitors preserves kidney functions in renal transplant recipients without allograft nephropathy. | 2010 | Transplant. Proc. | pmid:21094806 |
| Reimer J et al. | Quality of life after kidney transplantation--the impact of tacrolimus. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267573 |
| Fritsche L et al. | Conversion to mycophenolate mofetil for chronic progressive deterioration of renal allograft function: first clinical experiences in 44 patients. | 1998 | Transplant. Proc. | pmid:9636481 |
| Bing P et al. | Comparison of expression of TGF-beta1, its receptors TGFbeta1R-I and TGFbeta1R-II in rat kidneys during chronic nephropathy induced by cyclosporine and tacrolimus. | 2006 | Transplant. Proc. | pmid:16980036 |
| Goto S et al. | Effect of FK 506 and cyclosporine on heart allograft survival in rats. | 1991 | Transplant. Proc. | pmid:1703700 |