Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with tacrolimus
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Woodle ES et al. | FK 506: reversal of humorally mediated rejection following ABO-incompatible liver transplantation. | 1991 | Transplant. Proc. | pmid:1721337 |
Braun F et al. | Therapeutic drug monitoring of tacrolimus early after liver transplantation. | 2002 | Transplant. Proc. | pmid:12176473 |
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Porubsky M et al. | Excellent outcomes can be achieved in young pancreas transplant alone recipients by addition of sirolimus to maintenance immunosuppression regimen. | Transplant. Proc. | pmid:25131074 | |
Moro JA et al. | Randomized prospective study of the evolution of renal function depending on the anticalcineurin used. | 2008 | Transplant. Proc. | pmid:19010143 |
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Rosh JR et al. | Therapy with FK 506 in pediatric liver recipients. | 1994 | Transplant. Proc. | pmid:7509091 |
Nüssler NC et al. | CD8+ host cells infiltrate the intestinal mucosa after allogeneic small bowel transplantation even in the absence of acute rejection. | 1996 | Transplant. Proc. | pmid:8907898 |
Scantlebury VP et al. | Pediatric kidney transplantation at the University of Pittsburgh. | 1994 | Transplant. Proc. | pmid:7509095 |
Souza ER et al. | Acute effects of FK 506 on glomerular hemodynamics. | 1992 | Transplant. Proc. | pmid:1281585 |
Darras FS et al. | Transplantation of pediatric en bloc kidneys under FK 506 immunosuppression. | 1991 | Transplant. Proc. | pmid:1721368 |
Shapiro R et al. | Kidney transplantation under FK 506 immunosuppression. | 1991 | Transplant. Proc. | pmid:1703352 |
Todo S et al. | Clinical small bowel or small bowel plus liver transplantation under FK 506. | 1991 | Transplant. Proc. | pmid:1721369 |
Tzakis AG et al. | Use of FK 506 in pediatric patients. | 1991 | Transplant. Proc. | pmid:1703353 |
Pascual J et al. | A low incidence of new-onset insulin-dependent diabetes mellitus using tacrolimus in kidney recipients in Europe. | 2003 | Transplant. Proc. | pmid:12962785 |
Rashid I et al. | Medium-term outcome using sirolimus-tacrolimus combination in adult renal transplant recipients. | 2002 | Transplant. Proc. | pmid:12176520 |
Fukushima N et al. | Prolonged survival of pig cardiac xenografts in baboons by sequential cardiac transplantation. | 1998 | Transplant. Proc. | pmid:9838671 |
Schulz T et al. | Mycophenolate mofetil/prednisolone/single-shot ATG with tacrolimus or cyclosporine in pancreas/kidney transplantation: first results of an ongoing prospective randomized trial. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083251 |
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Chien YS et al. | Incidence and risk factors of new-onset diabetes mellitus after renal transplantation. | 2008 | Transplant. Proc. | pmid:18790250 |
Kim K et al. | Everolimus-Induced Systemic Serositis After Simultaneous Liver and Kidney Transplantation: A Case Report. | Transplant. Proc. | pmid:28104132 | |
Burke GW et al. | Donor bone marrow infusion in simultaneous pancreas/kidney transplantation with OKT3 induction: evidence for augmentation of chimerism. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123275 |
Becker G et al. | Tacrolimus (FK 506) therapy in simultaneous pancreas kidney transplantation. | 1996 | Transplant. Proc. | pmid:8962228 |
Büttemeyer R et al. | Peripheral nerve allotransplant immunosuppressed with FK 506: preliminary results. | 1995 | Transplant. Proc. | pmid:7536979 |
Lopez OL et al. | Neuropathologic findings in liver transplantation: a comparative study of cyclosporine and FK 506. | 1991 | Transplant. Proc. | pmid:1721400 |
Takaya S et al. | Use of prostaglandin E1 in crossmatch-negative liver transplant recipients treated with FK 506. | 1993 | Transplant. Proc. | pmid:7685953 |
Ali IH et al. | Incidence and risk factors for post-renal transplant diabetes mellitus. | 2011 | Transplant. Proc. | pmid:21440763 |
Yasunami Y et al. | Effects of a novel immunosuppressive agent, FK-506, on islet allograft survival in the rat. | 1989 | Transplant. Proc. | pmid:2468234 |
Jonas S et al. | Corticosteroid-free therapy after tacrolimus-based dual immunosuppression versus cyclosporine-based quadruple-induction therapy. | 2001 | Transplant. Proc. | pmid:11377511 |
Boucher A et al. | Impact of immunosuppressive regimen on cardiovascular risk factors in kidney transplant recipients. | 2002 | Transplant. Proc. | pmid:12176582 |
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Suwelack B et al. | Replacement of calcineurin inhibitors by mycophenolate mofetil: effect on hemoglobine levels. | 2002 | Transplant. Proc. | pmid:12176585 |
Jiang H et al. | IL-10: a tacrolimus-specific cytotoxic mediator in ongoing allograft rejection. | 2001 Feb-Mar | Transplant. Proc. | pmid:11266931 |
Orsenigo R et al. | FK506 and SMS 201-995: effect on heterotopic heart transplantation in rats. | 2001 Feb-Mar | Transplant. Proc. | pmid:11266956 |
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Levy GA | Neoral is superior to FK 506 in liver transplantation. | 1998 | Transplant. Proc. | pmid:9723293 |
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Valdivia LA et al. | Differential survival of hamster-to-rat liver and cardiac xenografts under FK 506 immunosuppression. | 1991 | Transplant. Proc. | pmid:1721432 |
Kawano K et al. | FK506 reduces oxidative hepatic injury following cold ischemic preservation and transplantation. | 1996 | Transplant. Proc. | pmid:8658938 |
Sanghvi A et al. | FK-506 enhances cyclosporine uptake by peripheral blood lymphocytes. | 1987 | Transplant. Proc. | pmid:2445074 |
Ochiai T et al. | Prolongation of canine renal allograft survival by treatment with FK-506. | 1987 | Transplant. Proc. | pmid:2445075 |
Zajicek A et al. | Thirteen years' experience in pediatric liver transplantation: differences between tacrolimus and cyclosporine. | 2002 | Transplant. Proc. | pmid:12176653 |
Peltekian K et al. | De novo use of low-dose tacrolimus and sirolimus in liver transplantation. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267318 |
Fukuoka N et al. | Micafungin does not influence the concentration of tacrolimus in patients after allogeneic hematopoietic stem cell transplantation. | 2010 | Transplant. Proc. | pmid:20832577 |
Gómez G et al. | Acute tacrolimus nephrotoxicity in renal transplant patients treated with clarithromycin. | 1999 | Transplant. Proc. | pmid:10500563 |
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Dall'Agnol DJ et al. | Effects of immunosuppressive drugs on gastrointestinal transit of rats: effects of tacrolimus, cyclosporine, and prednisone. | Transplant. Proc. | pmid:25131057 | |
McManus BM et al. | Impact of FK 506 on myocarditis in the enteroviral murine model. | 1991 | Transplant. Proc. | pmid:1721463 |
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Bahra M et al. | Significance of mycophenolate mofetil treatment in patients with HCV reinfection after liver transplantation: impact on clinical course and histologic damage. | 2002 | Transplant. Proc. | pmid:12431663 |
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