Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with tacrolimus
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Panackal AA et al. | Spinal Arachnoiditis as a Complication of Cryptococcal Meningoencephalitis in Non-HIV Previously Healthy Adults. | 2017 | Clin. Infect. Dis. | pmid:28011613 |
Gupta AK and Versteeg SG | Topical Treatment of Facial Seborrheic Dermatitis: A Systematic Review. | 2017 | Am J Clin Dermatol | pmid:27804089 |
Chakkera HA et al. | Calcineurin Inhibitors: Pharmacologic Mechanisms Impacting Both Insulin Resistance and Insulin Secretion Leading to Glucose Dysregulation and Diabetes Mellitus. | 2017 | Clin. Pharmacol. Ther. | pmid:27804122 |
Lombardi A et al. | Impaired mitochondrial calcium uptake caused by tacrolimus underlies beta-cell failure. | 2017 | Cell Commun. Signal | pmid:29132395 |
Suda M et al. | Effectiveness of multi-target therapy in anti-melanoma differentiation-associated gene 5 antibody-positive dermatomyositis with early-stage interstitial lung disease. | 2017 | Scand. J. Rheumatol. | pmid:28649889 |
Chen B et al. | Population pharmacokinetics and Bayesian estimation of tacrolimus exposure in Chinese liver transplant patients. | 2017 | J Clin Pharm Ther | pmid:28833329 |
Baron PW et al. | Post-Transplant Diabetes Mellitus After Kidney Transplant in Hispanics and Caucasians Treated with Tacrolimus-Based Immunosuppression. | 2017 | Ann. Transplant. | pmid:28533501 |
Dorr CR et al. | CRISPR/Cas9 Genetic Modification of in HuH-7 Human Hepatocyte Cell Line Leads to Cell Lines with Increased Midazolam and Tacrolimus Metabolism. | 2017 | Drug Metab. Dispos. | pmid:28533324 |
Karchin JM et al. | Small Molecule-Induced Domain Swapping as a Mechanism for Controlling Protein Function and Assembly. | 2017 | Sci Rep | pmid:28287617 |
de Graav GN et al. | A Randomized Controlled Clinical Trial Comparing Belatacept With Tacrolimus After De Novo Kidney Transplantation. | 2017 | Transplantation | pmid:28403127 |
Genvigir FDV et al. | Influence of ABCC2, CYP2C8, and CYP2J2 Polymorphisms on Tacrolimus and Mycophenolate Sodium-Based Treatment in Brazilian Kidney Transplant Recipients. | 2017 | Pharmacotherapy | pmid:28316087 |
Mertens JS et al. | Morphea and Eosinophilic Fasciitis: An Update. | 2017 | Am J Clin Dermatol | pmid:28303481 |
Unadkat JV et al. | Single Implantable FK506 Disk Prevents Rejection in Vascularized Composite Allotransplantation. | 2017 | Plast. Reconstr. Surg. | pmid:28121868 |
TruneÄka P | Once-daily tacrolimus in liver transplantation: a 'me-too drug', or a therapeutic advantage. | 2017 | Curr Opin Organ Transplant | pmid:28079558 |
Riva N et al. | Adequate exposure to tacrolimus with sublingual administration in pediatric liver transplant patients. | 2017 | Int J Clin Pharmacol Ther | pmid:28079516 |
Kim MJ et al. | The Anti-Inflammatory Effects of Oral-Formulated Tacrolimus in Mice with Experimental Autoimmune Encephalomyelitis. | 2017 | J. Korean Med. Sci. | pmid:28776347 |
Mussin N et al. | Sirolimus and Metformin Synergistically Inhibits Colon Cancer In Vitro and In Vivo. | 2017 | J. Korean Med. Sci. | pmid:28776332 |
Veenhof H et al. | Clinical Validation of Simultaneous Analysis of Tacrolimus, Cyclosporine A, and Creatinine in Dried Blood Spots in Kidney Transplant Patients. | 2017 | Transplantation | pmid:27906832 |
Nanmoku K et al. | Effective and Safe Reduction of Conventional Immunosuppressants Using Everolimus in Maintenance Kidney Transplant Recipients. | 2017 | Transplant. Proc. | pmid:28923615 |
Tourret J et al. | Immunosuppressive Treatment Alters Secretion of Ileal Antimicrobial Peptides and Gut Microbiota, and Favors Subsequent Colonization by Uropathogenic Escherichia coli. | 2017 | Transplantation | pmid:27681266 |