tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Jordan ML et al. | Tacrolimus for rescue of refractory renal allograft rejection. | 1998 | Transplant. Proc. | pmid:9636511 |
| Reduced incidence of acute, refractory acute, and chronic rejection after liver transplantation with FK506-based immunosuppression. European FK506 Multicentre Liver Study Group. | 1994 | Transplant. Proc. | pmid:7527960 | |
| Neuhaus PJ | Optimised first-line FK506-based protocols in liver transplantation: experience from the University Hospital Rudolf Virchow, Berlin. | 1994 | Transplant. Proc. | pmid:7527961 |
| Klintmalm GB et al. | Use of FK 506 for the prevention of recurrent allograft rejection after successful conversion from cyclosporine for refractory rejection. US Multicenter FK 506 Liver Study Group. | 1993 | Transplant. Proc. | pmid:7679826 |
| Fukuzawa M and Okada A | Analysis of mouse xenogeneic T-cell responses and the effect of FK 506 on these responses and on xeno-skin graft rejection. | 1994 | Transplant. Proc. | pmid:7513483 |
| Wang XH et al. | Tacrolimus vs CyA Neoral in combination with MMF and steroids after cadaveric renal transplantation. | 2000 | Transplant. Proc. | pmid:11119899 |
| Jordan ML et al. | FK 506 salvage of renal allografts with ongoing rejection failing cyclosporine immunosuppression. | 1993 | Transplant. Proc. | pmid:7679827 |
| Warty VS et al. | Practical aspects of FK 506 analysis (Pittsburgh experience). | 1991 | Transplant. Proc. | pmid:1721259 |
| Jusko WJ and D'Ambrosio R | Monitoring FK 506 concentrations in plasma and whole blood. | 1991 | Transplant. Proc. | pmid:1721260 |
| Sher LS et al. | Tacrolimus (FK 506) for rescue of chronic rejection following orthotopic liver transplantation. | 1996 | Transplant. Proc. | pmid:8623212 |
| Millis JM et al. | Treatment of steroid-resistant rejection with tacrolimus prior to OKT3 in liver transplant recipients. | 1996 | Transplant. Proc. | pmid:8623213 |
| Yamamoto S et al. | FK778 controls acute rejection after rat liver allotransplantation showing positive interaction with FK506. | 2005 Jan-Feb | Transplant. Proc. | pmid:15808570 |
| Aravot D et al. | A new immunosuppressive protocol for lung transplantation: early promising results. | 2003 | Transplant. Proc. | pmid:12644072 |
| Mollevà DG et al. | Late xenograft rejection: comparison between liver and heart xenografts under low-dose tacrolimus. | 2002 | Transplant. Proc. | pmid:11959212 |
| Cai TH et al. | Improved immunosuppression with combination tacrolimus (FK506) and mycophenolic acid in orthotopic liver transplantation. | 1998 | Transplant. Proc. | pmid:9636572 |
| Bond MMK et al. | Cyclosporine Versus Tacrolimus: Which Calcineurin Inhibitor Has Influence on Cytomegalovirus Infection in Cardiac Transplantation? | 2018 | Transplant. Proc. | pmid:29661443 |
| Kay JE et al. | The mechanism of action of FK 506. | 1990 | Transplant. Proc. | pmid:1689914 |
| Lo CM et al. | More effective immunosuppression with the use of FK506 after liver transplantation. | 2000 | Transplant. Proc. | pmid:11120161 |
| Moriuchi H et al. | Mechanisms of immunosuppressive effects of FK 506 in light of apoptosis of hepatocytes and infiltrating lymphocytes in rat allografted livers. | 2000 | Transplant. Proc. | pmid:11120182 |
| Santos L et al. | New-onset diabetes after transplantation: drug-related risk factors. | 2012 | Transplant. Proc. | pmid:23146462 |
| van Hooff JP et al. | Dosing and management guidelines for tacrolimus in renal transplant patients. | 1999 | Transplant. Proc. | pmid:10576046 |
| McLachlan G et al. | Growth inhibition of the MOLT-4 human T-leukemia cell line. A comparison of cyclosporine and FK 506. | 1991 | Transplant. Proc. | pmid:1721291 |
| Oliveira DB and Chang R | Report of the first 118 tacrolimus-treated patients at St George's Hospital, London. | 1999 | Transplant. Proc. | pmid:10576047 |
| Asano T et al. | Increased tacrolimus trough levels in association with severe diarrhea, a case report. | 2004 | Transplant. Proc. | pmid:15518758 |
| D'Silva M et al. | Immunosuppressive effect of brequinar on rat cardiac allograft survival in combination with leflunomide or FK 506. | 1996 | Transplant. Proc. | pmid:8623476 |
| Ichimaru N et al. | Risk factors and incidence for lipid abnormalities in kidney transplant patients. | 2015 | Transplant. Proc. | pmid:25891708 |
| Merli M et al. | Conversion from twice-daily to once-daily tacrolimus administration in liver transplant patient. | 2010 | Transplant. Proc. | pmid:20534292 |
| Goulet O et al. | Small bowel transplantation alone or with the liver in children: changes by using FK506. | 1998 | Transplant. Proc. | pmid:9636636 |
| Gerber DA et al. | Immunosuppressive agents: recent developments in molecular action and clinical application. | 1998 | Transplant. Proc. | pmid:9636637 |
| Fan Y et al. | Tacrolimus versus cyclosporine for adult lung transplant recipients: a meta-analysis. | 2009 | Transplant. Proc. | pmid:19545736 |
| Tiebosch A et al. | Side effects of FK 506 in cynomolgus monkeys: a histopathologic study. | 1990 | Transplant. Proc. | pmid:1697115 |
| Masri M et al. | Prograf five milligrams versus Tacrolimus medis in healthy volunteers: a bioequivalence study. | 2013 | Transplant. Proc. | pmid:24314930 |
| Xu M et al. | Effect of peritransplant FTY720 alone or in combination with posttransplant FK 506 in a rat model of cardiac allotransplantation. | 1997 | Transplant. Proc. | pmid:9365631 |
| Jacob DA et al. | Liver transplantation for primary biliary cirrhosis: influence of primary immunosuppression on survival. | 2005 | Transplant. Proc. | pmid:15919432 |
| Spada M et al. | Monitoring of intestinal myoelectrical activity after isolated small bowel transplantation in FK 506 immunosuppressed pigs. | 1994 | Transplant. Proc. | pmid:7518141 |
| Ziolkowski J et al. | Renal function after liver transplantation: calcineurin inhibitor nephrotoxicity. | 2003 | Transplant. Proc. | pmid:14529923 |
| Junge G et al. | Withdrawal of steroids: a randomized prospective study of prednisone and tacrolimus versus mycophenolate mofetil and tacrolimus in liver transplant recipients with autoimmune hepatitis. | 2005 | Transplant. Proc. | pmid:15919434 |
| Takai K et al. | Delayed graft function after renal transplantation from a non-heart-beating donors. | 2003 | Transplant. Proc. | pmid:12591320 |
| Yasunami Y et al. | Induction of donor-specific unresponsiveness in rat islet allografts by FK 506. | 1992 | Transplant. Proc. | pmid:1376510 |
| Martinez OM et al. | Molecular markers of Epstein-Barr virus infection in the circulation of transplant recipients. | 1995 | Transplant. Proc. | pmid:7533372 |
| Ciancio G et al. | Pilot Randomized Trial of Tacrolimus/Everolimus vs Tacrolimus/Enteric-Coated Mycophenolate Sodium in Adult, Primary Kidney Transplant Recipients at a Single Center. | Transplant. Proc. | pmid:27569936 | |
| Wilusz M et al. | Effect of immunosuppressive therapy on the serum fatty acids of phospholipids fraction in patients after heart transplantation. | 2014 | Transplant. Proc. | pmid:25380928 |
| Motta I et al. | FK 506 favors the generation of memory T cells in vitro. | 1991 | Transplant. Proc. | pmid:1721324 |
| Isai H et al. | FK 506 and orthotopic liver transplantation in the rat. | 1990 | Transplant. Proc. | pmid:1699329 |
| Tannuri AC et al. | Effects of immunosuppressants on hepatocyte cell mitosis during liver regeneration in growing animal models of partial hepatectomy. | 2008 | Transplant. Proc. | pmid:18589165 |
| Loh PT et al. | Significant impact of gene polymorphisms on tacrolimus but not cyclosporine dosing in Asian renal transplant recipients. | 2008 | Transplant. Proc. | pmid:18589174 |
| Mayer AD | Chronic rejection and graft half-life: five-year follow-up of the European Tacrolimus Multicenter Renal Study. | 2002 | Transplant. Proc. | pmid:12176452 |
| Orlandi V et al. | Tacrolimus-associated myositis: a case report in a renal transplant patient. | 2004 | Transplant. Proc. | pmid:15110639 |
| Pohanka E et al. | Improved attainment of NKF classified lipid target levels after conversion from cyclosporine to tacrolimus in renal graft recipients. | 2005 | Transplant. Proc. | pmid:15919490 |
| Laskow DA et al. | Phase II FK 506 multicenter concentration control study: one-year follow-up. | 1995 | Transplant. Proc. | pmid:7533431 |
| Shapiro R et al. | A prospective, randomized trial of FK 506/prednisone vs FK 506/azathioprine/prednisone in renal transplant patients. | 1995 | Transplant. Proc. | pmid:7533432 |
| Reyes J et al. | Posttransplant lymphoproliferative disorders occurring under primary FK 506 immunosuppression. | 1991 | Transplant. Proc. | pmid:1721355 |
| Whiteside TL et al. | Serial monitoring of immunologic function and phenotype of lymphocytes in the blood of transplanted patients randomized to cyclosporine or FK 506. | 1991 | Transplant. Proc. | pmid:1721356 |
| Fischereder M et al. | Gynaecomastia following solid organ transplantation. | 2002 | Transplant. Proc. | pmid:12270376 |
| Budde K et al. | Five year outcome of tacrolimus rescue therapy in late rejection after renal transplantation. | 2002 | Transplant. Proc. | pmid:12176499 |
| Iaria G et al. | Switch to tacrolimus for cyclosporine-induced gynecomastia in liver transplant recipients. | 2005 Jul-Aug | Transplant. Proc. | pmid:16182769 |
| Kociszewska-Najman B et al. | Congenital Infections in Neonates of Women With Liver or Kidney Transplants. | 2016 | Transplant. Proc. | pmid:27496446 |
| Shu KH et al. | A multicenter trial of FK506 as rescue therapy for renal transplant recipients in Taiwan. | 1998 | Transplant. Proc. | pmid:9838570 |
| Bennett WM | Renal complications after heart transplantation. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083019 |
| Ko S et al. | Predominant role of local immunosuppressive effect in enhanced efficacy of liposomal FK506 in organ transplantation. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123117 |
| Rao AS et al. | Augmentation of natural chimerism with donor bone marrow in orthotopic liver recipients. | 1996 | Transplant. Proc. | pmid:8908140 |
| Kim YI et al. | FK 506 prevents critical warm ischemia damage to the pig liver and improves hepatic microcirculation. | 1994 | Transplant. Proc. | pmid:7520636 |
| Thomson AW et al. | Immunosuppressive activity, T-cell subset analysis, and acute toxicity of FK-506 in rats. | 1989 | Transplant. Proc. | pmid:2468203 |
| Hossein-Nia M et al. | Urinary proteins as a marker of drug-induced renal damage following treatment with cyclosporine or FK 506. | 1991 | Transplant. Proc. | pmid:1721388 |
| Baran DA et al. | Tacrolimus and new onset diabetes mellitus: the effect of steroid weaning. | 2002 | Transplant. Proc. | pmid:12176547 |
| Paul LC | Overview of side effects of immunosuppressive therapy. | 2001 | Transplant. Proc. | pmid:11377462 |
| Rodrigo E et al. | Histopathological findings according to Banff-97 classification system comparing tacrolimus versus cyclosporine. | 2002 | Transplant. Proc. | pmid:12176550 |
| Jordán de Luna C et al. | Pharmacogenetic study of ABCB1 and CYP3A5 genes during the first year following heart transplantation regarding tacrolimus or cyclosporine levels. | 2011 Jul-Aug | Transplant. Proc. | pmid:21839244 |
| Shapiro R et al. | A prospective, randomized trial of tacrolimus/prednisone vs tacrolimus/prednisone/mycophenolate mofetil in renal transplantation: 1-year actuarial follow-up. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083507 |
| Elinav H et al. | Plasma oxidizability and plasma carbonyls, markers of oxidative stress, in liver transplant patients. | 2001 | Transplant. Proc. | pmid:11543789 |
| Opelz G | Immunosuppression with FK 506 does not improve kidney graft survival. Collaborative Transplant Study. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083513 |
| Batten P et al. | Effect of cyclosporine A and FK 506 on human T cell responses to xenogeneic and allogeneic endothelium: relative resistance of T cell/porcine endothelial interactions. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123582 |
| Troppmann C et al. | FK 506 versus cyclosporine A for steroid-free synergistic combination therapy with rapamycin in a discordant large animal donor xenoislet transplant model. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123585 |
| Braun N et al. | Impairment of renal function following liver transplantation. | 2003 | Transplant. Proc. | pmid:12826191 |
| Cooper MH et al. | The induction of pseudo-graft-versus-host disease following syngeneic bone marrow transplantation using FK 506. | 1991 | Transplant. Proc. | pmid:1721419 |
| Yagura K et al. | Pharmacokinetic characteristics of two types of liposomal FK 506. | 1996 | Transplant. Proc. | pmid:8658708 |
| Taber DJ et al. | Drug-drug interaction between chloramphenicol and tacrolimus in a liver transplant recipient. | 2000 | Transplant. Proc. | pmid:10812156 |
| Beckebaum S et al. | Impact of combined mycophenolate mofetil and low-dose calcineurin inhibitor therapy on renal function, cardiovascular risk factors, and graft function in liver transplant patients: preliminary results of an open prospective study. | 2004 | Transplant. Proc. | pmid:15621120 |
| El-Sabrout R et al. | Sirolimus in combination with tacrolimus or mycophenolate mofetil for minimizing acute rejection risk in renal transplant recipients--a single center experience. | 2003 | Transplant. Proc. | pmid:12742474 |
| Filler G et al. | One-year glomerular filtration rate predicts graft survival in pediatric renal recipients: a randomized trial of tacrolimus vs cyclosporine microemulsion. | 2002 | Transplant. Proc. | pmid:12176634 |
| Rintala JM et al. | The effect of leflunomide analogue FK778 on development of chronic rat renal allograft rejection and transforming growth factor-BETA expression. | 2006 | Transplant. Proc. | pmid:17175234 |
| Sahara H et al. | Thymectomy does not abrogate long-term acceptance of MHC class I-disparate lung allografts in miniature Swine. | 2006 | Transplant. Proc. | pmid:17175240 |
| Ishikawa S et al. | Management of Juvenile Idiopathic Arthritis in ABO-incompatible Kidney Transplantation: A Case Report. | 2018 | Transplant. Proc. | pmid:29661455 |
| Glanemann M et al. | Mycophenolate mofetil is superior in combination with tacrolimus compared to cyclosporine for immunosuppressive therapy after liver transplantation. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267194 |
| Atillasoy E et al. | Cholesterol levels long-term after liver transplant. | 1998 | Transplant. Proc. | pmid:9723387 |
| Quijano Y et al. | Tolerance: a study in long-term surviving animals after small bowel transplantation. | 1998 | Transplant. Proc. | pmid:9745494 |
| Ybarra J et al. | Reflex sympathetic dystrophy syndrome in renal transplanted patients under immunosuppression with tacrolimus. | 2003 | Transplant. Proc. | pmid:14697943 |
| Neff GW et al. | Sirolimus therapy in orthotopic liver transplant recipients with calcineurin inhibitor related chronic renal insufficiency. | 2003 | Transplant. Proc. | pmid:14697970 |
| Yumiba T et al. | Immunosuppressive and diabetogenic effect of FK 506 on pancreatic islet xenotransplantation. | 1995 | Transplant. Proc. | pmid:7540780 |
| Nikolaidis NL et al. | Metabolic effects of FK 506 in patients with severe psoriasis: short-term follow-up of seven cases. | 1991 | Transplant. Proc. | pmid:1721450 |
| Velioglu A et al. | Association of BK Virus Titers With Lymphocyte Count in Renal Transplant Patients. | 2015 | Transplant. Proc. | pmid:26093733 |
| Abu-Elmagd K et al. | Efficacy of FK 506 in the treatment of recalcitrant pyoderma gangrenosum. | 1991 | Transplant. Proc. | pmid:1721451 |
| Ochiai T et al. | Studies on FK506 in experimental organ transplantation. | 1988 | Transplant. Proc. | pmid:2450414 |
| Immunosuppression: FK506. | 1988 | Transplant. Proc. | pmid:2450415 | |
| Mehra MR et al. | Racial differences in clinical outcome using tacrolimus and mycophenolate mofetil immunosuppression in heart transplantation. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267442 |
| Yura H et al. | Development of a macromolecular prodrug of FK 506: II: In vitro study for FK 506-dextran conjugate. | 1998 | Transplant. Proc. | pmid:9636416 |
| Simmons RL and Wang SC | New horizons in immunosuppression. | 1991 | Transplant. Proc. | pmid:1714645 |
| Wu J et al. | Comparative immunoregulatory effects of rapamycin, FK 506 and cyclosporine on mitogen-induced cytokine production and lymphoproliferation. | 1991 | Transplant. Proc. | pmid:1703683 |
| Boggi U et al. | Use of basiliximab in conjunction with either Neora/MMF/steroids or Prograf/MMF/steroids in simultaneous pancreas-kidney transplantation. | 2001 Nov-Dec | Transplant. Proc. | pmid:11750373 |
| Copley JB et al. | Cyclosporine to tacrolimus: effect on hypertension and lipid profiles in renal allografts. | 1998 | Transplant. Proc. | pmid:9636510 |