tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Frei U and Wagner K | Renal function in liver transplant patients receiving FK506 or cyclosporin A immunosuppressive therapy. | 1994 | Transplant. Proc. | pmid:7527963 |
| Morris R | Modes of action of FK506, cyclosporin A, and rapamycin. | 1994 | Transplant. Proc. | pmid:7527964 |
| Ericzon BG | Early graft function in liver transplantation patients. | 1994 | Transplant. Proc. | pmid:7527965 |
| Ricordi C et al. | Donor bone marrow cell infusion without recipient cytoablation induces acceptance of rat islet allografts. | 1994 | Transplant. Proc. | pmid:7527967 |
| Lhöest GJ et al. | 15-Desmethyl FK-506 and 15,31-desmethyl FK-506 from human liver microsomes: isolation, identification (by fast atom bombardment mass spectrometry and NMR), and evaluation of in vitro immunosuppressive activity. | 1994 | Clin. Chem. | pmid:7513627 |
| Tsugita M et al. | Hepatocytes or liver nonparenchymal cells plus FK 506 prolong liver xenograft survival. | 1994 | Transplant. Proc. | pmid:7527969 |
| Ueda H et al. | FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. I. Taxonomy, fermentation, isolation, physico-chemical and biological properties, and antitumor activity. | 1994 | J. Antibiot. | pmid:7513682 |
| Asselin I et al. | Polymerase chain reaction-based assay to assess the success of myoblast transplantation in mdx mice. | 1994 | Transplant. Proc. | pmid:7527970 |
| Tai J et al. | Effect of FK506 on rat Leydig cell function--in vivo and in vitro study. | 1994 | Metab. Clin. Exp. | pmid:7513780 |
| Kinoshita I et al. | Immunosuppression with FK 506 insures good success of myoblast transplantation in MDX mice. | 1994 | Transplant. Proc. | pmid:7527978 |
| Egawa H et al. | FK506 conversion therapy in pediatric liver transplantation. | 1994 | Transplantation | pmid:7513911 |
| Reggiani P et al. | Conversion to rescue therapy with FK 506: data from eight liver transplant patients. | 1994 | Transplant. Proc. | pmid:7527982 |
| Cvetkovic M et al. | The deleterious effects of long-term cyclosporine A, cyclosporine G, and FK506 on bone mineral metabolism in vivo. | 1994 | Transplantation | pmid:7513912 |
| Arakawa H et al. | Molecular cloning and expression of a novel human gene that is highly homologous to human FK506-binding protein 12kDa (hFKBP-12) and characterization of two alternatively spliced transcripts. | 1994 | Biochem. Biophys. Res. Commun. | pmid:7513996 |
| Langrehr JM et al. | Mucosal recipient-type mononuclear repopulation and low-grade chronic rejection occur simultaneously in indefinitely surviving recipients of small bowel allografts. | 1994 | Transpl. Int. | pmid:7513999 |
| Leach KL et al. | A soluble binding assay for measuring 3H-FK506 binding to the hsp56 immunophilin. | 1994 | J Immunoassay | pmid:7530727 |
| Genestier L et al. | Cyclosporin A and FK506 inhibit activation-induced cell death in the murine WEHI-231 B cell line. | 1994 | Cell. Immunol. | pmid:7514101 |
| Atcherson MM and Trifillis AL | Cytotoxic effects of FK506 on human renal proximal tubule cells in culture. | 1994 | In Vitro Cell. Dev. Biol. Anim. | pmid:7529625 |
| Maruyama K et al. | FK 506 for vascular permeability factor production in minimal change nephrotic syndrome. | 1994 | Nephron | pmid:7517020 |
| High KP | The antimicrobial activities of cyclosporine, FK506, and rapamycin. | 1994 | Transplantation | pmid:7517076 |
| Peattie DA et al. | Three distinct messenger RNAs can encode the human immunosuppressant-binding protein FKBP12. | 1994 | Gene | pmid:7529739 |
| Yoshimura N et al. | The direct effect of FK506 and rapamycin on interleukin 1(beta) and immunoglobulin production in vitro. | 1994 | Transplantation | pmid:7517078 |
| Shipston MJ et al. | Glucocorticoid negative feedback in pituitary corticotropes. Pivotal role for calcineurin inhibition of adenylyl cyclase. | 1994 | Ann. N. Y. Acad. Sci. | pmid:7529975 |
| Firdaous I et al. | Pediatric intravenous FK506--how much are we really infusing? | 1994 | Transplantation | pmid:7517079 |
| Manez R et al. | Rejection and hepatitis in liver transplants. | 1994 | Transplantation | pmid:7517080 |
| Dawson VL et al. | Expression of inducible nitric oxide synthase causes delayed neurotoxicity in primary mixed neuronal-glial cortical cultures. | 1994 | Neuropharmacology | pmid:7532825 |
| Igarashi T et al. | Central nervous system toxicity related to FK506 in patients with Behçet's disease. | 1994 | Ann. Rheum. Dis. | pmid:7517134 |
| Eng WK et al. | The yeast FKS1 gene encodes a novel membrane protein, mutations in which confer FK506 and cyclosporin A hypersensitivity and calcineurin-dependent growth. | 1994 | Gene | pmid:7530227 |
| Ellis D et al. | Comparison of FK-506 and cyclosporine regimens in pediatric renal transplantation. | 1994 | Pediatr. Nephrol. | pmid:7517171 |
| Klintmalm GB | FK 506: an update. | 1994 | Clin Transplant | pmid:7517226 |
| Morikawa K et al. | Immunomodulatory effects of three macrolides, midecamycin acetate, josamycin, and clarithromycin, on human T-lymphocyte function in vitro. | 1994 | Antimicrob. Agents Chemother. | pmid:7532933 |
| Vischi S et al. | The maltose absorption test does not predict allograft rejection of small bowel transplantation in FK 506 immunosuppressed pigs. | 1994 | Transplant. Proc. | pmid:7518143 |
| Okamoto M et al. | Detection of allograft rejection in rat small bowel transplantation by analysing the in situ distribution of S-phase lymphocytes. | 1994 | Transplant. Proc. | pmid:7518145 |
| Ippoliti G et al. | Serum cytokine levels after small bowel transplantation in pigs. | 1994 | Transplant. Proc. | pmid:7518146 |
| Orita T et al. | Effect of FK 506 in combination with prednisolone on the graft-vs-host reaction after small bowel transplantation in rats. | 1994 | Transplant. Proc. | pmid:7518147 |
| Alessiani M et al. | Total orthotopic small bowel transplantation in swine under FK 506. | 1994 | Transplant. Proc. | pmid:7518148 |
| Jain A et al. | FK 506 in small bowel transplant recipients: pharmacokinetics and dosing. | 1994 | Transplant. Proc. | pmid:7518149 |
| Takara T et al. | Intraportal donor-specific transfusion given 24 hours before small bowel transplantation with cyclosporine and FK 506. | 1994 | Transplant. Proc. | pmid:7518150 |
| Kusne S et al. | Infectious complications after small bowel transplantation in adults. | 1994 | Transplant. Proc. | pmid:7518153 |
| Lee TK et al. | Bacterial translocation and the role of postoperative selective bowel decontamination in small intestinal transplantation. | 1994 | Transplant. Proc. | pmid:7518154 |
| Porayko MK et al. | Nephrotoxic effects of primary immunosuppression with FK-506 and cyclosporine regimens after liver transplantation. | 1994 | Mayo Clin. Proc. | pmid:7508536 |
| Martin MF | Nephrotoxic effects of immunosuppression. | 1994 | Mayo Clin. Proc. | pmid:7508537 |
| Jindal RM et al. | Diabetogenicity of FK506 versus cyclosporine in liver transplant recipients. | 1994 | Transplantation | pmid:7519799 |
| Mor E et al. | Reversal of severe FK506 side effects by conversion to cyclosporine-based immunosuppression. | 1994 | Transplantation | pmid:7519800 |
| Erden E et al. | Plasma FK506 levels in patients with histopathologically documented renal allograft rejection. | 1994 | Transplantation | pmid:7519801 |
| Dilling MB et al. | Rapamycin selectively inhibits the growth of childhood rhabdomyosarcoma cells through inhibition of signaling via the type I insulin-like growth factor receptor. | 1994 | Cancer Res. | pmid:7508822 |
| Randomised trial comparing tacrolimus (FK506) and cyclosporin in prevention of liver allograft rejection. European FK506 Multicentre Liver Study Group. | 1994 | Lancet | pmid:7520105 | |
| Yamamoto S et al. | Stimulation of hair growth by topical application of FK506, a potent immunosuppressive agent. | 1994 | J. Invest. Dermatol. | pmid:7508960 |
| Funauchi M et al. | Effects of an inhibitor for calcium/calmodulin-dependent protein phosphatase, calcineurin, on induction of long-term potentiation in rat visual cortex. | 1994 | Neurosci. Res. | pmid:7520143 |
| Ito T et al. | Protective effects of gabexate mesilate on acute pancreatitis induced by tacrolimus (FK-506) in rats in which the pancreas was stimulated by caerulein. | 1994 | J. Gastroenterol. | pmid:7520321 |
| Zeniya A et al. | Anti-ulcer effect of FK 506, immunosuppressive agent, in rats. | 1994 | J. Gastroenterol. | pmid:7520322 |
| Dawson TM et al. | Nitric oxide: cellular regulation and neuronal injury. | 1994 | Prog. Brain Res. | pmid:7533914 |
| Connelly PR et al. | Enthalpy of hydrogen bond formation in a protein-ligand binding reaction. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7510408 |
| Shiraga T et al. | Metabolism of FK506, a potent immunosuppressive agent, by cytochrome P450 3A enzymes in rat, dog and human liver microsomes. | 1994 | Biochem. Pharmacol. | pmid:7510480 |
| Hossain M et al. | Effects of various drugs (staurosporine, herbimycin A, ketotifen, theophylline, FK506 and cyclosporin A) on eosinophil viability. | 1994 | Arerugi | pmid:7520689 |
| Bell A et al. | Roles of peptidyl-prolyl cis-trans isomerase and calcineurin in the mechanisms of antimalarial action of cyclosporin A, FK506, and rapamycin. | 1994 | Biochem. Pharmacol. | pmid:7520696 |
| Paslaru L et al. | GRP78 induction by cyclosporin A in human HeLa cells. | 1994 | FEBS Lett. | pmid:7520875 |
| Gailliot FP et al. | Isolation and characterization of the major equilibrium product of FK-520. | 1994 | J. Antibiot. | pmid:7520900 |
| Stancato LF et al. | The native v-Raf.hsp90.p50 heterocomplex contains a novel immunophilin of the FK506 binding class. | 1994 | J. Biol. Chem. | pmid:7520912 |
| Hirano Y et al. | Mechanism of FK506-induced glucose intolerance in rats. | 1994 | J Toxicol Sci | pmid:7520947 |
| Tacrolimus (FK506) for organ transplants. | 1994 | Med Lett Drugs Ther | pmid:7520968 | |
| Bierer BE | Biology of cyclosporin A and FK506. | 1994 | Prog. Clin. Biol. Res. | pmid:7536944 |
| Malyszko J et al. | FK 506 affects platelet aggregation in vitro. | 1994 | Thromb. Res. | pmid:7521072 |
| Bram RJ and Crabtree GR | Calcium signalling in T cells stimulated by a cyclophilin B-binding protein. | 1994 | Nature | pmid:7522304 |
| Tanaka A et al. | Living related liver transplantation across ABO blood groups. | 1994 | Transplantation | pmid:7522363 |
| Devlin J et al. | Nitric oxide generation. A predictive parameter of acute allograft rejection. | 1994 | Transplantation | pmid:7522365 |
| Todo S et al. | Single-center experience with primary orthotopic liver transplantation with FK 506 immunosuppression. | 1994 | Ann. Surg. | pmid:7522431 |
| Ueda K et al. | Human P-glycoprotein as a multi-drug transporter analyzed by using transepithelial transport system. | 1994 | Jpn. J. Physiol. | pmid:7538609 |
| Lebeau MC et al. | Rabbit FKBP-59/HBI does not inhibit calcineurin activity in vitro. | 1994 | Biochem. Biophys. Res. Commun. | pmid:7522447 |
| Mouzaki A and Rungger D | Properties of transcription factors regulating interleukin-2 gene transcription through the NFAT binding site in untreated or drug-treated naive and memory T-helper cells. | 1994 | Blood | pmid:7522636 |
| Abu-Elmagd K et al. | Three years clinical experience with intestinal transplantation. | 1994 | J. Am. Coll. Surg. | pmid:7522850 |
| Singh N et al. | Infectious complications in liver transplant recipients on tacrolimus. Prospective analysis of 88 consecutive liver transplants. | 1994 | Transplantation | pmid:7524204 |
| Takahara S et al. | Clinical evaluation of trough levels and area under the curve in cyclosporine- and FK 506-treated kidney transplant recipients. | 1994 | Transplant. Proc. | pmid:7524219 |
| Heitman J et al. | Antifungal effects of cyclosporine and FK 506 are mediated via immunophilin-dependent calcineurin inhibition. | 1994 | Transplant. Proc. | pmid:7524220 |
| Yoshimura R et al. | Effect of immunosuppressive drugs (CsA, FK 506, rapamycin) on the kidney microsomal cytochrome P-450 system in the rat. | 1994 | Transplant. Proc. | pmid:7524223 |
| Kupferman JC et al. | Activation of the renal renin-angiotensin system by cyclosporine A and FK 506 in the rat. | 1994 | Transplant. Proc. | pmid:7524224 |
| Kattner A et al. | Conversion from CyA to CyA-NOF in a cholestatic liver grafted patient with CyA malabsorption. | 1994 | Transplant. Proc. | pmid:7524225 |
| Fung JJ and Starzl TE | FK 506 in solid organ transplantation. | 1994 | Transplant. Proc. | pmid:7524226 |
| Tacrolimus introduced for use in liver transplantation. | 1994 | Am J Hosp Pharm | pmid:7524317 | |
| Lauerma AI et al. | Topical FK506: suppression of allergic and irritant contact dermatitis in the guinea pig. | 1994 | Arch. Dermatol. Res. | pmid:7526805 |
| Bush KT et al. | Induction of the FK506-binding protein, FKBP13, under conditions which misfold proteins in the endoplasmic reticulum. | 1994 | Biochem. J. | pmid:7526846 |
| Kahan BD | New immunosuppressive drugs--pharmacologic approaches to alter immunoregulation. | 1994 | Ther Immunol | pmid:7584478 |
| Akamine S et al. | Monitoring canine lung allograft rejection using Ia antigen expression by bronchoalveolar lymphocytes. | 1994 | Surg. Today | pmid:7526914 |
| Tsuchida M et al. | The effects of FK506 and dexamethasone on rat thymocyte differentiation. | 1994 | Ther Immunol | pmid:7584489 |
| Lemoine A et al. | FK 506 renal toxicity and lack of detectable cytochrome P-450 3A in the liver graft of a patient undergoing liver transplantation. | 1994 | Hepatology | pmid:7527003 |
| Alnemri ES et al. | FKBP46, a novel Sf9 insect cell nuclear immunophilin that forms a protein-kinase complex. | 1994 | J. Biol. Chem. | pmid:7527037 |
| Todo S et al. | Small intestinal transplantation in humans with or without the colon. | 1994 | Transplantation | pmid:7512291 |
| Rosenwirth B et al. | Inhibition of human immunodeficiency virus type 1 replication by SDZ NIM 811, a nonimmunosuppressive cyclosporine analog. | 1994 | Antimicrob. Agents Chemother. | pmid:7527198 |
| Griffith BP et al. | A prospective randomized trial of FK506 versus cyclosporine after human pulmonary transplantation. | 1994 | Transplantation | pmid:7512292 |
| Shaw LM and Brayman KL | FK-506 therapeutic drug monitoring. | 1994 | Clin. Chem. | pmid:7527305 |
| Jordan ML et al. | FK506 "rescue" for resistant rejection of renal allografts under primary cyclosporine immunosuppression. | 1994 | Transplantation | pmid:7512293 |
| Winkler M et al. | Plasma vs whole blood for therapeutic drug monitoring of patients receiving FK 506 for immunosuppression. | 1994 | Clin. Chem. | pmid:7527306 |
| Wijdicks EF et al. | FK506-induced neurotoxicity in liver transplantation. | 1994 | Ann. Neurol. | pmid:7512320 |
| Lewis HM | Therapeutic progress. II: Treatment of psoriasis. | 1994 | J Clin Pharm Ther | pmid:7527403 |
| Cheng JW et al. | 15N NMR relaxation studies of the FK506 binding protein: dynamic effects of ligand binding and implications for calcineurin recognition. | 1994 | Biochemistry | pmid:7512379 |
| Mori A et al. | Regulation of interleukin-5 production by peripheral blood mononuclear cells from atopic patients with FK506, cyclosporin A and glucocorticoid. | 1994 | Int. Arch. Allergy Immunol. | pmid:7512393 |
| Okubo Y et al. | Cytokine production in patients with mite-sensitive bronchial asthma. | 1994 | Int. Arch. Allergy Immunol. | pmid:7512395 |
| Mor E et al. | Comparison of short and long-term renal function in liver transplant patients receiving cyclosporin or FK 506. | 1994 | Transpl. Int. | pmid:11271340 |
| Uemoto S et al. | Long-term use of FK 506 in living related liver transplantation. | 1994 | Transpl. Int. | pmid:11271341 |
| Dmitrewski J et al. | Steroid withdrawal 3 months after liver transplantation--does FK 506 confer any advantage over cyclosporin? | 1994 | Transpl. Int. | pmid:11271342 |