Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with tacrolimus
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Garcia CD et al. | Renal transplantation in children less than six years old. | 2001 Nov-Dec | Transplant. Proc. | pmid:11750527 |
Mendez R | FK 506 and mycophenolate mofetil in renal transplant recipients: six-month results of a multicenter, randomized dose ranging trial. FK 506 MMF Dose-Ranging Kidney Transplant Study Group. | 1998 | Transplant. Proc. | pmid:9636522 |
Kedzierska K et al. | Oxidative stress indices in rats under immunosuppression. | 2011 | Transplant. Proc. | pmid:22172876 |
Vanrenterghem Y et al. | Co-administration of tacrolimus and mycophenolate mofetil in cadaveric renal transplant recipients. | 1998 | Transplant. Proc. | pmid:9636523 |
Kang Y et al. | Acute hemodynamic effects of FK 506 during and after orthotopic liver transplantation. | 1990 | Transplant. Proc. | pmid:1689889 |
Lian Y et al. | Suppression of Delayed Xenograft Rejection by Resveratrol in a Hamster-to-Rat Cardiac Transplantation Model. | Transplant. Proc. | pmid:28736027 | |
Bilbao I et al. | Indications and management of everolimus after liver transplantation. | 2009 Jul-Aug | Transplant. Proc. | pmid:19715864 |
Marin-Gomez LM et al. | Evaluation of clinical safety of conversion to Advagraf therapy in liver transplant recipients: observational study. | 2009 Jul-Aug | Transplant. Proc. | pmid:19715867 |
Kahl A et al. | First results with a quadruple therapy regimen including tacrolimus and mycophenolate mofetil in patients after combined pancreas and kidney transplantation. | 1998 | Transplant. Proc. | pmid:9532149 |
Bruce DS et al. | Effects of tacrolimus, mycophenolate mofetil, and cyclosporine microemulsion on rejection incidence in synchronous pancreas-kidney transplantation. | 1998 | Transplant. Proc. | pmid:9532150 |
Tang J et al. | Cytokine Profile in Calcineurin Inhibitor-Induced Chronic Nephrotoxicity in Chinese Liver Transplant Recipients. | 2016 | Transplant. Proc. | pmid:27788813 |
Ortiz de Urbina J et al. | Advagraf de novo in liver transplantation: a single-center experience. | 2011 | Transplant. Proc. | pmid:21486583 |
Mueller AR et al. | Increased rejection after liver transplantation in FK 506-treated patients is associated with viral hepatitis C disease. | 1994 | Transplant. Proc. | pmid:7527984 |
Tanabe M et al. | The influence of donor and recipient strains in isolated small bowel transplantation in rats. | 1994 | Transplant. Proc. | pmid:7527986 |
Stock PG et al. | Standard sequential immunosuppression with Minnesota antilymphoblast globulin and cyclosporine vs FK 506: a comparison of early nephrotoxicity. | 1993 | Transplant. Proc. | pmid:7679838 |
Ichikura H et al. | Conversion of renal transplant immunosuppression from tacrolimus (FK 506) to cyclosporine: a single center experience. | 2000 | Transplant. Proc. | pmid:11119911 |
Tabasco-Minguillan J et al. | Long-term insulin requirement after liver transplantation with FK 506 in American veterans. | 1993 | Transplant. Proc. | pmid:7679839 |
Abu-Elmagd KM et al. | Four-hour versus 24-hour intravenous infusion of FK 506 in liver transplantation. | 1991 | Transplant. Proc. | pmid:1721271 |
Sakr M et al. | Effect of renal ischemia on plasma levels of FK 506 in rats. | 1992 | Transplant. Proc. | pmid:1371625 |
Abu-Elmagd KM et al. | Strategy of FK 506 therapy in liver transplant patients: effect of graft function. | 1991 | Transplant. Proc. | pmid:1721272 |
Kusne S et al. | Infections during a randomized trial comparing cyclosporine to FK 506 immunosuppression in liver transplantation. | 1992 | Transplant. Proc. | pmid:1371626 |
Smit JA et al. | Induction of primate TH2 lymphokines to suppress TH1 cells. | 1996 | Transplant. Proc. | pmid:8623334 |
Tanaka M et al. | Tacrolimus (FK 506)-dependent tolerance after liver and heart xenotransplantation: inhibition of humoral response and acceptance of donor organs. | 1996 | Transplant. Proc. | pmid:8623341 |
Takada Y et al. | Improvement of allograft viability with organs procured from non-heart-beating donors in porcine liver transplantation. | 2000 | Transplant. Proc. | pmid:10715416 |
Cantarovich M et al. | Optimal time points for the prediction of the area-under-the-curve in liver transplant patients receiving tacrolimus. | 1998 | Transplant. Proc. | pmid:9636592 |
Hachida M et al. | Combined use of deoxyspergualin and FK 506 for temporary circulatory assist. | 1999 | Transplant. Proc. | pmid:10455968 |
Yasunami Y et al. | Characterization of the immunosuppressive activity of FK 506 in rat islet allografts. | 1990 | Transplant. Proc. | pmid:1691557 |
Yoshimura N et al. | Combination therapy of tacrolimus (FK506) with azathioprine and steroids in renal transplant recipients. | 1998 | Transplant. Proc. | pmid:9474949 |
Akiyama T et al. | Mizoribine in combination therapy with tacrolimus for living donor renal transplantation: analysis of a nationwide study in Japan. | 2005 | Transplant. Proc. | pmid:15848551 |
Fukushima N et al. | Role of endothelial apoptosis in delayed xenograft rejection in pig-to-baboon cardiac transplantation. | 1999 | Transplant. Proc. | pmid:10578268 |
Kar S and Carr B | Gene expression of FK 506-binding protein. | 1991 | Transplant. Proc. | pmid:1721303 |
Moffatt SD and Metcalfe SM | FK 506 versus cyclosporine in combination with anti-CD4/CD8 monoclonal antibodies. | 1999 | Transplant. Proc. | pmid:10578271 |
Gagliano N et al. | A therapeutic dose of FK506 does not affect collagen turnover pathways in healthy human gingival fibroblasts. | 2008 | Transplant. Proc. | pmid:18589121 |
Wang SS et al. | Heart transplantation under cyclosporine or tacrolimus combined with mycophenolate mofetil or everolimus. | 2008 | Transplant. Proc. | pmid:18929814 |
Hohage H et al. | Differential effects of cyclosporine and tacrolimus on mycophenolate pharmacokinetics in patients with impaired kidney function. | 2005 | Transplant. Proc. | pmid:15919453 |
Bäckman L et al. | Chronic nephrotoxicity of FK 506 after liver transplantation. | 1994 | Transplant. Proc. | pmid:7518159 |
Sakai K et al. | The pathologic impact of tacrolimus on protocol biopsy in renal transplant patients with basiliximab-based immunosuppression. | 2005 | Transplant. Proc. | pmid:15919455 |
Izuishi K et al. | Effect of an immunosuppressive agent, tacroliums (FK-506), on the activities of cytochrome P-450-linked monooxygenase systems of rat liver microsomes. | 2003 | Transplant. Proc. | pmid:12591538 |
Kindt MV et al. | Tacrolimus toxicity in rhesus monkey: model for clinical side effects. | 1999 | Transplant. Proc. | pmid:10616519 |
Yagihashi A et al. | Changes in cell surface markers in human small bowel transplantation with FK 506. | 1992 | Transplant. Proc. | pmid:1376522 |
Sakimoto H et al. | Prolonged survival of hamster-to-rat pancreas xenografts by FK 506 and splenectomy. | 1995 | Transplant. Proc. | pmid:7533394 |
Lewis WD et al. | FK 506 rescue therapy in liver transplant recipients with drug-resistant rejection. | 1991 | Transplant. Proc. | pmid:1721336 |
Varo E et al. | Alternative immunosuppression for acute renal failure in liver transplantation: role of ultra-low dose tacrolimus and basiliximab. | 2002 | Transplant. Proc. | pmid:12176471 |
Braun F et al. | How to handle mycophenolate mofetil in combination with tacrolimus? | 1998 | Transplant. Proc. | pmid:9865309 |
Moro JA et al. | Randomized prospective study of the evolution of renal function depending on the anticalcineurin used. | 2008 | Transplant. Proc. | pmid:19010143 |
Ye Q et al. | Persistence of donor cells and incidence of graft-versus-host disease after simultaneous small bowel and bone marrow transplantation. | 1996 | Transplant. Proc. | pmid:8907895 |
Emiroglu R et al. | Tacrolimus-related neurologic and renal complications in liver transplantation: A single-center experience. | 2006 | Transplant. Proc. | pmid:16549190 |
Gregory CR | Immunosuppressive approaches to the prevention of graft vascular disease. | 1998 | Transplant. Proc. | pmid:9595134 |
Woo J et al. | FK 506 treatment following syngeneic bone marrow transplantation does not inhibit clonal deletion of V beta 5+ or V beta 11+ T cells. | 1992 | Transplant. Proc. | pmid:1281583 |
Souza ER et al. | Acute effects of FK 506 on glomerular hemodynamics. | 1992 | Transplant. Proc. | pmid:1281585 |
Japanese study of FK 506 on kidney transplantation: the benefit of monitoring the whole blood FK 506 concentration. Japanese FK 506 Study Group. | 1991 | Transplant. Proc. | pmid:1721367 | |
Nishi K et al. | The expression of intestinal CYP3A4 in the piglet model. | 2004 | Transplant. Proc. | pmid:15050159 |
Darras FS et al. | Transplantation of pediatric en bloc kidneys under FK 506 immunosuppression. | 1991 | Transplant. Proc. | pmid:1721368 |
Hernández D et al. | Cardiovascular risk profile in nondiabetic renal transplant patients: cyclosporine versus tacrolimus. | 2003 | Transplant. Proc. | pmid:12962773 |
Craig AM et al. | A cost-effectiveness analysis of tacrolimus versus cyclosporine microemulsion following kidney transplantation. | 2002 | Transplant. Proc. | pmid:12176519 |
Takeda M et al. | Immunologic factors contributing to acute rejection in lungs xenotransplanted between primates. | 1998 | Transplant. Proc. | pmid:9838670 |
Murase N et al. | Immunomodulation of intestinal transplant with allograft irradiation and simultaneous donor bone marrow infusion. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083238 |
Nishioka T et al. | Arterial stiffness after successful renal transplantation. | 2008 | Transplant. Proc. | pmid:18790249 |
Scott-Douglas N et al. | Treatment of acute renal transplant rejection with FK 506 in patients on cyclosporine after failure of standard antirejection therapy. | 1996 | Transplant. Proc. | pmid:8962226 |
Suzuki H et al. | Spleen grafting might induce transplantation tolerance in rats. | 1995 | Transplant. Proc. | pmid:7536973 |
Moutabarrik A et al. | Use of FK 506 in kidney transplantation. | 1993 | Transplant. Proc. | pmid:7685946 |
Mohacsi P et al. | Immunosuppression in ABO-incompatible transplantation. | 2001 | Transplant. Proc. | pmid:11377508 |
Artz MA et al. | Randomized conversion from cyclosporine to tacrolimus in renal transplant patients: improved lipid profile and unchanged plasma homocysteine levels. | 2002 | Transplant. Proc. | pmid:12176579 |
Jonas S et al. | Corticosteroid-free therapy after tacrolimus-based dual immunosuppression versus cyclosporine-based quadruple-induction therapy. | 2001 | Transplant. Proc. | pmid:11377511 |
Boucher A et al. | Impact of immunosuppressive regimen on cardiovascular risk factors in kidney transplant recipients. | 2002 | Transplant. Proc. | pmid:12176582 |
Opelz G | New immunosuppressants and HLA matching. | 2001 Feb-Mar | Transplant. Proc. | pmid:11266911 |
Jiang H et al. | IL-10: a tacrolimus-specific cytotoxic mediator in ongoing allograft rejection. | 2001 Feb-Mar | Transplant. Proc. | pmid:11266931 |
Fu F et al. | Systemic administration of CTLA4-Ig or anti-CD40 ligand antibody inhibits second-set rejection of mouse liver allografts. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083555 |
Cirocco RE et al. | Kidney recipient CMV incidence in the gancyclovir era: monitoring viral DNA by a CMV-PCR assay. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083604 |
Budde K et al. | Long-term outcome of tacrolimus rescue therapy in late rejection after renal transplantation. | 1998 | Transplant. Proc. | pmid:9723280 |
Levy GA | Neoral is superior to FK 506 in liver transplantation. | 1998 | Transplant. Proc. | pmid:9723293 |
Takahashi Y et al. | Pharmacokinetic Profile of Twice- and Once-daily Tacrolimus in Pediatric Kidney Transplant Recipients. | Transplant. Proc. | pmid:28104153 | |
Weir MR | Optimizing early de novo immunosuppression with sirolimus. | 2008 | Transplant. Proc. | pmid:19100903 |
Kanatani T et al. | Donor leukocytes combine with immunosuppressive drug therapy to prolong limb allograft survival. | 2005 | Transplant. Proc. | pmid:15964421 |
Langrehr JM et al. | FK 506 inhibits nitric oxide production by cells infiltrating sponge matrix allografts. | 1991 | Transplant. Proc. | pmid:1721430 |
Hayakawa K et al. | Maintenance of unresponsiveness by short-term pulse therapy with FK 506 in rat transplantation. | 1996 | Transplant. Proc. | pmid:8658904 |
Gotoh M et al. | Tolerance induction by liver grafting and FK 506 treatment in nonhuman primates. | 1991 | Transplant. Proc. | pmid:1721431 |
Ishikawa M et al. | Acetaminophen absorption test as a useful indicator of small intestinal rejection in rats. | 1996 | Transplant. Proc. | pmid:8658911 |
Asensio M et al. | Induction with basiliximab reduces acute rejection in pediatric liver transplant patients treated with tacrolimus and steroids. | 2002 | Transplant. Proc. | pmid:12176650 |
Eberlin M et al. | Increased medication compliance of liver transplant patients switched from a twice-daily to a once-daily tacrolimus-based immunosuppressive regimen. | 2013 Jul-Aug | Transplant. Proc. | pmid:23726723 |
Sperschneider H | A large, multicentre trial to compare the efficacy and safety of tacrolimus with cyclosporine microemulsion following renal transplantation. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267291 |
Dumortier J et al. | Introduction of mycophenolate mofetil in maintenance liver transplant recipients: what can we expect? Results of a 10-year experience. | 2010 | Transplant. Proc. | pmid:20832553 |
Fukuoka N et al. | Micafungin does not influence the concentration of tacrolimus in patients after allogeneic hematopoietic stem cell transplantation. | 2010 | Transplant. Proc. | pmid:20832577 |
Shapiro R | Tacrolimus in solid organ transplantation: an update. | 1999 | Transplant. Proc. | pmid:10500545 |
Martins L et al. | Conversion to tacrolimus in case-problem kidney transplant recipients under cyclosporine-based immunosuppression. | 2000 | Transplant. Proc. | pmid:11134735 |
Hanack U et al. | Is there a different impact of cyclosporine versus tacrolimus on delayed graft function after kidney transplantation? | 1998 | Transplant. Proc. | pmid:9723477 |
Valenzuela M et al. | Early steroid withdrawal in pediatric renal transplantation at a single center: preliminary report. | 2008 | Transplant. Proc. | pmid:19010242 |
Krämer BK et al. | Efficacy of Prolonged- and Immediate-release Tacrolimus in Kidney Transplantation: A Pooled Analysis of Two Large, Randomized, Controlled Trials. | 2017 | Transplant. Proc. | pmid:29149958 |
Alvarez-ElÃas AC et al. | CYP3A5 Genotype and Time to Reach Tacrolimus Therapeutic Levels in Renal Transplant Children. | 2016 | Transplant. Proc. | pmid:27110018 |
Bolton C | The ability of myelin basic protein-sensitised leukocytes to adoptively transfer experimental allergic encephalomyelitis following coculture with FK 506, cyclosporine, or prednisolone. | 1991 | Transplant. Proc. | pmid:1721462 |
Nichelle L et al. | Arterial hypertension in renal transplant recipients treated with tacrolimus or cyclosporine-Neoral. | 2002 | Transplant. Proc. | pmid:12431623 |
Barten MJ et al. | Assessment of immunosuppression by lymphocyte functions in human blood. | 2002 | Transplant. Proc. | pmid:12431640 |
Uemoto S et al. | Safety and efficacy of once-daily modified-release tacrolimus in liver transplant recipients: a multicenter postmarketing surveillance in Japan. | 2014 | Transplant. Proc. | pmid:24767340 |
Wang M et al. | Acute influence of FK506 on T-lymphocyte populations of peripheral blood and spleen in rats. | 2007 Jan-Feb | Transplant. Proc. | pmid:17275526 |
Lo A et al. | Ganciclovir prophylaxis for cytomegalovirus infection in simultaneous kidney-pancreas transplant recipients receiving tacrolimus, mycophenolate mofetil, and prednisone. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267516 |
Reimer J et al. | Quality of life after kidney transplantation--the impact of tacrolimus. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267573 |
Rao V et al. | A non-induction renal sparing approach after liver transplantation: high dose mycophenolate mofetil with delayed, low-dose tacrolimus. | 2013 Jan-Feb | Transplant. Proc. | pmid:23267806 |
Fritsche L et al. | Conversion to mycophenolate mofetil for chronic progressive deterioration of renal allograft function: first clinical experiences in 44 patients. | 1998 | Transplant. Proc. | pmid:9636481 |
GarcÃa-Bello JA et al. | Effect of Immunosuppressive Therapy on Cardiovascular Risk Factor Prevalence in Kidney-Transplanted Children: Comparative Study. | 2016 | Transplant. Proc. | pmid:27110020 |
Morris RE et al. | Use of rapamycin for the suppression of alloimmune reactions in vivo: schedule dependence, tolerance induction, synergy with cyclosporine and FK 506, and effect on host-versus-graft and graft-versus-host reactions. | 1991 | Transplant. Proc. | pmid:1703698 |