tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Gaweco AS et al. | Distinct intragraft cytokine gene expression patterns during acute hepatic rejection under cyclosporine versus FK 506 primary immunosuppression. | 1994 | Transplant. Proc. | pmid:7527948 |
| Fruman DA et al. | Immunophilins in protein folding and immunosuppression. | 1994 | FASEB J. | pmid:7513288 |
| Mathieu C et al. | Potential role of 1,25(OH)2 vitamin D3 as a dose-reducing agent for cyclosporine and FK 506. | 1994 | Transplant. Proc. | pmid:7527950 |
| Piekoszewski W et al. | Pharmacokinetic and pharmacodynamic effects of coadministration of methylprednisolone and tacrolimus in rabbits. | 1994 | J. Pharmacol. Exp. Ther. | pmid:7513355 |
| Mueller AR et al. | Severe neurotoxicity after liver transplantation: association between FK 506 therapy and hepatitis C virus disease. | 1994 | Transplant. Proc. | pmid:7527951 |
| Ueki M et al. | Peritoneal-omental pouch as a site for islet allotransplantation. | 1994 | Transplant. Proc. | pmid:7513462 |
| Platz KP et al. | Causes of death following liver transplantation in FK 506- and cyclosporine-treated patients. | 1994 | Transplant. Proc. | pmid:7527952 |
| Yasunami Y et al. | Acceptance of donor-specific islet allografts in rat by intraportal preimmunization with islets and FK 506. | 1994 | Transplant. Proc. | pmid:7513467 |
| Christe W | Neurological disorders in liver and kidney transplant recipients. | 1994 | Transplant. Proc. | pmid:7527953 |
| Ueki M et al. | Functional and morphologic characterization of renal subcapsular islet isografts in rats treated with FK 506. | 1994 | Transplant. Proc. | pmid:7513469 |
| Tze WJ et al. | Immunohistochemical studies of pig islet xenograft in rats immunosuppressed with FK 506. | 1994 | Transplant. Proc. | pmid:7513470 |
| Tze WJ et al. | Prolongation of pig islet xenograft survival in rats by local immunosuppression with FK 506. | 1994 | Transplant. Proc. | pmid:7513471 |
| Fukuzaki T et al. | Nonvascularized islet xenograft rejection in a mouse-to-rat combination where the vascularized heart is rapidly rejected. | 1994 | Transplant. Proc. | pmid:7513472 |
| Hachida M et al. | [The rescue effect of FK506 in refractory rejection after cardiac transplantation]. | 1994 | Nihon Kyobu Geka Gakkai Zasshi | pmid:7528255 |
| Sugiyama E et al. | FK506, an immunosuppressant, partially inhibits interleukin 6 production by adherent rheumatoid synovial cells. | 1994 | J. Rheumatol. | pmid:7528280 |
| Bennett WM et al. | Nephrotoxicity of immunosuppressive drugs. | 1994 | Nephrol. Dial. Transplant. | pmid:7528363 |
| Bennett WM et al. | Nephrotoxicity of immunosuppressive drugs. | 1994 | Miner Electrolyte Metab | pmid:7531274 |
| McCashland TM et al. | Bile acid metabolism and biliary secretion in patients receiving orthotopic liver transplants: differing effects of cyclosporine and FK 506. | 1994 | Hepatology | pmid:7514561 |
| Husi H et al. | Mapping of the immunophilin-immunosuppressant site of interaction on calcineurin. | 1994 | J. Biol. Chem. | pmid:7514602 |
| Moudgil A et al. | Inhibition of in vitro immunoglobulin production by a novel immunosuppressive drug brequinar sodium. | 1994 | Transplant Sci | pmid:7528627 |
| Sekigawa I et al. | FK506 can inhibit apoptotic cell death induced by the HIV-1 envelope glycoprotein gp120. | 1994 | AIDS | pmid:7531458 |
| Mazariegos GV et al. | Rubella infection after orthotopic liver transplantation. | 1994 | Pediatr. Infect. Dis. J. | pmid:7514783 |
| Klaus GG et al. | Properties of mouse CD40. Ligation of CD40 activates B cells via a Ca(++)-dependent, FK506-sensitive pathway. | 1994 | Eur. J. Immunol. | pmid:7528676 |
| Mañez R et al. | Fluconazole therapy in transplant recipients receiving FK506. | 1994 | Transplantation | pmid:7515201 |
| Tzakis AG et al. | Intestinal transplantation. | 1994 | Annu. Rev. Med. | pmid:7515221 |
| Foster CA et al. | Pharmacological modulation of endothelial cell-associated adhesion molecule expression: implications for future treatment of dermatological diseases. | 1994 | J. Dermatol. | pmid:7531725 |
| Mulkey RM et al. | Involvement of a calcineurin/inhibitor-1 phosphatase cascade in hippocampal long-term depression. | 1994 | Nature | pmid:7515479 |
| Nishimori H et al. | Combination therapy with FK 506 and splenectomy may induce tolerance in cardiac xenografts. | 1994 | Transplant. Proc. | pmid:7518102 |
| Kawauchi M et al. | Cardiac xenotransplantation from pig to Japanese monkey with splenectomy, tacrolims, filtration plasmapheresis, and nafamstat mesilate. | 1994 | Transplant. Proc. | pmid:7518105 |
| Ohtsuka S et al. | Effect of splenectomy on hamster-to-rat pancreas xenotransplantation. | 1994 | Transplant. Proc. | pmid:7518109 |
| Yasutomi M et al. | Mechanism of antibody production in hamster-to-rat concordant xenotransplantation: establishment of a simple model using intravenous injection of concordant splenocytes. | 1994 | Transplant. Proc. | pmid:7518110 |
| Miyazawa H et al. | Mechanisms of hamster kidney graft rejection in the rat. | 1994 | Transplant. Proc. | pmid:7518111 |
| Nardo B et al. | Pretransplant xenogeneic blood transfusion combined with FK 506 prolongs hamster-to-rat liver xenograft survival. | 1994 | Transplant. Proc. | pmid:7518112 |
| Pan F et al. | FK 506 prolongs survival of liver but not heart mouse-to-rat vascularized xenografts. | 1994 | Transplant. Proc. | pmid:7518113 |
| Valdivia LA et al. | Complement and target cells belong to the same species after liver xenografting: protection from hyperacute rejection. | 1994 | Transplant. Proc. | pmid:7518123 |
| Helekar SA et al. | Prolyl isomerase requirement for the expression of functional homo-oligomeric ligand-gated ion channels. | 1994 | Neuron | pmid:7507339 |
| Parsons JN et al. | Regulation of calcineurin phosphatase activity and interaction with the FK-506.FK-506 binding protein complex. | 1994 | J. Biol. Chem. | pmid:7518461 |
| Cunningham KW and Fink GR | Calcineurin-dependent growth control in Saccharomyces cerevisiae mutants lacking PMC1, a homolog of plasma membrane Ca2+ ATPases. | 1994 | J. Cell Biol. | pmid:7507493 |
| Wang T et al. | Specific interaction of type I receptors of the TGF-beta family with the immunophilin FKBP-12. | 1994 | Science | pmid:7518616 |
| Fealy MJ et al. | Efficacy of rapamycin and FK 506 in prolonging rat hind limb allograft survival. | 1994 | Ann. Surg. | pmid:7507657 |
| Tanabe M et al. | Combined immunosuppressive therapy with low dose FK506 and antimetabolites in rat allogeneic heart transplantation. | 1994 | Transplantation | pmid:7518619 |
| Bossard MJ et al. | Catalytic and ligand binding properties of the FK506 binding protein FKBP12: effects of the single amino acid substitution of Tyr82 to Leu. | 1994 | Biochem. J. | pmid:7507662 |
| Tamura K et al. | Interaction of tacrolimus(FK506) and its metabolites with FKBP and calcineurin. | 1994 | Biochem. Biophys. Res. Commun. | pmid:7518678 |
| Hooks MA | Tacrolimus, a new immunosuppressant--a review of the literature. | 1994 | Ann Pharmacother | pmid:7518710 |
| Frizell E et al. | FK506 enhances fibrogenesis in in vitro and in vivo models of liver fibrosis in rats. | 1994 | Gastroenterology | pmid:7518783 |
| Fujimura A and Ebihara A | Administration time-dependent toxicity of a new immunosuppressive agent, tacrolimus (FK 506). | 1994 | Life Sci. | pmid:7518886 |
| Gottschalk AR et al. | Identification of immunosuppressant-induced apoptosis in a murine B-cell line and its prevention by bcl-x but not bcl-2. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7518929 |
| Nakata S et al. | Immunosuppressive mechanisms of deoxymethylspergualin and FK 506 on in vitro cytotoxic T lymphocytes. | 1994 | Transplant. Proc. | pmid:7520613 |
| Morphopathological findings of renal allografts under FK 506 therapy. Japanese FK 506 Study Group. | 1994 | Transplant. Proc. | pmid:7520614 | |
| Imanishi M et al. | Induction of tolerance by intrathymic injection of donor bone marrow cells in the rat: simultaneous heart and skin allograft model. | 1994 | Transplant. Proc. | pmid:7520615 |
| Charters AR et al. | Immunochemical analysis of FK506 binding proteins in neuronal cell lines and rat brain. | 1994 | Biochem. Soc. Trans. | pmid:7535258 |
| Matsuura T et al. | Organ-specific tolerance induced by intrathymic injection of donor bone marrow cells and FK 506 or antilymphocyte serum in rat heart transplantation. | 1994 | Transplant. Proc. | pmid:7520616 |
| Andoh TF et al. | Enhancement of FK506 nephrotoxicity by sodium depletion in an experimental rat model. | 1994 | Transplantation | pmid:7509514 |
| Charters AR et al. | The subcellular distribution of FK506 binding proteins in rat brain. | 1994 | Biochem. Soc. Trans. | pmid:7535259 |
| Ota K | Living donor kidney transplantation in Japan. | 1994 | Transplant. Proc. | pmid:7520622 |
| Bäckman L et al. | FK506 trough levels in whole blood and plasma in liver transplant recipients. Correlation with clinical events and side effects. | 1994 | Transplantation | pmid:7509516 |
| Hirose M and Kuroda Y | Reinforcement of cyclosporin A-induced red cell destruction by superoxide. | 1994 | Tokushima J. Exp. Med. | pmid:7535479 |
| Takahara S et al. | Monitoring of FK 506 blood levels in kidney transplant recipients. | 1994 | Transplant. Proc. | pmid:7520623 |
| Sun CK et al. | Intensive care after orthotopic liver transplantation. | 1994 | Transplant. Proc. | pmid:7520627 |
| Sato K et al. | Effectiveness of triple regimen immunosuppression in canine pancreatic allotransplantation. | 1994 | Transplant. Proc. | pmid:7520628 |
| Thomson AW | Immunosuppressive drugs and the induction of transplantation tolerance. | 1994 | Transpl. Immunol. | pmid:7535641 |
| Woo J et al. | FK506 inhibits the differentiation of developing thymocytes but not negative selection of T cell receptor V beta 5+ and V beta 11+ T lymphocytes in vivo. | 1994 | Transpl. Immunol. | pmid:7521743 |
| Kasiske BL | The effects of immunosuppressive agents on plasma lipoproteins after organ transplantation. | 1994 | J. Lab. Clin. Med. | pmid:7521894 |
| Krentz AJ et al. | Serum lipids and apolipoproteins in liver transplant recipients: a comparative study of cyclosporin A and FK 506. | 1994 | J. Lab. Clin. Med. | pmid:7521895 |
| Jensen C et al. | Interaction between tacrolimus and erythromycin. | 1994 | Lancet | pmid:7521928 |
| Karmann K et al. | Endothelial cell-induced resistance to cyclosporin A in human peripheral blood T cells requires contact-dependent interactions involving CD2 but not CD28. | 1994 | J. Immunol. | pmid:7523510 |
| Hiromura K et al. | FK506 inhibits renal glomerular thrombosis induced in rats by nephrotoxic serum and lipopolysaccharide. | 1994 | Kidney Int. | pmid:7523750 |
| Ohtomo Y et al. | Coexisting NPY and NE synergistically regulate renal tubular Na+, K(+)-ATPase activity. | 1994 | Kidney Int. | pmid:7523751 |
| Siekierka JJ | Probing T-cell signal transduction pathways with the immunosuppressive drugs, FK-506 and rapamycin. | 1994 | Immunol. Res. | pmid:7539823 |
| Moore R and Lord R | Tacrolimus (FK506) versus cyclosporin in prevention of liver allograft rejection. | 1994 | Lancet | pmid:7523805 |
| Krentz AJ et al. | Tacrolimus (FK506) versus cyclosporin in prevention of liver allograft rejection. | 1994 | Lancet | pmid:7523806 |
| Collins RH | Tacrolimus (FK506) versus cyclosporin in prevention of liver allograft rejection. | 1994 | Lancet | pmid:7523807 |
| Schmidt A et al. | Two FK506 resistance-conferring genes in Saccharomyces cerevisiae, TAT1 and TAT2, encode amino acid permeases mediating tyrosine and tryptophan uptake. | 1994 | Mol. Cell. Biol. | pmid:7523855 |
| A comparison of tacrolimus (FK 506) and cyclosporine for immunosuppression in liver transplantation. The U.S. Multicenter FK506 Liver Study Group. | 1994 | N. Engl. J. Med. | pmid:7523946 | |
| Tamir H et al. | Secretogogue-induced gating of chloride channels in the secretory vesicles of parafollicular cells. | 1994 | Endocrinology | pmid:7525261 |
| Shafiee A et al. | Enzymology of FK-506 biosynthesis. Purification and characterization of 31-O-desmethylFK-506 O:methyltransferase from Streptomyces sp. MA6858. | 1994 | Eur. J. Biochem. | pmid:7525282 |
| Benton BM et al. | A novel FK506- and rapamycin-binding protein (FPR3 gene product) in the yeast Saccharomyces cerevisiae is a proline rotamase localized to the nucleolus. | 1994 | J. Cell Biol. | pmid:7525596 |
| Gruber SA et al. | Pharmacokinetics of FK506 after intravenous and oral administration in patients awaiting renal transplantation. | 1994 | J Clin Pharmacol | pmid:7525661 |
| Funk JO and Maibach HI | Horizons in pharmacologic intervention in allergic contact dermatitis. | 1994 | J. Am. Acad. Dermatol. | pmid:7525668 |
| Mukaida N et al. | Molecular mechanism of interleukin-8 gene expression. | 1994 | J. Leukoc. Biol. | pmid:7525815 |
| Hiromatsu Y et al. | Inhibitory effect of FK506 on intercellular adhesion molecule-1 (ICAM-1) expression on cultured thyroid cells. | 1994 | Kurume Med J | pmid:7526029 |
| Matsunami H et al. | New technique for measuring tacrolimus concentrations in blood. | 1994 | Am J Hosp Pharm | pmid:7510929 |
| Renoir JM et al. | Effects of immunosuppressants FK506 and rapamycin on the heterooligomeric form of the progesterone receptor. | 1994 | J. Steroid Biochem. Mol. Biol. | pmid:7510997 |
| Lea JP et al. | Evidence that the inhibition of Na+/K(+)-ATPase activity by FK506 involves calcineurin. | 1994 | Kidney Int. | pmid:7527873 |
| Dmitrewski J et al. | Steroid withdrawal 3 months after liver transplantation--does FK 506 confer any advantage over cyclosporin? | 1994 | Transpl. Int. | pmid:11271342 |
| Nielsen FT et al. | Nephrotoxity of FK 506: a preliminary study on comparative aspects of FK 506 and cyclosporine nephrotoxicity. | 1994 | Transplant. Proc. | pmid:7527946 |
| Fisher A et al. | Gastrointestinal toxicity associated with FK 506 in liver transplant recipients. | 1994 | Transplant. Proc. | pmid:7527947 |
| Assan R et al. | FK 506/fluconazole interaction enhances FK 506 nephrotoxicity. | 1994 Jan-Feb | Diabete Metab | pmid:7520007 |
| Perotti BY et al. | FK 506 metabolism in male and female rat liver microsomes. | 1994 Jan-Feb | Drug Metab. Dispos. | pmid:7512020 |
| Akita K et al. | Effect of FK506 and anti-CD4 therapy on fetal pig pancreas xenografts and host lymphoid cells in nod/Lt, CBA, and BALB/c mice. | 1994 Jan-Feb | Cell Transplant | pmid:7512875 |
| Yasunami Y et al. | Donor-specific unresponsiveness induced by intraportal grafting and FK506 in rat islet allografts: importance of low temperature culture and transplant site on induction and maintenance. | 1994 Jan-Feb | Cell Transplant | pmid:7512876 |
| Yoshida Y et al. | Comparison of cardiac rejection in heart and heart-lung concordant xenotransplantation. | 1994 Mar-Apr | J. Heart Lung Transplant. | pmid:7518252 |
| Kay AB | Immunosuppressive agents in chronic severe asthma. | 1994 May-Jun | Allergy Proc | pmid:7523242 |
| von Asmuth EJ et al. | IL-6, IL-8 and TNF production by cytokine and lipopolysaccharide-stimulated human renal cortical epithelial cells in vitro. | 1994 May-Jun | Eur. Cytokine Netw. | pmid:7524716 |
| Ryffel B et al. | Nephrotoxicity of immunosuppressants in rats: comparison of macrolides with cyclosporin. | 1994 Nov-Dec | Exp. Nephrol. | pmid:7532090 |
| Cacciarelli TV et al. | Influence of the timing of FK 506 (Tacrolimus) administration on recovery of renal function from warm ischemic injury in rats. | 1994 Oct-Dec | ASAIO J. | pmid:7532042 |
| Karanam BV et al. | FK 506 metabolism in human liver microsomes: investigation of the involvement of cytochrome P450 isozymes other than CYP3A4. | 1994 Sep-Oct | Drug Metab. Dispos. | pmid:7530623 |
| Senninger N et al. | Glucose metabolism following liver transplantation and immunosuppression with cyclosporine A or FK 506. | 1995 | Transplant. Proc. | pmid:7533364 |
| Gonschior AK et al. | Simplified high-performance liquid chromatography-mass spectrometry assay for measurement of tacrolimus and its metabolites and cross-validation with microparticle enzyme immunoassay. | 1995 | Ther Drug Monit | pmid:8585114 |
| Keenan RJ et al. | Clinical trial of tacrolimus versus cyclosporine in lung transplantation. | 1995 | Ann. Thorac. Surg. | pmid:7545889 |