tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Andoh TF et al. | Functional and structural characteristics of experimental FK 506 nephrotoxicity. | 1995 | Clin. Exp. Pharmacol. Physiol. | pmid:8542679 |
| Fukunaga T et al. | Osteogenesis in xenogeneic bone transplantation, using an immunosuppressant. Rabbit-rat experiments. | 1995 | Acta Orthop Scand | pmid:8553828 |
| Ryffel B et al. | Interleukin-2 receptor (CD25) upregulation on human T-lymphocytes: sensitivity to immunosuppressants is defined by the mode of T-lymphocyte activation. | 1995 | Immunopharmacology | pmid:8557519 |
| Stillman IE et al. | FK506 nephrotoxicity: morphologic and physiologic characterization of a rat model. | 1995 | Lab. Invest. | pmid:8558840 |
| Gjertson DW et al. | The relative effects of FK506 and cyclosporine on short- and long-term kidney graft survival. | 1995 | Transplantation | pmid:8545861 |
| Shirakata Y et al. | Inhibitory effect of plasma FKBP12 on immunosuppressive activity of FK506. | 1995 | Transplantation | pmid:8545894 |
| Aoyama H et al. | Successful treatment of resistant facial lesions of atopic dermatitis with 0.1% FK506 ointment. | 1995 | Br. J. Dermatol. | pmid:8547017 |
| Gharpure VS et al. | Thrombotic thrombocytopenic purpura associated with FK506 following bone marrow transplantation. | 1995 | Bone Marrow Transplant. | pmid:8547871 |
| Klintmalm GB and Gonwa TA | Nephrotoxicity associated with cyclosporine and FK506. | 1995 | Liver Transpl Surg | pmid:9346596 |
| Wong PY et al. | FK506 in liver transplantation for chronic hepatitis B: in vitro studies on lymphocyte activation and virus replication. | 1995 | Liver Transpl Surg | pmid:9346613 |
| Coghlan VM et al. | Association of protein kinase A and protein phosphatase 2B with a common anchoring protein. | 1995 | Science | pmid:7528941 |
| Marx SO et al. | Rapamycin-FKBP inhibits cell cycle regulators of proliferation in vascular smooth muscle cells. | 1995 | Circ. Res. | pmid:7532117 |
| Clardy J | The chemistry of signal transduction. | 1995 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7529414 |
| Kawai M et al. | Pyrrolidine dithiocarbamate inhibits intercellular adhesion molecule-1 biosynthesis induced by cytokines in human fibroblasts. | 1995 | J. Immunol. | pmid:7532665 |
| Venkataraman L et al. | FK506 inhibits antigen receptor-mediated induction of c-rel in B and T lymphoid cells. | 1995 | J. Exp. Med. | pmid:7532676 |
| Loss M et al. | Influence of long-term cyclosporine or FK 506 therapy on glucose and lipid metabolism in stable liver graft recipients. | 1995 | Transplant. Proc. | pmid:7533365 |
| Büttemeyer R et al. | Peripheral nerve allograft transplantation with FK506: functional, histological, and immunological results before and after discontinuation of immunosuppression. | 1995 | Ann Plast Surg | pmid:8585683 |
| Lang T et al. | Distinct patterns of Th2 cytokine production during immune activation in pediatric liver allograft recipients. | 1995 | Transplant. Proc. | pmid:7533367 |
| Takeda Y et al. | Effect of FK 506 on the expression of endothelin receptor mRNA in the vasculature. | 1995 | J. Cardiovasc. Pharmacol. | pmid:8587392 |
| O'Rourke M et al. | Recovery of delayed-type hypersensitivity following liver transplantation. | 1995 | Transplant. Proc. | pmid:7533369 |
| Goodall T et al. | FK506-induced endothelin release by cultured rat mesangial cells. | 1995 | J. Cardiovasc. Pharmacol. | pmid:8587453 |
| Gaweco AS et al. | Common and sequential overexpression patterns of T-helper cytokines during acute (cellular) rejection, and correlation of proinflammatory cytokine expression with chronic (ductopenic) rejection of human liver allografts: a study under cyclosporine, FK 506, and quadruple BT 563 immunosuppression. | 1995 | Transplant. Proc. | pmid:7533370 |
| Soldin SJ | Receptor (immunophilin-binding) assay for immunosuppressive drugs. | 1995 | Ther Drug Monit | pmid:8588223 |
| Armstrong VW et al. | Metabolic liver function and lipoprotein metabolism after orthotopic liver transplantation in patients on immunosuppressive therapy with FK 506 or cyclosporine. | 1995 | Transplant. Proc. | pmid:7533371 |
| Thomson AW et al. | Mode of action of tacrolimus (FK506): molecular and cellular mechanisms. | 1995 | Ther Drug Monit | pmid:8588225 |
| Martinez OM et al. | Molecular markers of Epstein-Barr virus infection in the circulation of transplant recipients. | 1995 | Transplant. Proc. | pmid:7533372 |
| Fung JJ and Starzl TE | FK506 in solid organ transplantation. | 1995 | Ther Drug Monit | pmid:8588226 |
| Langrehr JM et al. | Liver transplantation in hepatitis B surface antigen positive patients with postoperative long-term immunoprophylaxis. | 1995 | Transplant. Proc. | pmid:7533373 |
| Jusko WJ | Analysis of tacrolimus (FK 506) in relation to therapeutic drug monitoring. | 1995 | Ther Drug Monit | pmid:8588227 |
| Vargas V et al. | Alpha-interferon for acute hepatitis C in liver transplant patients. | 1995 | Transplant. Proc. | pmid:7533374 |
| McMaster P et al. | Therapeutic drug monitoring of tacrolimus in clinical transplantation. | 1995 | Ther Drug Monit | pmid:8588228 |
| Barkholt LM et al. | New criteria for diagnosing cytomegalovirus hepatitis in liver transplant patients. | 1995 | Transplant. Proc. | pmid:7533375 |
| Jusko WJ et al. | Consensus document: therapeutic monitoring of tacrolimus (FK-506). | 1995 | Ther Drug Monit | pmid:8588229 |
| Chakraborty TK et al. | Design and synthesis of a rapamycin-based high affinity binding FKBP12 ligand. | 1995 | Chem. Biol. | pmid:9383417 |
| Shirakata Y et al. | The minimum graft size for successful orthotopic partial liver transplantation in the canine model. | 1995 | Transplant. Proc. | pmid:7533422 |
| Kumano K et al. | Role of endothelin in FK 506-induced renal hypoperfusion in rats. | 1995 | Transplant. Proc. | pmid:7533423 |
| Izutani H et al. | Graft coronary arteriosclerosis in rat heart transplant model with FK 506 short-term administration. | 1995 | Transplant. Proc. | pmid:7533425 |
| Funayama Y et al. | Changes in cell adhesion molecules after small bowel transplantation in rats. | 1995 | Transplant. Proc. | pmid:7533426 |
| Laskow DA et al. | Phase II FK 506 multicenter concentration control study: one-year follow-up. | 1995 | Transplant. Proc. | pmid:7533431 |
| Shapiro R et al. | A prospective, randomized trial of FK 506/prednisone vs FK 506/azathioprine/prednisone in renal transplant patients. | 1995 | Transplant. Proc. | pmid:7533432 |
| Winkler M et al. | Comparison of plasma vs whole blood as matrix for FK 506 drug level monitoring. | 1995 | Transplant. Proc. | pmid:7533433 |
| Sakamoto K et al. | Sodium-losing nephropathy and distal tubular damage of transplant kidneys with FK506 administration. | 1995 | Transplant. Proc. | pmid:7533434 |
| Ochiai T et al. | Phase III study of FK 506 in kidney transplantation. Japanese FK 506 Study Group. | 1995 | Transplant. Proc. | pmid:7533435 |
| Jiang H et al. | Induction of anagen in telogen mouse skin by topical application of FK506, a potent immunosuppressant. | 1995 | J. Invest. Dermatol. | pmid:7535825 |
| Atkison P et al. | Hypertrophic cardiomyopathy associated with tacrolimus in paediatric transplant patients. | 1995 | Lancet | pmid:7535875 |
| Shaffer D et al. | Normal pancreas allograft function following simultaneous pancreas kidney transplantation after rescue therapy with tacrolimus (FK506). | 1995 | Transplantation | pmid:7535958 |
| Bronster DJ et al. | Demyelinating sensorimotor polyneuropathy after administration of FK506. | 1995 | Transplantation | pmid:7535959 |
| Sheppard KE | Cyclosporin A and FK506 are potent activators of proopiomelanocortin-derived peptide secretion without affecting corticotrope glucocorticoid receptor function. | 1995 | J. Neuroendocrinol. | pmid:8748119 |
| Iwasaki K et al. | Further metabolism of FK506 (tacrolimus). Identification and biological activities of the metabolites oxidized at multiple sites of FK506. | 1995 | Drug Metab. Dispos. | pmid:7536652 |
| Winkler M and Christians U | A risk-benefit assessment of tacrolimus in transplantation. | 1995 | Drug Saf | pmid:7545405 |
| Miranker A and Karplus M | An automated method for dynamic ligand design. | 1995 | Proteins | pmid:8749844 |
| Marumo T et al. | Cyclosporin A inhibits nitric oxide synthase induction in vascular smooth muscle cells. | 1995 | Hypertension | pmid:7536714 |
| Nowaczyk M et al. | 2-Chlorodeoxyadenosine: lack of synergism with cyclosporine A and tacrolimus (FK 506). | 1995 | Arch. Immunol. Ther. Exp. (Warsz.) | pmid:8744655 |
| Schwaninger M et al. | Involvement of the Ca(2+)-dependent phosphatase calcineurin in gene transcription that is stimulated by cAMP through cAMP response elements. | 1995 | J. Biol. Chem. | pmid:7536740 |
| Ockenfels HM et al. | Cyclosporin A, FK506 and dithranol after tyrosine-specific protein phosphorylation in HaCaT keratinocytes. | 1995 | Arch. Dermatol. Res. | pmid:7541191 |
| Victor RG et al. | Presynaptic modulation of cortical synaptic activity by calcineurin. | 1995 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7541535 |
| Kaufman DB et al. | The successful use of tacrolimus (FK506) in a pancreas/kidney transplant recipient with recurrent cyclosporine-associated hemolytic uremic syndrome. | 1995 | Transplantation | pmid:7541579 |
| McDiarmid SV et al. | The treatment of intractable rejection with tacrolimus (FK506) in pediatric liver transplant recipients. | 1995 | J. Pediatr. Gastroenterol. Nutr. | pmid:7541834 |
| Kobayashi I et al. | Combination therapy with tacrolimus and betamethasone for a patient with X-linked auto-immune enteropathy. | 1995 | Eur. J. Pediatr. | pmid:7556338 |
| Adachi M et al. | IL-2-induced gene expression of protein-tyrosine phosphatase LC-PTP requires acidic and serine-rich regions within IL-2 receptor beta chain. | 1995 | FEBS Lett. | pmid:7556630 |
| David M et al. | [Occurrence of suspicious changes in cervix cytology in women after liver transplantation]. | 1995 | Geburtshilfe Frauenheilkd | pmid:7557217 |
| Mills RA et al. | Topical FK-506 prevents experimental corneal allograft rejection. | 1995 | Cornea | pmid:7538061 |
| [Experimental and clinical studies on the effectiveness of new immunosuppressive agents used in heart transplantation and transplantation-related complications]. | 1995 | Nihon Kyobu Geka Gakkai Zasshi | pmid:7561285 | |
| Lee TK et al. | Postoperative selective bowel decontamination prevents gram-negative bacterial translocation in small-bowel graft recipients. | 1995 | J. Surg. Res. | pmid:7538186 |
| Asano K et al. | Generation of effector T cells in Hymenolepis nana-infected, FK-506-treated BALB/c mice. | 1995 | Immunol. Lett. | pmid:7590919 |
| Lam E et al. | A novel FK506 binding protein can mediate the immunosuppressive effects of FK506 and is associated with the cardiac ryanodine receptor. | 1995 | J. Biol. Chem. | pmid:7592869 |
| Galat A and Metcalfe SM | Peptidylproline cis/trans isomerases. | 1995 | Prog. Biophys. Mol. Biol. | pmid:7538221 |
| Goldfeld AE et al. | Cyclosporin A and FK506 block induction of the Epstein-Barr virus lytic cycle by anti-immunoglobulin. | 1995 | Virology | pmid:7538254 |
| Kanda T et al. | Synergistic effects of tacrolimus and human interferon-alpha A/D in murine viral myocarditis. | 1995 | J. Pharmacol. Exp. Ther. | pmid:7542339 |
| Jurim O et al. | Living-donor liver transplantation at UCLA. | 1995 | Am. J. Surg. | pmid:7538267 |
| Canzanello VJ et al. | Renal sodium handling with cyclosporin A and FK506 after orthotopic liver transplantation. | 1995 | J. Am. Soc. Nephrol. | pmid:7542491 |
| Conde M et al. | Inhibitory effect of cyclosporin A and FK506 on nitric oxide production by cultured macrophages. Evidence of a direct effect on nitric oxide synthase activity. | 1995 | Immunology | pmid:7538492 |
| Skeen MJ and Ziegler HK | Activation of gamma delta T cells for production of IFN-gamma is mediated by bacteria via macrophage-derived cytokines IL-1 and IL-12. | 1995 | J. Immunol. | pmid:7538532 |
| Columbo M et al. | Human skin mast cells express functional beta 1 integrins that mediate adhesion to extracellular matrix proteins. | 1995 | J. Immunol. | pmid:7538541 |
| Pearlman DA and Connelly PR | Determination of the differential effects of hydrogen bonding and water release on the binding of FK506 to native and Tyr82-->Phe82 FKBP-12 proteins using free energy simulations. | 1995 | J. Mol. Biol. | pmid:7538591 |
| Deschler DG et al. | Posttransplantation lymphoproliferative disorder in patients under primary tacrolimus (FK 506) immunosuppression. | 1995 | Arch. Otolaryngol. Head Neck Surg. | pmid:7544136 |
| Rouvière-Fourmy N et al. | 1H and 15N assignment of NMR spectrum, secondary structure and global folding of the immunophilin-like domain of the 59-kDa FK506-binding protein. | 1995 | Eur. J. Biochem. | pmid:7544285 |
| Sakamoto K et al. | A new assay method for immunosuppressants with a tacrolimus (FK506)-like mode of action. | 1995 | J. Antibiot. | pmid:7544337 |
| Natazuka T et al. | Immunosuppressive drugs and hypertrophic cardiomyopathy. | 1995 | Lancet | pmid:7540241 |
| Lee MJ et al. | Combined inhibition effects of tacrolimus and methylprednisolone on in vitro human lymphocyte proliferation. | 1995 | Immunopharmacol Immunotoxicol | pmid:7544367 |
| Dhawan A et al. | Immunosuppressive drugs and hypertrophic cardiomyopathy. | 1995 | Lancet | pmid:7540242 |
| Sauer P et al. | In patients with orthotopic liver transplantation, serum markers of cholestasis are unreliable indicators of biliary secretion. | 1995 | J. Hepatol. | pmid:7544368 |
| Nielsen FT et al. | Nephrotoxicity of FK-506 in the rat. Studies on glomerular and tubular function, and on the relationship between efficacy and toxicity. | 1995 | Nephrol. Dial. Transplant. | pmid:7540737 |
| Chang HY et al. | Asymmetric retraction of growth cone filopodia following focal inactivation of calcineurin. | 1995 | Nature | pmid:7544441 |
| Reichenspurner H et al. | First experience with FK 506 for treatment of chronic pulmonary rejection. | 1995 | Transplant. Proc. | pmid:7540775 |
| Murio JE et al. | Compassionate use of FK 506 in liver transplantation. | 1995 | Transplant. Proc. | pmid:7544501 |
| Yumiba T et al. | Immunosuppressive and diabetogenic effect of FK 506 on pancreatic islet xenotransplantation. | 1995 | Transplant. Proc. | pmid:7540780 |
| Llull R et al. | Multilineage amplification of graft-vs-host disease-resistant chimerism following rat vascularized bone marrow allotransplantation. | 1995 | Transplant. Proc. | pmid:7544504 |
| Horne SM and Young KD | Escherichia coli and other species of the Enterobacteriaceae encode a protein similar to the family of Mip-like FK506-binding proteins. | 1995 | Arch. Microbiol. | pmid:7540828 |
| Teutsch M et al. | Induction of CD5 on B and T cells is suppressed by cyclosporin A, FK-520 and rapamycin. | 1995 | Int. Immunol. | pmid:7540861 |
| Mori A et al. | IL-5 production by CD4+ T cells of asthmatic patients is suppressed by glucocorticoids and the immunosuppressants FK506 and cyclosporin A. | 1995 | Int. Immunol. | pmid:7540862 |
| Tashiro H et al. | Monitoring for engraftment following rat orthotopic liver transplantation by in vitro amplification of Y-chromosome gene using polymerase chain reaction. | 1995 | Cell Transplant | pmid:7540919 |
| Platz KP et al. | Toxicity versus rejection--or why conversions between cyclosporine A and FK506 were performed after liver transplantation. | 1995 | Clin Transplant | pmid:7549052 |
| Mueller AR et al. | The optimal immunosuppressant after liver transplantation according to diagnosis: cyclosporine A or FK506? | 1995 | Clin Transplant | pmid:7549057 |
| Nagai H et al. | Effect of some immunosuppressors on allergic bronchial inflammation and airway hyperresponsiveness in mice. | 1995 | Int. Arch. Allergy Immunol. | pmid:7549508 |
| Ma J et al. | Rectification of skeletal muscle ryanodine receptor mediated by FK506 binding protein. | 1995 | Biophys. J. | pmid:8599646 |
| Jung-Testas I et al. | Cyclosporin A promotes nuclear transfer of a cytoplasmic progesterone receptor mutant. | 1995 | C. R. Acad. Sci. III, Sci. Vie | pmid:7583777 |
| Kissinger CR et al. | Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex. | 1995 | Nature | pmid:8524402 |
| Cardenas ME et al. | Molecular mechanisms of immunosuppression by cyclosporine, FK506, and rapamycin. | 1995 | Curr. Opin. Nephrol. Hypertens. | pmid:8591053 |
| Lake KD and Canafax DM | Important interactions of drugs with immunosuppressive agents used in transplant recipients. | 1995 | J. Antimicrob. Chemother. | pmid:8601538 |