Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with tacrolimus
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Timerman AP et al. | Characterization of an exchange reaction between soluble FKBP-12 and the FKBP.ryanodine receptor complex. Modulation by FKBP mutants deficient in peptidyl-prolyl isomerase activity. | 1995 | J. Biol. Chem. | pmid:7531689 |
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Masri MA | Comparative study of toxicity and efficacy of cyclosporine, cyclosporine G (OG37), FK 506, and rapamycin in BALB/c mice with fitted skin grafts. | 1995 | Transplant. Proc. | pmid:7533412 |
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Woo J et al. | Combined effects of FK506 (tacrolimus) and cyclophosphamide on atypical B220+ T cells, cytokine gene expression and disease activity in MRL/MpJ-lpr/lpr mice. | 1995 | Clin. Exp. Immunol. | pmid:7535208 |
Jusko WJ et al. | Pharmacokinetics of tacrolimus in liver transplant patients. | 1995 | Clin. Pharmacol. Ther. | pmid:7535213 |
Hadley S et al. | Major infectious complications after orthotopic liver transplantation and comparison of outcomes in patients receiving cyclosporine or FK506 as primary immunosuppression. | 1995 | Transplantation | pmid:7535482 |
Victor RG et al. | Presynaptic modulation of cortical synaptic activity by calcineurin. | 1995 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7541535 |
Kaufman DB et al. | The successful use of tacrolimus (FK506) in a pancreas/kidney transplant recipient with recurrent cyclosporine-associated hemolytic uremic syndrome. | 1995 | Transplantation | pmid:7541579 |
McDiarmid SV et al. | The treatment of intractable rejection with tacrolimus (FK506) in pediatric liver transplant recipients. | 1995 | J. Pediatr. Gastroenterol. Nutr. | pmid:7541834 |
Kanamaru A et al. | FK506 treatment of graft-versus-host disease developing or exacerbating during prophylaxis and therapy with cyclosporin and/or other immunosuppressants. Japanese FK506 BMT Study Group. | 1995 | Bone Marrow Transplant. | pmid:7581086 |
Koehler MT et al. | FK506 (tacrolimus) in the treatment of steroid-resistant acute graft-versus-host disease in children undergoing bone marrow transplantation. | 1995 | Bone Marrow Transplant. | pmid:7581088 |
Reisman L et al. | Modulation of interleukin-1 secretion by immunosuppressive drugs, alone and in combination. | 1995 | Transpl. Immunol. | pmid:7551978 |
Woo J et al. | Effects of FK 506 on chimerism and the induction of donor-specific unresponsiveness following fully allogeneic bone marrow transplantation in mice. | 1995 | Transpl. Immunol. | pmid:7551985 |
Tanida I et al. | Cooperation of calcineurin and vacuolar H(+)-ATPase in intracellular Ca2+ homeostasis of yeast cells. | 1995 | J. Biol. Chem. | pmid:7537264 |
Kelly PA et al. | Tacrolimus: a new immunosuppressive agent. | 1995 | Am J Health Syst Pharm | pmid:7552894 |
Koch K et al. | The C-32 triacetyl-L-rhamnose derivative of ascomycin: a potent, orally active macrolactone immunosuppressant. | 1995 | J. Med. Chem. | pmid:7537331 |
Torii N et al. | An inhibitor for calcineurin, FK506, blocks induction of long-term depression in rat visual cortex. | 1995 | Neurosci. Lett. | pmid:7537357 |
Miyazawa H et al. | Hamster to rat kidney xenotransplantation. Effects of FK 506, cyclophosphamide, organ perfusion, and complement inhibition. | 1995 | Transplantation | pmid:7537396 |
Pockley AG et al. | Effect of cyclosporin A, FK506 and rapamycin on proliferation and soluble IL-2 receptor release from mitogenically stimulated rat spleen cells. | 1995 | Biochem. Soc. Trans. | pmid:8654800 |
Furlan V et al. | Interactions between FK506 and rifampicin or erythromycin in pediatric liver recipients. | 1995 | Transplantation | pmid:7537398 |
Romero DF et al. | Rapamycin: a bone sparing immunosuppressant? | 1995 | J. Bone Miner. Res. | pmid:7543725 |
Rebollo A et al. | Differential effect of rapamycin and cyclosporin A in proliferation in a murine T cell line expressing either intermediate or high affinity receptor for IL-2. | 1995 | Cytokine | pmid:7543780 |
Lam E et al. | Isolation of a cDNA encoding a novel human FK506-binding protein homolog containing leucine zipper and tetratricopeptide repeat motifs. | 1995 | Gene | pmid:7543869 |
Minamoto A et al. | Suppression of corneal graft rejection by subconjunctival injection of FK-506 in a rat model of penetrating keratoplasty. | 1995 | Jpn. J. Ophthalmol. | pmid:7543958 |
Ueda M et al. | A proposal of FK506 optimal dosing in living related liver transplantations. | 1995 | Transplantation | pmid:7544035 |
Tamura K et al. | Transcriptional inhibition of insulin by FK506 and possible involvement of FK506 binding protein-12 in pancreatic beta-cell. | 1995 | Transplantation | pmid:7539960 |
Fisher A et al. | FK506 hepatotoxicity in liver allograft recipients. | 1995 | Transplantation | pmid:7539961 |
Nash RA et al. | Tacrolimus (FK506) alone or in combination with methotrexate or methylprednisolone for the prevention of acute graft-versus-host disease after marrow transplantation from HLA-matched siblings: a single-center study. | 1995 | Blood | pmid:7540071 |
Bennett WM | The nephrotoxicity of immunosuppressive drugs. | 1995 | Clin. Nephrol. | pmid:7540121 |
Ito T et al. | Immunosuppressive agents induce the reduction of local pancreatic blood flow. | 1995 | Pancreas | pmid:7545292 |
Han CW et al. | Differential effects of the immunosuppressants cyclosporin A, FK506 and KM2210 on cytokine gene expression. | 1995 | Bone Marrow Transplant. | pmid:7545487 |
Hattori Y and Nakanishi N | Effects of cyclosporin A and FK506 on nitric oxide and tetrahydrobiopterin synthesis in bacterial lipopolysaccharide-treated J774 macrophages. | 1995 | Cell. Immunol. | pmid:7545550 |
Han JW et al. | Rapamycin, wortmannin, and the methylxanthine SQ20006 inactivate p70s6k by inducing dephosphorylation of the same subset of sites. | 1995 | J. Biol. Chem. | pmid:7545671 |
Yeh WC et al. | Rapamycin inhibits clonal expansion and adipogenic differentiation of 3T3-L1 cells. | 1995 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7479942 |
Ruff VA and Leach KL | Direct demonstration of NFATp dephosphorylation and nuclear localization in activated HT-2 cells using a specific NFATp polyclonal antibody. | 1995 | J. Biol. Chem. | pmid:7545680 |
Shaw KT et al. | Immunosuppressive drugs prevent a rapid dephosphorylation of transcription factor NFAT1 in stimulated immune cells. | 1995 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7479966 |
Matsuo S and Okamoto K | Enhancement of FK-506 activities by ganglioside (GM3) in vivo. | 1995 | Life Sci. | pmid:7545772 |
Annesley TM et al. | Stability of tacrolimus (FK 506) and cyclosporin G in whole blood. | 1995 | Ther Drug Monit | pmid:7482690 |
Lampen A et al. | Metabolism of the immunosuppressant tacrolimus in the small intestine: cytochrome P450, drug interactions, and interindividual variability. | 1995 | Drug Metab. Dispos. | pmid:8689938 |
Lake JR et al. | The impact of immunosuppressive regimens on the cost of liver transplantation--results from the U.S. FK506 multicenter trial. | 1995 | Transplantation | pmid:7482713 |
Mathew A et al. | Reversal of steroid-resistant rejection in renal allograft recipients using FK506. | 1995 | Transplantation | pmid:7482730 |
DÃaz M et al. | [Tacrolimus (FK 506): an immunosuppression alternative in solid organ transplantation. (Part 2)]. | 1995 Apr-Jun | Rev Med Univ Navarra | pmid:7569553 |
Hisatomi K et al. | Effect of dose of cyclosporine or FK506 and antithrombotic agents on cardiac allograft vascular disease in heterotopically transplanted hearts in rats. | 1995 Jan-Feb | J. Heart Lung Transplant. | pmid:7537098 |
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Kawahara K et al. | Effects of deoxyspergualin on bronchial anastomosis healing in canine pulmonary allografts. | 1995 Jul-Aug | J. Heart Lung Transplant. | pmid:7578196 |
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Okudaira H et al. | Enhanced production and gene expression of interleukin-5 in patients with bronchial asthma: possible management of atopic diseases by down-regulation of interleukin-5 gene transcription. | 1995 May-Jun | Int. Arch. Allergy Immunol. | pmid:7542077 |
Su Q et al. | Nephrotoxicity of cyclosporin A and FK506: inhibition of calcineurin phosphatase. | 1995 May-Jun | Ren. Physiol. Biochem. | pmid:7542793 |
Hayashi S et al. | Evidence that donor pretreatment with FK506 has a synergistic effect on graft prolongation in hamster-to-rat heart xenotransplantation. | 1995 May-Jun | J. Heart Lung Transplant. | pmid:7544621 |
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Seifeldin R | Drug interactions in transplantation. | 1995 Nov-Dec | Clin Ther | pmid:8750397 |
Schreiber SL and Crabtree GR | Immunophilins, ligands, and the control of signal transduction. | 1995-1996 | Harvey Lect. | pmid:9127988 |
Roth D et al. | A prospective study of hepatitis C virus infection in renal allograft recipients. | 1996 | Transplantation | pmid:8623154 |
Koprak S et al. | Depletion of the mature CD4+8- thymocyte subset by FK506 analogs correlates with their immunosuppressive and calcineurin inhibitory activities. | 1996 | Transplantation | pmid:8623162 |
Harrison DM et al. | Reduction in hospital stay after liver transplantation. | 1996 | Transplant. Proc. | pmid:8623451 |
Andrews WS et al. | Comparison of cyclosporine- vs tacrolimus-based immunosuppression in pediatric liver transplantation. | 1996 | Transplant. Proc. | pmid:8623452 |
Muraoka K et al. | Immunosuppressant FK506 induces interleukin-6 production through the activation of transcription factor nuclear factor (NF)-kappa(B). Implications for FK506 nephropathy. | 1996 | J. Clin. Invest. | pmid:8647935 |
Brunke M et al. | Luciferase assembly after transport into mammalian microsomes involves molecular chaperones and peptidyl-prolyl cis/trans-isomerases. | 1996 | J. Biol. Chem. | pmid:8798557 |
Zhang Q et al. | Activation of Jak/STAT proteins involved in signal transduction pathway mediated by receptor for interleukin 2 in malignant T lymphocytes derived from cutaneous anaplastic large T-cell lymphoma and Sezary syndrome. | 1996 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8799169 |
Ronchetti F et al. | Mucosal hyaluronic acid quantification in small bowel transplantation in pigs. | 1996 | Transplant. Proc. | pmid:8907950 |
Costa A et al. | Stimulatory effect of FK506 and erythromycin on pig intestinal motility. | 1996 | Transplant. Proc. | pmid:8907957 |
Woodle ES et al. | A multicenter trial of FK506 (tacrolimus) therapy in refractory acute renal allograft rejection. A report of the Tacrolimus Kidney Transplantation Rescue Study Group. | 1996 | Transplantation | pmid:8830821 |
Tanaka M et al. | Effect of anticomplement agent K76 COOH on hamster-to-rat and guinea pig-to-rat heart xenotransplantation. | 1996 | Transplantation | pmid:8830837 |
Jonas S et al. | Posttransplant malignancy and newer immunosuppressive protocols after liver transplantation. | 1996 | Transplant. Proc. | pmid:8962257 |
Shinozuka N et al. | Correlation between simplified immunocompetence assay and clinical graft states in kidney or liver transplant recipients. | 1996 | Transplant. Proc. | pmid:8658649 |
Nishimura Y et al. | Whole organ vascularized thymus allografting effectively modulates cardiac rejection. | 1996 | Transplant. Proc. | pmid:8658660 |
Cai W et al. | Transcription-modulating drugs: mechanism and selectivity. | 1996 | Curr. Opin. Biotechnol. | pmid:8939643 |
Freiberg RA et al. | Specific triggering of the Fas signal transduction pathway in normal human keratinocytes. | 1996 | J. Biol. Chem. | pmid:8940187 |
Thompson PA and Mosley CA | Tacrolimus-phenytoin interaction. | 1996 | Ann Pharmacother | pmid:8740340 |
Christophers E | Psoriasis: mechanisms and entry points for possible therapeutic interventions. | 1996 | Australas. J. Dermatol. | pmid:8713012 |
Small SL et al. | Immunosuppression-induced leukoencephalopathy from tacrolimus (FK506) | 1996 | Ann. Neurol. | pmid:8871576 |
Stempfle HU | [Osteoporosis following heart transplantation. Pathogenesis and therapy]. | 1996 | Dtsch. Med. Wochenschr. | pmid:8846757 |
Akashi T et al. | Quantitative determination of tautomeric FK506 by reversed-phase liquid chromatography. | 1996 | J Pharm Biomed Anal | pmid:8851758 |
Vincenti F et al. | One-year follow-up of an open-label trial of FK506 for primary kidney transplantation. A report of the U.S. Multicenter FK506 Kidney Transplant Group. | 1996 | Transplantation | pmid:8669100 |
Uchikoshi F et al. | Restoration of immune abnormalities in diabetic BB rats after pancreas transplantation. I. Macrochimerism of donor-graft-derived RT6+ T cells responsible for restoration of immune responsiveness and suppression of autoimmune reaction. | 1996 | Transplantation | pmid:8669109 |
Taylor PJ et al. | Sensitive, specific quantitative analysis of tacrolimus (FK506) in blood by liquid chromatography-electrospray tandem mass spectrometry. | 1996 | Clin. Chem. | pmid:8595724 |