tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Frassetto LA et al. | Best single time point correlations with AUC for cyclosporine and tacrolimus in HIV-infected kidney and liver transplant recipients. | 2014 | Transplantation | pmid:24389906 |
| Lerut JP et al. | Is minimal, [almost] steroid-free immunosuppression a safe approach in adult liver transplantation? Long-term outcome of a prospective, double blind, placebo-controlled, randomized, investigator-driven study. | 2014 | Ann. Surg. | pmid:25379858 |
| Hitzler JK et al. | Outcome of transplantation for acute lymphoblastic leukemia in children with Down syndrome. | 2014 | Pediatr Blood Cancer | pmid:24391118 |
| Wu Y et al. | Increased macrophage activation inhibited by tacrolimus in the kidney of diabetic rats. | 2014 | Nephron Exp. Nephrol. | pmid:25376933 |
| Levitsky J and Feng S | Sirolimus and mTOR inhibitors in liver transplantation: the wheel has come full circle. | 2014 | Am. J. Transplant. | pmid:24620373 |
| Catalano G et al. | Everolimus-based immunosuppression in a case of ABO-incompatible liver transplantation with calcineurin inhibitor-related posterior occipital syndrome. | 2014 | Transpl. Int. | pmid:24606320 |
| Zhang Y et al. | Genome-wide identification and analysis of FK506-binding protein gene family in peach (Prunus persica). | 2014 | Gene | pmid:24342662 |
| Muhetaer G et al. | Clinical significance of peripheral blood lymphocyte sensitivity to glucocorticoids for the differentiation of high-risk patients with decreased allograft function after glucocorticoid withdrawal in renal transplantation. | 2014 | Clin Ther | pmid:25037282 |
| Shin BH et al. | Regulation of anti-HLA antibody-dependent natural killer cell activation by immunosuppressive agents. | 2014 | Transplantation | pmid:24342979 |
| Siddiqui A et al. | Chemometric methods for the quantification of crystalline tacrolimus in solid dispersion by powder X-ray diffractrometry. | 2014 | J Pharm Sci | pmid:24585357 |
| Shivaswamy V et al. | Tacrolimus and sirolimus have distinct effects on insulin signaling in male and female rats. | 2014 | Transl Res | pmid:24361102 |
| Uesugi S et al. | Calcineurin inhibitors suppress the high-temperature stress sensitivity of the yeast ubiquitin ligase Rsp5 mutant: a new method of screening for calcineurin inhibitors. | 2014 | FEMS Yeast Res. | pmid:25035868 |
| Goldberg NR et al. | Success with single-agent immunosuppression for multifocal choroidopathies. | 2014 | Am. J. Ophthalmol. | pmid:25194229 |
| Liu Y et al. | Role of retrograde trafficking in stress response, host cell interactions, and virulence of Candida albicans. | 2014 | Eukaryotic Cell | pmid:24363364 |
| Qin XL et al. | Effect of Tacrolimus on the pharmacokinetics of bioactive lignans of Wuzhi tablet (Schisandra sphenanthera extract) and the potential roles of CYP3A and P-gp. | 2014 | Phytomedicine | pmid:24462213 |
| Asrani SK et al. | De novo sirolimus and reduced-dose tacrolimus versus standard-dose tacrolimus after liver transplantation: the 2000-2003 phase II prospective randomized trial. | 2014 | Am. J. Transplant. | pmid:24456026 |
| Oellerich M et al. | Use of graft-derived cell-free DNA as an organ integrity biomarker to reexamine effective tacrolimus trough concentrations after liver transplantation. | 2014 | Ther Drug Monit | pmid:24452066 |
| Suarez-Kurtz G et al. | Pharmacogenomic implications of population admixture: Brazil as a model case. | 2014 | Pharmacogenomics | pmid:24444410 |
| Kurzawski M et al. | CYP3A5 and CYP3A4, but not ABCB1 polymorphisms affect tacrolimus dose-adjusted trough concentrations in kidney transplant recipients. | 2014 | Pharmacogenomics | pmid:24444408 |
| Ducroux E et al. | Hidradenitis suppurativa after renal transplantation: complete remission after switching from oral cyclosporine to oral tacrolimus. | 2014 | J. Am. Acad. Dermatol. | pmid:25437996 |
| Khorrami A et al. | Tacrolimus ameliorates functional disturbances and oxidative stress in isoproterenol-induced myocardial infarction. | 2014 | Daru | pmid:25312839 |
| Hu YM et al. | Casein kinase II inhibition reverses pain hypersensitivity and potentiated spinal N-methyl-D-aspartate receptor activity caused by calcineurin inhibitor. | 2014 | J. Pharmacol. Exp. Ther. | pmid:24610957 |
| Chen YK et al. | Personalized tacrolimus dose requirement by CYP3A5 but not ABCB1 or ACE genotyping in both recipient and donor after pediatric liver transplantation. | 2014 | PLoS ONE | pmid:25310192 |
| Bäckman L and Persson CA | An observational study evaluating tacrolimus dose, exposure, and medication adherence after conversion from twice- to once-daily tacrolimus in liver and kidney transplant recipients. | 2014 | Ann. Transplant. | pmid:24637379 |
| Mai HL et al. | IL-7 receptor blockade following T cell depletion promotes long-term allograft survival. | 2014 | J. Clin. Invest. | pmid:24569454 |
| Tokuoka H et al. | Nurr1 expression is regulated by voltage-dependent calcium channels and calcineurin in cultured hippocampal neurons. | 2014 | Neurosci. Lett. | pmid:24291696 |
| Hancock WW | Effects of histone deacetylase inhibitors on alloresponses. | 2014 | Lancet Oncol. | pmid:24295573 |
| Fuchs U et al. | Clinical outcome in heart transplant recipients receiving everolimus in combination with dosage reduction of the calcineurin inhibitor cyclosporine A or tacrolimus. | 2014 | Transpl. Immunol. | pmid:24932812 |
| Zhu X et al. | Pilot study using tacrolimus rather than cyclosporine plus antithymocyte globulin as an immunosuppressive therapy regimen option for severe aplastic anemia in adults. | 2014 | Blood Cells Mol. Dis. | pmid:24931461 |
| Han N et al. | Population pharmacokinetic-pharmacogenetic model of tacrolimus in the early period after kidney transplantation. | 2014 | Basic Clin. Pharmacol. Toxicol. | pmid:24238261 |
| Taguchi K et al. | False tacrolimus concentrations measured by antibody-conjugated magnetic immunoassay in liver transplant patient: 2 case reports and literature review. | 2014 | Exp Clin Transplant | pmid:24206050 |
| Rangel EB | Tacrolimus in pancreas transplant: a focus on toxicity, diabetogenic effect and drug-drug interactions. | 2014 | Expert Opin Drug Metab Toxicol | pmid:25255841 |
| Trotter JF and Lizardo-Sanchez L | Everolimus in liver transplantation. | 2014 | Curr Opin Organ Transplant | pmid:25254569 |
| RodrÃguez-Serrano M et al. | Does the calcineurin inhibitor have influence on cytomegalovirus infection in heart transplantation? | 2014 | Clin Transplant | pmid:24325305 |
| Souza MC et al. | Tacrolimus-loaded PLGA implants: in vivo release and ocular toxicity. | 2014 | Curr. Eye Res. | pmid:24325382 |
| Sharp WW et al. | Dynamin-related protein 1 (Drp1)-mediated diastolic dysfunction in myocardial ischemia-reperfusion injury: therapeutic benefits of Drp1 inhibition to reduce mitochondrial fission. | 2014 | FASEB J. | pmid:24076965 |
| Al-Harbi NO et al. | Protection against tacrolimus-induced cardiotoxicity in rats by olmesartan and aliskiren. | 2014 | Toxicol. Mech. Methods | pmid:25199528 |
| Notaro E et al. | Dose conversion factor between cyclosporine and tacrolimus in pediatric heart transplant recipients. | 2014 | J. Heart Lung Transplant. | pmid:24854566 |
| Lan CC et al. | Tacrolimus abrogates TGF-β1-induced type I collagen production in normal human fibroblasts through suppressing p38MAPK signalling pathway: implications on treatment of chronic atopic dermatitis lesions. | 2014 | J Eur Acad Dermatol Venereol | pmid:23301526 |
| Sæves I et al. | Tacrolimus exposure and mycophenolate pharmacokinetics and pharmacodynamics early after liver transplantation. | 2014 | Ther Drug Monit | pmid:24081206 |
| Burroughs LM et al. | Treosulfan-based conditioning and hematopoietic cell transplantation for nonmalignant diseases: a prospective multicenter trial. | 2014 | Biol. Blood Marrow Transplant. | pmid:25196857 |
| Musuamba FT et al. | Population pharmacokinetic analysis of tacrolimus early after pediatric liver transplantation. | 2014 | Ther Drug Monit | pmid:24081207 |
| Ghanem RC et al. | Tacrolimus for the treatment of subepithelial infiltrates resistant to topical steroids after adenoviral keratoconjunctivitis. | 2014 | Cornea | pmid:25188789 |
| Mabe S et al. | Detecting protein-protein interactions based on kinase-mediated growth induction of mammalian cells. | 2014 | Sci Rep | pmid:25135216 |
| Sol Fustiñana M et al. | Protein degradation by ubiquitin-proteasome system in formation and labilization of contextual conditioning memory. | 2014 | Learn. Mem. | pmid:25135196 |
| Hagihara Y et al. | Infliximab and/or immunomodulators inhibit immune responses to trivalent influenza vaccination in adults with inflammatory bowel disease. | 2014 | J Crohns Colitis | pmid:24011513 |
| Takeuchi T et al. | Tacrolimus-induced left ventricular apical hypertrophy in a patient with post-allogeneic hematopoietic stem cell transplantation. | 2014 | Int. J. Cardiol. | pmid:25131917 |
| Kilinc S et al. | The effects of preoperative immunosuppressive therapy on ischemia and reperfusion (I/R) injury in healthy rats. | 2014 | Int Urol Nephrol | pmid:24014133 |
| Gürkan A et al. | Alpha 2 integrin gene (ITGA2) polymorphism in renal transplant recipients with and without drug induced gingival overgrowth. | 2014 | Arch. Oral Biol. | pmid:24581850 |
| Spasovski G and Masin-Spasovska J | How to improve the survival of the kidney transplant - is it only the pharmaceutical management? | 2014 | Expert Opin Pharmacother | pmid:24617949 |
| Choi SW et al. | Vorinostat plus tacrolimus and mycophenolate to prevent graft-versus-host disease after related-donor reduced-intensity conditioning allogeneic haemopoietic stem-cell transplantation: a phase 1/2 trial. | 2014 | Lancet Oncol. | pmid:24295572 |
| Kim JS et al. | Effects of FK-506 and CTLA4--Ig on nerve allografts in mice. | 2014 | J Plast Reconstr Aesthet Surg | pmid:24120418 |
| Wang B et al. | Multifaceted interaction of the traditional Chinese medicinal herb Schisandra chinensis with cytochrome P450-mediated drug metabolism in rats. | 2014 | J Ethnopharmacol | pmid:25091466 |
| Bao J and Liang H | Tacrolimus-induced permanent asymptomatic pontine myelinolysis after liver transplantation. | 2014 | Intern. Med. | pmid:25088893 |
| Purani JM and Purani HJ | Treatment of geographic tongue with topical tacrolimus. | 2014 | BMJ Case Rep | pmid:25085945 |
| Kornblit B et al. | A randomized phase II trial of tacrolimus, mycophenolate mofetil and sirolimus after non-myeloablative unrelated donor transplantation. | 2014 | Haematologica | pmid:25085357 |
| Verghese PS et al. | Calcineurin inhibitors in HLA-identical living related donor kidney transplantation. | 2014 | Nephrol. Dial. Transplant. | pmid:24414376 |
| Da-Long S et al. | Tacrolimus on Kimura's disease: a case report. | 2014 | Oral Surg Oral Med Oral Pathol Oral Radiol | pmid:22939325 |
| Kyriakou A et al. | Therapeutic efficacy of topical calcineurin inhibitors in plasma cell balanitis: case series and review of the literature. | 2014 | Dermatology (Basel) | pmid:24434685 |
| Thapa RK and Yoo BK | Evaluation of the effect of tacrolimus-loaded liquid crystalline nanoparticles on psoriasis-like skin inflammation. | 2014 | J Dermatolog Treat | pmid:23210668 |
| Viecelli A et al. | Diagnostic and management dilemma of a pancreas-kidney transplant recipient with aplastic anaemia. | 2014 | BMJ Case Rep | pmid:25257886 |
| Yamazoe K et al. | Efficacy and safety of systemic tacrolimus in high-risk penetrating keratoplasty after graft failure with systemic cyclosporine. | 2014 | Cornea | pmid:25255133 |
| Segarra-Medrano A et al. | Evolution of antibody titre against the M-type phospholipase A2 receptor and clinical response in idiopathic membranous nephropathy patients treated with tacrolimus. | 2014 | Nefrologia | pmid:25036063 |
| Boschetti G et al. | Tacrolimus induction followed by maintenance monotherapy is useful in selected patients with moderate-to-severe ulcerative colitis refractory to prior treatment. | 2014 | Dig Liver Dis | pmid:25023007 |
| John K et al. | Role of dendritic cells in the context of acute cellular rejection: comparison between tacrolimus- or cyclosporine A-treated heart transplanted recipients. | 2014 | Cytometry B Clin Cytom | pmid:24668729 |
| Okamoto T et al. | Clinically mild encephalitis/encephalopathy with a reversible splenial lesion associated with febrile urinary tract infection. | 2014 | Eur. J. Pediatr. | pmid:24221606 |
| Steinebrunner N et al. | Reduced residual gene expression of nuclear factor of activated T cells-regulated genes correlates with the risk of cytomegalovirus infection after liver transplantation. | 2014 | Transpl Infect Dis | pmid:24666466 |
| Dessilly G et al. | ABCB1 1199G>A genetic polymorphism (Rs2229109) influences the intracellular accumulation of tacrolimus in HEK293 and K562 recombinant cell lines. | 2014 | PLoS ONE | pmid:24621983 |
| Terada Y et al. | Intestinal P-glycoprotein expression is multimodally regulated by intestinal ischemia-reperfusion. | 2014 | J Pharm Pharm Sci | pmid:24934555 |
| Mai S et al. | In vitro and in vivo release characteristics of Tacrolimus (FK506) from an episcleral drug-delivery implant. | 2014 | J Ocul Pharmacol Ther | pmid:24933028 |
| Nomura H et al. | A patient with lupus miliaris disseminatus faciei treated successfully with a combination of oral metronidazole and topical tacrolimus. | 2014 | J. Dermatol. | pmid:24931738 |
| Fuchs U et al. | Incidence of malignant neoplasia after heart transplantation--a comparison between cyclosporine a and tacrolimus. | 2014 | Ann. Transplant. | pmid:24953848 |
| Rahman Z et al. | Near-infrared and fourier transform infrared chemometric methods for the quantification of crystalline tacrolimus from sustained-release amorphous solid dispersion. | 2014 | J Pharm Sci | pmid:24931728 |
| Elamin S et al. | Co-administration of ketoconazole and tacrolimus to kidney transplant recipients: cost minimization and potential metabolic benefits. | 2014 | Saudi J Kidney Dis Transpl | pmid:24969193 |
| Kim SH et al. | Expression, purification and characterization of soluble recombinant peptidyl-prolyl cis/trans isomerase from Vibrio anguillarum. | 2014 | Protein Expr. Purif. | pmid:24931498 |
| Gibbs BF et al. | Highly specific targeting of human leukocytes using gold nanoparticle-based biologically active conjugates. | 2014 | J Biomed Nanotechnol | pmid:24804546 |
| Richards KR et al. | Tacrolimus trough level at discharge predicts acute rejection in moderately sensitized renal transplant recipients. | 2014 | Transplantation | pmid:24784360 |
| Cutler C et al. | Tacrolimus/sirolimus vs tacrolimus/methotrexate as GVHD prophylaxis after matched, related donor allogeneic HCT. | 2014 | Blood | pmid:24982504 |
| Liu Z et al. | Tacrolimus-based versus cyclosporine-based immunosuppression in hepatitis C virus-infected patients after liver transplantation: a meta-analysis and systematic review. | 2014 | PLoS ONE | pmid:25198195 |
| Katayama M et al. | Preliminary study of interaction of clarithromycin with tacrolimus in cats. | 2014 | J. Vet. Med. Sci. | pmid:25099737 |
| Tran D et al. | Conversion from twice-daily to once-daily extended-release tacrolimus in renal transplant recipients: 2-year results and review of the literature. | 2014 | Exp Clin Transplant | pmid:24844288 |
| Kahvecioglu S et al. | Effects of calcineurin inhibitors on paraoxonase and arylesterase activity after a kidney transplant. | 2014 | Exp Clin Transplant | pmid:24447269 |
| Marin-Casino M et al. | Significant tacrolimus and dronedarone interaction in a kidney transplant recipient. | 2014 | Transplantation | pmid:25243519 |
| Kalkan G et al. | An alternative treatment model: the combination therapy of narrow band ultraviolet B phototherapy and tacrolimus ointment 0.1% in biphasic amyloidosis. | 2014 | J Pak Med Assoc | pmid:25272550 |
| Chamienia A et al. | Open prospective study to evaluate cardiovascular risk factors and renal function in 2 dosage regimens of tacrolimus combined with mycophenolate mofetil and steroids in renal transplant patients: 5-year results. | 2014 | Transplant. Proc. | pmid:25380901 |
| Fazal MA et al. | Dyslipidaemia among renal transplant recipients: cyclosporine versus tacrolimus. | 2014 | J Pak Med Assoc | pmid:25272531 |
| Doren EL and Aya-ay ML | Pyoderma gangrenosum following breast reduction: treatment with topical tacrolimus and steroids. | 2014 | Aesthet Surg J | pmid:24448967 |
| Lin YH and Pratt MR | A dual small-molecule rheostat for precise control of protein concentration in Mammalian cells. | 2014 | Chembiochem | pmid:24615791 |
| Mita A et al. | Optimal initial dose of orally administered once-daily extended-release tacrolimus following intravenous tacrolimus therapy after liver transplantation. | 2014 | Transplant. Proc. | pmid:24767351 |
| Hashi S et al. | Assessment of four methodologies (microparticle enzyme immunoassay, chemiluminescent enzyme immunoassay, affinity column-mediated immunoassay, and flow injection assay-tandem mass spectrometry) for measuring tacrolimus blood concentration in Japanese liver transplant recipients. | 2014 | Transplant. Proc. | pmid:24767342 |
| Uemoto S et al. | Safety and efficacy of once-daily modified-release tacrolimus in liver transplant recipients: a multicenter postmarketing surveillance in Japan. | 2014 | Transplant. Proc. | pmid:24767340 |
| Zhang X et al. | Profiling of drug binding proteins by monolithic affinity chromatography in combination with liquid chromatography-tandem mass spectrometry. | 2014 | J Chromatogr A | pmid:25064533 |
| Borda B et al. | Side effects of the calcineurin inhibitor, such as new-onset diabetes after kidney transplantation. | 2014 | Acta Physiol Hung | pmid:25183511 |
| Lin Q et al. | Pharmacological mobilization of endogenous stem cells significantly promotes skin regeneration after full-thickness excision: the synergistic activity of AMD3100 and tacrolimus. | 2014 | J. Invest. Dermatol. | pmid:24682043 |
| DÃaz-GarcÃa C et al. | Pregnancy after allogeneic uterus transplantation in the rat: perinatal outcome and growth trajectory. | 2014 | Fertil. Steril. | pmid:25439799 |
| Tsunashima D et al. | Assessment of tacrolimus absorption from the human intestinal tract: open-label, randomized, 4-way crossover study. | 2014 | Clin Ther | pmid:24680768 |
| Ibrahim O et al. | The role of infliximab in the treatment of superficial granulomatous pyoderma of the head and neck. | 2014 | J. Am. Acad. Dermatol. | pmid:25438004 |
| Kraaij MD et al. | Human monocytes produce interferon-gamma upon stimulation with LPS. | 2014 | Cytokine | pmid:24680476 |
| Sawamoto K et al. | Mechanisms of lower maintenance dose of tacrolimus in obese patients. | 2014 | Drug Metab. Pharmacokinet. | pmid:24670405 |
| Xie M et al. | Brucellosis infection in an adult liver transplant recipient. | 2014 | Transpl Infect Dis | pmid:24666385 |