Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with tacrolimus
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Alloway RR et al. | Conversion from cyclosporine to tacrolimus in kidney, kidney/pancreas, and pancreas alone transplant recipients: the Memphis experience. | 1996 | Transplant. Proc. | pmid:8623494 |
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Busuttil RW et al. | General guidelines for the use of tacrolimus in adult liver transplant patients. | 1996 | Transplantation | pmid:8607197 |
Esquivel CO et al. | Suggested guidelines for the use of tacrolimus in pediatric liver transplant patients. | 1996 | Transplantation | pmid:8607198 |
Peters KP et al. | The automatic search for ligand binding sites in proteins of known three-dimensional structure using only geometric criteria. | 1996 | J. Mol. Biol. | pmid:8609611 |
Singh N et al. | Pulmonary infections in liver transplant recipients receiving tacrolimus. Changing pattern of microbial etiologies. | 1996 | Transplantation | pmid:8610349 |
Yanchar NL et al. | Tacrolimus (FK506)--its effects on intestinal glucose transport. | 1996 | Transplantation | pmid:8610392 |
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Yocum DE | Cyclosporine, FK-506, rapamycin, and other immunomodulators. | 1996 | Rheum. Dis. Clin. North Am. | pmid:8907069 |
Lu YF et al. | FK506, a Ca2+/calmodulin-dependent phosphatase inhibitor, inhibits the induction of long-term potentiation in the rat hippocampus. | 1996 | Neurosci. Lett. | pmid:8907327 |
Ye Q et al. | Persistence of donor cells and incidence of graft-versus-host disease after simultaneous small bowel and bone marrow transplantation. | 1996 | Transplant. Proc. | pmid:8907895 |
Walgenbach KJ et al. | Increased presence of mast cells and interleukin-4 during chronic rejection of rat intestinal allografts. | 1996 | Transplant. Proc. | pmid:8907896 |
Nüssler NC et al. | CD8+ host cells infiltrate the intestinal mucosa after allogeneic small bowel transplantation even in the absence of acute rejection. | 1996 | Transplant. Proc. | pmid:8907898 |
Wu J et al. | Reversal of multidrug resistance by tacrolimus hydrate. | 1996 | Methods Find Exp Clin Pharmacol | pmid:9121220 |
Perego C et al. | Orthotopic liver-small bowel transplantation in pigs: study of immunologic parameters during therapy with FK 506-based immunosuppressive regimens. | 1996 | Transplant. Proc. | pmid:8907908 |
Rokaw MD et al. | FK-506 and rapamycin but not cyclosporin inhibit aldosterone-stimulated sodium transport in A6 cells. | 1996 | Am. J. Physiol. | pmid:8760046 |
Alessiani M et al. | Combined FK 506 and mycophenolate mofetil immunosuppression prolongs survival after small bowel transplantation in pigs. | 1996 | Transplant. Proc. | pmid:8907922 |
Tomono M et al. | Calcineurin is essential for DNA synthesis in Swiss 3T3 fibroblasts. | 1996 | Biochem. J. | pmid:8760349 |
Becker G et al. | Diltiazem minimizes tubular damage due to FK506-mediated nephrotoxicity following ischemia and reperfusion in rats. | 1996 | Transpl. Immunol. | pmid:8762016 |
Paus R et al. | Hair growth control by immunosuppression. | 1996 | Arch. Dermatol. Res. | pmid:8818191 |
Michel G et al. | FK506 in the treatment of inflammatory skin disease: promises and perspectives. | 1996 | Immunol. Today | pmid:8820265 |
Boeve BF et al. | Dysarthria and apraxia of speech associated with FK-506 (tacrolimus). | 1996 | Mayo Clin. Proc. | pmid:8820772 |
Komatsu K et al. | Prolonged survival of hamster-to-rat pulmonary xenografts by tacrolimus (FK506) and cyclophosphamide. | 1996 | J. Heart Lung Transplant. | pmid:8820789 |
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Weppler D et al. | Status of liver and gastrointestinal transplantation at the University of Miami. | 1996 | Clin Transpl | pmid:9286568 |
Antoniou E et al. | Effect of RS61443 in combination with leflunomide or FK506 on rat heart allograft survival. | 1996 | Transpl. Int. | pmid:8959858 |
Golbaekdal K et al. | The acute effects of FK-506 on renal haemodynamics, water and sodium excretion and plasma levels of angiotensin II, aldosterone, atrial natriuretic peptide and vasopressin in pigs. | 1996 | J. Pharm. Pharmacol. | pmid:8961168 |
Schumacher G et al. | Neurologic symptoms improve in patients with Wilson's disease despite immunosuppression. | 1996 | Transplant. Proc. | pmid:8962200 |
Woodle ES et al. | Tacrolimus therapy for refractory acute renal allograft rejection: a prospective multicenter trial. Tacrolimus Kidney Transplantation Rescue Study Group. | 1996 | Transplant. Proc. | pmid:8962225 |
Scott-Douglas N et al. | Treatment of acute renal transplant rejection with FK 506 in patients on cyclosporine after failure of standard antirejection therapy. | 1996 | Transplant. Proc. | pmid:8962226 |
Kliem V et al. | FK 506 in the treatment of steroid- and OKT3-resistant rejection in renal transplant recipients: reduced dosage and anti-infective prophylaxis. | 1996 | Transplant. Proc. | pmid:8962227 |
Becker G et al. | Tacrolimus (FK 506) therapy in simultaneous pancreas kidney transplantation. | 1996 | Transplant. Proc. | pmid:8962228 |
Rambusch EG and Manns MP | [Therapy of autoimmune hepatitis]. | 1996 | Dtsch. Med. Wochenschr. | pmid:8998922 |
Silva ND and Prendergast FG | Tryptophan dynamics of the FK506 binding protein: time-resolved fluorescence and simulations. | 1996 | Biophys. J. | pmid:8785272 |
Kiuchi T et al. | Experience of tacrolimus-based immunosuppression in living-related liver transplantation complicated with graft tuberculosis: interaction with rifampicin and side effects. | 1996 | Transplant. Proc. | pmid:8962229 |
Wagenknecht T et al. | Cryoelectron microscopy resolves FK506-binding protein sites on the skeletal muscle ryanodine receptor. | 1996 | Biophys. J. | pmid:8785329 |
Guckelberger O et al. | Does the choice of primary immunosuppression influence the prevalence of cardiovascular risk factors after liver transplantation? | 1996 | Transplant. Proc. | pmid:8962230 |
Dumont FJ et al. | Mixed agonist/antagonist activity of an FK-506-related immunosuppressant: biological and biochemical characterization. | 1996 | J. Pharmacol. Exp. Ther. | pmid:8786538 |
Braun F et al. | Clinical relevance of monitoring tacrolimus: comparison of microparticle enzyme immunoassay, enzyme-linked immunosorbent assay, and liquid chromatography mass spectrometry in renal transplant recipients converted from cyclosporine to tacrolimus. | 1996 | Transplant. Proc. | pmid:8962231 |
Michel G et al. | Antioncogene P53 and mitogenic cytokine interleukin-8 aberrantly expressed in psoriatic skin are inversely regulated by the antipsoriatic drug tacrolimus (FK506). | 1996 | Biochem. Pharmacol. | pmid:8787547 |
Gonschior AK et al. | Tacrolimus (FK506) metabolite patterns in blood from liver and kidney transplant patients. | 1996 | Clin. Chem. | pmid:8787699 |
Ikebe S et al. | Immunosuppressive effect of tacrolimus (FK-506). Bone xenografts in rabbits. | 1996 | Acta Orthop Scand | pmid:8792745 |
Masaki Y et al. | Microchimerism and rat small bowel transplantation combined with donor-type bone marrow cells. | 1996 | Transplant. Proc. | pmid:8769154 |
Jordan ML et al. | Tacrolimus rescue therapy for renal transplant rejection. | 1996 | Transplant. Proc. | pmid:8769174 |
Taylor P et al. | Conformational polymorphism in peptidic and nonpeptidic drug molecules. | 1996 | Biopolymers | pmid:9101762 |
Soldin SJ | Receptor assays in the clinical laboratory. | 1996 | Clin. Biochem. | pmid:8884064 |
Woodle ES et al. | FK 506 therapy for refractory renal allograft rejection: lessons from liver transplantation. | 1996 | Clin Transplant | pmid:8884103 |
Karashima T et al. | FK506 and cyclosporin A inhibit growth factor-stimulated human keratinocyte proliferation by blocking cells in the G0/G1 phases of the cell cycle. | 1996 | J. Dermatol. Sci. | pmid:8884530 |
Monfar M and Blenis J | Inhibition of p70/p85 S6 kinase activities in T cells by dexamethasone. | 1996 | Mol. Endocrinol. | pmid:8885245 |
Andoh TF et al. | Comparison of acute rapamycin nephrotoxicity with cyclosporine and FK506. | 1996 | Kidney Int. | pmid:8887267 |
Shapiro R et al. | "Suboptimal" kidney donors: the experience with tacrolimus-based immunosuppression. | 1996 | Transplantation | pmid:8932264 |
Mysliwiec J et al. | The effect of tacrolimus (FK506) and cyclosporin A (CyA) on peripheral serotonergic mechanisms in uremic rats. | 1996 | Thromb. Res. | pmid:8837316 |
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Park KM et al. | Bone loss after orthotopic liver transplantation: FK 506 versus cyclosporine. | 1996 | Transplant. Proc. | pmid:8658863 |
Kakefuda T et al. | Detection of nitrosylhemoglobin in liver allograft in rats by using near-infrared spectroscopy. | 1996 | Transplant. Proc. | pmid:8658885 |
Kawabe A et al. | Anti-adhesion (anti-ICAM-1 and anti-LFA-1) therapy in a rat pancreas transplantation model. | 1996 | Transplant. Proc. | pmid:8658893 |
Hayakawa K et al. | Maintenance of unresponsiveness by short-term pulse therapy with FK 506 in rat transplantation. | 1996 | Transplant. Proc. | pmid:8658904 |
Ishikawa M et al. | Acetaminophen absorption test as a useful indicator of small intestinal rejection in rats. | 1996 | Transplant. Proc. | pmid:8658911 |
Kawano K et al. | FK506 reduces oxidative hepatic injury following cold ischemic preservation and transplantation. | 1996 | Transplant. Proc. | pmid:8658938 |
Kanzler S et al. | Complete reversal of FK 506 induced diabetes in a liver transplant recipient by change of immunosuppression to cyclosporine A. | 1996 | Z Gastroenterol | pmid:8659188 |
Schaefer A et al. | Ca2+/calmodulin-dependent and -independent down-regulation of c-myb mRNA levels in erythropoietin-responsive murine erythroleukemia cells. The role of calcineurin. | 1996 | J. Biol. Chem. | pmid:8662717 |
Christians U et al. | Identification of drugs inhibiting the in vitro metabolism of tacrolimus by human liver microsomes. | 1996 | Br J Clin Pharmacol | pmid:8866917 |
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Cox KL and Freese DK | Tacrolimus (FK506): the pros and cons of its use as an immunosuppressant in pediatric liver transplantation. | 1996 | Clin Invest Med | pmid:8889279 |
Bridges ND et al. | Lung transplantation in infancy and early childhood. | 1996 | J. Heart Lung Transplant. | pmid:8889985 |
Iwasaki K et al. | Binding of tacrolimus (FK506) with human plasma proteins re-evaluation and effect of mycophenolic acid. | 1996 | Res. Commun. Mol. Pathol. Pharmacol. | pmid:9029671 |
Bousvaros A et al. | Tacrolimus (FK-506) treatment of fulminant colitis in a child. | 1996 | J. Pediatr. Gastroenterol. Nutr. | pmid:8890089 |
De Rie MA et al. | Soluble interleukin-2 receptor (sIL-2R) is a marker of disease activity in psoriasis: a comparison of sIL-2R, sCD27, sCD4, sCD8 and sICAM-1. | 1996 | Acta Derm. Venereol. | pmid:8891007 |
Timmerman LA et al. | Rapid shuttling of NF-AT in discrimination of Ca2+ signals and immunosuppression. | 1996 | Nature | pmid:8893011 |
Mach-Pascual S et al. | Microangiopathic hemolytic anemia complicating FK506 (tacrolimus) therapy. | 1996 | Am. J. Hematol. | pmid:8701950 |
Hemenway CS and Heitman J | Immunosuppressant target protein FKBP12 is required for P-glycoprotein function in yeast. | 1996 | J. Biol. Chem. | pmid:8702500 |
Tyedmers J et al. | Efficient folding of firefly luciferase after transport into mammalian microsomes in the absence of luminal chaperones and folding catalysts. | 1996 | J. Biol. Chem. | pmid:8702642 |
Raufman JP et al. | Calcineurin mediates calcium-induced potentiation of adenylyl cyclase activity in dispersed chief cells from guinea pig stomach. Further evidence for cross-talk between signal transduction pathways that regulate pepsinogen secretion. | 1996 | J. Biol. Chem. | pmid:8702699 |
Timerman AP et al. | Selective binding of FKBP12.6 by the cardiac ryanodine receptor. | 1996 | J. Biol. Chem. | pmid:8702774 |
Shih M and Malbon CC | Protein kinase C deficiency blocks recovery from agonist-induced desensitization. | 1996 | J. Biol. Chem. | pmid:8702931 |
Ohtomo Y et al. | C-peptide stimulates rat renal tubular Na+, K(+)-ATPase activity in synergism with neuropeptide Y. | 1996 | Diabetologia | pmid:8635672 |
Eckert B et al. | Calcium-mobilizing insulin secretagogues stimulate transcription that is directed by the cyclic adenosine 3',5'-monophosphate/calcium response element in a pancreatic islet beta-cell line. | 1996 | Endocrinology | pmid:8536617 |
Wesselborg S et al. | Identification of a physical interaction between calcineurin and nuclear factor of activated T cells (NFATp). | 1996 | J. Biol. Chem. | pmid:8576111 |
Furth S et al. | Diabetes as a complication of tacrolimus (FK506) in pediatric renal transplant patients. | 1996 | Pediatr. Nephrol. | pmid:8611359 |
Brousse N and Goulet O | Small bowel transplantation. | 1996 | BMJ | pmid:8611766 |