tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kim YJ et al. | Impact of combined acute rejection on BK virus-associated nephropathy in kidney transplantation. | 2013 | J. Korean Med. Sci. | pmid:24339698 |
| Howell J et al. | Cyclosporine and tacrolimus have inhibitory effects on toll-like receptor signaling after liver transplantation. | 2013 | Liver Transpl. | pmid:23894100 |
| Zhang CW et al. | [Establishment of a real-time PCR assay for simultaneously detecting human BKV and CMV DNA and its application in renal transplantation recipients]. | 2013 | Bing Du Xue Bao | pmid:23895006 |
| Gray FL et al. | Predictive value of the Pediatric Ulcerative Colitis Activity Index in the surgical management of ulcerative colitis. | 2013 | J. Pediatr. Surg. | pmid:23895969 |
| Foroncewicz B et al. | A comparison between two tacrolimus-based immunosuppression regimens in renal transplant recipients: 7-year follow-up. | 2013 | Ann. Transplant. | pmid:23896824 |
| Armenti VT et al. | Breastfeeding and tacrolimus: is it a reasonable approach? | 2013 | Expert Rev Clin Immunol | pmid:23899232 |
| Danby SG and Cork MJ | The effects of pimecrolimus on the innate immune response in atopic dermatitis. | 2013 | Br. J. Dermatol. | pmid:23362967 |
| Gómez-Bravo MA et al. | Impact of donor and recipient CYP3A5 and ABCB1 genetic polymorphisms on tacrolimus dosage requirements and rejection in Caucasian Spanish liver transplant patients. | 2013 | J Clin Pharmacol | pmid:23900887 |
| Yoon SH et al. | CYP3A and ABCB1 genetic polymorphisms on the pharmacokinetics and pharmacodynamics of tacrolimus and its metabolites (M-I and M-III). | 2013 | Transplantation | pmid:23364483 |
| Yu JJ et al. | Inhibition of calcineurin in the prefrontal cortex induced depressive-like behavior through mTOR signaling pathway. | 2013 | Psychopharmacology (Berl.) | pmid:22875481 |
| Rosado-Rubio C et al. | Delayed introduction of tacrolimus in sub-optimal kidneys. A short-term follow-up study in the University Hospital of Salamanca. | 2013 | Nefrologia | pmid:23364645 |
| Spriet I et al. | Switching from intravenous to oral tacrolimus and voriconazole leads to a more pronounced drug-drug interaction. | 2013 | Eur. J. Clin. Pharmacol. | pmid:22878691 |
| Neto P et al. | De novo tacrolimus- associated hemolytic uremic syndrome after renal transplantation - case report. | 2013 | Nefrologia | pmid:23364650 |
| Abei M et al. | [Nonspecific reacting materials that interferes tacrolimus assay by ACMIA]. | 2013 | Rinsho Byori | pmid:24450102 |
| Yuda S et al. | [Sodium-losing nephropathy caused by tacrolimus after allogeneic hematopoietic stem cell transplantation]. | 2013 | Rinsho Ketsueki | pmid:24452151 |
| Nakane S | [Calcineurin inhibitors and IVIg in the treatment of myasthenia gravis]. | 2013 | Rinsho Shinkeigaku | pmid:24291970 |
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| Gijsen VM et al. | Prevalence of renal dysfunction in tacrolimus-treated pediatric transplant recipients: a systematic review. | 2013 | Pediatr Transplant | pmid:23448292 |
| Okamoto M et al. | Successful treatment with tacrolimus in a case of lung-dominant connective tissue disease. | 2013 | Intern. Med. | pmid:23448773 |
| Muili KA et al. | Bile acids induce pancreatic acinar cell injury and pancreatitis by activating calcineurin. | 2013 | J. Biol. Chem. | pmid:23148215 |
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| Akelma AZ et al. | A diagnostic dilemma: inflammatory linear verrucous epidermal nevus versus linear psoriasis. | 2013 | J. Pediatr. | pmid:23149170 |
| Lemaitre F et al. | Monitoring of tacrolimus concentrations in peripheral blood mononuclear cells: application to cardiac transplant recipients. | 2013 | Clin. Biochem. | pmid:23454394 |
| Park JH et al. | The effectiveness of early treatment in segmental vitiligo: retrospective study according to disease duration. | 2013 | Photodermatol Photoimmunol Photomed | pmid:23458396 |
| Zuo XC et al. | Effects of CYP3A4 and CYP3A5 polymorphisms on tacrolimus pharmacokinetics in Chinese adult renal transplant recipients: a population pharmacokinetic analysis. | 2013 | Pharmacogenet. Genomics | pmid:23459029 |
| Boivin AA et al. | Influence of SLCO1B3 genetic variations on tacrolimus pharmacokinetics in renal transplant recipients. | 2013 | Drug Metab. Pharmacokinet. | pmid:23149872 |
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| Praehauser C et al. | Risk factors and outcome of expanded-criteria donor kidney transplants in patients with low immunological risk. | 2013 | Swiss Med Wkly | pmid:24222631 |
| Matsuoka K and Hibi T | Treatment guidelines in inflammatory bowel disease: the Japanese perspectives. | 2013 | Dig Dis | pmid:24246989 |
| PalacÃn M et al. | FK506 affects mitochondrial protein synthesis and oxygen consumption in human cells. | 2013 | Cell Biol. Toxicol. | pmid:24077807 |
| Hu AB et al. | Safety and efficacy of four steroid-minimization protocols in liver transplant recipients: 3-year follow-up in a single center. | 2013 | J Dig Dis | pmid:23134408 |
| Skytte DM et al. | Some transformations of tacrolimus, an immunosuppressive drug. | 2013 | Eur J Pharm Sci | pmid:23238171 |
| Verma S et al. | Preradial myxedema in a euthyroid male: A distinct rarity. | 2013 | Dermatol. Online J. | pmid:24021369 |
| Yosipovitch G et al. | A comparative study of clinical characteristics, work-up, treatment, and association to malignancy in dermatomyositis between two tertiary skin centers in the USA and Singapore. | 2013 | Int. J. Dermatol. | pmid:22835263 |
| Issa N et al. | Calcineurin inhibitor nephrotoxicity: a review and perspective of the evidence. | 2013 | Am. J. Nephrol. | pmid:23796509 |
| Hirsch HH et al. | Polyomavirus BK replication in de novo kidney transplant patients receiving tacrolimus or cyclosporine: a prospective, randomized, multicenter study. | 2013 | Am. J. Transplant. | pmid:23137180 |
| Durand P et al. | Tacrolimus dose requirement in pediatric liver transplantation: influence of CYP3A5 gene polymorphism. | 2013 | Pharmacogenomics | pmid:23837476 |
| Lamoth F et al. | In vitro activity of calcineurin and heat shock protein 90 Inhibitors against Aspergillus fumigatus azole- and echinocandin-resistant strains. | 2013 | Antimicrob. Agents Chemother. | pmid:23165466 |
| Gijsen VM et al. | CYP3A4*22 and CYP3A combined genotypes both correlate with tacrolimus disposition in pediatric heart transplant recipients. | 2013 | Pharmacogenomics | pmid:23837477 |
| Zhu Q et al. | Pluronic F127-modified liposome-containing tacrolimus-cyclodextrin inclusion complexes: improved solubility, cellular uptake and intestinal penetration. | 2013 | J. Pharm. Pharmacol. | pmid:23837579 |
| Augusto JF et al. | Long-term maintenance immunosuppressive regimen with tacrolimus monotherapy. | 2013 | Ann. Transplant. | pmid:23872516 |
| Piram M et al. | Short- and long-term outcome of linear morphoea in children. | 2013 | Br. J. Dermatol. | pmid:24032480 |
| Mouzaki M et al. | Basiliximab with delayed introduction of calcineurin inhibitors as a renal-sparing protocol following liver transplantation in children with renal impairment. | 2013 | Pediatr Transplant | pmid:24118898 |
| Vannaprasaht S et al. | Personalized tacrolimus doses determined by CYP3A5 genotype for induction and maintenance phases of kidney transplantation. | 2013 | Clin Ther | pmid:24120259 |
| Zlotkowski K et al. | Small-molecule mechanism of action studies in Caenorhabditis elegans. | 2013 | Chembiochem | pmid:24123757 |
| Sapoznikov D et al. | Heart rate response to blood pressure variations: sympathetic activation versus baroreflex response in patients with end-stage renal disease. | 2013 | PLoS ONE | pmid:24124623 |
| Fujii H et al. | Nonlinear decoding and asymmetric representation of neuronal input information by CaMKIIα and calcineurin. | 2013 | Cell Rep | pmid:23602566 |
| Hodge G et al. | Up-regulation of alternate co-stimulatory molecules on proinflammatory CD28null T cells in bronchiolitis obliterans syndrome. | 2013 | Clin. Exp. Immunol. | pmid:23607447 |
| RodrÃguez-Perálvarez M et al. | Early tacrolimus exposure after liver transplantation: relationship with moderate/severe acute rejection and long-term outcome. | 2013 | J. Hepatol. | pmid:23023010 |
| Ben Fredj N et al. | Tacrolimus therapeutic drug monitoring in Tunisian renal transplant recipients: effect of post-transplantation period. | 2013 | Transpl. Immunol. | pmid:23608723 |
| Yin ZQ et al. | Effects of topical tacrolimus 0.03% on long-term suberythemal ultraviolet B-irradiated epidermal Langerhans cells in mice. | 2013 | J Eur Acad Dermatol Venereol | pmid:22471949 |
| De Bruyne R et al. | Post-transplant food allergy in children is associated with liver and not with renal transplantation: a monocentric comparative study. | 2013 | Eur. J. Pediatr. | pmid:23609525 |
| Ciftci HS et al. | Effect of MDR1 polymorphisms on the blood concentrations of tacrolimus in Turkish renal transplant patients. | 2013 | Transplant. Proc. | pmid:23622581 |
| Cotovio P et al. | New-onset diabetes after transplantation: assessment of risk factors and clinical outcomes. | 2013 | Transplant. Proc. | pmid:23622631 |
| Hammerstrom AE et al. | Tacrolimus-associated posterior reversible encephalopathy syndrome in hematopoietic allogeneic stem cell transplantation. | 2013 | Am. J. Hematol. | pmid:23460378 |
| McDiarmid SV | Adolescence: challenges and responses. | 2013 | Liver Transpl. | pmid:24166838 |
| Gorgan M et al. | Pulmonary hemorrhage with capillaritis secondary to mycophenolate mofetil in a heart-transplant patient. | 2013 | Arch. Pathol. Lab. Med. | pmid:24168511 |
| Vafadari R et al. | Tacrolimus inhibits NF-κB activation in peripheral human T cells. | 2013 | PLoS ONE | pmid:23573283 |
| Elens L et al. | Single-nucleotide polymorphisms in P450 oxidoreductase and peroxisome proliferator-activated receptor-α are associated with the development of new-onset diabetes after transplantation in kidney transplant recipients treated with tacrolimus. | 2013 | Pharmacogenet. Genomics | pmid:24113216 |
| Sinha R and Marks SD | Tacrolimus toxicity secondary to diarrhoea in nephrotic syndrome. | 2013 | Acta Paediatr. | pmid:23573873 |
| Magalhaes OA et al. | Topical 0.03% tacrolimus preventing rejection in high-risk corneal transplantation: a cohort study. | 2013 | Br J Ophthalmol | pmid:24008822 |
| Hung TC et al. | Investigation of SSEA-4 binding protein in breast cancer cells. | 2013 | J. Am. Chem. Soc. | pmid:23574147 |
| Keating GM and Lyseng-Williamson KA | Everolimus: a guide to its use in liver transplantation. | 2013 | BioDrugs | pmid:23696253 |
| Quaglia M et al. | Severe acute nephrotoxicity in a kidney transplant patient despite low tacrolimus levels: a possible interaction between donor and recipient genetic polymorphisms. | 2013 | J Clin Pharm Ther | pmid:23574377 |
| Trotter JF et al. | Early use of renal-sparing agents in liver transplantation: a closer look. | 2013 | Liver Transpl. | pmid:23696464 |
| Wang R et al. | Systemic lupus erythematosus associated with Moyamoya syndrome: a case report and literature review. | 2013 | Lupus | pmid:23574743 |
| Karapetyan YE et al. | Unique drug screening approach for prion diseases identifies tacrolimus and astemizole as antiprion agents. | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23576755 |
| Miyoshi J et al. | Mucosal healing with oral tacrolimus is associated with favorable medium- and long-term prognosis in steroid-refractory/dependent ulcerative colitis patients. | 2013 | J Crohns Colitis | pmid:23680174 |
| Xia M et al. | Enhanced FK506 production in Streptomyces tsukubaensis by rational feeding strategies based on comparative metabolic profiling analysis. | 2013 | Biotechnol. Bioeng. | pmid:23682004 |
| Nwaba A et al. | Tacrolimus-induced thrombotic microangiopathy in orthotopic liver transplant patients: case series of four patients. | 2013 | Intern Med J | pmid:23441660 |
| Hofmann M et al. | Validation of Dermaphot(®) for the assessment of steroid-induced skin atrophy. | 2013 | Arch. Dermatol. Res. | pmid:23242470 |
| Koop DR et al. | Analysis of tacrolimus and creatinine from a single dried blood spot using liquid chromatography tandem mass spectrometry. | 2013 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:23548676 |
| Lewis RE et al. | Tacrolimus enhances the potency of posaconazole against Rhizopus oryzae in vitro and in an experimental model of mucormycosis. | 2013 | J. Infect. Dis. | pmid:23242544 |
| Vafadari R et al. | Genetic polymorphisms in ABCB1 influence the pharmacodynamics of tacrolimus. | 2013 | Ther Drug Monit | pmid:23743668 |
| Pople PV and Singh KK | Development and evaluation of colloidal modified nanolipid carrier: application to topical delivery of tacrolimus, Part II--in vivo assessment, drug targeting, efficacy, and safety in treatment for atopic dermatitis. | 2013 | Eur J Pharm Biopharm | pmid:23246619 |
| Sevc J et al. | Effective long-term immunosuppression in rats by subcutaneously implanted sustained-release tacrolimus pellet: effect on spinally grafted human neural precursor survival. | 2013 | Exp. Neurol. | pmid:23748136 |
| Cristelli MP et al. | Safety profile comparing azathioprine and mycophenolate in kidney transplant recipients receiving tacrolimus and corticosteroids. | 2013 | Transpl Infect Dis | pmid:23701592 |
| Siegfried EC et al. | Topical calcineurin inhibitors and lymphoma risk: evidence update with implications for daily practice. | 2013 | Am J Clin Dermatol | pmid:23703374 |
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| Murase S | Signal transducer and activator of transcription 3 (STAT3) degradation by proteasome controls a developmental switch in neurotrophin dependence. | 2013 | J. Biol. Chem. | pmid:23733189 |
| Min SI et al. | Conversion of twice-daily tacrolimus to once-daily tacrolimus formulation in stable pediatric kidney transplant recipients: pharmacokinetics and efficacy. | 2013 | Am. J. Transplant. | pmid:23734831 |
| Valdivieso N et al. | Tacrolimus dose individualization in "de novo" patients after 10 years of experience in liver transplantation: pharmacokinetic considerations and patient pathophysiology. | 2013 | Int J Clin Pharmacol Ther | pmid:23735178 |
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| Zhou X et al. | A genome-wide screening of potential target genes to enhance the antifungal activity of micafungin in Schizosaccharomyces pombe. | 2013 | PLoS ONE | pmid:23738021 |
| Hebert MF et al. | Interpreting tacrolimus concentrations during pregnancy and postpartum. | 2013 | Transplantation | pmid:23274970 |
| Chitnis SD et al. | Concentration of tacrolimus and major metabolites in kidney transplant recipients as a function of diabetes mellitus and cytochrome P450 3A gene polymorphism. | 2013 | Xenobiotica | pmid:23278282 |
| Bunnapradist S et al. | Conversion from twice-daily tacrolimus to once-daily extended release tacrolimus (LCPT): the phase III randomized MELT trial. | 2013 | Am. J. Transplant. | pmid:23279614 |
| Böer TM et al. | Correlation of thermal analysis and pyrolysis coupled to GC-MS in the characterization of tacrolimus. | 2013 | J Pharm Biomed Anal | pmid:22361660 |
| Bootun R | Effects of immunosuppressive therapy on wound healing. | 2013 | Int Wound J | pmid:22364410 |
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| Khaled SK et al. | A phase II study of sirolimus, tacrolimus and rabbit anti-thymocyte globulin as GVHD prophylaxis after unrelated-donor PBSC transplant. | 2013 | Bone Marrow Transplant. | pmid:23000644 |
| MartÃnez-Castro M et al. | Taxonomy and chemically semi-defined media for the analysis of the tacrolimus producer 'Streptomyces tsukubaensis'. | 2013 | Appl. Microbiol. Biotechnol. | pmid:22990582 |
| Gladstone DE et al. | Partially mismatched transplantation and human leukocyte antigen donor-specific antibodies. | 2013 | Biol. Blood Marrow Transplant. | pmid:23353119 |
| Sharma P and Barman P | Everolimus for liver transplant recipients: is it ready for prime time? | 2013 | Gastroenterology | pmid:23260492 |
| Nara M et al. | Effect of itraconazole on the concentrations of tacrolimus and cyclosporine in the blood of patients receiving allogeneic hematopoietic stem cell transplants. | 2013 | Eur. J. Clin. Pharmacol. | pmid:23354810 |
| Tanaka Y et al. | [Effect of tacrolimus on the pharmacokinetics and glucuronidation of SN-38, an active metabolite of irinotecan]. | 2013 | Yakugaku Zasshi | pmid:23328499 |
| Wong R and Lin AN | Efficacy of topical calcineurin inhibitors in vitiligo. | 2013 | Int. J. Dermatol. | pmid:23331250 |
| Mori T et al. | Effective treatment of a 13-year-old boy with steroid-dependent ocular myasthenia gravis using tacrolimus. | 2013 | Brain Dev. | pmid:22840813 |