tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Mazariegos GV et al. | Weaning of immunosuppression in liver transplant recipients. | 1997 | Transplantation | pmid:9020325 |
| Marks WH et al. | Asialoglycoprotein/asialoglycoprotein receptor (AGP-AGPr) interaction is an important mechanism for the uptake of FK506 by hepatocytes. | 1997 | Transplantation | pmid:9020333 |
| [Tacrolimus--a new perspective in kidney transplantation]. | 1996 | Urologe A | pmid:9022401 | |
| Aiko S et al. | Effects of cyclosporine or FK506 in chronic colitis. | 1997 | J. Pharmacol. Exp. Ther. | pmid:9023326 |
| Budde K et al. | Differing proteinuria control with cyclosporin and tacrolimus. | 1997 | Lancet | pmid:9024386 |
| Lo Russo A et al. | Cyclosporin A potentiates receptor-activated [Ca2+]c increase. | 1997 Jan-May | J. Recept. Signal Transduct. Res. | pmid:9029487 |
| Iwasaki K et al. | Binding of tacrolimus (FK506) with human plasma proteins re-evaluation and effect of mycophenolic acid. | 1996 | Res. Commun. Mol. Pathol. Pharmacol. | pmid:9029671 |
| Alak AM et al. | A highly sensitive enzyme-linked immunosorbent assay for the determination of tacrolimus in atopic dermatitis patients. | 1997 | Ther Drug Monit | pmid:9029754 |
| Padhi ID et al. | Interaction between tacrolimus and erythromycin. | 1997 | Ther Drug Monit | pmid:9029762 |
| Markus PM et al. | Allogeneic hepatocyte transplantation using FK 506. | 1997 Jan-Feb | Cell Transplant | pmid:9040958 |
| Tsuchida Y et al. | Limb allografts in rats treated with anti-ICAM-1 and anti-LFA-1 monoclonal antibodies. | 1997 | J Reconstr Microsurg | pmid:9044184 |
| Wang W et al. | c-Rel is a target of pentoxifylline-mediated inhibition of T lymphocyte activation. | 1997 | Immunity | pmid:9047238 |
| Steiner JP et al. | Neurotrophic immunophilin ligands stimulate structural and functional recovery in neurodegenerative animal models. | 1997 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9050897 |
| Seidel ER and Ragan VL | Inhibition by rapamycin of ornithine decarboxylase and epithelial cell proliferation in intestinal IEC-6 cells in culture. | 1997 | Br. J. Pharmacol. | pmid:9051292 |
| Bagnis C et al. | Comparative acute nephrotoxicity of FK-506 and ciclosporin in an isolated in situ autoperfused rat kidney model. | 1997 | Am. J. Nephrol. | pmid:9057948 |
| Ivery MT and Weiler L | Modeling the interaction between FK506 and FKBP12: a mechanism for formation of the calcineurin inhibitory complex. | 1997 | Bioorg. Med. Chem. | pmid:9061187 |
| Garcia-Morales R et al. | The effects of chimeric cells following donor bone marrow infusions as detected by PCR-flow assays in kidney transplant recipients. | 1997 | J. Clin. Invest. | pmid:9062371 |
| Göthel SF et al. | An internal FK506-binding domain is the catalytic core of the prolyl isomerase activity associated with the Bacillus subtilis trigger factor. | 1997 | Eur. J. Biochem. | pmid:9063446 |
| Motamedi H et al. | Structural organization of a multifunctional polyketide synthase involved in the biosynthesis of the macrolide immunosuppressant FK506. | 1997 | Eur. J. Biochem. | pmid:9063448 |
| Guckelberger O et al. | Cardiovascular risk factors in long-term follow-up after orthotopic liver transplantation. | 1997 | Clin Transplant | pmid:9067697 |
| Singh N et al. | Clinical spectrum of invasive cryptococcosis in liver transplant recipients receiving tacrolimus. | 1997 | Clin Transplant | pmid:9067698 |
| Victor RG et al. | Mechanism of Ca(2+)-dependent inactivation of L-type Ca2+ channels in GH3 cells: direct evidence against dephosphorylation by calcineurin. | 1997 | J. Membr. Biol. | pmid:9070464 |
| Grobecker HF et al. | Cyclosporine A-induced hypertension in SHR and WKY: role of the sympatho-adrenal system. | 1995 | Clin Exp Pharmacol Physiol Suppl | pmid:9072458 |
| Guo Z et al. | In vivo effects of leflunomide on normal pancreatic islet and syngeneic islet graft function. | 1997 | Transplantation | pmid:9075844 |
| Ciancio G et al. | Use of intravenous FK506 to treat acute rejection in simultaneous pancreas-kidney transplant recipients on maintenance oral FK506. | 1997 | Transplantation | pmid:9075856 |
| Mirza DF et al. | Reduced acute rejection after liver transplantation with Neoral-based triple immunosuppression. | 1997 | Lancet | pmid:9078209 |
| Yoshikawa H et al. | FK506 prevents induction of rat experimental autoimmune myasthenia gravis. | 1997 | J. Autoimmun. | pmid:9080295 |
| de Paulis A et al. | Human synovial mast cells. II. Heterogeneity of the pharmacologic effects of antiinflammatory and immunosuppressive drugs. | 1997 | Arthritis Rheum. | pmid:9082935 |
| Ohashi Y et al. | Successful treatment of steroid-resistant severe acute GVHD with 24-h continuous infusion of FK506. | 1997 | Bone Marrow Transplant. | pmid:9085743 |
| Oz HS and Hughes WT | Novel anti-Pneumocystis carinii effects of the immunosuppressant mycophenolate mofetil in contrast to provocative effects of tacrolimus, sirolimus, and dexamethasone. | 1997 | J. Infect. Dis. | pmid:9086147 |
| Wagner K et al. | New-onset diabetes mellitus in pediatric thoracic organ recipients receiving tacrolimus-based immunosuppression. | 1997 | J. Heart Lung Transplant. | pmid:9087870 |
| Yasutomi M et al. | Evaluation of tetrahydropyranyladriamycin as an immunosuppressant in concordant xenotransplantation. | 1997 | J. Heart Lung Transplant. | pmid:9087871 |
| Morrissey PE et al. | Correlation of clinical outcomes after tacrolimus conversion for resistant kidney rejection or cyclosporine toxicity with pathologic staging by the Banff criteria. | 1997 | Transplantation | pmid:9089224 |
| Kiuchi T et al. | A hepatic graft tuberculosis transmitted from a living-related donor. | 1997 | Transplantation | pmid:9089234 |
| Krämer BK and Schweda F | Differing proteinuria control with cyclosporin and tacrolimus. | 1997 | Lancet | pmid:9093272 |
| Maurer M et al. | Hair growth modulation by topical immunophilin ligands: induction of anagen, inhibition of massive catagen development, and relative protection from chemotherapy-induced alopecia. | 1997 | Am. J. Pathol. | pmid:9094998 |
| Steiner JP et al. | Neurotrophic actions of nonimmunosuppressive analogues of immunosuppressive drugs FK506, rapamycin and cyclosporin A. | 1997 | Nat. Med. | pmid:9095176 |
| Mori A et al. | Enhanced production and gene expression of IL-5 in bronchial asthma. Possible management of atopic diseases with IL-5 specific gene transcription inhibitor. | 1996 | Adv. Exp. Med. Biol. | pmid:9095279 |
| Blau CA et al. | A proliferation switch for genetically modified cells. | 1997 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9096348 |
| Bowman AR et al. | The role of testosterone in cyclosporine-induced osteopenia. | 1997 | J. Bone Miner. Res. | pmid:9101372 |
| Taylor P et al. | Conformational polymorphism in peptidic and nonpeptidic drug molecules. | 1996 | Biopolymers | pmid:9101762 |
| Guérette B et al. | Inflammatory damage following first-generation replication-defective adenovirus controlled by anti-LFA-1. | 1997 | J. Leukoc. Biol. | pmid:9103242 |
| Mori A et al. | IL-2-induced IL-5 synthesis, but not proliferation, of human CD4+ T cells is suppressed by FK506. | 1997 | J. Immunol. | pmid:9103428 |
| Hess DA et al. | The hydroxylamine of sulfamethoxazole synergizes with FK506 and cyclosporin A, inhibiting T-cell proliferation. | 1997 | J. Pharmacol. Exp. Ther. | pmid:9103542 |
| Kawamura N et al. | Extremely high serum level of IgE during immunosuppressive therapy: paradoxical effect of cyclosporine A and tacrolimus. | 1997 | Int. Arch. Allergy Immunol. | pmid:9104801 |
| Beals CR et al. | Nuclear localization of NF-ATc by a calcineurin-dependent, cyclosporin-sensitive intramolecular interaction. | 1997 | Genes Dev. | pmid:9106655 |
| Lee JW et al. | Tacrolimus (FK506): validation of a sensitive enzyme-linked immunosorbent assay kit for and application to a clinical pharmacokinetic study. | 1997 | Ther Drug Monit | pmid:9108651 |
| Holt DW and Johnston A | Tacrolimus quality assessment. | 1997 | Ther Drug Monit | pmid:9108659 |
| Pirsch JD et al. | A comparison of tacrolimus (FK506) and cyclosporine for immunosuppression after cadaveric renal transplantation. FK506 Kidney Transplant Study Group. | 1997 | Transplantation | pmid:9112351 |
| Hikita N et al. | Use of topical FK506 in a corneal graft rejection model in Lewis rats. | 1997 | Invest. Ophthalmol. Vis. Sci. | pmid:9112986 |