tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Garcia-Criado FJ et al. | Tacrolimus (FK506) down-regulates free radical tissue levels, serum cytokines, and neutrophil infiltration after severe liver ischemia. | 1997 | Transplantation | pmid:9293871 |
| Suzuki H et al. | Induction of transplantation tolerance in adult rats by vascularized spleen transplantation. | 1997 | Transplantation | pmid:9293881 |
| Alvaro D et al. | Role and mechanisms of action of acetylcholine in the regulation of rat cholangiocyte secretory functions. | 1997 | J. Clin. Invest. | pmid:9294100 |
| Ruzicka T et al. | A short-term trial of tacrolimus ointment for atopic dermatitis. European Tacrolimus Multicenter Atopic Dermatitis Study Group. | 1997 | N. Engl. J. Med. | pmid:9295241 |
| Alevizopoulos A et al. | Regulation of the transforming growth factor beta-responsive transcription factor CTF-1 by calcineurin and calcium/calmodulin-dependent protein kinase IV. | 1997 | J. Biol. Chem. | pmid:9295299 |
| Lal SM et al. | De novo membranous glomerulopathy in a renal transplant patient treated with FK 506. The first reported case. | 1997 | Int J Artif Organs | pmid:9298410 |
| Milićević NM and Milićević Z | Stereological study of splenic tissue compartments in FK506-treated rats. | 1997 | Histol. Histopathol. | pmid:9302561 |
| Sperr WR et al. | Inhibition of allergen-induced histamine release from human basophils by cyclosporine A and FK-506. | 1997 | Int. Arch. Allergy Immunol. | pmid:9303333 |
| Izuishi K et al. | Effects of an immunosuppressive agent, tacrolimus (FK-506), on the activities of cytochrome P-450-linked monooxygenase systems in rat liver microsomes. | 1997 | Int. J. Biochem. Cell Biol. | pmid:9304807 |
| Jonas S et al. | De novo malignancies after liver transplantation using tacrolimus-based protocols or cyclosporine-based quadruple immunosuppression with an interleukin-2 receptor antibody or antithymocyte globulin. | 1997 | Cancer | pmid:9305716 |
| Tze WJ et al. | Prolongation of pig islet xenograft survival in rats immunosuppressed with FK506. | 1997 | Diabetes Res. Clin. Pract. | pmid:9306035 |
| Tanaka H et al. | [Discovery and development of a novel immunosuppressant, tacrolimus hydrate]. | 1997 | Yakugaku Zasshi | pmid:9306728 |
| Kamada H et al. | Immunopharmacological studies on collagen-induced arthritis in dark Agouti (DA) rats. | 1997 | Jpn. J. Pharmacol. | pmid:9307327 |
| Ito A et al. | Donor-specific tolerance by perioperative intrathymic injection of bone marrow cells in the rat cardiac allograft model: use of FK506 can shorten the necessary duration of pretransplant intrathymic conditioning. | 1997 | Transplantation | pmid:9311715 |
| Atkison PR et al. | Arteritis and increased intracellular calcium as a possible mechanism for tacrolimus-related cardiac toxicity in a pediatric transplant recipient. | 1997 | Transplantation | pmid:9311719 |
| Graef IA et al. | Proximity and orientation underlie signaling by the non-receptor tyrosine kinase ZAP70. | 1997 | EMBO J. | pmid:9312021 |
| Wong BR et al. | TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun N-terminal kinase in T cells. | 1997 | J. Biol. Chem. | pmid:9312132 |
| Kageyama M et al. | FK506-binding proteins regulate smooth muscle contractility by altering neurotransmitter release. | 1997 | Eur. J. Pharmacol. | pmid:9314039 |
| Reynolds KA et al. | Biosynthesis of the shikimate-derived starter unit of the immunosuppressant ascomycin: stereochemistry of the 1,4-conjugate elimination. | 1997 | J. Antibiot. | pmid:9315087 |
| Alarcón CM and Heitman J | FKBP12 physically and functionally interacts with aspartokinase in Saccharomyces cerevisiae. | 1997 | Mol. Cell. Biol. | pmid:9315655 |
| Goodyear N et al. | The 37 kDa immunophilin has uracil DNA glycosylase but not rotamase activity. | 1997 | Clin. Biochem. | pmid:9316745 |
| Rudi J et al. | Prevalence of serum antibodies to Helicobacter pylori and to CagA protein in liver transplant recipients. | 1997 | Am. J. Gastroenterol. | pmid:9317070 |
| Kesten S et al. | Tacrolimus as rescue therapy for bronchiolitis obliterans syndrome. | 1997 | J. Heart Lung Transplant. | pmid:9322139 |
| Ko WJ et al. | Hypomagnesia and arrhythmia corrected by replacing cyclosporine with FK506 in a heart transplant recipient. | 1997 | J. Heart Lung Transplant. | pmid:9322151 |
| Arbustini E et al. | Acute rejection and heart infection rates in FK 506- versus cyclosporine A-treated heart transplant recipients: an endomyocardial biopsy pathologic study. | 1997 | J. Heart Lung Transplant. | pmid:9322152 |
| Denecker G et al. | Differential role of calcium in tumour necrosis factor-mediated apoptosis and secretion of granulocyte-macrophage colony-stimulating factor in a T cell hybridoma. | 1997 | Cytokine | pmid:9325011 |
| Fujita T et al. | Prolonged survival of rat skin allograft by treatment with FK506 ointment. | 1997 | Transplantation | pmid:9326422 |
| Pratschke J et al. | Treatment of cyclosporine-related adverse effects by conversion to tacrolimus after liver transplantation. | 1997 | Transplantation | pmid:9326428 |
| McGhee B et al. | Therapeutic use of an extemporaneously prepared oral suspension of tacrolimus in pediatric patients. | 1997 | Transplantation | pmid:9326429 |
| Ilan Y et al. | Transient immunosuppression with FK506 permits long-term expression of therapeutic genes introduced into the liver using recombinant adenoviruses in the rat. | 1997 | Hepatology | pmid:9328318 |
| Hara K et al. | Implantation of xenogeneic transgenic neural plate tissues into parkinsonian rat brain. | 1997 Sep-Oct | Cell Transplant | pmid:9331504 |
| Nagai H et al. | FK-506 and cyclosporin A potentiate the IgE antibody production by contact sensitization with hapten in mice. | 1997 | J. Pharmacol. Exp. Ther. | pmid:9336339 |
| Vella JP and Sayegh MH | Maintenance pharmacological immunosuppressive strategies in renal transplantation. | 1997 | Postgrad Med J | pmid:9338020 |
| Harihara Y and Makuuchi M | [Partial liver transplantation]. | 1997 | Nippon Naika Gakkai Zasshi | pmid:9340350 |
| Wallemacq PE et al. | IMx tacrolimus II vs IMx tacrolimus microparticle enzyme immunoassay evaluated in renal and hepatic transplant patients. | 1997 | Clin. Chem. | pmid:9342026 |
| Gold BG et al. | A nonimmunosuppressant FKBP-12 ligand increases nerve regeneration. | 1997 | Exp. Neurol. | pmid:9344552 |
| Klintmalm GB and Gonwa TA | Nephrotoxicity associated with cyclosporine and FK506. | 1995 | Liver Transpl Surg | pmid:9346596 |
| Wong PY et al. | FK506 in liver transplantation for chronic hepatitis B: in vitro studies on lymphocyte activation and virus replication. | 1995 | Liver Transpl Surg | pmid:9346613 |
| Cameron AM et al. | FKBP12 binds the inositol 1,4,5-trisphosphate receptor at leucine-proline (1400-1401) and anchors calcineurin to this FK506-like domain. | 1997 | J. Biol. Chem. | pmid:9346894 |
| Hosoi R et al. | Isoform-specific up-regulation by ouabain of Na+,K+-ATPase in cultured rat astrocytes. | 1997 | J. Neurochem. | pmid:9349566 |
| Krüger M et al. | Inhibition of CREB- and cAMP response element-mediated gene transcription by the immunosuppressive drugs cyclosporin A and FK506 in T cells. | 1997 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:9349628 |
| Prokisch H et al. | Impairment of calcineurin function in Neurospora crassa reveals its essential role in hyphal growth, morphology and maintenance of the apical Ca2+ gradient. | 1997 | Mol. Gen. Genet. | pmid:9349701 |
| Saitoh O et al. | Cyclosporine A inhibits interleukin-8 production in a human colon epithelial cell line (HT-29). | 1997 | J. Gastroenterol. | pmid:9349985 |
| Lang P and Baron C | Molecular mechanisms of immunosuppressive chemical agents recently introduced in clinical transplantation protocols. | 1997 | Nephrol. Dial. Transplant. | pmid:9351062 |
| Waer M | New immunosuppressive agents for organ transplantation. | 1997 | Acta Clin Belg | pmid:9351290 |
| Sheiner PA et al. | Increased risk of early rejection correlates with recovery of CD3 cell count after liver transplant in patients receiving OKT3 induction. | 1997 | Transplantation | pmid:9355846 |
| Karlsson H and Nässberger L | FK506 suppresses the mitogen-induced increase in lymphocyte adhesiveness to endothelial cells, but does not affect endothelial cell activation in response to inflammatory stimuli. | 1997 | Transplantation | pmid:9355847 |
| Ishida H et al. | Cataract development induced by repeated oral dosing with FK506 (tacrolimus) in adult rats. | 1997 | Toxicology | pmid:9355935 |
| Wang JH and Kelly PT | Attenuation of paired-pulse facilitation associated with synaptic potentiation mediated by postsynaptic mechanisms. | 1997 | J. Neurophysiol. | pmid:9356420 |
| Firdaous I et al. | Excretion of tacrolimus glucuronides in human bile. | 1997 Jul-Sep | Eur J Drug Metab Pharmacokinet | pmid:9358202 |