tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Högerle BA et al. | Challenging immunosuppression treatment in lung transplant recipients with kidney failure. | 2016 | Transpl. Immunol. | pmid:26892232 |
| Kimura H et al. | Has widespread use of biologic and immunosuppressant therapy for ulcerative colitis affected surgical trends? Results of a questionnaire survey of surgical institutions in Japan. | 2016 | Surg. Today | pmid:26467558 |
| Brooks E et al. | Population Pharmacokinetic Modelling and Bayesian Estimation of Tacrolimus Exposure: Is this Clinically Useful for Dosage Prediction Yet? | 2016 | Clin Pharmacokinet | pmid:27138787 |
| Vasu S et al. | Granulocyte Colony-Stimulating Factor-Mobilized Allografts Contain Activated Immune Cell Subsets Associated with Risk of Acute and Chronic Graft-versus-Host Disease. | 2016 | Biol. Blood Marrow Transplant. | pmid:26743340 |
| Haasova M et al. | Immunosuppressive therapy for kidney transplantation in children and adolescents: systematic review and economic evaluation. | 2016 | Health Technol Assess | pmid:27557331 |
| Ishiwata Y et al. | Effects of Miconazole Oral Gel on Blood Concentrations of Tacrolimus and Cyclosporine: A Retrospective Observational Study. | 2016 | Ther Drug Monit | pmid:27559841 |
| Woolner K and Sauder M | Periorbital erythema following alcohol ingestion during treatment with topical tacrolimus. | 2016 | CMAJ | pmid:26598374 |
| Menninga NJ et al. | Restless Legs Syndrome Following Lung Transplantation: Prevalence and Relationship With Tacrolimus Exposure. | 2016 | Prog Transplant | pmid:27207403 |
| Reeves TM et al. | Targeting Kv1.3 channels to reduce white matter pathology after traumatic brain injury. | 2016 | Exp. Neurol. | pmid:27302680 |
| Matsukawa T et al. | Reduced-dose methotrexate in combination with tacrolimus was associated with rapid engraftment and recovery from oral mucositis without affecting the incidence of GVHD. | 2016 | Int. J. Hematol. | pmid:27119977 |
| Ruangkanchanasetr P et al. | Beta Cell Function and Insulin Resistance After Conversion from Tacrolimus Twice-Daily to Extended-Release Tacrolimus Once-Daily in Stable Renal Transplant Recipients. | 2016 | Ann. Transplant. | pmid:27980321 |
| Yamamoto T et al. | Editorial: tacrolimus vs. anti-tumour necrosis factor agents for moderately to severely active ulcerative colitis--authors' reply. | 2016 | Aliment. Pharmacol. Ther. | pmid:27040167 |
| Imamura CK et al. | Impact of cytochrome P450 2C19 polymorphisms on the pharmacokinetics of tacrolimus when coadministered with voriconazole. | 2016 | J Clin Pharmacol | pmid:26239045 |
| Gu C et al. | Triptolide Reduces the Required Dose of Tacrolimus by Attenuating Inflammation, Enhancing Immunosuppression, and Increasing Donor Chimerism in a Heterotopic Hindlimb Transplantation Model. | 2016 | Plast. Reconstr. Surg. | pmid:27879593 |
| Caraveo G et al. | FKBP12 contributes to α-synuclein toxicity by regulating the calcineurin-dependent phosphoproteome. | 2017 | Proc. Natl. Acad. Sci. U.S.A. | pmid:29229832 |
| Varshosaz J et al. | Physicochemical, Pharmacodynamic and Pharmacokinetic Characterization of Soluplus Stabilized Nanosuspension of Tacrolimus. | 2017 | Curr Drug Deliv | pmid:27697037 |
| Liu C et al. | Tacrolimus Improves Symptoms of Children With Myasthenia Gravis Refractory to Prednisone. | 2017 | Pediatr. Neurol. | pmid:29074055 |
| Cheung AY et al. | Probable Donor-Derived Cytomegalovirus Disease After Keratolimbal Allograft Transplantation. | 2017 | Cornea | pmid:28614157 |
| Krenzien F et al. | Age-Dependent Metabolic and Immunosuppressive Effects of Tacrolimus. | 2017 | Am. J. Transplant. | pmid:27754593 |
| Weir MR et al. | Long-term Follow-up of Kidney Transplant Recipients in the Spare-the-Nephron-Trial. | 2017 | Transplantation | pmid:26950714 |
| Jouve T et al. | New formulations of tacrolimus and prevention of acute and chronic rejections in adult kidney-transplant recipients. | 2017 | Expert Opin Drug Saf | pmid:28494654 |
| Koo K et al. | Beyond monotherapy: a systematic review on creative strategies in topical therapy of psoriasis. | 2017 | J Dermatolog Treat | pmid:28481664 |
| Wolfshohl JA et al. | Improvement of erythema dyschromicum perstans using a combination of the 1,550-nm erbium-doped fractionated laser and topical tacrolimus ointment. | 2017 | Lasers Surg Med | pmid:27552666 |
| Gardenier JC et al. | Topical tacrolimus for the treatment of secondary lymphedema. | 2017 | Nat Commun | pmid:28186091 |
| Verga E et al. | Stoma Complications: Corticosteroid and Silver Nitrate-Resistant Inflammation Successfully Treated with Topical Tacrolimus. | 2017 | Dig Surg | pmid:28183090 |
| Kizilbash SJ et al. | Infection rates in tacrolimus versus cyclosporine-treated pediatric kidney transplant recipients on a rapid discontinuation of prednisone protocol: 1-year analysis. | 2017 | Pediatr Transplant | pmid:28371243 |
| Khimani F et al. | Predictors of overall survival among patients treated with sirolimus/tacrolimus vs methotrexate/tacrolimus for GvHD prevention. | 2017 | Bone Marrow Transplant. | pmid:28368376 |
| Gard L et al. | A delicate balance between rejection and BK polyomavirus associated nephropathy; A retrospective cohort study in renal transplant recipients. | 2017 | PLoS ONE | pmid:28609473 |
| Wang J et al. | Comparative proteomic and metabolomic analysis of Streptomyces tsukubaensis reveals the metabolic mechanism of FK506 overproduction by feeding soybean oil. | 2017 | Appl. Microbiol. Biotechnol. | pmid:28175948 |
| David-Neto E et al. | Longitudinal Pharmacokinetics of Tacrolimus in Elderly Compared With Younger Recipients in the First 6 Months After Renal Transplantation. | 2017 | Transplantation | pmid:27482958 |
| Ikeda K et al. | Intestinal perforation due to hemorrhagic Cytomegalovirus enteritis in a patient with severe uncontrolled lupus nephritis: a case and review of the literature. | 2017 | Rheumatol. Int. | pmid:28283734 |
| Toyota H et al. | Process optimization by use of design of experiments: Application for liposomalization of FK506. | 2017 | Eur J Pharm Sci | pmid:28279762 |
| Jackson MF et al. | Osteoclast precursors do not express CD68: results from CD68 promoter-driven RANK transgenic mice. | 2017 | FEBS Lett. | pmid:28173622 |
| Ribero S and Borradori L | Re: risk of malignancy and systemic absorption after application of topical tacrolimus in oral lichen planus. | 2017 | J Eur Acad Dermatol Venereol | pmid:27291784 |
| Hamada T et al. | Phenotypic analysis of circulating T-cell subset and its association with burden of skin disease in patients with chronic actinic dermatitis: a hematologic and clinicopathologic study of 20 subjects. | 2017 | Int. J. Dermatol. | pmid:28176301 |
| Piotti G et al. | Once-daily prolonged-release tacrolimus formulations for kidney transplantation: what the nephrologist needs to know. | 2017 | J. Nephrol. | pmid:27206763 |
| Ma TK et al. | Therapeutic drug monitoring of once-daily tacrolimus (Advagraf) in a gastrectomized kidney transplant recipient. | 2017 | Nephrology (Carlton) | pmid:28064453 |
| Schifferer M et al. | Reversible Chemical Dimerization by rCD1. | 2017 | Meth. Enzymol. | pmid:28063490 |
| Percy C et al. | Impact of Acute Infection Requiring Hospitalization on Tacrolimus Blood Levels in Kidney Transplant Recipients. | 2017 | Transplant. Proc. | pmid:29149962 |
| Obaidat RM et al. | Using Supercritical Fluid Technology (SFT) in Preparation of Tacrolimus Solid Dispersions. | 2017 | AAPS PharmSciTech | pmid:27116202 |
| Krämer BK et al. | Efficacy of Prolonged- and Immediate-release Tacrolimus in Kidney Transplantation: A Pooled Analysis of Two Large, Randomized, Controlled Trials. | 2017 | Transplant. Proc. | pmid:29149958 |
| de Menezes AF et al. | Pharmacologic Treatment of Vitiligo in Children and Adolescents: A Systematic Review. | 2017 | Pediatr Dermatol | pmid:27878842 |
| Taber DJ et al. | A Comparative Effectiveness Analysis of Early Steroid Withdrawal in Black Kidney Transplant Recipients. | 2017 | Clin J Am Soc Nephrol | pmid:27979979 |
| Flahault A et al. | Clinical impact of the CYP3A5 6986A>G allelic variant on kidney transplantation outcomes. | 2017 | Pharmacogenomics | pmid:27977332 |
| Tron C et al. | Tacrolimus: Does direct glucuronidation matter? An analytical and pharmacological perspective. | 2017 | Pharmacol. Res. | pmid:28366836 |
| Ganschow R et al. | Everolimus and reduced calcineurin inhibitor therapy in pediatric liver transplant recipients: Results from a multicenter, prospective study. | 2017 | Pediatr Transplant | pmid:28714558 |
| Bremer S et al. | NFAT-regulated cytokine gene expression during tacrolimus therapy early after renal transplantation. | 2017 | Br J Clin Pharmacol | pmid:28686294 |
| Tao X et al. | Long-term efficacy and side effects of low-dose tacrolimus for the treatment of Myasthenia Gravis. | 2017 | Neurol. Sci. | pmid:27873026 |
| Tsunashima D et al. | Development of extended-release solid dispersion granules of tacrolimus: evaluation of release mechanism and human oral bioavailability. | 2017 | J. Pharm. Pharmacol. | pmid:28872687 |
| Krüger-Genge A et al. | Effects of Tacrolimus or Sirolimus on the adhesion of vascular wall cells: Controlled in-vitro comparison study. | 2017 | Clin. Hemorheol. Microcirc. | pmid:28869461 |