tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Zhang Y et al. | Phosphatidylinositol 4-phosphate 5-kinase Its3 and calcineurin Ppb1 coordinately regulate cytokinesis in fission yeast. | 2000 | J. Biol. Chem. | pmid:10950958 |
| Jones JW et al. | Successful hand transplantation. One-year follow-up. Louisville Hand Transplant Team. | 2000 | N. Engl. J. Med. | pmid:10950668 |
| Verleden GM | Bronchiolitis obliterans syndrome after lung transplantation: medical treatment. | 2000 | Monaldi Arch Chest Dis | pmid:10949876 |
| Straatman LP and Coles JG | Pediatric utilization of rapamycin for severe cardiac allograft rejection. | 2000 | Transplantation | pmid:10949201 |
| Shoker A et al. | Heightened CD40 ligand gene expression in peripheral CD4+ T cells from patients with kidney allograft rejection. | 2000 | Transplantation | pmid:10949194 |
| Kohlhaw K et al. | [Clinical studies in liver transplantation]. | 2000 | Chirurg | pmid:10948733 |
| Li WE and Nagy JI | Connexin43 phosphorylation state and intercellular communication in cultured astrocytes following hypoxia and protein phosphatase inhibition. | 2000 | Eur. J. Neurosci. | pmid:10947839 |
| Sheiner PA | Hepatitis C after liver transplantation. | 2000 | Semin. Liver Dis. | pmid:10946424 |
| Masuda S et al. | Effect of intestinal P-glycoprotein on daily tacrolimus trough level in a living-donor small bowel recipient. | 2000 | Clin. Pharmacol. Ther. | pmid:10945321 |
| Misseghers BS et al. | Clinical observations of the treatment of canine perianal fistulas with topical tacrolimus in 10 dogs. | 2000 | Can. Vet. J. | pmid:10945128 |
| Youn HD et al. | Integration of calcineurin and MEF2 signals by the coactivator p300 during T-cell apoptosis. | 2000 | EMBO J. | pmid:10944115 |
| Flores F and Kerdel FA | Other novel immunosuppressants. | 2000 | Dermatol Clin | pmid:10943542 |
| Hübner GI and Sziegoleit W | Response to letter from van Gelder. Drug interaction between mycophenolate mofetil and tacrolimus detectable within therapeutic mycophenolic acid monitoring in renal transplant patients. | 2000 | Ther Drug Monit | pmid:10942194 |
| Bunn SK et al. | Treatment of microvillus inclusion disease by intestinal transplantation. | 2000 | J. Pediatr. Gastroenterol. Nutr. | pmid:10941971 |
| Woltman AM et al. | The effect of calcineurin inhibitors and corticosteroids on the differentiation of human dendritic cells. | 2000 | Eur. J. Immunol. | pmid:10940869 |
| Bertram PG et al. | Tripartite regulation of Gln3p by TOR, Ure2p, and phosphatases. | 2000 | J. Biol. Chem. | pmid:10940301 |
| Casson DH et al. | Topical tacrolimus may be effective in the treatment of oral and perineal Crohn's disease. | 2000 | Gut | pmid:10940284 |
| Uchida N et al. | Myocardial ischemia following allogeneic bone marrow transplantation: possible implication of tacrolimus overdose. | 2000 | Blood | pmid:10939803 |
| Matsuda S and Koyasu S | [A second target of cyclosporin A and FK506]. | 2000 | Tanpakushitsu Kakusan Koso | pmid:10936966 |
| Endoh M et al. | Nonmuscle myosin heavy chain and metalloproteinase-2 expression in concordant pulmonary xenografts. | 2000 | Transplant. Proc. | pmid:10936397 |
| Goller AL et al. | Loss of serum bicarbonate after discordant liver xenotransplantation. | 2000 | Transplant. Proc. | pmid:10936383 |
| Takayama K et al. | Nonmuscle myosin heavy chain and nuclear factor-kappa B expression in pig-to-primate xenotransplanted hearts. | 2000 | Transplant. Proc. | pmid:10936372 |
| Wada Y et al. | Expression of the transcriptional factor egr-1/BTEB2 in cardiac xenograft vascular remodeling. | 2000 | Transplant. Proc. | pmid:10936371 |
| Miki T et al. | Xenogeneic humoral graft-Vs-host disease following hamster-to-Rat bone marrow transplantation. | 2000 | Transplant. Proc. | pmid:10936339 |
| Song Z et al. | Protective effect of FK-506 in pig-to-rat islet xenotransplantation is abrogated by prednisolone. | 2000 | Transplant. Proc. | pmid:10936332 |
| Yin DP et al. | Efficacy of FK506, leflunomide, anti-CD4, and CTLA4IG treatments in rat to mouse pancreas xenograft transplantation. | 2000 | Transplant. Proc. | pmid:10936320 |
| Takayama K et al. | Hepatocyte growth factor and vascular endothelial growth factor expression in pig-to-primate xenotransplanted hearts. | 2000 | Transplant. Proc. | pmid:10936314 |
| Watanabe T et al. | Effects of the endothelin-1 receptor antagonist TAK-044 on pulmonary injury in discordant xenotransplantation. | 2000 | Transplant. Proc. | pmid:10936270 |
| Minamino T et al. | Chronic treatment with FK506 increases p70 S6 kinase activity associated with reduced nitric oxide synthase activity in rabbit hearts. | 2000 | Cardiovasc Drugs Ther | pmid:10935155 |
| Furlan V et al. | Conversion from cyclosporin A to tacrolimus in pediatric liver transplantation. | 2000 | Pediatr Transplant | pmid:10933321 |
| Chin C et al. | Lipoprotein abnormalities are highly prevalent in pediatric heart transplant recipients. | 2000 | Pediatr Transplant | pmid:10933319 |
| Gruber SA et al. | Initial results of solitary pancreas transplants performed without regard to donor/recipient HLA mismatching. | 2000 | Transplantation | pmid:10933170 |
| Kung L and Halloran PF | Immunophilins may limit calcineurin inhibition by cyclosporine and tacrolimus at high drug concentrations. | 2000 | Transplantation | pmid:10933159 |
| Schmutz J et al. | [Gingival hypertrophy and tacrolimus]. | 2000 Jun-Jul | Ann Dermatol Venereol | pmid:10930868 |
| Jimenez J and Young JB | Clinical challenges in thoracic organ transplantation: case studies in immunosuppressive therapy. | 2000 | J. Heart Lung Transplant. | pmid:10930823 |
| Sakuma S et al. | FK506 potently inhibits T cell activation induced TNF-alpha and IL-1beta production in vitro by human peripheral blood mononuclear cells. | 2000 | Br. J. Pharmacol. | pmid:10928971 |
| Sugiura H et al. | Long-term efficacy of tacrolimus ointment for recalcitrant facial erythema resistant to topical corticosteroids in adult patients with atopic dermatitis. | 2000 | Arch Dermatol | pmid:10926750 |
| Reitamo S et al. | Safety and efficacy of 1 year of tacrolimus ointment monotherapy in adults with atopic dermatitis. The European Tacrolimus Ointment Study Group. | 2000 | Arch Dermatol | pmid:10926735 |
| Puig I Marà JM et al. | Reflex sympathetic dystrophy syndrome of the lower limbs in a renal transplant patient treated with tacrolimus. | 2000 | Transplantation | pmid:10919604 |
| Higgins RM et al. | Conversion from tacrolimus to cyclosporin in stable renal transplant patients: safety, metabolic changes, and pharmacokinetic comparison. | 2000 | Transplantation | pmid:10919600 |
| Younes BS et al. | The effect of immunosuppression on posttransplant lymphoproliferative disease in pediatric liver transplant patients. | 2000 | Transplantation | pmid:10919581 |
| Peduto G et al. | Long-term host unresponsiveness to encapsulated xenogeneic myoblasts after transient immunosuppression. | 2000 | Transplantation | pmid:10919579 |
| Yanik G et al. | Tacrolimus (FK506) and methotrexate as prophylaxis for acute graft-versus-host disease in pediatric allogeneic stem cell transplantation. | 2000 | Bone Marrow Transplant. | pmid:10918426 |
| Nieto Y et al. | Acute pancreatitis during immunosuppression with tacrolimus following an allogeneic umbilical cord blood transplantation. | 2000 | Bone Marrow Transplant. | pmid:10918414 |
| Lee TJ and Kennedy LA | Tacrolimus: an alternative for graft-versus-host disease prevention. | 2000 | Ann Pharmacother | pmid:10917386 |
| Mancilla UE et al. | Primary immunosuppression with tacrolimus in renal transplantation: a multicenter, open-label study. | 1999 Sep-Oct | Adv Ther | pmid:10915396 |
| Yang GS et al. | Intratympanic immunosuppressives for prevention of immune-mediated sensorineural hearing loss. | 2000 | Am J Otol | pmid:10912694 |
| Ellis D | Growth and renal function after steroid-free tacrolimus-based immunosuppression in children with renal transplants. | 2000 | Pediatr. Nephrol. | pmid:10912544 |
| Robertson RP | Successful islet transplantation for patients with diabetes--fact or fantasy? | 2000 | N. Engl. J. Med. | pmid:10911012 |
| Shapiro AM et al. | Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. | 2000 | N. Engl. J. Med. | pmid:10911004 |