Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with tacrolimus
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Reyes J et al. | Long-term results after conversion from cyclosporine to tacrolimus in pediatric liver transplantation for acute and chronic rejection. | 2000 | Transplantation | pmid:10910279 |
MacDonald AS | Management strategies for nephrotoxicity. | 2000 | Transplantation | pmid:10910262 |
Fisher NC et al. | The clinical impact of nephrotoxicity in liver transplantation. | 2000 | Transplantation | pmid:10910259 |
Wang L et al. | Reversal of anticancer drug resistance by macrolide antibiotics in vitro and in vivo. | 2000 | Clin. Exp. Pharmacol. Physiol. | pmid:10901387 |
Hishinuma S and Ogura K | Ca(2+)/calmodulin-mediated regulation of the desensitizing process in G(q) protein-coupled histamine H(1) receptor-mediated Ca(2+) responses in human U373 MG astrocytoma cells. | 2000 | J. Neurochem. | pmid:10899954 |
Mukerjee N et al. | Caspase-mediated proteolytic activation of calcineurin in thapsigargin-mediated apoptosis in SH-SY5Y neuroblastoma cells. | 2000 | Arch. Biochem. Biophys. | pmid:10898953 |
Yue G et al. | The effect of rapamycin on single ENaC channel activity and phosphorylation in A6 cells. | 2000 | Am. J. Physiol., Cell Physiol. | pmid:10898719 |
Mori A et al. | Control of IL-5 production by human helper T cells as a treatment for eosinophilic inflammation: comparison of in vitro and in vivo effects between selective and nonselective cytokine synthesis inhibitors. | 2000 | J. Allergy Clin. Immunol. | pmid:10887335 |
Hooijberg E et al. | NFAT-controlled expression of GFP permits visualization and isolation of antigen-stimulated primary human T cells. | 2000 | Blood | pmid:10887106 |
Arthur JM and Shamim S | Interaction of cyclosporine and FK506 with diuretics in transplant patients. | 2000 | Kidney Int. | pmid:10886578 |
Zaman AK | Effects of tacrolimus hydrate (FK-506) on the expression of tissue factor in THP-1 human monocyte cell line. | 2000 | Hokkaido Igaku Zasshi | pmid:10884973 |
Terashima A et al. | Rapamycin and FK506 induce long-term potentiation by pairing stimulation via an intracellular Ca(2+) signaling mechanism in rat hippocampal CA1 neurons. | 2000 | Neuropharmacology | pmid:10884573 |
Parker EM et al. | Rapamycin, but not FK506 and GPI-1046, increases neurite outgrowth in PC12 cells by inhibiting cell cycle progression. | 2000 | Neuropharmacology | pmid:10884572 |
Romano G et al. | Systemic and intratubular effects of cyclosporin-A and tacrolimus on the rat kidney. | 2000 | Eur. J. Pharmacol. | pmid:10884522 |
Ben Abraham R et al. | [FK506 (tacrolimus) does not increase hepatic damage due to hypoperfusion]. | 2000 | Harefuah | pmid:10883243 |
Hamazaki T et al. | [Prophylaxis with FK-506 for graft-versus-host disease after transplantation of bone marrow from unrelated donors]. | 2000 | Rinsho Ketsueki | pmid:10879106 |
Assmann T et al. | Applications of tacrolimus for the treatment of skin disorders. | 2000 | Immunopharmacology | pmid:10878290 |
Allison AC | Immunosuppressive drugs: the first 50 years and a glance forward. | 2000 | Immunopharmacology | pmid:10878284 |
Castilho RF et al. | FK506 and cyclosporin A enhance the survival of cultured and grafted rat embryonic dopamine neurons. | 2000 | Exp. Neurol. | pmid:10877919 |
Costantini LC and Isacson O | Immunophilin ligands and GDNF enhance neurite branching or elongation from developing dopamine neurons in culture. | 2000 | Exp. Neurol. | pmid:10877916 |
Morales JM et al. | Immunosuppression in older renal transplant patients. | 2000 | Drugs Aging | pmid:10874523 |
Queille-Roussel C et al. | SDZ ASM 981 is the first non-steroid that suppresses established nickel contact dermatitis elicited by allergen challenge. | 2000 | Contact Derm. | pmid:10871099 |
Au WY et al. | Tacrolimus (FK 506) induced thrombotic thrombocytopenic purpura after ABO mismatched second liver transplantation: salvage with plasmapheresis and prostacyclin. | 2000 | Haematologica | pmid:10870125 |
Neuhaus P et al. | Quadruple tacrolimus-based induction therapy including azathioprine and ALG does not significantly improve outcome after liver transplantation when compared with standard induction with tacrolimus and steroids: results of a prospective, randomized trial. | 2000 | Transplantation | pmid:10868638 |
Blakolmer K et al. | Chronic liver allograft rejection in a population treated primarily with tacrolimus as baseline immunosuppression: long-term follow-up and evaluation of features for histopathological staging. | 2000 | Transplantation | pmid:10868635 |
Yamani MH et al. | The impact of routine mycophenolate mofetil drug monitoring on the treatment of cardiac allograft rejection. | 2000 | Transplantation | pmid:10868634 |
Oike F et al. | A 12-day course of FK506 allows long-term acceptance of semi-identical liver allograft in inbred miniature swine. | 2000 | Transplantation | pmid:10868630 |
Wu K et al. | The FK520 gene cluster of Streptomyces hygroscopicus var. ascomyceticus (ATCC 14891) contains genes for biosynthesis of unusual polyketide extender units. | 2000 | Gene | pmid:10863099 |
Boubenider S et al. | Interaction between theophylline and tacrolimus in a renal transplant patient. | 2000 | Nephrol. Dial. Transplant. | pmid:10862651 |
Morelli AE et al. | Microchimerism, donor dendritic cells, and alloimmune reactivity in recipients of Flt3 ligand-mobilized hemopoietic cells: modulation by tacrolimus. | 2000 | J. Immunol. | pmid:10861056 |
McLaughlin GE et al. | Effect of aminophylline on urine flow in children with tacrolimus-induced renal insufficiency. | 2000 | Transplant. Proc. | pmid:10856596 |
Malinowski K et al. | Effect of different anti-rejection regimens on the expression of differentiation and activation markers on the surface of host lymphocytes. | 2000 | Transplant. Proc. | pmid:10856579 |
Gotsman I et al. | Effect of peripheral immune tolerance on liver-associated lymphocytes expressing NK1.1. | 2000 | Transplant. Proc. | pmid:10856569 |
Barak S et al. | Alveolar bone height in patients after liver transplantation. | 2000 | Transplant. Proc. | pmid:10856558 |
Ben-Ari Z et al. | Conversion of liver allograft recipients from cyclosporine A to FK 506 immunosuppressive therapy. | 2000 | Transplant. Proc. | pmid:10856553 |
Granot E et al. | Monitoring of Epstein-Barr virus serology in children after liver transplant: lack of clinical correlation. | 2000 | Transplant. Proc. | pmid:10856551 |
Bultynck G et al. | Effects of the immunosuppressant FK506 on intracellular Ca2+ release and Ca2+ accumulation mechanisms. | 2000 | J. Physiol. (Lond.) | pmid:10856121 |
Kochi S et al. | Induction of apoptosis in mouse brain capillary endothelial cells by cyclosporin A and tacrolimus. | 2000 | Life Sci. | pmid:10855946 |
Florio G et al. | The immunoglobulin superantigen-binding site of HIV-1 gp120 activates human basophils. | 2000 | AIDS | pmid:10853974 |
Rollins CT et al. | A ligand-reversible dimerization system for controlling protein-protein interactions. | 2000 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10852943 |
Schvarcz R et al. | Interaction between nelfinavir and tacrolimus after orthoptic liver transplantation in a patient coinfected with HIV and hepatitis C virus (HCV). | 2000 | Transplantation | pmid:10852623 |
Konrad T et al. | Regulation of glucose tolerance in patients after liver transplantation: impact of cyclosporin versus tacrolimus therapy. | 2000 | Transplantation | pmid:10852599 |
Gibson SW et al. | Nutritional immunomodulation leads to enhanced allograft survival in combination with cyclosporine A and rapamycin, but not FK506. | 2000 | Transplantation | pmid:10852592 |
Tyedmers J et al. | Assembly of heterodimeric luciferase after de novo synthesis of subunits in rabbit reticulocyte lysate involves hsc70 and hsp40 at a post-translational stage. | 2000 | Eur. J. Biochem. | pmid:10848974 |
Small bowel transplants in adults and multivisceral transplants in adults and children. | 1999 | Tecnologica MAP Suppl | pmid:10848042 | |
Zhang F et al. | Resistance to Friend murine leukemia virus infection conferred by the Fv-4 gene is recessive but appears dominant from the effect of the immune system. | 2000 | J. Virol. | pmid:10846105 |
Samsonov D et al. | Enhancement of immune tolerance via induction of NK1.1 positive liver-associated-lymphocytes under immunosuppressive conditions. | 2000 | J. Hepatol. | pmid:10845669 |
Nasr IS | Topical tacrolimus in dermatology. | 2000 | Clin. Exp. Dermatol. | pmid:10844509 |
Rabinowitz M et al. | Solid-phase/solution-phase combinatorial synthesis of neuroimmunophilin ligands. | 2000 | Bioorg. Med. Chem. Lett. | pmid:10843203 |
Yoshikawa T et al. | In vivo osteogenic capability of cultured allogeneic bone in porous hydroxyapatite: immunosuppressive and osteogenic potential of FK506 in vivo. | 2000 | J. Bone Miner. Res. | pmid:10841184 |