| MeSH term | MeSH ID | Detail |
|---|---|---|
| Inflammatory Bowel Diseases | D015212 | 9 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Diabetes Mellitus, Type 1 | D003922 | 56 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Fatty Liver | D005234 | 48 associated lipids |
| Cataract | D002386 | 34 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Mrowietz U et al. | The novel ascomycin derivative SDZ ASM 981 is effective for psoriasis when used topically under occlusion. | 1998 | Br. J. Dermatol. | pmid:9990361 |
| Hebert MF et al. | Effects of rifampin on tacrolimus pharmacokinetics in healthy volunteers. | 1999 | J Clin Pharmacol | pmid:9987705 |
| Nakahama H et al. | Effect of a novel immunosuppressant, FK 506, on autoimmune glomerulonephritis in Brown Norway rats. | 1999 | Nephron | pmid:9933758 |
| Hebebrand D et al. | [Genetic methods in experimental xenogenic nerve transplantation]. | 1998 | Langenbecks Arch Chir Suppl Kongressbd | pmid:9931858 |
| Takeda Y et al. | Mechanisms of FK 506-induced hypertension in the rat. | 1999 | Hypertension | pmid:9931093 |
| Al-Nasser IA | In vivo prevention of adriamycin cardiotoxicity by cyclosporin A or FK506. | 1998 | Toxicology | pmid:9928632 |
| Honoré P et al. | [Liver transplantation: experiences and results of a program at the University of Liege]. | 1998 | Rev Med Liege | pmid:9927867 |
| Cai Q et al. | Reduction of infarct size in isolated rat heart by CsA and FK506: possible role of phosphatase inhibition. | 1998 | Cardiovasc Drugs Ther | pmid:9926283 |
| Wingard JR et al. | Relationship of tacrolimus (FK506) whole blood concentrations and efficacy and safety after HLA-identical sibling bone marrow transplantation. | 1998 | Biol. Blood Marrow Transplant. | pmid:9923414 |
| Yoshida A et al. | Studies of repeated administration of FK-506 on myocardial metabolism in rats. | 1998 | J Toxicol Sci | pmid:9922943 |
| Randhawa PS et al. | Clinical significance of renal biopsies showing concurrent acute rejection and tacrolimus-associated tubular vacuolization. | 1999 | Transplantation | pmid:9921801 |
| Lee RK et al. | Prostaglandin E2 stimulates amyloid precursor protein gene expression: inhibition by immunosuppressants. | 1999 | J. Neurosci. | pmid:9920657 |
| Katznelson S et al. | Clinical aspects of sensitization. | 1997 | Clin Transpl | pmid:9919412 |
| Odorico JS et al. | Advances in pancreas transplantation: the University of Wisconsin experience. | 1997 | Clin Transpl | pmid:9919400 |
| Gruessner AC and Sutherland DE | Pancreas transplants for United States (US) and non-US cases as reported to the International Pancreas Transplant Registry (IPTR) and to the United Network for Organ Sharing (UNOS). | 1997 | Clin Transpl | pmid:9919390 |
| Skuk D et al. | Successful myoblast transplantation in primates depends on appropriate cell delivery and induction of regeneration in the host muscle. | 1999 | Exp. Neurol. | pmid:9918701 |
| Bochelen D et al. | Calcineurin inhibitors FK506 and SDZ ASM 981 alleviate the outcome of focal cerebral ischemic/reperfusion injury. | 1999 | J. Pharmacol. Exp. Ther. | pmid:9918571 |
| Kobashigawa JA | Advances in immunosuppression for heart transplantation. | 1998 | Adv Card Surg | pmid:9917904 |
| Reich K et al. | Topical tacrolimus for pyoderma gangrenosum. | 1998 | Br. J. Dermatol. | pmid:9892935 |
| Hamar P et al. | Coinhibition of immune and renin-angiotensin systems reduces the pace of glomerulosclerosis in the rat remnant kidney. | 1999 | J. Am. Soc. Nephrol. | pmid:9892170 |
| Soda Y et al. | Suppressed endothelin-1 production by FK506 and cyclosporin A in ischemia/reperfusion of rat small intestine. | 1999 | Surgery | pmid:9889794 |
| Yoshioka K et al. | Post-transplant diabetes with anti-glutamic acid decarboxylase antibody during tacrolimus therapy. | 1998 | Diabetes Res. Clin. Pract. | pmid:9886744 |
| Chen YW et al. | Ex vivo assessment of immunosuppression in undiluted whole blood from pigs dosed with tacrolimus (FK506). | 1999 | Clin. Immunol. | pmid:9884362 |
| Solez K et al. | Histopathologic findings from 2-year protocol biopsies from a U.S. multicenter kidney transplant trial comparing tarolimus versus cyclosporine: a report of the FK506 Kidney Transplant Study Group. | 1998 | Transplantation | pmid:9884269 |
| Fisher RA et al. | A prospective randomized trial of mycophenolate mofetil with neoral or tacrolimus after orthotopic liver transplantation. | 1998 | Transplantation | pmid:9884248 |
| Harrison S et al. | Stimulation of airway sensory nerves by cyclosporin A and FK506 in guinea-pig isolated bronchus. | 1998 | Br. J. Pharmacol. | pmid:9884067 |
| Herzberg GZ et al. | The effects of HLA mismatching and immunosuppressive therapy on early rejection outcome in pediatric heart transplant recipients. | 1998 | J. Heart Lung Transplant. | pmid:9883760 |
| Trajković V et al. | Cyclosporin A inhibits activation of inducible nitric oxide synthase in C6 glioma cell line. | 1999 | Brain Res. | pmid:9878697 |
| He G et al. | Modified surgical model of paratopic small bowel transplantation in mice. | 1998 | J. Surg. Res. | pmid:9878312 |
| Madsen JR et al. | Tacrolimus (FK506) increases neuronal expression of GAP-43 and improves functional recovery after spinal cord injury in rats. | 1998 | Exp. Neurol. | pmid:9878202 |
| Staruch MJ et al. | Distinctive calcineurin-dependent (FK506-sensitive) mechanisms regulate the production of the CC chemokines macrophage inflammatory protein (MIP)-1alpha, MIP-1beta, and RANTES vs IL-2 and TNF-alpha by activated human T cells. | 1998 | Cell. Immunol. | pmid:9878113 |
| Naruse K et al. | Uni-axial cyclic stretch induces c-src activation and translocation in human endothelial cells via SA channel activation. | 1998 | FEBS Lett. | pmid:9877176 |
| Murthy JN et al. | Tacrolimus metabolite cross-reactivity in different tacrolimus assays. | 1998 | Clin. Biochem. | pmid:9876892 |
| Takamatsu H et al. | Neuroprotective effects depend on the model of focal ischemia following middle cerebral artery occlusion. | 1998 | Eur. J. Pharmacol. | pmid:9874163 |
| Goulet MT et al. | C32-O-imidazol-2-yl-methyl ether derivatives of the immunosuppressant ascomycin with improved therapeutic potential. | 1998 | Bioorg. Med. Chem. Lett. | pmid:9873523 |
| Mohri T et al. | Rapid adhesion and spread of non-adherent colon cancer Colo201 cells induced by the protein kinase inhibitors, K252a and KT5720 and suppression of the adhesion by the immunosuppressants FK506 and cyclosporin A. | 1998 | Cell Struct. Funct. | pmid:9872566 |
| Schultz LW and Clardy J | Chemical inducers of dimerization: the atomic structure of FKBP12-FK1012A-FKBP12. | 1998 | Bioorg. Med. Chem. Lett. | pmid:9871618 |
| Kawai M et al. | Studies on an immunosuppressive macrolactam, ascomycin: synthesis of a C-33 hydroxyl derivative. | 1998 | Bioorg. Med. Chem. Lett. | pmid:9871515 |
| Pascual M et al. | Plasma exchange and tacrolimus-mycophenolate rescue for acute humoral rejection in kidney transplantation. | 1998 | Transplantation | pmid:9869086 |
| Sharma AK and Holder FE | Clostridium difficile diarrhea after use of tacrolimus following renal transplantation. | 1998 | Clin. Infect. Dis. | pmid:9868682 |
| Ong CS | Tacrolimus ointment for atopic dermatitis. | 1998 | N. Engl. J. Med. | pmid:9867560 |
| Marone G | Tacrolimus ointment for atopic dermatitis. | 1998 | N. Engl. J. Med. | pmid:9867559 |
| Onose J et al. | Ca2+-ATPase inhibitor induces IL-4 and MCP-1 production in RBL-2H3 cells. | 1998 | Immunol. Lett. | pmid:9865597 |
| Reis A et al. | Mycophenolate mofetil and FK506: two novel immunosuppressants in murine corneal transplantation. | 1998 | Transplant. Proc. | pmid:9865380 |
| EscartÃn A et al. | Analysis of pig-MAP after small bowel transplantation in pigs. | 1998 | Transplant. Proc. | pmid:9865377 |
| Odoul F et al. | Massive ingestion of tacrolimus in a young liver transplant patient. | 1998 | Transplant. Proc. | pmid:9865375 |
| Gerauer K et al. | Long-term cardiac allograft survival in mice treated with malononitrilamide 715. | 1998 | Transplant. Proc. | pmid:9865349 |
| Yokoyama I et al. | Immunosuppressant effect on Fas antigen expression and p53 of an experimental tumor. | 1998 | Transplant. Proc. | pmid:9865346 |
| Ahlmén J et al. | Positive effects of tacrolimus in a case of CIDP. | 1998 | Transplant. Proc. | pmid:9865344 |
| Schorlemmer HU and Kurrle R | Combination therapy of malononitrilamides and tacrolimus (FK 506) induced long-term xenograft survival. | 1998 | Transplant. Proc. | pmid:9865337 |
| Kilian K et al. | FK-506 (tacrolimus) therapy for an unusual SLE-like disease. | 1998 | Transplant. Proc. | pmid:9865322 |
| Metcalfe SM et al. | In vitro transcription and translation of the tumour suppressor protein P53: qualitative and quantitative effects of FK506 and rapamycin. | 1998 | Transplant. Proc. | pmid:9865315 |
| Schorlemmer HU et al. | Long-term allograft survival and tolerance induction by the synergistic activity of malononitrilamides and tacrolimus. | 1998 | Transplant. Proc. | pmid:9865312 |
| Braun F et al. | How to handle mycophenolate mofetil in combination with tacrolimus? | 1998 | Transplant. Proc. | pmid:9865309 |
| Daoud AJ et al. | A comparison of the safety and efficacy of mycophenolate mofetil, prednisone and cyclosporine and mycophenolate mofetil, and prednisone and tacrolimus. | 1998 | Transplant. Proc. | pmid:9865303 |
| du Toit DF et al. | Tacrolimus (FK506) monotherapy provides potent and significant suppression of allogeneic foetal rat pancreatic allograft rejection. | 1998 | Transplant. Proc. | pmid:9865300 |
| Fleck PR et al. | Tacrolimus use in kidney-pancreas recipients is associated with less acute renal dysfunction than cyclosporine. | 1998 | Transplant. Proc. | pmid:9865299 |
| Brunet M et al. | Therapeutic drug monitoring of tacrolimus in kidney transplantation: 9-month follow-up. | 1998 | Transplant. Proc. | pmid:9865298 |
| Moffatt SD et al. | Comparative efficacy of liposomal FK506 with FK506. | 1998 | Transplant. Proc. | pmid:9865297 |
| Opelz G | Evaluation of immunosuppressive induction regimens in renal transplantation. Collaborative Transplant Study. | 1998 | Transplant. Proc. | pmid:9865286 |
| Maggi U et al. | Hepatitis B and C virus-induced diseases and acute rejection after liver transplantation. | 1998 | Transplant. Proc. | pmid:9865255 |
| Shapiro VS et al. | Nuclear factor of activated T cells and AP-1 are insufficient for IL-2 promoter activation: requirement for CD28 up-regulation of RE/AP. | 1998 | J. Immunol. | pmid:9862666 |
| Paul C and Ho VC | Ascomycins in dermatology. | 1998 | Semin Cutan Med Surg | pmid:9859912 |
| Hamilton GS and Steiner JP | Immunophilins: beyond immunosuppression. | 1998 | J. Med. Chem. | pmid:9857082 |
| Olyaei AJ et al. | Interaction between tacrolimus and nefazodone in a stable renal transplant recipient. | 1998 Nov-Dec | Pharmacotherapy | pmid:9855339 |
| Hatori M et al. | Clinical and histopathologic examination of renal allografts treated with tacrolimus (FK506) for at least one year. | 1998 | Int. J. Urol. | pmid:9855119 |
| Brunet M et al. | Multicenter comparison of first- and second-generation IMx tacrolimus microparticle enzyme immunoassays in liver and kidney transplantation. | 1998 | Ther Drug Monit | pmid:9853987 |
| Pou L et al. | Therapeutic drug monitoring of tacrolimus in liver transplantation, phase III FK506 multicenter Spanish Study Group: a two-year follow-up. | 1998 | Ther Drug Monit | pmid:9853973 |
| Gammie JS et al. | Tacrolimus-based partial conditioning produces stable mixed lymphohematopoietic chimerism and tolerance for cardiac allografts. | 1998 | Circulation | pmid:9852899 |
| Nishida S et al. | Allograft rejection of small bowel transplantation in pigs. | 1998 | Surg. Today | pmid:9851621 |
| Laskow DA et al. | The role of tacrolimus in adult kidney transplantation: a review. | 1998 | Clin Transplant | pmid:9850440 |
| Reddy RK et al. | High-molecular-weight FK506-binding proteins are components of heat-shock protein 90 heterocomplexes in wheat germ lysate. | 1998 | Plant Physiol. | pmid:9847114 |
| Sohn HW et al. | Engagement of CD99 induces apoptosis through a calcineurin-independent pathway in Ewing's sarcoma cells. | 1998 | Am. J. Pathol. | pmid:9846983 |
| Jain AB et al. | A prospective randomized trial of tacrolimus and prednisone versus tacrolimus, prednisone, and mycophenolate mofetil in primary adult liver transplant recipients: an interim report. | 1998 | Transplantation | pmid:9846530 |
| Haug C et al. | Endothelin release by rabbit proximal tubule cells: modulatory effects of cyclosporine A, tacrolimus, HGF and EGF. | 1998 | Kidney Int. | pmid:9844139 |
| Aoki Y et al. | CsA-sensitive purine-box transcriptional regulator in bronchial epithelial cells contains NF45, NF90, and Ku. | 1998 | Am. J. Physiol. | pmid:9843854 |
| duBell WH et al. | Independent inhibition of calcineurin and K+ currents by the immunosuppressant FK-506 in rat ventricle. | 1998 | Am. J. Physiol. | pmid:9843803 |
| Wallemacq PE et al. | Pharmacokinetics of tacrolimus (FK506) in paediatric liver transplant recipients. | 1998 Jul-Sep | Eur J Drug Metab Pharmacokinet | pmid:9842978 |
| Hayashi M et al. | Characterization of allograft rejection in an experimental model of small intestinal transplantation. | 1998 Jul-Aug | J. Gastrointest. Surg. | pmid:9841989 |
| Kass L et al. | Inhibition of the calcineurin-like protein phosphatase activity in Limulus ventral eye photoreceptor cells alters the characteristics of the spontaneous quantal bumps and the light-mediated inward currents, and enhances arrestin phosphorylation. | 1998 Nov-Dec | Vis. Neurosci. | pmid:9839968 |
| del Castillo D et al. | Efficacy and safety of losartan in the treatment of hypertension in renal transplant recipients. | 1998 | Kidney Int. Suppl. | pmid:9839298 |
| Navarro-AntolÃn J et al. | CsA and FK506 up-regulate eNOS expression: role of reactive oxygen species and AP-1. | 1998 | Kidney Int. Suppl. | pmid:9839278 |
| Sho M et al. | Simultaneous inoculation of donor lymphocyte subsets with transplantation in a rat cardiac allograft model. | 1998 | Transplant. Proc. | pmid:9838696 |
| Sanada O et al. | Establishment of chimerism in donors by intraportal injection of recipient-type bone marrow cells with concomitant administration of FK 506 before liver transplantation prolongs liver allograft survival in rats. | 1998 | Transplant. Proc. | pmid:9838689 |
| Nishimura Y et al. | A trial to obtain donor-specific immunotolerance using a vascularized thymus allograft. | 1998 | Transplant. Proc. | pmid:9838684 |
| Fukushima N et al. | Prolonged survival of pig cardiac xenografts in baboons by sequential cardiac transplantation. | 1998 | Transplant. Proc. | pmid:9838671 |
| Takeda M et al. | Immunologic factors contributing to acute rejection in lungs xenotransplanted between primates. | 1998 | Transplant. Proc. | pmid:9838670 |
| Hattori R et al. | FK 506 in cadaveric kidney transplantation from non-heart-beating donors. | 1998 | Transplant. Proc. | pmid:9838666 |
| Watanabe Y et al. | Enteric absorption of FK 506: estimation by a block liver perfusion technique in rats. | 1998 | Transplant. Proc. | pmid:9838656 |
| Takada Y et al. | Energy metabolism of hepatic allografts subjected to prolonged warm ischemia and pharmacologic modulation with FK506 and platelet activating factor antagonist. | 1998 | Transplant. Proc. | pmid:9838621 |
| Watanabe K et al. | Prolongation effect of FK506 on the survival of 3-day preserved kidney allografts in dogs. | 1998 | Transplant. Proc. | pmid:9838579 |
| Yamauchi M et al. | Effects of FK506 on rat thymic microenvironment in thymocyte maturation, proliferation, and mobilization. | 1998 | Transplant. Proc. | pmid:9838578 |
| Yura H et al. | Development of a macromolecular prodrug of FK506: I. Synthesis of FK506-dextran conjugate. | 1998 | Transplant. Proc. | pmid:9838577 |
| Jeong HJ et al. | Vascular endothelin, TGF-beta, and PDGF expression in FK506 nephrotoxicity of rats. | 1998 | Transplant. Proc. | pmid:9838576 |
| Goh BL and Tan SY | FK506 "rescue" therapy complicated by renal tubular acidosis in renal allograft recipients. | 1998 | Transplant. Proc. | pmid:9838575 |
| Goh BL et al. | FK506 rescue therapy for acute renal allograft rejection. | 1998 | Transplant. Proc. | pmid:9838574 |
| Cheng HM et al. | Primary prophylaxis with tacrolimus in kidney transplants in China. | 1998 | Transplant. Proc. | pmid:9838573 |
| Hung CM et al. | Tacrolimus to rescue refractory hepatic allograft rejection: a collaborative study in Taiwan. | 1998 | Transplant. Proc. | pmid:9838572 |
| Lo CM et al. | Use of FK506 as primary or rescue therapy after liver transplantation in Hong Kong. | 1998 | Transplant. Proc. | pmid:9838571 |
| Shu KH et al. | A multicenter trial of FK506 as rescue therapy for renal transplant recipients in Taiwan. | 1998 | Transplant. Proc. | pmid:9838570 |