| MeSH term | MeSH ID | Detail |
|---|---|---|
| Inflammatory Bowel Diseases | D015212 | 9 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Diabetes Mellitus, Type 1 | D003922 | 56 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Fatty Liver | D005234 | 48 associated lipids |
| Cataract | D002386 | 34 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Carcas-Sansuán AJ | Limited sampling strategies for once daily tacrolimus exposure monitoring. | 2016 | Eur. J. Clin. Pharmacol. | pmid:26939899 |
| Hazama Y et al. | Effect of Physiological Changes in the Skin on Systemic Absorption of Tacrolimus Following Topical Application in Rats. | 2016 | Biol. Pharm. Bull. | pmid:26934927 |
| Iguchi A et al. | Graft-versus-host disease (GVHD) prophylaxis by using methotrexate decreases pre-engraftment syndrome and severe acute GVHD, and accelerates engraftment after cord blood transplantation. | 2016 | Pediatr Transplant | pmid:26526424 |
| Fukuta T et al. | Non-invasive evaluation of neuroprotective drug candidates for cerebral infarction by PET imaging of mitochondrial complex-I activity. | 2016 | Sci Rep | pmid:27440054 |
| Dugast E et al. | Failure of Calcineurin Inhibitor (Tacrolimus) Weaning Randomized Trial in Long-Term Stable Kidney Transplant Recipients. | 2016 | Am. J. Transplant. | pmid:27367750 |
| Lim SW et al. | Effect of Exendin-4 on Autophagy Clearance in Beta Cell of Rats with Tacrolimus-induced Diabetes Mellitus. | 2016 | Sci Rep | pmid:27436514 |
| Kolb M et al. | Risk Factors for Subtherapeutic Tacrolimus Levels after Conversion from Continuous Intravenous Infusion to Oral in Children after Allogeneic Hematopoietic Cell Transplantation. | 2016 | Biol. Blood Marrow Transplant. | pmid:26880117 |
| Arreola-Guerra JM et al. | Tacrolimus Trough Levels as a Risk Factor for Acute Rejection in Renal Transplant Patients. | 2016 | Ann. Transplant. | pmid:26879833 |
| Nie F et al. | [Post-transplant kidney from C-III donation after cardiac death of children: a clinicopathologic study of 20 cases]. | 2016 | Zhonghua Bing Li Xue Za Zhi | pmid:26879429 |
| Dharnidharka VR et al. | Differential risks for adverse outcomes 3 years after kidney transplantation based on initial immunosuppression regimen: a national study. | 2016 | Transpl. Int. | pmid:27564782 |
| Rostaing L et al. | Successful Transplantation in ABO- and HLA-Incompatible Living Kidney Transplant Patients: A Report on 12 Cases. | 2016 | Ther Apher Dial | pmid:27073167 |
| Armand P et al. | The addition of sirolimus to the graft-versus-host disease prophylaxis regimen in reduced intensity allogeneic stem cell transplantation for lymphoma: a multicentre randomized trial. | 2016 | Br. J. Haematol. | pmid:26729448 |
| Badr R et al. | Assessment of global ischemic/reperfusion and Tacrolimus administration on CA1 region of hippocampus: gene expression profiles of BAX and BCL2 genes. | 2016 | Bratisl Lek Listy | pmid:27546370 |
| Hanaoka K et al. | A chronic renal rejection model with a fully MHC-mismatched rat strain combination under immunosuppressive therapy. | 2016 | Transpl. Immunol. | pmid:27545900 |
| Matsa E et al. | Transcriptome Profiling of Patient-Specific Human iPSC-Cardiomyocytes Predicts Individual Drug Safety and Efficacy Responses In Vitro. | 2016 | Cell Stem Cell | pmid:27545504 |
| Thao le Q et al. | Pharmaceutical potential of tacrolimus-loaded albumin nanoparticles having targetability to rheumatoid arthritis tissues. | 2016 | Int J Pharm | pmid:26657273 |
| Mokuda S and Oiwa H | Successful treatment of FKBP51-expressed multicentric reticulohistiocytosis using combination therapy with low-dose denosumab and tacrolimus. | 2016 | Scand. J. Rheumatol. | pmid:26652057 |
| Yu H et al. | Risk factors for new-onset diabetes mellitus after living donor kidney transplantation in Korea - a retrospective single center study. | 2016 | BMC Nephrol | pmid:27473469 |
| Sakai R et al. | A comparison of tacrolimus and cyclosporine combined with methotrexate for graft-versus-host disease prophylaxis, stratified by stem cell source: a retrospective nationwide survey. | 2016 | Int. J. Hematol. | pmid:26800676 |
| Milgrom SA et al. | Graft-versus-host disease after radiation therapy in patients who have undergone allogeneic stem cell transplantation: two case reports. | 2016 | J Med Case Rep | pmid:27465468 |
| Pouché L et al. | New challenges and promises in solid organ transplantation pharmacogenetics: the genetic variability of proteins involved in the pharmacodynamics of immunosuppressive drugs. | 2016 | Pharmacogenomics | pmid:26799749 |
| Constantinescu AA et al. | Differential influence of tacrolimus and sirolimus on mitochondrial-dependent signaling for apoptosis in pancreatic cells. | 2016 | Mol. Cell. Biochem. | pmid:27344165 |
| Shao K et al. | Different Effects of Tacrolimus on Innate and Adaptive Immune Cells in the Allograft Transplantation. | 2016 | Scand. J. Immunol. | pmid:26524694 |
| Cena T et al. | De novo noncutaneous malignancies after kidney transplantation are associated with an increased risk of graft failure: results from a time-dependent analysis on 672 patients. | 2016 | Transpl. Int. | pmid:27343849 |
| Binkhathlan Z et al. | Reutilization of Tacrolimus Extracted from Expired Prograf® Capsules: Physical, Chemical, and Pharmacological Assessment. | 2016 | AAPS PharmSciTech | pmid:26729529 |
| Chacon A and Mercer J | Successful management of angiolymphoid hyperplasia with eosinophilia in a split-face trial of topical tacrolimus and timolol solution. | 2016 | G Ital Dermatol Venereol | pmid:25014586 |
| Pizzo HP et al. | Sirolimus and tacrolimus coefficient of variation is associated with rejection, donor-specific antibodies, and nonadherence. | 2016 | Pediatr. Nephrol. | pmid:27286686 |
| Fernández de Castillo Torras L et al. | Treatment with ulipristal acetate (Esmya(®)) and plasma levels of tacrolimus: a case report. | 2016 | Eur. J. Obstet. Gynecol. Reprod. Biol. | pmid:27282803 |
| Ferjani H et al. | The evaluate and compare the effects of the Tacrolimus and Sirolimus on the intestinal system using an intestinal cell culture model. | 2016 | Toxicol. Mech. Methods | pmid:26460985 |
| Serrano-Mollar A et al. | Safety and Tolerability of Alveolar Type II Cell Transplantation in Idiopathic Pulmonary Fibrosis. | 2016 | Chest | pmid:27020420 |
| Seok J et al. | Recalcitrant steroid-induced rosacea successfully treated with 0.03% tacrolimus and 595-nm pulsed dye laser. | 2016 | Eur J Dermatol | pmid:27193042 |
| Sisti A et al. | Effectiveness and safety of topical tacrolimus monotherapy for repigmentation in vitiligo: a comprehensive literature review. | 2016 | An Bras Dermatol | pmid:27192518 |
| Rao B et al. | Use of Everolimus After Multivisceral Transplantation: A Report of Two Cases. | 2016 | Transplant. Proc. | pmid:27109983 |
| Chang HK et al. | Ten-Year Experience With Bowel Transplantation at Seoul St. Mary's Hospital. | 2016 | Transplant. Proc. | pmid:27109981 |
| Felix MJ et al. | Time-Dependent and Immunosuppressive Drug-Associated Adverse Event Profiles in De Novo Kidney Transplant Recipients Converted from Tacrolimus to Sirolimus Regimens. | 2016 | Pharmacotherapy | pmid:26799522 |
| Kishida N et al. | Increased Incidence of Thrombotic Microangiopathy After ABO-Incompatible Living Donor Liver Transplantation. | 2016 | Ann. Transplant. | pmid:27956735 |
| Jimbo H et al. | Telangiectatic lichen sclerosus on the cheek successfully treated with topical tacrolimus. | 2016 | Eur J Dermatol | pmid:27033557 |
| Shimizu K et al. | Specific delivery of an immunosuppressive drug to splenic B cells by antigen-modified liposomes and its antiallergic effect. | 2016 | J Drug Target | pmid:27030163 |
| Ha DH et al. | Potential differentiation ability of gingiva originated human mesenchymal stem cell in the presence of tacrolimus. | 2016 | Sci Rep | pmid:27721434 |
| Li H et al. | Resistance reversal induced by a combination of fluconazole and tacrolimus (FK506) in Candida glabrata. | 2015 | J. Med. Microbiol. | pmid:25355935 |
| Pamuk F et al. | Evaluation of gingival alterations in rats medicated with cyclosporine A, tacrolimus and sirolimus: a stereological study. | 2015 | J. Periodont. Res. | pmid:25399832 |
| Koreth J et al. | A Bortezomib-Based Regimen Offers Promising Survival and Graft-versus-Host Disease Prophylaxis in Myeloablative HLA-Mismatched and Unrelated Donor Transplantation: A Phase II Trial. | 2015 | Biol. Blood Marrow Transplant. | pmid:26055298 |
| Sikma MA et al. | Pharmacokinetics and Toxicity of Tacrolimus Early After Heart and Lung Transplantation. | 2015 | Am. J. Transplant. | pmid:26053114 |
| Rozman Peterka T et al. | Solid state compatibility study and characterization of a novel degradation product of tacrolimus in formulation. | 2015 | J Pharm Biomed Anal | pmid:25804434 |
| Cortes X et al. | Successful use of infliximab and tacrolimus in a patient with Crohn's disease. | 2015 | Int J Clin Pharmacol Ther | pmid:25997551 |
| Takahashi N et al. | Concomitant methotrexate and tacrolimus augment the clinical response to abatacept in patients with rheumatoid arthritis with a prior history of biological DMARD use. | 2015 | Rheumatol. Int. | pmid:25991396 |
| Brännström M et al. | Livebirth after uterus transplantation. | 2015 | Lancet | pmid:25301505 |
| de Weerd AE et al. | ABO-incompatible kidney transplant recipients have a higher bleeding risk after antigen-specific immunoadsorption. | 2015 | Transpl. Int. | pmid:25070762 |
| Yahng SA et al. | A well-tolerated regimen of 800 cGy TBI-fludarabine-busulfan-ATG for reliable engraftment after unmanipulated haploidentical peripheral blood stem cell transplantation in adult patients with acute myeloid leukemia. | 2015 | Biol. Blood Marrow Transplant. | pmid:25300871 |
| Cheng S and Rodier F | Manipulating senescence in health and disease: emerging tools. | 2015 | Cell Cycle | pmid:25928330 |
| Hricik DE et al. | Adverse Outcomes of Tacrolimus Withdrawal in Immune-Quiescent Kidney Transplant Recipients. | 2015 | J. Am. Soc. Nephrol. | pmid:25925687 |
| Matas AJ and Gaston RS | Moving Beyond Minimization Trials in Kidney Transplantation. | 2015 | J. Am. Soc. Nephrol. | pmid:25925686 |
| Bogéa TH et al. | Light Induces Ultrastructural Changes in Rod Outer and Inner Segments, Including Autophagy, in a Transgenic Xenopus laevis P23H Rhodopsin Model of Retinitis Pigmentosa. | 2015 | Invest. Ophthalmol. Vis. Sci. | pmid:26720441 |
| Hiraoka S et al. | The earliest trough concentration predicts the dose of tacrolimus required for remission induction therapy in ulcerative colitis patients. | 2015 | BMC Gastroenterol | pmid:25925267 |
| Falloon K et al. | Characterization of the FKBP12-Encoding Genes in Aspergillus fumigatus. | 2015 | PLoS ONE | pmid:26366742 |
| Nashan B et al. | Evaluating the efficacy, safety and evolution of renal function with early initiation of everolimus-facilitated tacrolimus reduction in de novo liver transplant recipients: Study protocol for a randomized controlled trial. | 2015 | Trials | pmid:25873064 |
| Ramachandran R et al. | Chronic nephrotoxicity limits successful use of Tacrolimus in the management of adult steroid-dependent minimal change disease. | 2015 | Nephrology (Carlton) | pmid:25872662 |
| Shahraki M et al. | Influence of Tacrolimus (FK506) on Nerve Regeneration Using Allografts: A Rat Sciatic Nerve Model. | 2015 | J. Oral Maxillofac. Surg. | pmid:25869987 |
| Zhu L et al. | Effects of CYP3A5 genotypes, ABCB1 C3435T and G2677T/A polymorphism on pharmacokinetics of Tacrolimus in Chinese adult liver transplant patients. | 2015 | Xenobiotica | pmid:25869250 |
| Dastgheib L et al. | Assessment of the adjuvant effect of tacrolimus in the management of pemphigus vulgaris: A randomized controlled trial. | 2015 | J Dermatolog Treat | pmid:24552352 |
| RodrÃguez-RodrÃguez AE et al. | Glucose homeostasis changes and pancreatic β-cell proliferation after switching to cyclosporin in tacrolimus-induced diabetes mellitus. | 2015 | Nefrologia | pmid:26299169 |
| Hlavaty KA et al. | Cellular and molecular targeting for nanotherapeutics in transplantation tolerance. | 2015 | Clin. Immunol. | pmid:25805659 |
| Halvorsen JA and Aasebø W | Oral tacrolimus treatment of pruritus in prurigo nodularis. | 2015 | Acta Derm. Venereol. | pmid:25804254 |
| Sigurgeirsson B et al. | Safety and efficacy of pimecrolimus in atopic dermatitis: a 5-year randomized trial. | 2015 | Pediatrics | pmid:25802354 |
| Garritsen FM et al. | Ten years experience with oral immunosuppressive treatment in adult patients with atopic dermatitis in two academic centres. | 2015 | J Eur Acad Dermatol Venereol | pmid:25752497 |
| Wu D et al. | BK Virus-Associated Nephropathy with Plasma Cell-Rich Infiltrates Treated by Bortezomib-Based Regimen. | 2015 | Exp Clin Transplant | pmid:25748726 |
| Jo GA et al. | Isolation and characterization of a 17-kDa FKBP-type peptidyl-prolyl cis/trans isomerase from Vibrio anguillarum. | 2015 | Protein Expr. Purif. | pmid:25747528 |
| Tachibana T et al. | Successful Engraftment and Durable Graft-versus-host Disease Control with Haploidentical Peripheral Blood and a Short-term Conditioning Regimen for Primary Graft Failure. | 2015 | Intern. Med. | pmid:26521905 |
| Liu J et al. | Adherence to Immunosuppressive Medication in Renal Transplant Recipients From Follow-up Outpatient in China: Association of 2 Different Measurement Methods. | 2015 | Clin Ther | pmid:26519232 |
| Guerra Júnior AA et al. | Cyclosporine versus tacrolimus: cost-effectiveness analysis for renal transplantation in Brazil. | 2015 | Rev Saude Publica | pmid:25741648 |
| Kawakami K et al. | Effects of oral tacrolimus as a rapid induction therapy in ulcerative colitis. | 2015 | World J. Gastroenterol. | pmid:25684955 |
| Al Gain M et al. | [Sirolimus-induced lymphedema in a kidney-transplant recipient: Partial recovery after changeover to tacrolimus]. | 2015 | Ann Dermatol Venereol | pmid:25683011 |
| Ikeya K et al. | Tacrolimus for remission induction in ulcerative colitis: Mayo endoscopic subscore 0 and 1 predict long-term prognosis. | 2015 | Dig Liver Dis | pmid:25682993 |
| Zhao L et al. | Bovine serum albumin nanoparticles for delivery of tacrolimus to reduce its kidney uptake and functional nephrotoxicity. | 2015 | Int J Pharm | pmid:25681723 |
| Kim S et al. | Reduction of increased calcineurin activity rescues impaired homeostatic synaptic plasticity in presenilin 1 M146V mutant. | 2015 | Neurobiol. Aging | pmid:26455952 |
| Fukuta T et al. | Treatment of stroke with liposomal neuroprotective agents under cerebral ischemia conditions. | 2015 | Eur J Pharm Biopharm | pmid:26455340 |
| BuendÃa JA et al. | Combinational Effect of CYP3A5 and MDR-1 Polymorphisms on Tacrolimus Pharmacokinetics in Liver Transplant Patients. | 2015 | Exp Clin Transplant | pmid:26450467 |
| Cuellar-Rodriguez J et al. | Matched related and unrelated donor hematopoietic stem cell transplantation for DOCK8 deficiency. | 2015 | Biol. Blood Marrow Transplant. | pmid:25636378 |
| Schoettler M et al. | Treatment and outcomes of immune cytopenias following solid organ transplant in children. | 2015 | Pediatr Blood Cancer | pmid:25308853 |
| Chung H et al. | Renal transplantation: better fat than thin. | 2015 | J. Surg. Res. | pmid:25634827 |
| Pennington CA and Park JM | Sublingual tacrolimus as an alternative to oral administration for solid organ transplant recipients. | 2015 | Am J Health Syst Pharm | pmid:25631834 |
| Mok CC | Mycophenolate mofetil for lupus nephritis: an update. | 2015 | Expert Rev Clin Immunol | pmid:26364748 |
| Satake K et al. | Olopatadine hydrochloride suppresses hot flashes induced by topical treatment with tacrolimus ointment in rats. | 2015 | Eur. J. Pharmacol. | pmid:26362749 |
| Gao L and Sun Y | In vitro interactions of antifungal agents and tacrolimus against Aspergillus biofilms. | 2015 | Antimicrob. Agents Chemother. | pmid:26303797 |
| Iwamoto T et al. | Effect of Genetic Polymorphism of CYP3A5 and CYP2C19 and Concomitant Use of Voriconazole on Blood Tacrolimus Concentration in Patients Receiving Hematopoietic Stem Cell Transplantation. | 2015 | Ther Drug Monit | pmid:25565672 |
| Yao X et al. | Limited Sampling Strategy for Mycophenolic Acid in Chinese Kidney Transplant Recipients Receiving Enteric-Coated Mycophenolate Sodium and Tacrolimus During the Early Posttransplantation Phase. | 2015 | Ther Drug Monit | pmid:25565669 |
| Nelson R et al. | Sirolimus, tacrolimus and antithymocyte globulin as GVHD prophylaxis in HLA-mismatched unrelated donor hematopoietic cell transplantation: a single institution experience. | 2015 | Bone Marrow Transplant. | pmid:26301969 |
| Lemaitre F et al. | Pharmacokinetics and pharmacodynamics of tacrolimus in liver transplant recipients: inside the white blood cells. | 2015 | Clin. Biochem. | pmid:25562187 |
| Tedesco-Silva H et al. | Reduced Incidence of Cytomegalovirus Infection in Kidney Transplant Recipients Receiving Everolimus and Reduced Tacrolimus Doses. | 2015 | Am. J. Transplant. | pmid:25988935 |
| Bauters T et al. | Practical considerations in the use of intravenous tacrolimus in hematopoietic stem cell transplantation patients. | 2015 | J Oncol Pharm Pract | pmid:24748582 |
| Tornatore KM et al. | Influence of sex and race on mycophenolic acid pharmacokinetics in stable African American and Caucasian renal transplant recipients. | 2015 | Clin Pharmacokinet | pmid:25511793 |
| Zhu LQ et al. | Posterior reversible encephalopathy syndrome and graft-versus-host disease after liver transplantation: a case report and review of the literature. | 2015 | Int J Clin Pharmacol Ther | pmid:26227100 |
| Lu YX et al. | A population pharmacokinetic study of tacrolimus in healthy Chinese volunteers and liver transplant patients. | 2015 | Acta Pharmacol. Sin. | pmid:25500866 |
| Zhang JJ et al. | The genetic polymorphisms of POR*28 and CYP3A5*3 significantly influence the pharmacokinetics of tacrolimus in Chinese renal transplant recipients. | 2015 | Int J Clin Pharmacol Ther | pmid:26227094 |
| Jung JW et al. | Long-term result of maintenance treatment with tacrolimus ointment in chronic ocular graft-versus-host disease. | 2015 | Am. J. Ophthalmol. | pmid:25498356 |
| Roberts WK et al. | A destructive feedback loop mediated by CXCL10 in central nervous system inflammatory disease. | 2015 | Ann. Neurol. | pmid:26224283 |
| Kloster-Jensen K et al. | Intracellular sirolimus concentration is reduced by tacrolimus in human pancreatic islets in vitro. | 2015 | Transpl. Int. | pmid:26046470 |
| Peake RW et al. | Multicenter evaluation of the thermo scientific prelude for measurement of immunosuppressant drugs using sample preparation liquid chromatography-tandem mass spectrometry. | 2015 | Ther Drug Monit | pmid:25072947 |
| Mettang T and Kremer AE | Uremic pruritus. | 2015 | Kidney Int. | pmid:24402092 |
| Lancia P et al. | Choosing the right dose of tacrolimus. | 2015 | Arch. Dis. Child. | pmid:25416736 |