| MeSH term | MeSH ID | Detail |
|---|---|---|
| Inflammatory Bowel Diseases | D015212 | 9 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Diabetes Mellitus, Type 1 | D003922 | 56 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Fatty Liver | D005234 | 48 associated lipids |
| Cataract | D002386 | 34 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Velasco-Guardado A et al. | Potential protective effect of Helicobacter pylori on the development of gastrointestinal GvHD. | 2016 | Bone Marrow Transplant. | pmid:26950379 |
| Kloster-Jensen K et al. | Treatment with Tacrolimus and Sirolimus Reveals No Additional Adverse Effects on Human Islets In Vitro Compared to Each Drug Alone but They Are Reduced by Adding Glucocorticoids. | 2016 | J Diabetes Res | pmid:26885529 |
| Shen X et al. | Calcineurin inhibitors cyclosporin A and tacrolimus protect against podocyte injury induced by puromycin aminonucleoside in rodent models. | 2016 | Sci Rep | pmid:27580845 |
| Khan S et al. | Tacrolimus-loaded nanostructured lipid carriers for oral delivery-in vivo bioavailability enhancement. | 2016 | Eur J Pharm Biopharm | pmid:27793753 |
| Andrews LM et al. | Consideration of the ethnic prevalence of genotypes in the clinical use of tacrolimus. | 2016 | Pharmacogenomics | pmid:27790923 |
| Högerle BA et al. | Challenging immunosuppression treatment in lung transplant recipients with kidney failure. | 2016 | Transpl. Immunol. | pmid:26892232 |
| Kimura H et al. | Has widespread use of biologic and immunosuppressant therapy for ulcerative colitis affected surgical trends? Results of a questionnaire survey of surgical institutions in Japan. | 2016 | Surg. Today | pmid:26467558 |
| Brooks E et al. | Population Pharmacokinetic Modelling and Bayesian Estimation of Tacrolimus Exposure: Is this Clinically Useful for Dosage Prediction Yet? | 2016 | Clin Pharmacokinet | pmid:27138787 |
| Rebora A | Tacrolimus and oral lichen planus. Possible absorption after mucosal application? | 2016 | J Eur Acad Dermatol Venereol | pmid:26372839 |
| Ohe M et al. | A case of lupus nephritis treated with clarithromycin, tacrolimus, and glucocorticoids. | 2016 | Kaohsiung J. Med. Sci. | pmid:27638410 |
| Wang N et al. | Paclitaxel and Tacrolimus Coencapsulated Polymeric Micelles That Enhance the Therapeutic Effect of Drug-Resistant Ovarian Cancer. | 2016 | ACS Appl Mater Interfaces | pmid:26809267 |
| Gabriel D et al. | Improved topical delivery of tacrolimus: A novel composite hydrogel formulation for the treatment of psoriasis. | 2016 | J Control Release | pmid:27639683 |
| Vasu S et al. | Granulocyte Colony-Stimulating Factor-Mobilized Allografts Contain Activated Immune Cell Subsets Associated with Risk of Acute and Chronic Graft-versus-Host Disease. | 2016 | Biol. Blood Marrow Transplant. | pmid:26743340 |
| Yoo EC et al. | Developmental changes of MPA exposure in children. | 2016 | Pediatr. Nephrol. | pmid:26743220 |
| Sommerer C et al. | Design and rationale of the ATHENA study--A 12-month, multicentre, prospective study evaluating the outcomes of a de novo everolimus-based regimen in combination with reduced cyclosporine or tacrolimus versus a standard regimen in kidney transplant patients: study protocol for a randomised controlled trial. | 2016 | Trials | pmid:26888217 |
| Haasova M et al. | Immunosuppressive therapy for kidney transplantation in children and adolescents: systematic review and economic evaluation. | 2016 | Health Technol Assess | pmid:27557331 |
| Bapur Erduran F and Adışen E | Comparison of the efficacy of 308-nm excimer lamp monotherapy with topical tacrolimus or clobetasol 17-propionate combination therapies in localized vitiligo. | 2016 | Photodermatol Photoimmunol Photomed | pmid:27552312 |
| Tsuji T et al. | Therapeutic approach to mite-induced intractable dermatitis using novel immunomodulator FTY720 ointment (fingolimod) in NC/Nga mice. | 2016 | Allergol Int | pmid:26666476 |
| Speckmann T et al. | Npas4 Transcription Factor Expression Is Regulated by Calcium Signaling Pathways and Prevents Tacrolimus-induced Cytotoxicity in Pancreatic Beta Cells. | 2016 | J. Biol. Chem. | pmid:26663079 |
| Ren H et al. | Phosphatase inhibition increases AQP2 accumulation in the rat IMCD apical plasma membrane. | 2016 | Am. J. Physiol. Renal Physiol. | pmid:27488997 |
| Woolner K and Sauder M | Periorbital erythema following alcohol ingestion during treatment with topical tacrolimus. | 2016 | CMAJ | pmid:26598374 |
| Park JS et al. | A rapid and sensitive method to determine tacrolimus in rat whole blood using liquid-liquid extraction with mild temperature ultrasonication and LC-MS/MS. | 2016 | Arch. Pharm. Res. | pmid:26589688 |
| Dabrowska-Zamojcin E et al. | CCL2 gene polymorphism is associated with post-transplant diabetes mellitus. | 2016 | Int. Immunopharmacol. | pmid:26802601 |
| Tanriover B et al. | Acute Rejection Rates and Graft Outcomes According to Induction Regimen among Recipients of Kidneys from Deceased Donors Treated with Tacrolimus and Mycophenolate. | 2016 | Clin J Am Soc Nephrol | pmid:27364616 |
| Ordóñez-Robles M et al. | Target genes of the Streptomyces tsukubaensis FkbN regulator include most of the tacrolimus biosynthesis genes, a phosphopantetheinyl transferase and other PKS genes. | 2016 | Appl. Microbiol. Biotechnol. | pmid:27357227 |
| Handisurya A et al. | Conversion from Tacrolimus to Cyclosporine A Improves Glucose Tolerance in HCV-Positive Renal Transplant Recipients. | 2016 | PLoS ONE | pmid:26735686 |
| Tsuji H et al. | Efficacy and Safety of Grapefruit Juice Intake Accompanying Tacrolimus Treatment in Connective Tissue Disease Patients. | 2016 | Intern. Med. | pmid:27301503 |
| Menninga NJ et al. | Restless Legs Syndrome Following Lung Transplantation: Prevalence and Relationship With Tacrolimus Exposure. | 2016 | Prog Transplant | pmid:27207403 |
| Jebabli N et al. | Consequences of erroneous phone transmission of tacrolimus blood concentration: A case report. | 2016 | Therapie | pmid:27203160 |
| Reeves TM et al. | Targeting Kv1.3 channels to reduce white matter pathology after traumatic brain injury. | 2016 | Exp. Neurol. | pmid:27302680 |
| Matsukawa T et al. | Reduced-dose methotrexate in combination with tacrolimus was associated with rapid engraftment and recovery from oral mucositis without affecting the incidence of GVHD. | 2016 | Int. J. Hematol. | pmid:27119977 |
| Peng L et al. | Comparison of different therapies in high-risk patients with idiopathic membranous nephropathy. | 2016 | J. Formos. Med. Assoc. | pmid:26315481 |
| Ruangkanchanasetr P et al. | Beta Cell Function and Insulin Resistance After Conversion from Tacrolimus Twice-Daily to Extended-Release Tacrolimus Once-Daily in Stable Renal Transplant Recipients. | 2016 | Ann. Transplant. | pmid:27980321 |
| Castagna L et al. | Tacrolimus compared with cyclosporine A after haploidentical T-cell replete transplantation with post-infusion cyclophosphamide. | 2016 | Bone Marrow Transplant. | pmid:26595078 |
| Yamamoto T et al. | Editorial: tacrolimus vs. anti-tumour necrosis factor agents for moderately to severely active ulcerative colitis--authors' reply. | 2016 | Aliment. Pharmacol. Ther. | pmid:27040167 |
| Taylor KM and Sparrow MP | Editorial: tacrolimus vs. anti-tumour necrosis factor agents for moderately to severely active ulcerative colitis. | 2016 | Aliment. Pharmacol. Ther. | pmid:27040166 |
| Lonowski S et al. | Vitiligo: a potential autoimmune sequela of DRESS syndrome. | 2016 | Br. J. Dermatol. | pmid:27038429 |
| GarcÃa-Bello JA et al. | Effect of Immunosuppressive Therapy on Cardiovascular Risk Factor Prevalence in Kidney-Transplanted Children: Comparative Study. | 2016 | Transplant. Proc. | pmid:27110020 |
| Gu C et al. | Triptolide Reduces the Required Dose of Tacrolimus by Attenuating Inflammation, Enhancing Immunosuppression, and Increasing Donor Chimerism in a Heterotopic Hindlimb Transplantation Model. | 2016 | Plast. Reconstr. Surg. | pmid:27879593 |
| Meng QH et al. | Falsely elevated tacrolimus concentrations on the Dimension Xpand. | 2015 | Clin. Biochem. | pmid:26160209 |
| Fischer L et al. | Three-year Outcomes in De Novo Liver Transplant Patients Receiving Everolimus With Reduced Tacrolimus: Follow-Up Results From a Randomized, Multicenter Study. | 2015 | Transplantation | pmid:26151607 |
| Spolidorio LC et al. | The long-term administration of calcineurin inhibitors decreases antioxidant enzyme activity in the rat parotid and submandibular salivary glands. | 2015 | Life Sci. | pmid:26006038 |
| Ali H et al. | Mycophenolate mofetil-based salvage as acute GVHD prophylaxis after early discontinuation of tacrolimus and/or sirolimus. | 2015 | Bone Marrow Transplant. | pmid:25365064 |
| Lee SC et al. | Calcineurin orchestrates dimorphic transitions, antifungal drug responses and host-pathogen interactions of the pathogenic mucoralean fungus Mucor circinelloides. | 2015 | Mol. Microbiol. | pmid:26010100 |
| Sato K et al. | Late onset of progressive speech impairment due to tacrolimus-associated leukoencephalopathy after kidney transplantation. | 2015 | Int Urol Nephrol | pmid:26071870 |
| Pulk RA et al. | Multigene predictors of tacrolimus exposure in kidney transplant recipients. | 2015 | Pharmacogenomics | pmid:26067485 |
| Chen YB et al. | Phase II Trial of Tandem High-Dose Chemotherapy with Autologous Stem Cell Transplantation Followed by Reduced-Intensity Allogeneic Stem Cell Transplantation for Patients with High-Risk Lymphoma. | 2015 | Biol. Blood Marrow Transplant. | pmid:26009261 |
| Ribero S et al. | Efficacy of topical tacrolimus for oral lichen planus: real-life experience in a retrospective cohort of patients with a review of the literature. | 2015 | J Eur Acad Dermatol Venereol | pmid:25308924 |
| Revollo J | Update on the clinical utility of once-daily tacrolimus in the management of transplantation. | 2015 | Drug Des Devel Ther | pmid:26005334 |
| Qasim W et al. | Immunotherapy of HCC metastases with autologous T cell receptor redirected T cells, targeting HBsAg in a liver transplant patient. | 2015 | J. Hepatol. | pmid:25308176 |
| Chan TM | Treatment of severe lupus nephritis: the new horizon. | 2015 | Nat Rev Nephrol | pmid:25421826 |
| Andreu F et al. | Development of a population PK model of tacrolimus for adaptive dosage control in stable kidney transplant patients. | 2015 | Ther Drug Monit | pmid:25254416 |
| Fussner LA et al. | Cardiovascular disease after liver transplantation: When, What, and Who Is at Risk. | 2015 | Liver Transpl. | pmid:25880971 |
| Abuabara K et al. | Atopic dermatitis disease control and age: A cohort study. | 2015 | J. Allergy Clin. Immunol. | pmid:25935107 |
| Clark SL et al. | Making every drop count for pediatric kidney transplant patients. | 2015 | Hosp Pediatr | pmid:25934814 |
| Ikitimur B et al. | Long-Term Impact of Different Immunosuppressive Drugs on QT and PR Intervals in Renal Transplant Patients. | 2015 | Ann Noninvasive Electrocardiol | pmid:25367596 |
| Ganetsky A et al. | Lack of a significant pharmacokinetic interaction between maraviroc and tacrolimus in allogeneic HSCT recipients. | 2015 | J. Antimicrob. Chemother. | pmid:25881619 |
| Goldthorpe H et al. | Occlusive lung arterial lesions in endothelial-targeted, fas-induced apoptosis transgenic mice. | 2015 | Am. J. Respir. Cell Mol. Biol. | pmid:25879383 |
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| Chapron B et al. | Reversible, time-dependent inhibition of CYP3A-mediated metabolism of midazolam and tacrolimus by telaprevir in human liver microsomes. | 2015 | J Pharm Pharm Sci | pmid:25877445 |
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| Luo X et al. | Evaluation of 6β-Hydroxycortisol and 6β-Hydroxycortisone as Biomarkers for Cytochrome P450 3A Activity: Insight into Their Predictive Value for Estimating Oral Immunosuppressant Metabolism. | 2015 | J Pharm Sci | pmid:26150050 |
| Chen QJ et al. | Tacrolimus decreases insulin sensitivity without reducing fasting insulin concentration: a 2-year follow-up study in kidney transplant recipients. | 2015 | Ren Fail | pmid:25644968 |
| Herbst S et al. | Phagocytosis-dependent activation of a TLR9-BTK-calcineurin-NFAT pathway co-ordinates innate immunity to Aspergillus fumigatus. | 2015 | EMBO Mol Med | pmid:25637383 |
| Joneja U and Uppal G | Pseudo-Pelger-Huët anomaly in a patient on tacrolimus. | 2015 | Blood | pmid:26371350 |
| Ustundag UV et al. | The effects of tacrolimus on the activity and expression of tissue factor in the rat ovary with ischemia-reperfusion induced injury. | 2015 | Reprod Biol | pmid:26370456 |
| Kawahara T et al. | Cyclosporine A and tacrolimus inhibit bladder cancer growth through down-regulation of NFATc1. | 2015 | Oncotarget | pmid:25638160 |
| Dagher M et al. | Overweight, central obesity, and cardiometabolic risk factors in pediatric liver transplantation. | 2015 | Pediatr Transplant | pmid:25581506 |
| Kita A et al. | Imp2, the PSTPIP homolog in fission yeast, affects sensitivity to the immunosuppressant FK506 and membrane trafficking in fission yeast. | 2015 | Biochem. Biophys. Res. Commun. | pmid:25580011 |
| Cortina G et al. | De novo tacrolimus-induced thrombotic microangiopathy in the early stage after renal transplantation successfully treated with conversion to everolimus. | 2015 | Pediatr. Nephrol. | pmid:25577332 |
| Annunziato RA et al. | Can transition to adult care for transplant recipients be improved by intensified services while patients are still in pediatrics? | 2015 | Prog Transplant | pmid:26308783 |
| Pape E et al. | Management of Tacrolimus-Telaprevir Drug-Drug Interaction in a Liver Transplant Patient With Hepatitis C Virus: Practical Considerations. | 2015 | Transplantation | pmid:26308424 |
| Park J et al. | Iron overload triggers mitochondrial fragmentation via calcineurin-sensitive signals in HT-22 hippocampal neuron cells. | 2015 | Toxicology | pmid:26318285 |
| Kurita T et al. | The efficacy of tacrolimus in patients with interstitial lung diseases complicated with polymyositis or dermatomyositis. | 2015 | Rheumatology (Oxford) | pmid:24764266 |
| Cavalié M et al. | Maintenance therapy of adult vitiligo with 0.1% tacrolimus ointment: a randomized, double blind, placebo-controlled study. | 2015 | J. Invest. Dermatol. | pmid:25521460 |
| Reddy YN et al. | Is there a genetic predisposition to new-onset diabetes after kidney transplantation? | 2015 | Saudi J Kidney Dis Transpl | pmid:26586047 |
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| Millner L et al. | A clinical approach to solving discrepancies in therapeutic drug monitoring results for patients on sirolimus or tacrolimus: Towards personalized medicine, immunosuppression and pharmacogenomics. | 2015 | Clin. Chim. Acta | pmid:26232156 |
| Li JL et al. | Interactive effects of CYP3A4, CYP3A5, MDR1 and NR1I2 polymorphisms on tracrolimus trough concentrations in early postrenal transplant recipients. | 2015 | Pharmacogenomics | pmid:26228923 |
| Li YX and Dijkers PF | Specific calcineurin isoforms are involved in Drosophila toll immune signaling. | 2015 | J. Immunol. | pmid:25429067 |
| Allison SJ | Lupus nephritis: Multitarget induction therapy for LN. | 2015 | Nat Rev Nephrol | pmid:25421833 |
| Tan ES et al. | Effective treatment of scrotal lichen simplex chronicus with 0.1% tacrolimus ointment: an observational study. | 2015 | J Eur Acad Dermatol Venereol | pmid:24666218 |