| MeSH term | MeSH ID | Detail |
|---|---|---|
| Inflammatory Bowel Diseases | D015212 | 9 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Diabetes Mellitus, Type 1 | D003922 | 56 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Fatty Liver | D005234 | 48 associated lipids |
| Cataract | D002386 | 34 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kiang D et al. | Cloning the gene encoding Schistosoma mansoni p50, an immunophilin. | 1996 | Gene | pmid:8621074 |
| Roth D et al. | A prospective study of hepatitis C virus infection in renal allograft recipients. | 1996 | Transplantation | pmid:8623154 |
| Koprak S et al. | Depletion of the mature CD4+8- thymocyte subset by FK506 analogs correlates with their immunosuppressive and calcineurin inhibitory activities. | 1996 | Transplantation | pmid:8623162 |
| Ciancio G et al. | Current advantage of FK 506 in cadaveric kidney transplantation. | 1996 | Transplant. Proc. | pmid:8623207 |
| Pham SM et al. | Tacrolimus (FK 506) in clinical cardiac transplantation: a five-year experience. | 1996 | Transplant. Proc. | pmid:8623208 |
| Satomura K et al. | Pharmacokinetics of FK 506 in living-related liver transplantation. | 1996 | Transplant. Proc. | pmid:8623209 |
| Loss M et al. | Glucose and lipid metabolism in liver transplant patients under long-term tacrolimus (FK 506) monotherapy. | 1996 | Transplant. Proc. | pmid:8623210 |
| Bechstein WO et al. | Tacrolimus (FK 506) therapy is associated with a significant reduction in immunosuppressive treatment failures following primary liver transplantation. | 1996 | Transplant. Proc. | pmid:8623211 |
| Kogi M et al. | Effects of calyculin A and FK506 on the O2- generation of rat peritoneal macrophages. | 1996 | Tokai J. Exp. Clin. Med. | pmid:9239803 |
| Harrison DM et al. | Reduction in hospital stay after liver transplantation. | 1996 | Transplant. Proc. | pmid:8623451 |
| Andrews WS et al. | Comparison of cyclosporine- vs tacrolimus-based immunosuppression in pediatric liver transplantation. | 1996 | Transplant. Proc. | pmid:8623452 |
| Ketel BL et al. | Tacrolimus-based vs cyclosporine-based immunotherapy in combined kidney-pancreas transplantation. | 1996 | Transplant. Proc. | pmid:8623453 |
| Kyo M et al. | Results with histological diagnosis in kidney transplant rejections treated with 15-deoxyspergualin. | 1996 | Transplant. Proc. | pmid:8623457 |
| D'Silva M et al. | Immunosuppressive effect of RS-61443 on rat cardiac allograft survival in combination with leflunomide or FK 506. | 1996 | Transplant. Proc. | pmid:8623467 |
| Pirenne J et al. | Bone marrow augmentation of kidney allografts can cause graft-versus-host disease in immunosuppressed recipients. | 1996 | Transplant. Proc. | pmid:8623472 |
| Ciancio G et al. | Human donor bone marrow cells can enhance hyporeactivity in renal transplantation using maintenance FK 506 and OKT3 induction therapy. | 1996 | Transplant. Proc. | pmid:8623473 |
| D'Silva M et al. | Immunosuppressive effect of brequinar on rat cardiac allograft survival in combination with leflunomide or FK 506. | 1996 | Transplant. Proc. | pmid:8623476 |
| Muraoka K et al. | Immunosuppressant FK506 induces interleukin-6 production through the activation of transcription factor nuclear factor (NF)-kappa(B). Implications for FK506 nephropathy. | 1996 | J. Clin. Invest. | pmid:8647935 |
| Platz KP et al. | Management of acute steroid-resistant rejection after liver transplantation. | 1996 | World J Surg | pmid:8798364 |
| Brunke M et al. | Luciferase assembly after transport into mammalian microsomes involves molecular chaperones and peptidyl-prolyl cis/trans-isomerases. | 1996 | J. Biol. Chem. | pmid:8798557 |
| Zhang Q et al. | Activation of Jak/STAT proteins involved in signal transduction pathway mediated by receptor for interleukin 2 in malignant T lymphocytes derived from cutaneous anaplastic large T-cell lymphoma and Sezary syndrome. | 1996 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8799169 |
| Spencer DM et al. | Functional analysis of Fas signaling in vivo using synthetic inducers of dimerization. | 1996 | Curr. Biol. | pmid:8805308 |
| Franke EK and Luban J | Inhibition of HIV-1 replication by cyclosporine A or related compounds correlates with the ability to disrupt the Gag-cyclophilin A interaction. | 1996 | Virology | pmid:8806510 |
| Ichikawa Y et al. | Three-times-daily monotherapy with tacrolimus (FK 506) in kidney transplantation. | 1996 | Int. J. Urol. | pmid:8776613 |
| Mugiya S et al. | Renal blood flow and serotonin metabolism in tacrolimus treated rats. | 1996 | Int. J. Urol. | pmid:8776615 |
| Dmitrewski J et al. | Recurrence of primary biliary cirrhosis in the liver allograft: the effect of immunosuppression. | 1996 | J. Hepatol. | pmid:8778189 |
| Schwarz A | [Drug-induced kidney damage]. | 1996 | Z Arztl Fortbild (Jena) | pmid:8779233 |
| Yocum DE | Cyclosporine, FK-506, rapamycin, and other immunomodulators. | 1996 | Rheum. Dis. Clin. North Am. | pmid:8907069 |
| Lu YF et al. | FK506, a Ca2+/calmodulin-dependent phosphatase inhibitor, inhibits the induction of long-term potentiation in the rat hippocampus. | 1996 | Neurosci. Lett. | pmid:8907327 |
| Ye Q et al. | Persistence of donor cells and incidence of graft-versus-host disease after simultaneous small bowel and bone marrow transplantation. | 1996 | Transplant. Proc. | pmid:8907895 |
| Walgenbach KJ et al. | Increased presence of mast cells and interleukin-4 during chronic rejection of rat intestinal allografts. | 1996 | Transplant. Proc. | pmid:8907896 |
| Nüssler NC et al. | CD8+ host cells infiltrate the intestinal mucosa after allogeneic small bowel transplantation even in the absence of acute rejection. | 1996 | Transplant. Proc. | pmid:8907898 |
| Wu J et al. | Reversal of multidrug resistance by tacrolimus hydrate. | 1996 | Methods Find Exp Clin Pharmacol | pmid:9121220 |
| Perego C et al. | Orthotopic liver-small bowel transplantation in pigs: study of immunologic parameters during therapy with FK 506-based immunosuppressive regimens. | 1996 | Transplant. Proc. | pmid:8907908 |
| Alessiani M et al. | Combined FK 506 and mycophenolate mofetil immunosuppression prolongs survival after small bowel transplantation in pigs. | 1996 | Transplant. Proc. | pmid:8907922 |
| Cohen DS et al. | Porcine small bowel transplantation with rapamycin-based induction immunosuppression and short-course cyclosporine or FK 506 therapy. | 1996 | Transplant. Proc. | pmid:8907923 |
| Toyama Y et al. | Prolonged small bowel graft survival using photochemotherapy and low-dose FK 506. | 1996 | Transplant. Proc. | pmid:8907924 |
| Woodle ES et al. | A multicenter trial of FK506 (tacrolimus) therapy in refractory acute renal allograft rejection. A report of the Tacrolimus Kidney Transplantation Rescue Study Group. | 1996 | Transplantation | pmid:8830821 |
| Tanaka M et al. | Effect of anticomplement agent K76 COOH on hamster-to-rat and guinea pig-to-rat heart xenotransplantation. | 1996 | Transplantation | pmid:8830837 |
| Opelz G | Comparison of FK506 and cyclosporine. | 1996 | Transplantation | pmid:8830844 |
| Ho S et al. | The mechanism of action of cyclosporin A and FK506. | 1996 | Clin. Immunol. Immunopathol. | pmid:8811062 |
| Nishino H et al. | 3-Nitropropionic acid produces striatum selective lesions accompanied by iNOS expression. | 1996 | J. Chem. Neuroanat. | pmid:8811425 |
| Sonatore LM et al. | The utility of FK506-binding protein as a fusion partner in scintillation proximity assays: application to SH2 domains. | 1996 | Anal. Biochem. | pmid:8811923 |
| Jonas S et al. | Conversion to tacrolimus after liver transplantation. | 1996 | Transpl. Int. | pmid:8748407 |
| Cooley HM et al. | Resolution of pyoderma gangrenosum using tacolimus (FK-506) | 1996 | Aust N Z J Med | pmid:8744629 |
| Hashino S et al. | Antitumor effect in cyclosporine A- or FK506-treated mice after syngeneic bone marrow transplantation. | 1996 | Leuk. Lymphoma | pmid:8726416 |
| Woodle ES et al. | Tacrolimus therapy for refractory acute renal allograft rejection: a prospective multicenter trial. Tacrolimus Kidney Transplantation Rescue Study Group. | 1996 | Transplant. Proc. | pmid:8962225 |
| Scott-Douglas N et al. | Treatment of acute renal transplant rejection with FK 506 in patients on cyclosporine after failure of standard antirejection therapy. | 1996 | Transplant. Proc. | pmid:8962226 |
| Kliem V et al. | FK 506 in the treatment of steroid- and OKT3-resistant rejection in renal transplant recipients: reduced dosage and anti-infective prophylaxis. | 1996 | Transplant. Proc. | pmid:8962227 |
| Becker G et al. | Tacrolimus (FK 506) therapy in simultaneous pancreas kidney transplantation. | 1996 | Transplant. Proc. | pmid:8962228 |
| Kiuchi T et al. | Experience of tacrolimus-based immunosuppression in living-related liver transplantation complicated with graft tuberculosis: interaction with rifampicin and side effects. | 1996 | Transplant. Proc. | pmid:8962229 |
| Guckelberger O et al. | Does the choice of primary immunosuppression influence the prevalence of cardiovascular risk factors after liver transplantation? | 1996 | Transplant. Proc. | pmid:8962230 |
| Braun F et al. | Clinical relevance of monitoring tacrolimus: comparison of microparticle enzyme immunoassay, enzyme-linked immunosorbent assay, and liquid chromatography mass spectrometry in renal transplant recipients converted from cyclosporine to tacrolimus. | 1996 | Transplant. Proc. | pmid:8962231 |
| Wilczek HE et al. | Renal transplant histopathologic changes during the first year in patients with tacrolimus (FK 506). | 1996 | Transplant. Proc. | pmid:8962232 |
| Harihara Y et al. | Effects of interferon alpha/beta on cardiac allografts. | 1996 | Transplant. Proc. | pmid:8658645 |
| Shinozuka N et al. | Correlation between simplified immunocompetence assay and clinical graft states in kidney or liver transplant recipients. | 1996 | Transplant. Proc. | pmid:8658649 |
| Nishimura Y et al. | Whole organ vascularized thymus allografting effectively modulates cardiac rejection. | 1996 | Transplant. Proc. | pmid:8658660 |
| Tanabe K et al. | Diabetes mellitus after renal transplantation under FK 506 (tacrolimus) as primary immunosuppression. | 1996 | Transplant. Proc. | pmid:8658670 |
| Sugito K et al. | A comparative study of clinicopathologic characteristics of renal allografts under cyclosporine and FK506 immunosuppression. | 1996 | Transplant. Proc. | pmid:8658683 |
| Degawa H et al. | Blocking of ICAM-1 and LFA-1 in rat liver transplantation. | 1996 | Transplant. Proc. | pmid:8658695 |
| Watanabe K et al. | Immunosuppressive effect of bactobolamine in rat liver allotransplantation. | 1996 | Transplant. Proc. | pmid:8658697 |
| Tojimbara T et al. | Cyclosporine and tacrolimus both suppress activation of Kupffer cells in vitro. | 1996 | Transplant. Proc. | pmid:8658704 |
| Yuzawa K et al. | Topical immunosuppression in skin grafting with FK 506 ointment. | 1996 | Transplant. Proc. | pmid:8658707 |
| Karashima T et al. | FK506 and cyclosporin A inhibit growth factor-stimulated human keratinocyte proliferation by blocking cells in the G0/G1 phases of the cell cycle. | 1996 | J. Dermatol. Sci. | pmid:8884530 |
| Monfar M and Blenis J | Inhibition of p70/p85 S6 kinase activities in T cells by dexamethasone. | 1996 | Mol. Endocrinol. | pmid:8885245 |
| Andoh TF et al. | Comparison of acute rapamycin nephrotoxicity with cyclosporine and FK506. | 1996 | Kidney Int. | pmid:8887267 |
| Shapiro R et al. | "Suboptimal" kidney donors: the experience with tacrolimus-based immunosuppression. | 1996 | Transplantation | pmid:8932264 |
| Mysliwiec J et al. | The effect of tacrolimus (FK506) and cyclosporin A (CyA) on peripheral serotonergic mechanisms in uremic rats. | 1996 | Thromb. Res. | pmid:8837316 |
| Devlin J and Williams R | Transplantation for fulminant hepatic failure: comparing tacrolimus versus cyclosporine for immunosuppression and the outcome in elective transplants. European FK506 Liver Study Group. | 1996 | Transplantation | pmid:8932266 |
| Lamb GD and Stephenson DG | Effects of FK506 and rapamycin on excitation-contraction coupling in skeletal muscle fibres of the rat. | 1996 | J. Physiol. (Lond.) | pmid:8842013 |
| Curran CF et al. | Acute overdoses of tacrolimus. | 1996 | Transplantation | pmid:8932293 |
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| Bader A et al. | Tacrolimus (FK 506) biotransformation in primary rat hepatocytes depends on extracellular matrix geometry. | 1996 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:8935714 |
| Thompson PA and Mosley CA | Tacrolimus-phenytoin interaction. | 1996 | Ann Pharmacother | pmid:8740340 |
| Christophers E | Psoriasis: mechanisms and entry points for possible therapeutic interventions. | 1996 | Australas. J. Dermatol. | pmid:8713012 |
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| Beretta L et al. | Rapamycin blocks the phosphorylation of 4E-BP1 and inhibits cap-dependent initiation of translation. | 1996 | EMBO J. | pmid:8599949 |
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