| MeSH term | MeSH ID | Detail |
|---|---|---|
| Inflammatory Bowel Diseases | D015212 | 9 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Diabetes Mellitus, Type 1 | D003922 | 56 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Fatty Liver | D005234 | 48 associated lipids |
| Cataract | D002386 | 34 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ushigome H et al. | Two cases of tacrolimus-induced alopecia following kidney transplantation. | 1999 | Transplant. Proc. | pmid:10578326 |
| Bush WW | Overview of transplantation immunology and the pharmacotherapy of adult solid organ transplant recipients: focus on immunosuppression. | 1999 | AACN Clin Issues | pmid:10578712 |
| Lowry PW et al. | Combination therapy with oral tacrolimus (FK506) and azathioprine or 6-mercaptopurine for treatment-refractory Crohn's disease perianal fistulae. | 1999 | Inflamm. Bowel Dis. | pmid:10579116 |
| Mathieu P et al. | Conversion of cyclosporine A to tacrolimus following heart transplantation. | 1999 | Can J Cardiol | pmid:10579737 |
| Horigome A et al. | Lymphocyte-sensitivity to glucocorticoid correlates with the sensitivity to cyclosporin A and tacrolimus in chronic renal failure patients. | 1999 | Br J Clin Pharmacol | pmid:10583028 |
| Busque S et al. | [Hypertrichosis and gingival hypertrophy regression in renal transplants following the substitution of cyclosporin by tacrolimus]. | 1999 | Ann Chir | pmid:10584376 |
| Wong TY et al. | Parvovirus B19 infection causing red cell aplasia in renal transplantation on tacrolimus. | 1999 | Am. J. Kidney Dis. | pmid:10585325 |
| Le Bricon T et al. | Changes in plasma cystatin C after renal transplantation and acute rejection in adults. | 1999 | Clin. Chem. | pmid:10585359 |
| Miyamoto S and Safer B | Immunosuppressants FK506 and rapamycin have different effects on the biosynthesis of cytoplasmic actin during the early period of T cell activation. | 1999 | Biochem. J. | pmid:10585867 |
| Tsuchida M et al. | T cell activation up-regulates the expression of the focal adhesion kinase Pyk2: opposing roles for the activation of protein kinase C and the increase in intracellular Ca2+. | 1999 | J. Immunol. | pmid:10586059 |
| Agarwala S et al. | Co-administration of co-trimoxazole does not augment tacrolimus-induced impairment in kidney function in rats. | 1999 | Ren Fail | pmid:10586426 |
| von Baum H et al. | Prevalence of vancomycin-resistant enterococci among children with end-stage renal failure. Mid-European Pediatric Peritoneal Dialysis Study Group. | 1999 | Clin. Infect. Dis. | pmid:10589909 |
| Maes BD et al. | Differences in gastric motor activity in renal transplant recipients treated with FK-506 versus cyclosporine. | 1999 | Transplantation | pmid:10589943 |
| Fernandez LA et al. | The effects of maintenance doses of FK506 versus cyclosporin A on glucose and lipid metabolism after orthotopic liver transplantation. | 1999 | Transplantation | pmid:10589951 |
| Batten P et al. | Human T cell responses to human and porcine endothelial cells are highly sensitive to cyclosporin A and FK506 in vitro. | 1999 | Transplantation | pmid:10589954 |
| Dickenmann MJ et al. | Blood eosinophilia in tacrolimus-treated patients: an indicator of Pneumocystis carinii pneumonia. | 1999 | Transplantation | pmid:10589963 |
| Yamashita N et al. | Nuclear factor kappa B mediates interleukin-8 production in eosinophils. | 1999 | Int. Arch. Allergy Immunol. | pmid:10592469 |
| Shimoyama M et al. | Calcineurin plays a critical role in pressure overload-induced cardiac hypertrophy. | 1999 | Circulation | pmid:10595959 |
| Camacho R et al. | Hypothemycin inhibits the proliferative response and modulates the production of cytokines during T cell activation. | 1999 | Immunopharmacology | pmid:10598882 |
| Briggs CJ et al. | Comparison of the effect of FK506 and cyclosporin A on virus production in H9 cells chronically and newly infected by HIV-1. | 1999 | Arch. Virol. | pmid:10603169 |
| Xu L et al. | Potential for pharmacology of ryanodine receptor/calcium release channels. | 1998 | Ann. N. Y. Acad. Sci. | pmid:10603942 |
| Bers DM et al. | Factors that control sarcoplasmic reticulum calcium release in intact ventricular myocytes. | 1998 | Ann. N. Y. Acad. Sci. | pmid:10603944 |
| MacFarlane GD et al. | Analysis of whole blood tacrolimus concentrations in liver transplant patients exhibiting impaired liver function. | 1999 | Ther Drug Monit | pmid:10604816 |
| Wright DC et al. | A comparison of the sensitivity of pig and human peripheral blood mononuclear cells to the antiproliferative effects of traditional and newer immunosuppressive agents. | 1999 | Transpl. Immunol. | pmid:10608297 |
| Qi Z et al. | Malononitrilamides and tacrolimus additively prevent acute rejection in rat cardiac allografts. | 1999 | Transpl. Immunol. | pmid:10608300 |
| Olyaei AJ et al. | Immunosuppressant-induced nephropathy: pathophysiology, incidence and management. | 1999 | Drug Saf | pmid:10612271 |
| Freudenberger R et al. | Antithrombotic effect of FK506 vs cyclosporine in cardiac transplant recipients: potential implications in transplant arteriopathy. | 1999 | J. Heart Lung Transplant. | pmid:10612383 |
| Yen MT et al. | Oscillopsia and pseudonystagmus in kidney transplant patients. | 1999 | Am. J. Ophthalmol. | pmid:10612521 |
| Bitker MO et al. | [Combined renal and pancreas transplantation as treatment for chronic renal insufficiency of diabetic origin: a series of 50 consecutive transplantations]. | 1999 | Chirurgie | pmid:10615774 |
| Crétolle-Vastel C et al. | [Role of calcineurin-dependent drugs on the immunosuppressive effect induced by the anti-LFA-1 antibody in a fetal intestinal transplantation model in mice]. | 1999 | Chirurgie | pmid:10615777 |
| van Hooff JP and Christiaans MH | Use of tacrolimus in renal transplantation. | 1999 | Transplant. Proc. | pmid:10616483 |
| Charco R et al. | CD28 regulation in liver transplant recipients treated with two different immunosuppressive regimens. | 1999 | Transplant. Proc. | pmid:10616508 |
| Kindt MV et al. | Tacrolimus toxicity in rhesus monkey: model for clinical side effects. | 1999 | Transplant. Proc. | pmid:10616519 |
| Gaston RS | Potential utility of rapamycin and tacrolimus in long-term, low-toxicity regimens. | 1999 | Transplant. Proc. | pmid:10616556 |
| Land W | Mycophenolate mofetil-based immunosuppressive therapy: induction, maintenance, and conversion protocols in renal transplantation. | 1999 | Transplant. Proc. | pmid:10616558 |
| Hida H et al. | Dopa-producing astrocytes generated by adenoviral transduction of human tyrosine hydroxylase gene: in vitro study and transplantation to hemiparkinsonian model rats. | 1999 | Neurosci. Res. | pmid:10616914 |
| Hashii M et al. | cADP-ribose potentiates cytosolic Ca2+ elevation and Ca2+ entry via L-type voltage-activated Ca2+ channels in NG108-15 neuronal cells. | 2000 | Biochem. J. | pmid:10620496 |
| Uchino T et al. | Effect of FK 506 and lipo prostaglandin E1 on heart allograft survival in rats. | 1999 | Scand. Cardiovasc. J. | pmid:10622549 |
| Patella V et al. | HIV-1 gp120 induces IL-4 and IL-13 release from human Fc epsilon RI+ cells through interaction with the VH3 region of IgE. | 2000 | J. Immunol. | pmid:10623799 |
| Mehta P et al. | Increased clearance of tacrolimus in children: need for higher doses and earlier initiation prior to bone marrow transplantation. | 1999 | Bone Marrow Transplant. | pmid:10627642 |
| Shapiro R et al. | Posttransplant lymphoproliferative disorders in adult and pediatric renal transplant patients receiving tacrolimus-based immunosuppression. | 1999 | Transplantation | pmid:10628763 |
| Haines DD et al. | Cardioprotective effects of the calcineurin inhibitor FK506 and the PAF receptor antagonist and free radical scavenger, EGb 761, in isolated ischemic/reperfused rat hearts. | 2000 | J. Cardiovasc. Pharmacol. | pmid:10630731 |
| Paul LC | Dialysis and transplantation. | 1999 | Curr. Opin. Nephrol. Hypertens. | pmid:10630810 |
| Vanrenterghem YF | Which calcineurin inhibitor is preferred in renal transplantation: tacrolimus or cyclosporine? | 1999 | Curr. Opin. Nephrol. Hypertens. | pmid:10630811 |
| Wang-Fan W et al. | Application of centrifugal counter-current chromatography to the separation of macrolide antibiotic analogues. I. Selection of solvent systems based on solubility and partition coefficient investigations. | 1999 | J Chromatogr A | pmid:10630872 |
| Furutani M et al. | FK506 binding protein from a thermophilic archaeon, Methanococcus thermolithotrophicus, has chaperone-like activity in vitro. | 2000 | Biochemistry | pmid:10631007 |
| Thiers BH | Topical tacrolimus: treatment failure in a patient with alopecia areata. | 2000 | Arch Dermatol | pmid:10632221 |
| Lipper GM et al. | Recent therapeutic advances in dermatology. | 2000 | JAMA | pmid:10634322 |
| Richter-Hintz D et al. | Topical tacrolimus (FK 506) is effective in the treatment of pyoderma gangrenosum. | 2000 | J. Am. Acad. Dermatol. | pmid:10642695 |
| Bekersky I et al. | Dose linearity after oral administration of tacrolimus 1-mg capsules at doses of 3, 7, and 10 mg. | 1999 | Clin Ther | pmid:10645753 |
| Fuseler JW et al. | FK506 attenuates developing and established joint inflammation and suppresses interleukin 6 and nitric oxide expression in bacterial cell wall induced polyarthritis. | 2000 | J. Rheumatol. | pmid:10648038 |
| Schrama YC et al. | Concealed by veils. | 2000 | Nephrol. Dial. Transplant. | pmid:10648679 |
| Reddy KS et al. | Simultaneous kidney-pancreas transplantation without antilymphocyte induction. | 2000 | Transplantation | pmid:10653379 |
| Jain A et al. | Conversion to neoral for neurotoxicity after primary adult liver transplantation under tacrolimus. | 2000 | Transplantation | pmid:10653398 |
| Wu GS et al. | Deoxyspergualin delays xenograft rejection in the guinea pig-to-C6-deficient rat heart transplantation model. | 1999 | Transpl. Int. | pmid:10654352 |
| Novelli M et al. | Oral absorption of tacrolimus in children with intestinal failure due to short or absent small bowel. | 1999 | Transpl. Int. | pmid:10654359 |
| Tamura J et al. | [The role of protein kinases and phosphatases in erythroid colony formation of elderly]. | 1999 | Nihon Ronen Igakkai Zasshi | pmid:10655734 |
| Tamura A et al. | Immunosuppressive therapy using FTY720 combined with tacrolimus in rat liver transplantation. | 2000 | Surgery | pmid:10660758 |
| Schuppe H et al. | Topical tacrolimus for recalcitrant leg ulcer in rheumatoid arthritis. | 2000 | Rheumatology (Oxford) | pmid:10662882 |
| McAlister VC et al. | Sirolimus-tacrolimus combination immunosuppression. | 2000 | Lancet | pmid:10665560 |
| Chenhsu RY et al. | Renal allograft dysfunction associated with rifampin-tacrolimus interaction. | 2000 | Ann Pharmacother | pmid:10669182 |
| Tyagi MG and Thomas M | Enhanced cardiovascular reactivity to desmopressin in water-restricted rats: facilitatory role of immunosuppression. | 1999 | Methods Find Exp Clin Pharmacol | pmid:10669908 |
| Winter C et al. | The immunophilin ligand FK506, but not GPI-1046, protects against neuronal death and inhibits c-Jun expression in the substantia nigra pars compacta following transection of the rat medial forebrain bundle. | 2000 | Neuroscience | pmid:10670442 |
| Furukawa H et al. | Prolongation of canine liver allograft survival by a novel immunosuppressant, FTY720: effect of monotherapy and combined treatment with conventional drugs. | 2000 | Transplantation | pmid:10670633 |
| Jordan ML et al. | Results of pancreas transplantation after steroid withdrawal under tacrolimus immunosuppression. | 2000 | Transplantation | pmid:10670637 |
| Hirose R et al. | Experience with daclizumab in liver transplantation: renal transplant dosing without calcineurin inhibitors is insufficient to prevent acute rejection in liver transplantation. | 2000 | Transplantation | pmid:10670644 |
| Sayo Y et al. | Transforming growth factor beta induction of insulin gene expression is mediated by pancreatic and duodenal homeobox gene-1 in rat insulinoma cells. | 2000 | Eur. J. Biochem. | pmid:10672004 |
| Misawa A et al. | FK506-induced intractable leukoencephalopathy following allogeneic bone marrow transplantation. | 2000 | Bone Marrow Transplant. | pmid:10673708 |
| de Mattos AM et al. | Nephrotoxicity of immunosuppressive drugs: long-term consequences and challenges for the future. | 2000 | Am. J. Kidney Dis. | pmid:10676738 |
| Tisdale JF et al. | Cyclophosphamide and other new agents for the treatment of severe aplastic anemia. | 2000 | Semin. Hematol. | pmid:10676915 |
| Skuk D and Tremblay JP | Progress in myoblast transplantation: a potential treatment of dystrophies. | 2000 Feb 1-15 | Microsc. Res. Tech. | pmid:10679968 |
| Del Poeta M et al. | Synergistic antifungal activities of bafilomycin A(1), fluconazole, and the pneumocandin MK-0991/caspofungin acetate (L-743,873) with calcineurin inhibitors FK506 and L-685,818 against Cryptococcus neoformans. | 2000 | Antimicrob. Agents Chemother. | pmid:10681348 |
| Filler G et al. | Pharmacokinetics of mycophenolate mofetil are influenced by concomitant immunosuppression. | 2000 | Pediatr. Nephrol. | pmid:10684356 |
| Sengoku T et al. | FK506 inhibition of histamine release and cytokine production by mast cells and basophils. | 2000 | Int. J. Immunopharmacol. | pmid:10685002 |
| Li XC and Strom TB | Blocking T-cell costimulation in transplantation: opportunities and challenges. | 2000 | Transfusion | pmid:10685997 |
| Oppenheimer F | Steroid withdrawal in renal transplant recipients. | 2000 | Transplant. Proc. | pmid:10686314 |
| Glynne R et al. | How self-tolerance and the immunosuppressive drug FK506 prevent B-cell mitogenesis. | 2000 | Nature | pmid:10688206 |
| Suga Y et al. | A case of ichthyosis linearis circumflexa successfully treated with topical tacrolimus. | 2000 | J. Am. Acad. Dermatol. | pmid:10688732 |
| LaPres JJ et al. | ARA9 modifies agonist signaling through an increase in cytosolic aryl hydrocarbon receptor. | 2000 | J. Biol. Chem. | pmid:10692406 |
| Davis DL et al. | Minor immunophilin binding of tacrolimus and sirolimus metabolites. | 2000 | Clin. Biochem. | pmid:10693980 |
| Bader A et al. | Primary porcine enterocyte and hepatocyte cultures to study drug oxidation reactions. | 2000 | Br. J. Pharmacol. | pmid:10694240 |
| Aronowski J et al. | Interplay between the gamma isoform of PKC and calcineurin in regulation of vulnerability to focal cerebral ischemia. | 2000 | J. Cereb. Blood Flow Metab. | pmid:10698072 |
| White SA et al. | Effect of acute rejection on expression of fibrosis associated genes in renal transplant recipients. | 2000 | Transplant. Proc. | pmid:10700949 |
| Braun F et al. | Living-related versus living-unrelated kidney transplantation using tacrolimus initial immunosuppression. | 2000 | Transplant. Proc. | pmid:10700989 |
| White SA et al. | Influence of delayed graft function in renal transplants from cadaveric or non-heart-beating donors. | 2000 | Transplant. Proc. | pmid:10701018 |
| Williams ST et al. | Preliminary analysis of a randomized trial comparing microemulsion cyclosporine and tacrolimus for recipients of renal transplants from non-heart-beating donors. | 2000 | Transplant. Proc. | pmid:10701022 |
| Migita K et al. | FK506 augments glucocorticoid-mediated cyclooxygenase-2 down-regulation in human rheumatoid synovial fibroblasts. | 2000 | Lab. Invest. | pmid:10701683 |
| Rovira P et al. | The impact of immunosuppressive drugs on the analysis of T cell activation. | 2000 | Curr. Med. Chem. | pmid:10702633 |
| Dumont FJ | FK506, an immunosuppressant targeting calcineurin function. | 2000 | Curr. Med. Chem. | pmid:10702636 |
| Soran A et al. | Outcome of kidney transplantation under tacrolimus-based immunosuppression in elderly patients. | 1999 | J Transpl Coord | pmid:10703390 |
| Ulsh PJ et al. | New strategies using 'low-dose' mycophenolate mofetil to reduce acute rejection in patients following kidney transplantation. | 1999 | J Transpl Coord | pmid:10703393 |
| Bartucci MR | Issues in cyclosporine drug substitution: implications for patient management. | 1999 | J Transpl Coord | pmid:10703396 |
| James JA et al. | Reduction in gingival overgrowth associated with conversion from cyclosporin A to tacrolimus. | 2000 | J. Clin. Periodontol. | pmid:10703661 |
| Lapa e Silva JR et al. | Prevention of antigen-induced bronchial hyperreactivity and airway inflammation in sensitized guinea-pigs by tacrolimus. | 1999 | Mediators Inflamm. | pmid:10704085 |
| Singh N et al. | Immunosuppressive-associated leukoencephalopathy in organ transplant recipients. | 2000 | Transplantation | pmid:10708096 |
| Kuriyama S et al. | Immunomodulation with FK506 around the time of intravenous re-administration of an adenoviral vector facilitates gene transfer into primed rat liver. | 2000 | Int. J. Cancer | pmid:10709105 |
| Kitabayashi H et al. | FTY720 prevents development of experimental autoimmune myocarditis through reduction of circulating lymphocytes. | 2000 | J. Cardiovasc. Pharmacol. | pmid:10710126 |
| DuBell WH et al. | K(+) currents responsible for repolarization in mouse ventricle and their modulation by FK-506 and rapamycin. | 2000 | Am. J. Physiol. Heart Circ. Physiol. | pmid:10710358 |
| Egner R et al. | The transmembrane domain 10 of the yeast Pdr5p ABC antifungal efflux pump determines both substrate specificity and inhibitor susceptibility. | 2000 | Mol. Microbiol. | pmid:10712705 |
| Mamane Y et al. | Posttranslational regulation of IRF-4 activity by the immunophilin FKBP52. | 2000 | Immunity | pmid:10714679 |