| MeSH term | MeSH ID | Detail |
|---|---|---|
| Fatty Liver | D005234 | 48 associated lipids |
| Precancerous Conditions | D011230 | 48 associated lipids |
| Psoriasis | D011565 | 47 associated lipids |
| Leukemia P388 | D007941 | 43 associated lipids |
| Hypersensitivity, Delayed | D006968 | 43 associated lipids |
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Ischemic Attack, Transient | D002546 | 42 associated lipids |
| Hyperalgesia | D006930 | 42 associated lipids |
| Hypotension | D007022 | 41 associated lipids |
| Leukemia, Erythroblastic, Acute | D004915 | 41 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- J. Pharmacol. Exp. Ther. (1)
- Am. J. Physiol. Renal Physiol. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Shirakata Y et al. | Inhibitory effect of plasma FKBP12 on immunosuppressive activity of FK506. | 1995 | Transplantation | pmid:8545894 |
| Aoyama H et al. | Successful treatment of resistant facial lesions of atopic dermatitis with 0.1% FK506 ointment. | 1995 | Br. J. Dermatol. | pmid:8547017 |
| Gharpure VS et al. | Thrombotic thrombocytopenic purpura associated with FK506 following bone marrow transplantation. | 1995 | Bone Marrow Transplant. | pmid:8547871 |
| Koch K et al. | CP-123,369: a potent, orally active immunosuppressive agent. | 1995 | Inflamm. Res. | pmid:8548388 |
| Hamasaki Y et al. | Inhibition of leukotriene production by FK506 in rat basophilic leukemia-1 cells. | 1995 | Pharmacology | pmid:7538218 |
| Clardy J | The chemistry of signal transduction. | 1995 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7529414 |
| Braun W et al. | Three-dimensional structure and actions of immunosuppressants and their immunophilins. | 1995 | FASEB J. | pmid:7529736 |
| Kawai M et al. | Pyrrolidine dithiocarbamate inhibits intercellular adhesion molecule-1 biosynthesis induced by cytokines in human fibroblasts. | 1995 | J. Immunol. | pmid:7532665 |
| Venkataraman L et al. | FK506 inhibits antigen receptor-mediated induction of c-rel in B and T lymphoid cells. | 1995 | J. Exp. Med. | pmid:7532676 |
| Wang CR et al. | T cell receptor-mediated signaling events in CD4+CD8+ thymocytes undergoing thymic selection: requirement of calcineurin activation for thymic positive selection but not negative selection. | 1995 | J. Exp. Med. | pmid:7532685 |
| Martinez OM et al. | Molecular markers of Epstein-Barr virus infection in the circulation of transplant recipients. | 1995 | Transplant. Proc. | pmid:7533372 |
| Fung JJ and Starzl TE | FK506 in solid organ transplantation. | 1995 | Ther Drug Monit | pmid:8588226 |
| Langrehr JM et al. | Liver transplantation in hepatitis B surface antigen positive patients with postoperative long-term immunoprophylaxis. | 1995 | Transplant. Proc. | pmid:7533373 |
| Jusko WJ | Analysis of tacrolimus (FK 506) in relation to therapeutic drug monitoring. | 1995 | Ther Drug Monit | pmid:8588227 |
| Vargas V et al. | Alpha-interferon for acute hepatitis C in liver transplant patients. | 1995 | Transplant. Proc. | pmid:7533374 |
| McMaster P et al. | Therapeutic drug monitoring of tacrolimus in clinical transplantation. | 1995 | Ther Drug Monit | pmid:8588228 |
| Barkholt LM et al. | New criteria for diagnosing cytomegalovirus hepatitis in liver transplant patients. | 1995 | Transplant. Proc. | pmid:7533375 |
| Jusko WJ et al. | Consensus document: therapeutic monitoring of tacrolimus (FK-506). | 1995 | Ther Drug Monit | pmid:8588229 |
| Teraoka S et al. | Effect of rescue therapy using FK 506 on relapsing rejection after combined pancreas and kidney transplantation. | 1995 | Transplant. Proc. | pmid:7533381 |
| Lohse DL et al. | Insights derived from the structures of the Ser/Thr phosphatases calcineurin and protein phosphatase 1. | 1995 | Structure | pmid:8590008 |
| Fay JW et al. | FK 506-based immunosuppression for prevention of graft versus host disease after unrelated donor marrow transplantation. | 1995 | Transplant. Proc. | pmid:7533383 |
| Shapiro R et al. | A prospective, randomized trial of FK 506/prednisone vs FK 506/azathioprine/prednisone in renal transplant patients. | 1995 | Transplant. Proc. | pmid:7533432 |
| Winkler M et al. | Comparison of plasma vs whole blood as matrix for FK 506 drug level monitoring. | 1995 | Transplant. Proc. | pmid:7533433 |
| Sakamoto K et al. | Sodium-losing nephropathy and distal tubular damage of transplant kidneys with FK506 administration. | 1995 | Transplant. Proc. | pmid:7533434 |
| Ochiai T et al. | Phase III study of FK 506 in kidney transplantation. Japanese FK 506 Study Group. | 1995 | Transplant. Proc. | pmid:7533435 |
| Scantlebury VP et al. | Renal transplantation under cyclosporine and FK 506 for hemolytic uremic syndrome. | 1995 | Transplant. Proc. | pmid:7533436 |
| Hanafusa T et al. | Long-term impact of hepatitis virus infection on kidney transplant recipients and a pilot study of the effects of interferon alpha on chronic hepatitis C. | 1995 | Transplant. Proc. | pmid:7533440 |
| Iwasaki K et al. | Further metabolism of FK506 (tacrolimus). Identification and biological activities of the metabolites oxidized at multiple sites of FK506. | 1995 | Drug Metab. Dispos. | pmid:7536652 |
| Tumlin JA et al. | Expression of calcineurin activity and alpha-subunit isoforms in specific segments of the rat nephron. | 1995 | Am. J. Physiol. | pmid:7485542 |
| Furukawa F et al. | FK506: therapeutic effects on lupus dermatoses in autoimmune-prone MRL/Mp-lpr/lpr mice. | 1995 | Arch. Dermatol. Res. | pmid:7487142 |
| Miranker A and Karplus M | An automated method for dynamic ligand design. | 1995 | Proteins | pmid:8749844 |
| Marumo T et al. | Cyclosporin A inhibits nitric oxide synthase induction in vascular smooth muscle cells. | 1995 | Hypertension | pmid:7536714 |
| Nowaczyk M et al. | 2-Chlorodeoxyadenosine: lack of synergism with cyclosporine A and tacrolimus (FK 506). | 1995 | Arch. Immunol. Ther. Exp. (Warsz.) | pmid:8744655 |
| Schwaninger M et al. | Involvement of the Ca(2+)-dependent phosphatase calcineurin in gene transcription that is stimulated by cAMP through cAMP response elements. | 1995 | J. Biol. Chem. | pmid:7536740 |
| Min Z and Jones NF | Limb transplantation in rats: immunosuppression with FK-506. | 1995 | J Hand Surg Am | pmid:7536766 |
| Lyons WE et al. | Neuronal regeneration enhances the expression of the immunophilin FKBP-12. | 1995 | J. Neurosci. | pmid:7536825 |
| Yamamoto S et al. | Cross-species transplantation of photoreceptors with tacrolimus hydrate (FK506) treatment. | 1995 | Jpn. J. Ophthalmol. | pmid:8926639 |
| Lam E et al. | A novel FK506 binding protein can mediate the immunosuppressive effects of FK506 and is associated with the cardiac ryanodine receptor. | 1995 | J. Biol. Chem. | pmid:7592869 |
| Kanda T et al. | Synergistic effects of tacrolimus and human interferon-alpha A/D in murine viral myocarditis. | 1995 | J. Pharmacol. Exp. Ther. | pmid:7542339 |
| Canzanello VJ et al. | Renal sodium handling with cyclosporin A and FK506 after orthotopic liver transplantation. | 1995 | J. Am. Soc. Nephrol. | pmid:7542491 |
| Conde M et al. | Inhibitory effect of cyclosporin A and FK506 on nitric oxide production by cultured macrophages. Evidence of a direct effect on nitric oxide synthase activity. | 1995 | Immunology | pmid:7538492 |
| Garrett-Engele P et al. | Calcineurin, the Ca2+/calmodulin-dependent protein phosphatase, is essential in yeast mutants with cell integrity defects and in mutants that lack a functional vacuolar H(+)-ATPase. | 1995 | Mol. Cell. Biol. | pmid:7542741 |
| Skeen MJ and Ziegler HK | Activation of gamma delta T cells for production of IFN-gamma is mediated by bacteria via macrophage-derived cytokines IL-1 and IL-12. | 1995 | J. Immunol. | pmid:7538532 |
| Baughman G et al. | FKBP51, a novel T-cell-specific immunophilin capable of calcineurin inhibition. | 1995 | Mol. Cell. Biol. | pmid:7542743 |
| Columbo M et al. | Human skin mast cells express functional beta 1 integrins that mediate adhesion to extracellular matrix proteins. | 1995 | J. Immunol. | pmid:7538541 |
| Pearlman DA and Connelly PR | Determination of the differential effects of hydrogen bonding and water release on the binding of FK506 to native and Tyr82-->Phe82 FKBP-12 proteins using free energy simulations. | 1995 | J. Mol. Biol. | pmid:7538591 |
| Sauer P et al. | In patients with orthotopic liver transplantation, serum markers of cholestasis are unreliable indicators of biliary secretion. | 1995 | J. Hepatol. | pmid:7544368 |
| Chang HY et al. | Asymmetric retraction of growth cone filopodia following focal inactivation of calcineurin. | 1995 | Nature | pmid:7544441 |
| Murio JE et al. | Compassionate use of FK 506 in liver transplantation. | 1995 | Transplant. Proc. | pmid:7544501 |
| Llull R et al. | Multilineage amplification of graft-vs-host disease-resistant chimerism following rat vascularized bone marrow allotransplantation. | 1995 | Transplant. Proc. | pmid:7544504 |
| Horne SM and Young KD | Escherichia coli and other species of the Enterobacteriaceae encode a protein similar to the family of Mip-like FK506-binding proteins. | 1995 | Arch. Microbiol. | pmid:7540828 |
| Teutsch M et al. | Induction of CD5 on B and T cells is suppressed by cyclosporin A, FK-520 and rapamycin. | 1995 | Int. Immunol. | pmid:7540861 |
| Hoshino H et al. | Effects of FK506 on an experimental model of colitis in rats. | 1995 | Aliment. Pharmacol. Ther. | pmid:7544633 |
| Mori A et al. | IL-5 production by CD4+ T cells of asthmatic patients is suppressed by glucocorticoids and the immunosuppressants FK506 and cyclosporin A. | 1995 | Int. Immunol. | pmid:7540862 |
| Tashiro H et al. | Monitoring for engraftment following rat orthotopic liver transplantation by in vitro amplification of Y-chromosome gene using polymerase chain reaction. | 1995 | Cell Transplant | pmid:7540919 |
| Hikita N et al. | Effects of topical FK506 on endotoxin-induced uveitis (EIU) in the Lewis rat. | 1995 | Curr. Eye Res. | pmid:7540967 |
| Cardenas ME et al. | Targets of immunophilin-immunosuppressant complexes are distinct highly conserved regions of calcineurin A. | 1995 | EMBO J. | pmid:7540976 |
| Mueller AR et al. | The optimal immunosuppressant after liver transplantation according to diagnosis: cyclosporine A or FK506? | 1995 | Clin Transplant | pmid:7549057 |
| Nagai H et al. | Effect of some immunosuppressors on allergic bronchial inflammation and airway hyperresponsiveness in mice. | 1995 | Int. Arch. Allergy Immunol. | pmid:7549508 |
| Jung-Testas I et al. | Cyclosporin A promotes nuclear transfer of a cytoplasmic progesterone receptor mutant. | 1995 | C. R. Acad. Sci. III, Sci. Vie | pmid:7583777 |
| Kissinger CR et al. | Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex. | 1995 | Nature | pmid:8524402 |
| Lauerma AI | Immunomodulation of contact dermatitis. | 1995 | Curr. Probl. Dermatol. | pmid:7587333 |
| Cardenas ME et al. | Molecular mechanisms of immunosuppression by cyclosporine, FK506, and rapamycin. | 1995 | Curr. Opin. Nephrol. Hypertens. | pmid:8591053 |
| Cameron AM et al. | Calcineurin associated with the inositol 1,4,5-trisphosphate receptor-FKBP12 complex modulates Ca2+ flux. | 1995 | Cell | pmid:8521476 |
| Tamura K | FK506: mechanism of immunosuppression and adverse-effects. | 1995 | J Toxicol Sci | pmid:8531246 |
| DÃaz M et al. | [Tacrolimus (FK 506): an immunosuppression alternative in solid organ transplantation. (Part 2)]. | 1995 Apr-Jun | Rev Med Univ Navarra | pmid:7569553 |
| Hisatomi K et al. | Effect of dose of cyclosporine or FK506 and antithrombotic agents on cardiac allograft vascular disease in heterotopically transplanted hearts in rats. | 1995 Jan-Feb | J. Heart Lung Transplant. | pmid:7537098 |
| DÃaz M et al. | [Tacrolimus (FK 506): immunosuppressive alternative to solid organ transplant (Part 1)]. | 1995 Jan-Mar | Rev Med Univ Navarra | pmid:14735715 |
| Kawahara K et al. | Effects of deoxyspergualin on bronchial anastomosis healing in canine pulmonary allografts. | 1995 Jul-Aug | J. Heart Lung Transplant. | pmid:7578196 |
| Motoyama K et al. | Pretransplant intrathymic inoculation of donor antigen combined with FK506 treatment: prolongation of survival of cardiac, but not renal, allografts in rats. | 1995 Mar-Apr | World J Surg | pmid:7538717 |
| Okudaira H et al. | Enhanced production and gene expression of interleukin-5 in patients with bronchial asthma: possible management of atopic diseases by down-regulation of interleukin-5 gene transcription. | 1995 May-Jun | Int. Arch. Allergy Immunol. | pmid:7542077 |
| Su Q et al. | Nephrotoxicity of cyclosporin A and FK506: inhibition of calcineurin phosphatase. | 1995 May-Jun | Ren. Physiol. Biochem. | pmid:7542793 |
| Hayashi S et al. | Evidence that donor pretreatment with FK506 has a synergistic effect on graft prolongation in hamster-to-rat heart xenotransplantation. | 1995 May-Jun | J. Heart Lung Transplant. | pmid:7544621 |
| Castillo Lugo JA | Clinical and experimental immunosuppression. | 1995 May-Jun | Bol Asoc Med P R | pmid:8573248 |
| Seifeldin R | Drug interactions in transplantation. | 1995 Nov-Dec | Clin Ther | pmid:8750397 |
| Schreiber SL and Crabtree GR | Immunophilins, ligands, and the control of signal transduction. | 1995-1996 | Harvey Lect. | pmid:9127988 |
| Panyi G et al. | Immunosuppressors inhibit voltage-gated potassium channels in human peripheral blood lymphocytes. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8619842 |
| Kiang D et al. | Cloning the gene encoding Schistosoma mansoni p50, an immunophilin. | 1996 | Gene | pmid:8621074 |
| Sung RS et al. | Survival of human islet xenografts irradiated with ultraviolet B in diabetic rats. | 1996 | Transplant. Proc. | pmid:8623427 |
| Stratta RJ et al. | FK 506 induction and rescue therapy in pancreas transplant recipients. | 1996 | Transplant. Proc. | pmid:8623492 |
| Fay JW et al. | FK506 (Tacrolimus) monotherapy for prevention of graft-versus-host disease after histocompatible sibling allogenic bone marrow transplantation. | 1996 | Blood | pmid:8605372 |
| Greeno EW et al. | Exchange transfusion the hard way: massive hemolysis following transplantation of bone marrow with minor ABO incompatibility. | 1996 | Transfusion | pmid:8607158 |
| Weinzweig N et al. | Peripheral-nerve allotransplantation in rats immunosuppressed with transient or long-term FK-506. | 1996 | J Reconstr Microsurg | pmid:8905545 |
| Nagai H et al. | The role of interleukin-5 (IL-5) in allergic airway hyperresponsiveness in mice. | 1996 | Ann. N. Y. Acad. Sci. | pmid:8906215 |
| Brunner T et al. | Activation-induced cell death in murine T cell hybridomas. Differential regulation of Fas (CD95) versus Fas ligand expression by cyclosporin A and FK506. | 1996 | Int. Immunol. | pmid:8757947 |
| Gusev AI et al. | A quantitative study of in vitro hepatic metabolism of tacrolimus (FK506) using secondary ion and matrix-assisted laser desorption/ionization mass spectrometry. | 1996 | Rapid Commun. Mass Spectrom. | pmid:8759330 |
| Corey HE et al. | Improved renal allograft survival in children treated with FK 506 (tacrolimus) rescue therapy. | 1996 | Pediatr. Nephrol. | pmid:8971888 |
| Fändrich F et al. | Circumvention of natural killer cell and T-cell mediated allogeneic target killing with tacrolimus (FK506) in small bowel transplantation related graft-vs-host disease. | 1996 | Transpl. Int. | pmid:8959843 |
| Antoniou E et al. | Effect of RS61443 in combination with leflunomide or FK506 on rat heart allograft survival. | 1996 | Transpl. Int. | pmid:8959858 |
| Licitra EJ and Liu JO | A three-hybrid system for detecting small ligand-protein receptor interactions. | 1996 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8917502 |
| Woodle ES et al. | Treatment of acute glomerular rejection with FK 506. | 1996 | Clin Transplant | pmid:8826664 |
| Yamashita M et al. | Non-T cell-derived IL-4 plays an important role in IgE production induced by antigen resensitization and is resistant to FK506. | 1996 | J. Immunol. | pmid:8752921 |
| Silva ND and Prendergast FG | Tryptophan dynamics of the FK506 binding protein: time-resolved fluorescence and simulations. | 1996 | Biophys. J. | pmid:8785272 |
| Devine SM et al. | Tacrolimus (FK506)-induced cerebral blindness following bone marrow transplantation. | 1996 | Bone Marrow Transplant. | pmid:8879619 |
| Ikegami S et al. | A facilitatory effect on the induction of long-term potentiation in vivo by chronic administration of antisense oligodeoxynucleotides against catalytic subunits of calcineurin. | 1996 | Brain Res. Mol. Brain Res. | pmid:8883951 |
| Zou XM et al. | Immunosuppressive effect of FK506 on orthotopic liver and small bowel xenotransplantation (xenoOLTx and SBTx). | 1996 | Transplant. Proc. | pmid:8658729 |
| Kokado Y et al. | Hypertension in renal transplant recipients and its effect on long-term renal allograft survival. | 1996 | Transplant. Proc. | pmid:8658802 |
| Takuma T et al. | Dephosphorylation of cofilin in parotid acinar cells. | 1996 | J. Biochem. | pmid:8864841 |
| Shaw LM et al. | Toxic effects of immunosuppressive drugs: mechanisms and strategies for controlling them. | 1996 | Clin. Chem. | pmid:8697605 |
| Dhar DK et al. | FK506 maintains cellular calcium homeostasis in ischemia-reperfusion injury of the canine liver. | 1996 | J. Surg. Res. | pmid:8592405 |