| MeSH term | MeSH ID | Detail |
|---|---|---|
| Papillomavirus Infections | D030361 | 4 associated lipids |
| Denys-Drash Syndrome | D030321 | 1 associated lipids |
| Pulmonary Disease, Chronic Obstructive | D029424 | 16 associated lipids |
| Polyomavirus Infections | D027601 | 1 associated lipids |
| Coronary Stenosis | D023921 | 6 associated lipids |
| Lacerations | D022125 | 1 associated lipids |
| Brachial Plexus Neuritis | D020968 | 2 associated lipids |
| Neuroaspergillosis | D020953 | 2 associated lipids |
| Hypoxia-Ischemia, Brain | D020925 | 22 associated lipids |
| Central Nervous System Viral Diseases | D020805 | 1 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Gonzalez Molina M et al. | Renal function in patients with cadaveric kidney transplants treated with tacrolimus or cyclosporine. | 2007 | Transplant. Proc. | pmid:17889126 |
| Charpentier B | Induction versus non-induction protocols in anti-calcineurin-based immunosuppression. | 2001 Nov-Dec | Transplant. Proc. | pmid:11750425 |
| Christiaans M et al. | Effect of breakfast on the oral bioavailability of tacrolimus and changes in pharmacokinetics at different times posttransplant in renal transplant recipients. | 1998 | Transplant. Proc. | pmid:9636516 |
| Gavela E et al. | Histological findings of early graft biopsies in old donor renal transplant patients receiving induction therapy. | 2009 Jul-Aug | Transplant. Proc. | pmid:19715842 |
| Wang SS et al. | Clinical experience of tacrolimus with everolimus in heart transplantation. | 2012 | Transplant. Proc. | pmid:22564581 |
| Pérez-Flores I et al. | Intracellular ATP levels in CD4+ lymphocytes are a risk marker of rejection and infection in renal graft recipients. | 2009 Jul-Aug | Transplant. Proc. | pmid:19715845 |
| Smoter P et al. | Risk factors of acute renal failure after orthotopic liver transplantation: single-center experience. | 2014 | Transplant. Proc. | pmid:25380918 |
| Ricordi C et al. | Donor bone marrow cell infusion without recipient cytoablation induces acceptance of rat islet allografts. | 1994 | Transplant. Proc. | pmid:7527967 |
| Nazmul MN et al. | Severe Hyperkalemia Complicating Voriconazole Treatment in a Kidney Transplant Recipient With Histoplasmosis: A Case Report. | 2017 | Transplant. Proc. | pmid:29198681 |
| Tanabe K et al. | ABO-incompatible living donor kidney transplantation under tacrolimus immunosuppression. | 2000 | Transplant. Proc. | pmid:11119903 |
| Jang HJ et al. | Conversion from cyclosporine to tacrolimus in renal allograft recipients with delayed graft function from severe acute tubular necrosis. | 2000 | Transplant. Proc. | pmid:11119904 |
| Kobayashi M et al. | Production of monoclonal antibody against recombinant human FKBP-12 and subcellular localization of FKBP-12 in human mononuclear and polymorphonuclear cells. | 1993 | Transplant. Proc. | pmid:7679832 |
| Friob MC et al. | A combined HPLC-ELISA evaluation of FK 506 in transplant patients. | 1991 | Transplant. Proc. | pmid:1721265 |
| Nakajima H and Oka T | The inhibition of T-cell-receptor-induced Fas ligand upregulation by cyclosporine and FK 506. | 1996 | Transplant. Proc. | pmid:8623224 |
| Berman M et al. | Lipid metabolism and immunosuppressive therapy in heart transplant recipients. | 2003 | Transplant. Proc. | pmid:12644091 |
| Rajnoch J et al. | Regulators of angiogenesis in renal ischemia/reperfusion injury in normotensive and hypertensive rats: effect of tacrolimus. | 2005 Jan-Feb | Transplant. Proc. | pmid:15808641 |
| Fung JJ et al. | Conversion from cyclosporine to FK 506 in liver allograft recipients with cyclosporine-related complications. | 1990 | Transplant. Proc. | pmid:1689901 |
| Sahar G et al. | Glucose metabolism in heart transplant recipients treated with FK506 or cyclosporine. | 2003 | Transplant. Proc. | pmid:12644092 |
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| Sgrosso JL et al. | Tacrolimus pharmacokinetics in heart transplant. | 2002 | Transplant. Proc. | pmid:11959225 |
| Langrehr JM et al. | Comparison of quadruple induction including ATG or IL-2R antibody with FK506-based therapy after liver transplantation. | 1998 | Transplant. Proc. | pmid:9636583 |
| Boran M et al. | Determining renal resistive and pulsatility indexes long-term after kidney transplantation in kidney transplant recipients on cyclosporine a-, tacrolimus-, or sirolimus-based regimens. | 2014 | Transplant. Proc. | pmid:24935296 |
| Yoshida S et al. | Combination therapy with FK 506 and RS61443 for rejection following allogeneic small bowel transplantation in rats. | 2000 | Transplant. Proc. | pmid:11120262 |
| McKenna BA et al. | Tacrolimus (FK 506): a whole blood assay as measured on the Abbott IMx analyzer. | 1996 | Transplant. Proc. | pmid:8623491 |
| Jordan ML et al. | Outcome of tacrolimus conversion therapy for renal allograft rejection: 5-year follow-up. | 1999 | Transplant. Proc. | pmid:10576052 |
| Tanida I et al. | Yeast cyclophilin-related gene encodes a nonessential second peptidyl-prolyl cis-trans isomerase associated with the secretory pathway. | 1991 | Transplant. Proc. | pmid:1721297 |
| Nicoluzzi J et al. | One hundred pancreas transplants performed in a Brazilian institution. | 2009 | Transplant. Proc. | pmid:20005382 |
| Kolonko A et al. | Improved kidney graft function after conversion from twice daily tacrolimus to a once daily prolonged-release formulation. | 2011 | Transplant. Proc. | pmid:21996198 |
| Tai HC et al. | Urachal adenocarcinoma following kidney transplantation: the first case report. | 2009 | Transplant. Proc. | pmid:19545760 |
| Orita T et al. | Effect of FK 506 in combination with prednisolone on the graft-vs-host reaction after small bowel transplantation in rats. | 1994 | Transplant. Proc. | pmid:7518147 |
| Ge J et al. | Impact of FOXP3 Polymorphisms on the Blood Level of Tacrolimus in Renal Transplant Recipients. | Transplant. Proc. | pmid:27569929 | |
| Masuda S et al. | Initial dosage adjustment for oral administration of tacrolimus using the intestinal MDR1 level in living-donor liver transplant recipients. | 2005 | Transplant. Proc. | pmid:15919446 |
| Ogasa N et al. | Successful transplantation of newborn rat intestine as a free graft. | 1992 | Transplant. Proc. | pmid:1376514 |
| Alessiani M et al. | Total orthotopic small bowel transplantation in swine under FK 506. | 1994 | Transplant. Proc. | pmid:7518148 |
| Graeb C et al. | Cytoimmunologic monitoring of small bowel allograft recipients. | 1992 | Transplant. Proc. | pmid:1376515 |
| Fay JW et al. | FK 506-based immunosuppression for prevention of graft versus host disease after unrelated donor marrow transplantation. | 1995 | Transplant. Proc. | pmid:7533383 |
| Liu B et al. | Single-center experience: tacrolimus and mycophenolate mofetil in early stage of kidney transplantation with liver dysfunction. | 2003 | Transplant. Proc. | pmid:12591396 |
| Hultsch T and Hohman RJ | Categorizing receptor-signaling pathways with FK 506 and rapamycin. | 1991 | Transplant. Proc. | pmid:1721328 |
| Date K et al. | Effect of FK 506 on graft survival in rat small intestinal allografts. | 1992 | Transplant. Proc. | pmid:1376516 |
| Murase N et al. | Bone marrow augmentation for heart, liver, and small bowel transplantation: prolongation of graft survival and incidence of graft-versus-host disease. | 1995 | Transplant. Proc. | pmid:7533386 |
| Yang SS et al. | A single center, open-label, randomized pilot study to evaluate the safety and efficacy of tacrolimus modified release, Advagraf, versus tacrolimus twice daily, Prograf, in stable renal recipients (single). | 2015 | Transplant. Proc. | pmid:25891697 |
| Takai K et al. | Immunosuppressive effects of FK 506 on rat lymphoid organs. | 1991 | Transplant. Proc. | pmid:1721329 |
| Ogino S et al. | Conversion from tacrolimus to cyclosporine microemulsion therapy in liver transplant recipients. | 2004 | Transplant. Proc. | pmid:15041357 |
| Hassoun Z et al. | The choice of calcineurin inhibitor does not influence centrilobular necrosis after orthotopic liver transplantation. | 2002 | Transplant. Proc. | pmid:12176464 |
| Opelz G | Evaluation of immunosuppressive induction regimens in renal transplantation. Collaborative Transplant Study. | 1998 | Transplant. Proc. | pmid:9865286 |
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| Zegarska J et al. | Tacrolimus Metabolite M-III May Have Nephrotoxic and Myelotoxic Effects and Increase the Incidence of Infections in Kidney Transplant Recipients. | 2016 | Transplant. Proc. | pmid:27496443 |
| Spada M et al. | Tacrolimus and mycophenolate mofetil in pig small bowel transplantation: different protocols and their outcome. | 1997 | Transplant. Proc. | pmid:9142286 |
| Weber M et al. | Decreased rejection episodes in African-American renal transplant recipients receiving mycophenolate mofetil/tacrolimus therapy. | 1997 | Transplant. Proc. | pmid:9414883 |
| Gelens MA et al. | Do blood pressure and arterial wall properties change after conversion from cyclosporine to tacrolimus? | 2005 | Transplant. Proc. | pmid:15919498 |
| Scantlebury VP et al. | Outcome of kidney transplantation in African-Americans using tacrolimus. | 1997 | Transplant. Proc. | pmid:9414906 |
| Hanafusa T et al. | Long-term impact of hepatitis virus infection on kidney transplant recipients and a pilot study of the effects of interferon alpha on chronic hepatitis C. | 1995 | Transplant. Proc. | pmid:7533440 |
| Shapiro R et al. | FK 506 in clinical kidney transplantation. | 1991 | Transplant. Proc. | pmid:1721361 |
| Jiménez O et al. | Defining the initial doses of sirolimus and tacrolimus in the period immediately after renal transplantation. | 2003 | Transplant. Proc. | pmid:12962758 |
| Sánchez-Fructuoso AI et al. | Daclizumab induction as an immunosuppressive regimen for renal transplant recipients from non-heart-beating donors. | 2003 | Transplant. Proc. | pmid:12962759 |
| Teebken OE et al. | Primary immunosuppression with tacrolimus and mycophenolate mofetil versus cyclosporine and azathioprine in heart transplant recipients. | 2002 | Transplant. Proc. | pmid:12072335 |
| Burke GW et al. | Randomized trial of three different immunosuppressive regimens to prevent chronic renal allograft rejection. | 2002 | Transplant. Proc. | pmid:12176505 |
| Miyazawa H et al. | Graft immunomodulation by donor irradiation and recipient-specific bone marrow cells in rat small bowel transplantation. | 2002 | Transplant. Proc. | pmid:12072357 |
| Coupes BM et al. | Tacrolimus monotherapy in renal transplantation: four-year data. | 2002 | Transplant. Proc. | pmid:12176506 |
| Feitoza CQ et al. | A role for HO-1 in renal function impairment in animals subjected to ischemic and reperfusion injury and treated with immunosuppressive drugs. | 2007 | Transplant. Proc. | pmid:17362747 |
| Goh BL et al. | FK506 rescue therapy for acute renal allograft rejection. | 1998 | Transplant. Proc. | pmid:9838574 |
| Goh BL and Tan SY | FK506 "rescue" therapy complicated by renal tubular acidosis in renal allograft recipients. | 1998 | Transplant. Proc. | pmid:9838575 |
| Melk A et al. | P-glycoprotein expression in patients before and after kidney transplantation. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083115 |
| Tacrolimus in renal transplantation: a comparison of induction vs noninduction therapy (triple therapy): three-month results. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083131 | |
| Villanueva ME et al. | Alemtuzumab induction with tacrolimus monotherapy in de novo renal transplantation. | 2008 | Transplant. Proc. | pmid:18790198 |
| Katoh H et al. | Effectiveness of 15-deoxyspergualin on steroid-resistant acute rejection in living related liver transplantation. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123125 |
| Meiser BM et al. | Tacrolimus (FK506) proves superior to OKT3 for treating episodes of persistent rejection following intrathoracic transplantation. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123150 |
| Carroll PB et al. | Synexin: a target protein for toxic effects of cyclosporine and FK 506 in endocrine cells. | 1991 | Transplant. Proc. | pmid:1721394 |
| Gerhardt U et al. | High QT dispersion in tacrolimus-treated kidney transplant recipients. | 2001 | Transplant. Proc. | pmid:11377482 |
| Toda F et al. | Tacrolimus trough level adjustment after administration of fluconazole to kidney recipients. | 2002 | Transplant. Proc. | pmid:12176555 |
| Lauro A et al. | Rejection episodes and 3-year graft survival under sirolimus and tacrolimus treatment after adult intestinal transplantation. | 2007 | Transplant. Proc. | pmid:17580204 |
| Yamashita K et al. | Effect of a novel immunosuppressant, FTY720, on heart and liver transplantations in rats. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083526 |
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| Murase N et al. | Lymphocyte traffic and graft-versus-host disease after fully allogeneic small bowel transplantation. | 1991 | Transplant. Proc. | pmid:1721424 |
| Takeda M et al. | Pretreatment with splenectomy and FK506 in xeno-lung transplantation. | 1996 | Transplant. Proc. | pmid:8658728 |
| Langrehr JM et al. | Indefinite small bowel allograft survival after limited immunosuppressive therapy is not due to specific hyporesponsiveness. | 1991 | Transplant. Proc. | pmid:1721425 |
| Wiseman AC et al. | Fixed-dose sirolimus with reduced dose calcineurin inhibitor: the University of Colorado experience. | 2003 | Transplant. Proc. | pmid:12742482 |
| Moura Neto A et al. | Frequency of Thyroid Dysfunction in Patients With Diabetes Mellitus Before and After Liver Transplantation. | 2018 | Transplant. Proc. | pmid:29661439 |
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| Pankewycz O et al. | Conversion to low-dose tacrolimus or rapamycin 3 months after kidney transplantation: a prospective, protocol biopsy-guided study. | 2011 | Transplant. Proc. | pmid:21440749 |
| Yoshimura R et al. | Effect of immunosuppressive drugs (CsA, FK 506, rapamycin) on the kidney microsomal cytochrome P-450 system in the rat. | 1994 | Transplant. Proc. | pmid:7524223 |
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| Kahl A et al. | Long-term prednisolone withdrawal after pancreas and kidney transplantation in patients treated with ATG, tacrolimus, and mycophenolate mofetil. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267473 |
| McCauley J et al. | Long-term lipid metabolism in combined kidney-pancreas transplant recipients under tacrolimus immunosuppression. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267475 |
| Sessa A et al. | Cardiovascular risk factors in renal transplant patients after switch from standard tacrolimus to prolonged-release tacrolimus. | 2012 | Transplant. Proc. | pmid:22974866 |
| Rieber J et al. | Effects of tacrolimus and cyclosporine on the coronary microcirculation after heart transplantation: a prospective study with serial intracoronary flow measurements. | 1998 | Transplant. Proc. | pmid:9636446 |
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| Kanatani T et al. | Experimental limb transplantation, part III: induction of tolerance in the rigorous strain combination of Brown Norway donor to Lewis recipient. | 2004 | Transplant. Proc. | pmid:15686745 |
| Katayama Y et al. | Immunosuppressive effects of FK 506 and 15-deoxyspergualin in rat lung transplantation. | 1991 | Transplant. Proc. | pmid:1703690 |