tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Gao G et al. | Rapamycin inhibits hydrogen peroxide-induced loss of vascular contractility. | 2011 | Am. J. Physiol. Heart Circ. Physiol. | pmid:21357511 |
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| Kohno M et al. | A new cardioprotective agent, JTV519, improves defective channel gating of ryanodine receptor in heart failure. | 2003 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12433661 |
| Gómez AM et al. | FKBP12.6 overexpression decreases Ca2+ spark amplitude but enhances [Ca2+]i transient in rat cardiac myocytes. | 2004 | Am. J. Physiol. Heart Circ. Physiol. | pmid:15271664 |
| Sasamori K et al. | Cyclic ADP-ribose, a putative Ca2+-mobilizing second messenger, operates in submucosal gland acinar cells. | 2004 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:14990397 |
| Lum H et al. | Protein phosphatase 2B inhibitor potentiates endothelial PKC activity and barrier dysfunction. | 2001 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:11504680 |
| Yaghi A and Sims SM | Constrictor-induced translocation of NFAT3 in human and rat pulmonary artery smooth muscle. | 2005 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:16055480 |
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| Ren H et al. | Phosphatase inhibition increases AQP2 accumulation in the rat IMCD apical plasma membrane. | 2016 | Am. J. Physiol. Renal Physiol. | pmid:27488997 |
| Thai TL et al. | ADP-ribosyl cyclase and ryanodine receptor activity contribute to basal renal vasomotor tone and agonist-induced renal vasoconstriction in vivo. | 2007 | Am. J. Physiol. Renal Physiol. | pmid:17652368 |
| Peherstorfer E et al. | Effects of microinjection of synthetic Bcl-2 domain peptides on apoptosis of renal tubular epithelial cells. | 2002 | Am. J. Physiol. Renal Physiol. | pmid:12060601 |
| Axelsson J et al. | Scavengers of reactive oxygen species, paracalcitol, RhoA, and Rac-1 inhibitors and tacrolimus inhibit angiotensin II-induced actions on glomerular permeability. | 2013 | Am. J. Physiol. Renal Physiol. | pmid:23657856 |
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| Cho SG et al. | Drp1 dephosphorylation in ATP depletion-induced mitochondrial injury and tubular cell apoptosis. | 2010 | Am. J. Physiol. Renal Physiol. | pmid:20410216 |
| De Miguel C et al. | Infiltrating T lymphocytes in the kidney increase oxidative stress and participate in the development of hypertension and renal disease. | 2011 | Am. J. Physiol. Renal Physiol. | pmid:21159736 |
| Rojas-Vega L et al. | Increased phosphorylation of the renal Na+-Cl- cotransporter in male kidney transplant recipient patients with hypertension: a prospective cohort. | 2015 | Am. J. Physiol. Renal Physiol. | pmid:26336164 |
| Edinger RS et al. | Effect of immunosuppressive agents on glucocorticoid receptor function in A6 cells. | 2002 | Am. J. Physiol. Renal Physiol. | pmid:12110508 |
| Ilori TO et al. | Acute calcineurin inhibition with tacrolimus increases phosphorylated UT-A1. | 2012 | Am. J. Physiol. Renal Physiol. | pmid:22205230 |
| Amberg GC et al. | Regulation of A-type potassium channels in murine colonic myocytes by phosphatase activity. | 2001 | Am. J. Physiol., Cell Physiol. | pmid:11698261 |
| Ahn HS et al. | Calcineurin-independent inhibition of KV1.3 by FK-506 (tacrolimus): a novel pharmacological property. | 2007 | Am. J. Physiol., Cell Physiol. | pmid:17166943 |
| Wang YX et al. | FKBP12.6 and cADPR regulation of Ca2+ release in smooth muscle cells. | 2004 | Am. J. Physiol., Cell Physiol. | pmid:14592808 |
| Sans MD and Williams JA | Calcineurin is required for translational control of protein synthesis in rat pancreatic acini. | 2004 | Am. J. Physiol., Cell Physiol. | pmid:15044154 |
| Bayguinov O et al. | Muscarinic stimulation increases basal Ca(2+) and inhibits spontaneous Ca(2+) transients in murine colonic myocytes. | 2001 | Am. J. Physiol., Cell Physiol. | pmid:11171588 |
| Angus LM et al. | Calcineurin-NFAT signaling, together with GABP and peroxisome PGC-1{alpha}, drives utrophin gene expression at the neuromuscular junction. | 2005 | Am. J. Physiol., Cell Physiol. | pmid:15930144 |
| Zhang Y et al. | K restriction inhibits protein phosphatase 2B (PP2B) and suppression of PP2B decreases ROMK channel activity in the CCD. | 2008 | Am. J. Physiol., Cell Physiol. | pmid:18184875 |
| Yue G et al. | The effect of rapamycin on single ENaC channel activity and phosphorylation in A6 cells. | 2000 | Am. J. Physiol., Cell Physiol. | pmid:10898719 |
| Nam JH et al. | Expression of TASK-2 and its upregulation by B cell receptor stimulation in WEHI-231 mouse immature B cells. | 2011 | Am. J. Physiol., Cell Physiol. | pmid:21307343 |
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| Deuse T et al. | Mechanisms behind local immunosuppression using inhaled tacrolimus in preclinical models of lung transplantation. | 2010 | Am. J. Respir. Cell Mol. Biol. | pmid:19880819 |
| Rolfe FG et al. | Cyclosporin A and FK506 reduce interleukin-5 mRNA abundance by inhibiting gene transcription. | 1997 | Am. J. Respir. Cell Mol. Biol. | pmid:9271313 |
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| Saeki K et al. | Endobronchial Lesions of Mycobacterium abscessus Infection in an Immunocompromised Patient. | 2017 | Am. J. Respir. Crit. Care Med. | pmid:28199133 |
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| Spiekerkoetter E et al. | Low-Dose FK506 (Tacrolimus) in End-Stage Pulmonary Arterial Hypertension. | 2015 | Am. J. Respir. Crit. Care Med. | pmid:26177174 |
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| Lee KK et al. | Successful treatment of ongoing intestinal allograft rejection permits recovery of graft structure and function. | 1993 | Am. J. Surg. | pmid:7678188 |