tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ma R et al. | FK506 ameliorates podocyte injury in type 2 diabetic nephropathy by down-regulating TRPC6 and NFAT expression. | 2015 | Int J Clin Exp Pathol | pmid:26823720 |
| Chung YW et al. | Transcriptional activation of nuclear-related factor 2 by FK506 in Jurkat T cells. | 2015 | Transplant. Proc. | pmid:25891728 |
| Tsai MK et al. | B cells and immunoglobulin in ABO-incompatible renal transplant patients receiving rituximab and double filtration plasmapheresis. | 2015 | J. Formos. Med. Assoc. | pmid:25839769 |
| Fujibayashi T et al. | Comparison of efficacy and safety of tacrolimus and methotrexate in combination with abatacept in patients with rheumatoid arthritis; a retrospective observational study in the TBC Registry. | 2015 | Mod Rheumatol | pmid:25775147 |
| Lightman S et al. | Pegylated interferon-α-2b reduces corticosteroid requirement in patients with Behçet's disease with upregulation of circulating regulatory T cells and reduction of Th17. | 2015 | Ann. Rheum. Dis. | pmid:25269831 |
| Adam R et al. | Improved survival in liver transplant recipients receiving prolonged-release tacrolimus in the European Liver Transplant Registry. | 2015 | Am. J. Transplant. | pmid:25703527 |
| Romanowski M et al. | Interleukin-17 gene polymorphisms in patients with post-transplant diabetes mellitus. | 2015 | Eur Rev Med Pharmacol Sci | pmid:26400516 |
| Chittock J et al. | Comparing the Effect of a Twice-weekly Tacrolimus and Betamethasone Valerate Dose on the Subclinical Epidermal Barrier Defect in Atopic Dermatitis. | 2015 | Acta Derm. Venereol. | pmid:25594610 |
| Velioglu A et al. | Association of BK Virus Titers With Lymphocyte Count in Renal Transplant Patients. | 2015 | Transplant. Proc. | pmid:26093733 |
| Webb NJ et al. | Corticosteroid-free Kidney Transplantation Improves Growth: 2-Year Follow-up of the TWIST Randomized Controlled Trial. | 2015 | Transplantation | pmid:25539467 |
| Wardhana EA and Datau | A patient with plaque type morphea mimicking systemic lupus erythematosus. | 2015 | Acta Med Indones | pmid:26260557 |
| Inamoto Y et al. | Tacrolimus versus Cyclosporine after Hematopoietic Cell Transplantation for Acquired Aplastic Anemia. | 2015 | Biol. Blood Marrow Transplant. | pmid:26033280 |
| Bunnapradist S et al. | LCPT once-daily extended-release tacrolimus tablets versus twice-daily capsules: a pooled analysis of two phase 3 trials in important de novo and stable kidney transplant recipient subgroups. | 2016 | Transpl. Int. | pmid:26953629 |
| van der Schaft J et al. | First experience with extended release tacrolimus in the treatment of adult patients with severe, difficult to treat atopic dermatitis: Clinical efficacy, safety and dose finding. | 2016 | J. Dermatol. Sci. | pmid:26547110 |
| Gokhale NS | Systematic approach to managing vernal keratoconjunctivitis in clinical practice: Severity grading system and a treatment algorithm. | 2016 | Indian J Ophthalmol | pmid:27050351 |
| Parody R et al. | GvHD prophylaxis with tacrolimus plus sirolimus after reduced intensity conditioning allogeneic transplantation: results of a multicenter study. | 2016 | Bone Marrow Transplant. | pmid:27295268 |
| Rotenstein L et al. | Management of refractory autoimmune hemolytic anemia via allogeneic stem cell transplantation. | 2016 | Bone Marrow Transplant. | pmid:27272445 |
| Raschzok N et al. | The impact of directly acting antivirals on the enzymatic liver function of liver transplant recipients with recurrent hepatitis C. | 2016 | Transpl Infect Dis | pmid:27632190 |
| Nakamura H et al. | Usefulness of tacrolimus for refractory adult-onset still's disease: Report of six cases. | 2016 | Mod Rheumatol | pmid:25036233 |
| Wen Y et al. | Tacrolimus restores podocyte injury and stabilizes the expression of Cabin1 in 5/6 nephrectomized rats. | 2016 | Ren Fail | pmid:26905810 |
| Högerle BA et al. | Challenging immunosuppression treatment in lung transplant recipients with kidney failure. | 2016 | Transpl. Immunol. | pmid:26892232 |
| Kimura H et al. | Has widespread use of biologic and immunosuppressant therapy for ulcerative colitis affected surgical trends? Results of a questionnaire survey of surgical institutions in Japan. | 2016 | Surg. Today | pmid:26467558 |
| Törlén J et al. | A prospective randomized trial comparing cyclosporine/methotrexate and tacrolimus/sirolimus as graft-versus-host disease prophylaxis after allogeneic hematopoietic stem cell transplantation. | 2016 | Haematologica | pmid:27662016 |
| Zhang XS et al. | FkbN and Tcs7 are pathway-specific regulators of the FK506 biosynthetic gene cluster in Streptomyces tsukubaensis L19. | 2016 | J. Ind. Microbiol. Biotechnol. | pmid:27757551 |
| Martial LC et al. | A preliminary study searching for the right dose of tacrolimus in very young (≤4 years) renal transplant patients. | 2016 | J. Pharm. Pharmacol. | pmid:27669677 |
| Gaballa S et al. | Results of a 2-arm, phase 2 clinical trial using post-transplantation cyclophosphamide for the prevention of graft-versus-host disease in haploidentical donor and mismatched unrelated donor hematopoietic stem cell transplantation. | 2016 | Cancer | pmid:27404668 |
| Kim HY et al. | Tracking protein-protein interaction and localization in living cells using a high-affinity molecular binder. | 2016 | Biochem. Biophys. Res. Commun. | pmid:26820537 |
| Chang KT et al. | Tacrolimus suppresses atopic dermatitis-associated cytokines and chemokines in monocytes. | 2016 | J Microbiol Immunol Infect | pmid:25315214 |
| Brooks E et al. | Population Pharmacokinetic Modelling and Bayesian Estimation of Tacrolimus Exposure: Is this Clinically Useful for Dosage Prediction Yet? | 2016 | Clin Pharmacokinet | pmid:27138787 |
| Zeng W et al. | Hyaluronic acid-coated niosomes facilitate tacrolimus ocular delivery: Mucoadhesion, precorneal retention, aqueous humor pharmacokinetics, and transcorneal permeability. | 2016 | Colloids Surf B Biointerfaces | pmid:26820107 |
| Nuki Y et al. | Comparison of the therapeutic efficacy and safety between tacrolimus and infliximab for moderate-to-severe ulcerative colitis: a single center experience. | 2016 | Scand. J. Gastroenterol. | pmid:26818468 |
| Jin H et al. | Clinical study of double dose of valsartan combined with tacrolimus in treatment of diabetic nephropathy. | 2016 | Eur Rev Med Pharmacol Sci | pmid:26813471 |
| Joko T et al. | Therapeutic Effect of 0.1% Topical Tacrolimus for Childhood Interstitial Keratitis Refractory to Cyclosporine. | 2016 | J Nippon Med Sch | pmid:26960587 |
| Malachowski SJ et al. | Annular Lichenoid Dermatitis of Youth: A Chronic Case Managed Using Pimecrolimus. | 2016 | Pediatr Dermatol | pmid:27653808 |
| Sawada T et al. | Experimental Studies on Protective Effects of FK506 Against Hepatic Ischemia-Reperfusion Injury. | 2016 | J. Med. Invest. | pmid:27644569 |
| Hu X et al. | Chimeric Allografts Induced by Short-Term Treatment With Stem Cell-Mobilizing Agents Result in Long-Term Kidney Transplant Survival Without Immunosuppression: A Study in Rats. | 2016 | Am. J. Transplant. | pmid:26749344 |
| Cameron AM et al. | Chimeric Allografts Induced by Short-Term Treatment With Stem Cell Mobilizing Agents Result in Long-Term Kidney Transplant Survival Without Immunosuppression: II, Study in Miniature Swine. | 2016 | Am. J. Transplant. | pmid:26748958 |
| Chen CA et al. | Quantitative analysis of tissue inflammation and responses to treatment in immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome, and review of literature. | 2016 | J Microbiol Immunol Infect | pmid:26748735 |
| Karagüzel G et al. | Vitamin D status and the effects of oral vitamin D treatment in children with vitiligo: A prospective study. | 2016 | Clin Nutr ESPEN | pmid:28531780 |
| Yoshida T et al. | Oral tacrolimus oil formulations for enhanced lymphatic delivery and efficient inhibition of T-cell's interleukin-2 production. | 2016 | Eur J Pharm Biopharm | pmid:26748381 |
| Muñoz Gómez MM et al. | [Tacrolimus-induced gynecomastia in a patient with polymyositis]. | 2016 | Med Clin (Barc) | pmid:26678165 |
| Ferjani H et al. | Protective effect of mycophenolate mofetil against nephrotoxicity and hepatotoxicity induced by tacrolimus in Wistar rats. | 2016 | J. Physiol. Biochem. | pmid:26746208 |
| Vasu S et al. | Granulocyte Colony-Stimulating Factor-Mobilized Allografts Contain Activated Immune Cell Subsets Associated with Risk of Acute and Chronic Graft-versus-Host Disease. | 2016 | Biol. Blood Marrow Transplant. | pmid:26743340 |
| Yoo EC et al. | Developmental changes of MPA exposure in children. | 2016 | Pediatr. Nephrol. | pmid:26743220 |
| Pouché L et al. | A candidate gene approach of the calcineurin pathway to identify variants associated with clinical outcomes in renal transplantation. | 2016 | Pharmacogenomics | pmid:26894651 |
| Abdel-Kahaar E et al. | Analytical Validation and Cross-Validation of an NFAT-Regulated Gene Expression Assay for Pharmacodynamic Monitoring of Therapy With Calcineurin Inhibitors. | 2016 | Ther Drug Monit | pmid:27661400 |
| Radziejewski K and Balicki I | Comparative clinical evaluation of tacrolimus and cyclosporine eye drops for the treatment of canine keratoconjunctivitis sicca. | 2016 | Acta Vet. Hung. | pmid:27653428 |
| Kannegieter NM et al. | Conversion to Once-Daily Tacrolimus Results in Increased p38MAPK Phosphorylation in T Lymphocytes of Kidney Transplant Recipients. | 2016 | Ther Drug Monit | pmid:26606072 |
| Wang Z et al. | Nanocomposite microparticles (nCmP) for the delivery of tacrolimus in the treatment of pulmonary arterial hypertension. | 2016 | Int J Pharm | pmid:27568494 |
| Rahnama-Moghadam S et al. | Vesicular eruption in a 2-year-old boy. | 2016 | J Fam Pract | pmid:27565104 |
| Yang EM et al. | Tacrolimus for children with refractory nephrotic syndrome: a one-year prospective, multicenter, and open-label study of Tacrobell®, a generic formula. | 2016 | World J Pediatr | pmid:26684309 |
| Haasova M et al. | Immunosuppressive therapy for kidney transplantation in children and adolescents: systematic review and economic evaluation. | 2016 | Health Technol Assess | pmid:27557331 |
| Ishiwata Y et al. | Effects of Miconazole Oral Gel on Blood Concentrations of Tacrolimus and Cyclosporine: A Retrospective Observational Study. | 2016 | Ther Drug Monit | pmid:27559841 |
| Lee C et al. | Treatment of bleomycin-induced pulmonary fibrosis by inhaled tacrolimus-loaded chitosan-coated poly(lactic-co-glycolic acid) nanoparticles. | 2016 | Biomed. Pharmacother. | pmid:26898446 |
| Zegarska J et al. | Tacrolimus Metabolite M-III May Have Nephrotoxic and Myelotoxic Effects and Increase the Incidence of Infections in Kidney Transplant Recipients. | 2016 | Transplant. Proc. | pmid:27496443 |
| Bargnoux AS et al. | Evaluation of the New Siemens Tacrolimus Assay on the Dimension EXL Integrated Chemistry System Analyzer: Comparison With an Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry Method. | 2016 | Ther Drug Monit | pmid:27494947 |
| Arai K et al. | A Case Report of Drug-Induced Thrombocytopenia after Living Donor Liver Transplantation. | 2016 | Kobe J Med Sci | pmid:27492209 |
| Woolner K and Sauder M | Periorbital erythema following alcohol ingestion during treatment with topical tacrolimus. | 2016 | CMAJ | pmid:26598374 |
| Yoshida S et al. | Treatment with DHA/EPA ameliorates atopic dermatitis-like skin disease by blocking LTB4 production. | 2016 | J. Med. Invest. | pmid:27644556 |
| Kociszewska-Najman B et al. | Congenital Infections in Neonates of Women With Liver or Kidney Transplants. | 2016 | Transplant. Proc. | pmid:27496446 |
| Zmonarski SC et al. | Lowering of Messenger Ribonucleic Acid Toll-Like Receptors 2-4,9 in Peripheral Blood Mononuclear Cells in Kidney Allograft Recipients, Relationships With Immunosuppressive Treatment, and Delayed Graft Function Occurrence. | 2016 | Transplant. Proc. | pmid:27496439 |
| Ashizuka S et al. | Adrenomedullin Therapy in Patients with Refractory Ulcerative Colitis: A Case Series. | 2016 | Dig. Dis. Sci. | pmid:26470867 |
| Saito B et al. | Umbilical cord blood transplantation for adults using tacrolimus with two-day very-short-term methotrexate for graft-versus-host disease prophylaxis. | 2016 | Leuk. Res. | pmid:27376545 |
| Matsui K et al. | Betamethasone, but Not Tacrolimus, Suppresses the Development of Th2 Cells Mediated by Langerhans Cell-Like Dendritic Cells. | 2016 | Biol. Pharm. Bull. | pmid:27374298 |
| Kimsa M et al. | Transforming growth factor β-related genes in human retinal pigment epithelial cells after tacrolimus treatment. | 2016 | Pharmacol Rep | pmid:27372923 |
| GarcÃa-Delgado R et al. | Systemic Absorption of Topical Tacrolimus in Metastatic Crohn Disease With Skin Ulcers. | 2016 | Actas Dermosifiliogr | pmid:27372545 |
| Gray JM and Ameduri RK | Tacrolimus-associated hemolytic uremic syndrome in a pediatric heart transplant recipient. | 2016 | Pediatr Transplant | pmid:27371345 |
| Tanriover B et al. | Acute Rejection Rates and Graft Outcomes According to Induction Regimen among Recipients of Kidneys from Deceased Donors Treated with Tacrolimus and Mycophenolate. | 2016 | Clin J Am Soc Nephrol | pmid:27364616 |
| Watanabe R et al. | Successful multi-target therapy using corticosteroid, tacrolimus, cyclophosphamide, and rituximab for rapidly progressive interstitial lung disease in a patient with clinically amyopathic dermatomyositis. | 2016 | Mod Rheumatol | pmid:25698368 |
| Vignali D et al. | IL-7 Mediated Homeostatic Expansion of Human CD4+CD25+FOXP3+ Regulatory T Cells After Depletion With Anti-CD25 Monoclonal Antibody. | 2016 | Transplantation | pmid:27306531 |
| Berryhill A et al. | Cysteamine in renal transplantation: A report of two patients with nephropathic cystinosis and the successful re-initiation of cysteamine therapy during the immediate post-transplant period. | 2016 | Pediatr Transplant | pmid:26477696 |
| Saitman A et al. | Evaluation of the Waters MassTrak LC-MS/MS Assay for Tacrolimus and a Comparison to the Abbott Architect Immunoassay. | 2016 | Ther Drug Monit | pmid:26473523 |
| Metzker M et al. | Analytical evaluation of a real-time PCR-based DNA demethylation assay to assess the frequency of naturally occurring regulatory T cells in peripheral blood. | 2016 | Clin. Biochem. | pmid:27220060 |
| Tanzi MG et al. | Pharmacokinetics of prolonged-release tacrolimus and implications for use in solid organ transplant recipients. | 2016 | Clin Transplant | pmid:27220013 |
| Yamashita T et al. | Effects of CYP3A5 polymorphism on the pharmacokinetics of a once-daily modified-release tacrolimus formulation and acute kidney injury in hematopoietic stem cell transplantation. | 2016 | Cancer Chemother. Pharmacol. | pmid:27217047 |
| Narain S and Furie R | Update on clinical trials in systemic lupus erythematosus. | 2016 | Curr Opin Rheumatol | pmid:27314466 |
| Tremblay S et al. | Absence of the Effect of Pretransplant Body Mass Index on Post Kidney Transplant Outcomes. | 2016 | Prog Transplant | pmid:27207408 |
| Wen Y et al. | Effect of the knockdown of Cabin1 on p53 in glomerular podocyte. | 2016 | J. Recept. Signal Transduct. Res. | pmid:26400065 |
| Sharma A et al. | Perioperative Desensitization Improves Outcomes Among Crossmatch Positive Recipients of Deceased Donor Renal Transplants. | 2016 | Prog Transplant | pmid:27207404 |
| Emoto C et al. | Risk Assessment of Drug-Drug Interactions of Calcineurin Inhibitors Affecting Sirolimus Pharmacokinetics in Renal Transplant Patients. | 2016 | Ther Drug Monit | pmid:27310200 |
| Menninga NJ et al. | Restless Legs Syndrome Following Lung Transplantation: Prevalence and Relationship With Tacrolimus Exposure. | 2016 | Prog Transplant | pmid:27207403 |
| Badri PS et al. | Pharmacokinetics of Tacrolimus and Cyclosporine in Liver Transplant Recipients Receiving 3 Direct-Acting Antivirals as Treatment for Hepatitis C Infection. | 2016 | Ther Drug Monit | pmid:27310199 |
| Nankivell BJ et al. | Calcineurin Inhibitor Nephrotoxicity Through the Lens of Longitudinal Histology: Comparison of Cyclosporine and Tacrolimus Eras. | 2016 | Transplantation | pmid:27306529 |
| Reeves TM et al. | Targeting Kv1.3 channels to reduce white matter pathology after traumatic brain injury. | 2016 | Exp. Neurol. | pmid:27302680 |
| RodrÃguez-AusÃn P et al. | Topical tacrolimus 0.03% for the treatment of ocular psoriasis. | 2016 | Arch Soc Esp Oftalmol | pmid:27130870 |
| Stifft F et al. | Effect of Breakfast on the Exposure of the Once-Daily Tacrolimus Formulation in Stable Kidney Transplant Recipients. | 2016 | Ther Drug Monit | pmid:27128604 |
| Pirmez R et al. | Acne keloidalis nuchae in renal transplant patients receiving tacrolimus and sirolimus. | 2016 | Australas. J. Dermatol. | pmid:27124649 |
| Khaled SK et al. | Influence of Absorption, Distribution, Metabolism, and Excretion Genomic Variants on Tacrolimus/Sirolimus Blood Levels and Graft-versus-Host Disease after Allogeneic Hematopoietic Cell Transplantation. | 2016 | Biol. Blood Marrow Transplant. | pmid:26325438 |
| Matsukawa T et al. | Reduced-dose methotrexate in combination with tacrolimus was associated with rapid engraftment and recovery from oral mucositis without affecting the incidence of GVHD. | 2016 | Int. J. Hematol. | pmid:27119977 |
| Chauvet V et al. | [Removal of senescent cells: towards a better future?] | 2016 | Med Sci (Paris) | pmid:28008848 |
| Ruangkanchanasetr P et al. | Beta Cell Function and Insulin Resistance After Conversion from Tacrolimus Twice-Daily to Extended-Release Tacrolimus Once-Daily in Stable Renal Transplant Recipients. | 2016 | Ann. Transplant. | pmid:27980321 |
| Wang YY et al. | Characterization of Discrete Phosphopantetheinyl Transferases in Streptomyces tsukubaensis L19 Unveils a Complicate Phosphopantetheinylation Network. | 2016 | Sci Rep | pmid:27052100 |
| Lee DR et al. | Enhanced dissolution and oral absorption of tacrolimus by supersaturable self-emulsifying drug delivery system. | 2016 | Int J Nanomedicine | pmid:27051286 |
| Cai SC et al. | Topical calcineurin inhibitors in eczema and cancer association: A cohort study. | 2016 | J Dermatolog Treat | pmid:27049893 |
| Aldoss I et al. | Cytogenetics Does Not Impact Outcomes in Adult Patients with Acute Lymphoblastic Leukemia Undergoing Allogeneic Hematopoietic Cell Transplantation. | 2016 | Biol. Blood Marrow Transplant. | pmid:27044907 |
| Yamamoto T et al. | Editorial: tacrolimus vs. anti-tumour necrosis factor agents for moderately to severely active ulcerative colitis--authors' reply. | 2016 | Aliment. Pharmacol. Ther. | pmid:27040167 |
| Imamura CK et al. | Impact of cytochrome P450 2C19 polymorphisms on the pharmacokinetics of tacrolimus when coadministered with voriconazole. | 2016 | J Clin Pharmacol | pmid:26239045 |
| Albano L et al. | Dosing of Enteric-Coated Mycophenolate Sodium Under Routine Conditions: An Observational, Multicenter Study in Kidney Transplantation. | 2016 | Ann. Transplant. | pmid:27122116 |
| Gu C et al. | Triptolide Reduces the Required Dose of Tacrolimus by Attenuating Inflammation, Enhancing Immunosuppression, and Increasing Donor Chimerism in a Heterotopic Hindlimb Transplantation Model. | 2016 | Plast. Reconstr. Surg. | pmid:27879593 |
| Lee WS et al. | Efficacy and safety of low-dose tacrolimus for active rheumatoid arthritis with an inadequate response to methotrexate. | 2016 | Korean J. Intern. Med. | pmid:26961485 |