Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with tacrolimus
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Garcia CD et al. | Renal transplantation in children less than six years old. | 2001 Nov-Dec | Transplant. Proc. | pmid:11750527 |
Smoter P et al. | Risk factors of acute renal failure after orthotopic liver transplantation: single-center experience. | 2014 | Transplant. Proc. | pmid:25380918 |
Mendez R | FK 506 and mycophenolate mofetil in renal transplant recipients: six-month results of a multicenter, randomized dose ranging trial. FK 506 MMF Dose-Ranging Kidney Transplant Study Group. | 1998 | Transplant. Proc. | pmid:9636522 |
Yuan QS et al. | Rescue therapy with tacrolimus in renal graft patients with cyclosporine A-induced hepatotoxicity: a preliminary study. | 2000 | Transplant. Proc. | pmid:11119896 |
Kahl A et al. | First results with a quadruple therapy regimen including tacrolimus and mycophenolate mofetil in patients after combined pancreas and kidney transplantation. | 1998 | Transplant. Proc. | pmid:9532149 |
Sánchez-Fructuoso AI et al. | The prevalence of uridine diphosphate-glucuronosyltransferase 1A9 (UGT1A9) gene promoter region single-nucleotide polymorphisms T-275A and C-2152T and its influence on mycophenolic acid pharmacokinetics in stable renal transplant patients. | 2009 Jul-Aug | Transplant. Proc. | pmid:19715905 |
Asensio M et al. | Experience with tacrolimus as primary immunosuppressor in pediatric liver transplant. | 2002 | Transplant. Proc. | pmid:11959208 |
Sugioka A et al. | FK 506 inhibits tolerance induction in mice liver transplantation. | 2005 Jan-Feb | Transplant. Proc. | pmid:15808576 |
Mueller AR et al. | Increased rejection after liver transplantation in FK 506-treated patients is associated with viral hepatitis C disease. | 1994 | Transplant. Proc. | pmid:7527984 |
Stock PG et al. | Standard sequential immunosuppression with Minnesota antilymphoblast globulin and cyclosporine vs FK 506: a comparison of early nephrotoxicity. | 1993 | Transplant. Proc. | pmid:7679838 |
Abu-Elmagd KM et al. | Four-hour versus 24-hour intravenous infusion of FK 506 in liver transplantation. | 1991 | Transplant. Proc. | pmid:1721271 |
Sakr M et al. | Effect of renal ischemia on plasma levels of FK 506 in rats. | 1992 | Transplant. Proc. | pmid:1371625 |
Smit JA et al. | Induction of primate TH2 lymphokines to suppress TH1 cells. | 1996 | Transplant. Proc. | pmid:8623334 |
Hoffman AL et al. | The effect of FK 506 on small intestine allotransplantation in the rat. | 1990 | Transplant. Proc. | pmid:1689907 |
Bond MMK et al. | Cyclosporine Versus Tacrolimus: Which Calcineurin Inhibitor Has Influence on Cytomegalovirus Infection in Cardiac Transplantation? | 2018 | Transplant. Proc. | pmid:29661443 |
Bekersky I et al. | Bioequivalence of a new strength tacrolimus capsule under development. | 1998 | Transplant. Proc. | pmid:9636591 |
Kobashigawa JA | Postoperative management following heart transplantation. | 1999 | Transplant. Proc. | pmid:10455966 |
Koyamada N et al. | Strategy for chronic rejection in recipient of living-related liver transplantation. | 2000 | Transplant. Proc. | pmid:11120102 |
Cantarovich M et al. | Optimal time points for the prediction of the area-under-the-curve in liver transplant patients receiving tacrolimus. | 1998 | Transplant. Proc. | pmid:9636592 |
Hachida M et al. | Combined use of deoxyspergualin and FK 506 for temporary circulatory assist. | 1999 | Transplant. Proc. | pmid:10455968 |
Harihara Y et al. | Correlation between graft size and necessary tacrolimus dose after living-related liver transplantation. | 2000 | Transplant. Proc. | pmid:11120116 |
Kohnle M et al. | Conversion from cyclosporine to tacrolimus in renal transplant recipients with gum hyperplasia. | 1999 | Transplant. Proc. | pmid:10576043 |
van Hooff JP et al. | Tacrolimus and glucose metabolism. | 1999 | Transplant. Proc. | pmid:10576044 |
Watanabe K et al. | Synergistic effect of short-term fractionated lymphoid irradiation with initial high doses of FK506 on the induction of tolerance to kidney allografts in dogs. | 1998 | Transplant. Proc. | pmid:9474940 |
Torio A et al. | Effect of CYP3A51/3 polymorphism on blood pressure in renal transplant recipients. | 2012 | Transplant. Proc. | pmid:23146466 |
Yoshimura N et al. | Combination therapy of tacrolimus (FK506) with azathioprine and steroids in renal transplant recipients. | 1998 | Transplant. Proc. | pmid:9474949 |
Kim SJ et al. | Randomized trial of tacrolimus versus cyclosporine in steroid withdrawal in living donor renal transplant recipients. | 2004 | Transplant. Proc. | pmid:15518759 |
Kar S and Carr B | Gene expression of FK 506-binding protein. | 1991 | Transplant. Proc. | pmid:1721303 |
Masri M et al. | Prograf five milligrams versus Tacrolimus medis in healthy volunteers: a bioequivalence study. | 2013 | Transplant. Proc. | pmid:24314930 |
Mucha K et al. | 36-month follow-up of 75 renal allograft recipients treated with steroids, tacrolimus, and azathioprine or mycophenolate mofetil. | 2003 | Transplant. Proc. | pmid:14529880 |
Ushigome H et al. | Two cases of tacrolimus-induced alopecia following kidney transplantation. | 1999 | Transplant. Proc. | pmid:10578326 |
Junge G et al. | Withdrawal of steroids: a randomized prospective study of prednisone and tacrolimus versus mycophenolate mofetil and tacrolimus in liver transplant recipients with autoimmune hepatitis. | 2005 | Transplant. Proc. | pmid:15919434 |
Huang CT et al. | Higher Variability of Tacrolimus Trough Level Increases Risk of Acute Rejection in Kidney Transplant Recipients. | Transplant. Proc. | pmid:27569931 | |
Choi SJ et al. | Tacrolimus-induced apoptotic signal transduction pathway. | 2008 | Transplant. Proc. | pmid:18929848 |
Yang SS et al. | A single center, open-label, randomized pilot study to evaluate the safety and efficacy of tacrolimus modified release, Advagraf, versus tacrolimus twice daily, Prograf, in stable renal recipients (single). | 2015 | Transplant. Proc. | pmid:25891697 |
Loh PT et al. | Significant impact of gene polymorphisms on tacrolimus but not cyclosporine dosing in Asian renal transplant recipients. | 2008 | Transplant. Proc. | pmid:18589174 |
Lee TK et al. | Bacterial translocation and the role of postoperative selective bowel decontamination in small intestinal transplantation. | 1994 | Transplant. Proc. | pmid:7518154 |
Hranjec T et al. | Benign transient hyperphosphatasemia associated with Epstein-Barr virus enteritis in a pediatric liver transplant patient: a case report. | 2008 | Transplant. Proc. | pmid:18589195 |
Santiago SF et al. | Effect of short-term immunosuppressive therapy with FK 506 or CyA on the donor in small intestine allotransplantation in rats. | 1992 | Transplant. Proc. | pmid:1376520 |
Tanaka M et al. | Effect of anticomplement agent K-76 COOH in hamster-to-rat and guinea pig-to-rat xenotransplantation. | 1995 | Transplant. Proc. | pmid:7533392 |
Winkler M et al. | Use of FK 506 for treatment of chronic rejection after liver transplantation. | 1991 | Transplant. Proc. | pmid:1721334 |
Varo E et al. | Alternative immunosuppression for acute renal failure in liver transplantation: role of ultra-low dose tacrolimus and basiliximab. | 2002 | Transplant. Proc. | pmid:12176471 |
Braun F et al. | How to handle mycophenolate mofetil in combination with tacrolimus? | 1998 | Transplant. Proc. | pmid:9865309 |
Zegarska J et al. | Tacrolimus Metabolite M-III May Have Nephrotoxic and Myelotoxic Effects and Increase the Incidence of Infections in Kidney Transplant Recipients. | 2016 | Transplant. Proc. | pmid:27496443 |
Yuan-Xin L et al. | Preliminary experience with alemtuzumab induction therapy combined with maintenance low-dose tacrolimus monotherapy in small-bowel transplantation in China. | 2010 Jan-Feb | Transplant. Proc. | pmid:20172275 |
Colak T et al. | Effect of conversion from cyclosporine to tacrolimus on lipid profiles in renal transplant recipients. | 2002 | Transplant. Proc. | pmid:12270321 |
Woodside KJ et al. | Conversion from cyclosporine to tacrolimus results in improved creatinine but does not alter lipid profile. | 2005 | Transplant. Proc. | pmid:15919491 |
Sánchez-Pérez B et al. | Influence of immunosuppression and effect of hepatitis C virus on new onset of diabetes mellitus in liver transplant recipients. | 2008 | Transplant. Proc. | pmid:19010171 |
Ye Q et al. | Persistence of donor cells and incidence of graft-versus-host disease after simultaneous small bowel and bone marrow transplantation. | 1996 | Transplant. Proc. | pmid:8907895 |
Waller JR et al. | Primary immunosuppression with tacrolimus is associated with a reduction in renal allograft fibrosis compared with neoral therapy. | 2002 | Transplant. Proc. | pmid:12176496 |
Boggi U et al. | Neoral versus prograf in simultaneous pancreas-kidney transplantation with portal venous drainage: three-year results of a single-center, open-label, prospective, randomized pilot study. | 2005 Jul-Aug | Transplant. Proc. | pmid:16182772 |
Woo J et al. | FK 506 treatment following syngeneic bone marrow transplantation does not inhibit clonal deletion of V beta 5+ or V beta 11+ T cells. | 1992 | Transplant. Proc. | pmid:1281583 |
Japanese study of FK 506 on kidney transplantation: the benefit of monitoring the whole blood FK 506 concentration. Japanese FK 506 Study Group. | 1991 | Transplant. Proc. | pmid:1721367 | |
Starzl TE et al. | Selected topics on FK 506, with special references to rescue of extrahepatic whole organ grafts, transplantation of "forbidden organs," side effects, mechanisms, and practical pharmacokinetics. | 1991 | Transplant. Proc. | pmid:1703351 |
Watanabe Y et al. | Enteric absorption of FK 506: estimation by a block liver perfusion technique in rats. | 1998 | Transplant. Proc. | pmid:9838656 |
Rayes N et al. | Treatment of hepatitis B-reinfection or de novo-infection after liver transplantation with famciclovir--how effective is it? | 1999 Feb-Mar | Transplant. Proc. | pmid:10083200 |
Takayama K et al. | Nonmuscle myosin heavy chain and nuclear factor-kappa B expression in pig-to-primate xenotransplanted hearts. | 2000 | Transplant. Proc. | pmid:10936372 |
Goller AL et al. | Loss of serum bicarbonate after discordant liver xenotransplantation. | 2000 | Transplant. Proc. | pmid:10936383 |
Nakajima H and Oka T | Analysis of biochemical and biological functions of Fas-ligand (FasL) and Fas on activated T cells in allo-immune response. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123217 |
Akutsu N et al. | Two cases of calcineurin inhibitor-associated reversible posterior leukoencephalopathy syndrome in renal transplant recipients. | 2008 | Transplant. Proc. | pmid:18790253 |
Woodle ES et al. | Tacrolimus therapy for refractory acute renal allograft rejection: a prospective multicenter trial. Tacrolimus Kidney Transplantation Rescue Study Group. | 1996 | Transplant. Proc. | pmid:8962225 |
Boots JM et al. | Risk of adrenal insufficiency with steroid maintenance therapy in renal transplantation. | 2002 | Transplant. Proc. | pmid:12176541 |
Boots JM et al. | Early steroid withdrawal in renal transplantation with tacrolimus dual therapy: a pilot study. | 2002 | Transplant. Proc. | pmid:12176542 |
Cho JH et al. | Impact of cytochrome P450 3A and ATP-binding cassette subfamily B member 1 polymorphisms on tacrolimus dose-adjusted trough concentrations among Korean renal transplant recipients. | 2012 | Transplant. Proc. | pmid:22310591 |
Masaki Y et al. | Cellular basis of immunologic tolerance following total bowel transplantation in rats. II. Dominant role of suppressor T cells in adoptive transfer of acquired tolerance to vascularized allografts. | 1995 | Transplant. Proc. | pmid:7536972 |
Suzuki H et al. | Spleen grafting might induce transplantation tolerance in rats. | 1995 | Transplant. Proc. | pmid:7536973 |
Ji SM et al. | Conversion from cyclosporine to tacrolimus for chronic allograft nephropathy. | 2007 | Transplant. Proc. | pmid:17580148 |
Sakamoto K et al. | Analysis of long-term acceptance of xenografts in rats induced by short-term administration of FK506. | 1989 | Transplant. Proc. | pmid:2468222 |
Moutabarrik A et al. | Use of FK 506 in kidney transplantation. | 1993 | Transplant. Proc. | pmid:7685946 |
Nakajima K et al. | Effects of 15-deoxyspergualin and FK506 on the histology and survival of hamster-to-rat cardiac xenotransplantation. | 1989 | Transplant. Proc. | pmid:2468223 |
Opelz G | New immunosuppressants and HLA matching. | 2001 Feb-Mar | Transplant. Proc. | pmid:11266911 |
Falconer SJ et al. | Conversion from twice-daily to once-daily tacrolimus in simultaneous pancreas-kidney transplant patients. | 2014 | Transplant. Proc. | pmid:24935313 |
Fu F et al. | Systemic administration of CTLA4-Ig or anti-CD40 ligand antibody inhibits second-set rejection of mouse liver allografts. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083555 |
Tatekawa Y et al. | Intragraft expression of p38 in rat small bowel transplantation. | 2000 | Transplant. Proc. | pmid:10995948 |
Karamperis N et al. | Comparison of the pharmacokinetics of tacrolimus and cyclosporine at equivalent molecular doses. | 2003 | Transplant. Proc. | pmid:12826146 |
Budde K et al. | Long-term outcome of tacrolimus rescue therapy in late rejection after renal transplantation. | 1998 | Transplant. Proc. | pmid:9723280 |
Gibelli NE et al. | Sirolimus in pediatric liver transplantation: a single-center experience. | 2009 | Transplant. Proc. | pmid:19376384 |
Kamar N et al. | Efficacy and safety of induction therapy with rabbit antithymocyte globulins in liver transplantation for hepatitis C. | 2004 | Transplant. Proc. | pmid:15621141 |
Dette K et al. | Daclizumab and ATG versus ATG in combination with tacrolimus, mycophenolate mofetil, and steroids in simultaneous [correction of simultaneus] pancreas-kidney transplantation: analysis of early outcome. | 2002 | Transplant. Proc. | pmid:12176624 |
Sahara H et al. | Thymectomy does not abrogate long-term acceptance of MHC class I-disparate lung allografts in miniature Swine. | 2006 | Transplant. Proc. | pmid:17175240 |
de Bruin RW et al. | Fulminant graft-versus-host disease after FK 506 treatment in fully allogeneic small bowel transplantation. | 1991 | Transplant. Proc. | pmid:1721429 |
Kawabe A et al. | Anti-adhesion (anti-ICAM-1 and anti-LFA-1) therapy in a rat pancreas transplantation model. | 1996 | Transplant. Proc. | pmid:8658893 |
Moura Neto A et al. | Frequency of Thyroid Dysfunction in Patients With Diabetes Mellitus Before and After Liver Transplantation. | 2018 | Transplant. Proc. | pmid:29661439 |
Goto T et al. | Discovery of FK-506, a novel immunosuppressant isolated from Streptomyces tsukubaensis. | 1987 | Transplant. Proc. | pmid:2445072 |
Busque S et al. | Canadian multicentre trial of tacrolimus/azathioprine/steroids versus tacrolimus/mycophenolate mofetil/steroids versus neoral/mycophenolate mofetil/steroids in renal transplantation. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267285 |
Sperschneider H | A large, multicentre trial to compare the efficacy and safety of tacrolimus with cyclosporine microemulsion following renal transplantation. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267291 |
Shapiro R | Tacrolimus in solid organ transplantation: an update. | 1999 | Transplant. Proc. | pmid:10500545 |
Martins L et al. | Conversion to tacrolimus in case-problem kidney transplant recipients under cyclosporine-based immunosuppression. | 2000 | Transplant. Proc. | pmid:11134735 |
Fritsche L et al. | Late conversion to mycophenolate mofetil for chronic deterioration of renal allograft function. | 1998 | Transplant. Proc. | pmid:9723451 |
Fornairon S et al. | Can we improve the results of simultaneous pancreas-kidney transplantation? | 1998 | Transplant. Proc. | pmid:9745580 |
Hanack U et al. | Is there a different impact of cyclosporine versus tacrolimus on delayed graft function after kidney transplantation? | 1998 | Transplant. Proc. | pmid:9723477 |
Mohsin N et al. | Low tacrolimus dose requirements in renal transplant recipients in the omani population: implications for pharmacogenetics? | 2005 | Transplant. Proc. | pmid:16213259 |
Bolton C | The ability of myelin basic protein-sensitised leukocytes to adoptively transfer experimental allergic encephalomyelitis following coculture with FK 506, cyclosporine, or prednisolone. | 1991 | Transplant. Proc. | pmid:1721462 |
Lee CM et al. | Monotherapy with tacrolimus for heart and liver transplant: a case report. | 2014 | Transplant. Proc. | pmid:24767396 |
Spada M et al. | A cause of late graft dysfunction after liver transplantation in children: de-novo autoimmune hepatitis. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267495 |
Gotsman I et al. | Effect of peripheral immune tolerance on liver-associated lymphocytes expressing NK1.1. | 2000 | Transplant. Proc. | pmid:10856569 |
Socci C et al. | Pancreata from pediatric donors restore insulin independence in adult insulin-dependent diabetes mellitus recipients. | 2010 Jul-Aug | Transplant. Proc. | pmid:20692410 |
Matsumoto S et al. | ET-Kyoto ductal injection and density-adjusted purification combined with potent anti-inflammatory strategy facilitated single-donor islet transplantation: case reports. | 2010 Jul-Aug | Transplant. Proc. | pmid:20692433 |
Kuroki H et al. | Morphological and immunological analysis of rats with long-term-surviving limb allografts induced by a short course of FK 506 or cyclosporine. | 1991 | Transplant. Proc. | pmid:1703697 |
Morris RE et al. | Use of rapamycin for the suppression of alloimmune reactions in vivo: schedule dependence, tolerance induction, synergy with cyclosporine and FK 506, and effect on host-versus-graft and graft-versus-host reactions. | 1991 | Transplant. Proc. | pmid:1703698 |