Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with tacrolimus
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Bunnapradist S et al. | LCPT once-daily extended-release tacrolimus tablets versus twice-daily capsules: a pooled analysis of two phase 3 trials in important de novo and stable kidney transplant recipient subgroups. | 2016 | Transpl. Int. | pmid:26953629 |
Raschzok N et al. | The impact of directly acting antivirals on the enzymatic liver function of liver transplant recipients with recurrent hepatitis C. | 2016 | Transpl Infect Dis | pmid:27632190 |
Nakamura H et al. | Usefulness of tacrolimus for refractory adult-onset still's disease: Report of six cases. | 2016 | Mod Rheumatol | pmid:25036233 |
Khan S et al. | Tacrolimus-loaded nanostructured lipid carriers for oral delivery-in vivo bioavailability enhancement. | 2016 | Eur J Pharm Biopharm | pmid:27793753 |
Högerle BA et al. | Challenging immunosuppression treatment in lung transplant recipients with kidney failure. | 2016 | Transpl. Immunol. | pmid:26892232 |
Kimura H et al. | Has widespread use of biologic and immunosuppressant therapy for ulcerative colitis affected surgical trends? Results of a questionnaire survey of surgical institutions in Japan. | 2016 | Surg. Today | pmid:26467558 |
Gaballa S et al. | Results of a 2-arm, phase 2 clinical trial using post-transplantation cyclophosphamide for the prevention of graft-versus-host disease in haploidentical donor and mismatched unrelated donor hematopoietic stem cell transplantation. | 2016 | Cancer | pmid:27404668 |
Brooks E et al. | Population Pharmacokinetic Modelling and Bayesian Estimation of Tacrolimus Exposure: Is this Clinically Useful for Dosage Prediction Yet? | 2016 | Clin Pharmacokinet | pmid:27138787 |
Rebora A | Tacrolimus and oral lichen planus. Possible absorption after mucosal application? | 2016 | J Eur Acad Dermatol Venereol | pmid:26372839 |
Jin H et al. | Clinical study of double dose of valsartan combined with tacrolimus in treatment of diabetic nephropathy. | 2016 | Eur Rev Med Pharmacol Sci | pmid:26813471 |
Wang N et al. | Paclitaxel and Tacrolimus Coencapsulated Polymeric Micelles That Enhance the Therapeutic Effect of Drug-Resistant Ovarian Cancer. | 2016 | ACS Appl Mater Interfaces | pmid:26809267 |
Gabriel D et al. | Improved topical delivery of tacrolimus: A novel composite hydrogel formulation for the treatment of psoriasis. | 2016 | J Control Release | pmid:27639683 |
Muñoz Gómez MM et al. | [Tacrolimus-induced gynecomastia in a patient with polymyositis]. | 2016 | Med Clin (Barc) | pmid:26678165 |
Ferjani H et al. | Protective effect of mycophenolate mofetil against nephrotoxicity and hepatotoxicity induced by tacrolimus in Wistar rats. | 2016 | J. Physiol. Biochem. | pmid:26746208 |
Vasu S et al. | Granulocyte Colony-Stimulating Factor-Mobilized Allografts Contain Activated Immune Cell Subsets Associated with Risk of Acute and Chronic Graft-versus-Host Disease. | 2016 | Biol. Blood Marrow Transplant. | pmid:26743340 |
Yoo EC et al. | Developmental changes of MPA exposure in children. | 2016 | Pediatr. Nephrol. | pmid:26743220 |
Pouché L et al. | A candidate gene approach of the calcineurin pathway to identify variants associated with clinical outcomes in renal transplantation. | 2016 | Pharmacogenomics | pmid:26894651 |
Sommerer C et al. | Design and rationale of the ATHENA study--A 12-month, multicentre, prospective study evaluating the outcomes of a de novo everolimus-based regimen in combination with reduced cyclosporine or tacrolimus versus a standard regimen in kidney transplant patients: study protocol for a randomised controlled trial. | 2016 | Trials | pmid:26888217 |
Haasova M et al. | Immunosuppressive therapy for kidney transplantation in children and adolescents: systematic review and economic evaluation. | 2016 | Health Technol Assess | pmid:27557331 |
Tsuji T et al. | Therapeutic approach to mite-induced intractable dermatitis using novel immunomodulator FTY720 ointment (fingolimod) in NC/Nga mice. | 2016 | Allergol Int | pmid:26666476 |
Ishiwata Y et al. | Effects of Miconazole Oral Gel on Blood Concentrations of Tacrolimus and Cyclosporine: A Retrospective Observational Study. | 2016 | Ther Drug Monit | pmid:27559841 |
Griffin SP and Nelson JE | Impact of a Clinical Solid Organ Transplant Pharmacist on Tacrolimus Nephrotoxicity, Therapeutic Drug Monitoring, and Institutional Revenue Generation in Adult Kidney Transplant Recipients. | 2016 | Prog Transplant | pmid:27628498 |
Bargnoux AS et al. | Evaluation of the New Siemens Tacrolimus Assay on the Dimension EXL Integrated Chemistry System Analyzer: Comparison With an Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry Method. | 2016 | Ther Drug Monit | pmid:27494947 |
Faraj W et al. | Osteoporosis in Pediatric Liver Transplantation. | 2016 | Prog Transplant | pmid:27555069 |
Arai K et al. | A Case Report of Drug-Induced Thrombocytopenia after Living Donor Liver Transplantation. | 2016 | Kobe J Med Sci | pmid:27492209 |
Ren H et al. | Phosphatase inhibition increases AQP2 accumulation in the rat IMCD apical plasma membrane. | 2016 | Am. J. Physiol. Renal Physiol. | pmid:27488997 |
Woolner K and Sauder M | Periorbital erythema following alcohol ingestion during treatment with topical tacrolimus. | 2016 | CMAJ | pmid:26598374 |
Yoshida S et al. | Treatment with DHA/EPA ameliorates atopic dermatitis-like skin disease by blocking LTB4 production. | 2016 | J. Med. Invest. | pmid:27644556 |
Ashizuka S et al. | Adrenomedullin Therapy in Patients with Refractory Ulcerative Colitis: A Case Series. | 2016 | Dig. Dis. Sci. | pmid:26470867 |
Gray JM and Ameduri RK | Tacrolimus-associated hemolytic uremic syndrome in a pediatric heart transplant recipient. | 2016 | Pediatr Transplant | pmid:27371345 |
Tanriover B et al. | Acute Rejection Rates and Graft Outcomes According to Induction Regimen among Recipients of Kidneys from Deceased Donors Treated with Tacrolimus and Mycophenolate. | 2016 | Clin J Am Soc Nephrol | pmid:27364616 |
Watanabe R et al. | Successful multi-target therapy using corticosteroid, tacrolimus, cyclophosphamide, and rituximab for rapidly progressive interstitial lung disease in a patient with clinically amyopathic dermatomyositis. | 2016 | Mod Rheumatol | pmid:25698368 |
Vignali D et al. | IL-7 Mediated Homeostatic Expansion of Human CD4+CD25+FOXP3+ Regulatory T Cells After Depletion With Anti-CD25 Monoclonal Antibody. | 2016 | Transplantation | pmid:27306531 |
Tsuji H et al. | Efficacy and Safety of Grapefruit Juice Intake Accompanying Tacrolimus Treatment in Connective Tissue Disease Patients. | 2016 | Intern. Med. | pmid:27301503 |
Tremblay S et al. | Absence of the Effect of Pretransplant Body Mass Index on Post Kidney Transplant Outcomes. | 2016 | Prog Transplant | pmid:27207408 |
Sharma A et al. | Perioperative Desensitization Improves Outcomes Among Crossmatch Positive Recipients of Deceased Donor Renal Transplants. | 2016 | Prog Transplant | pmid:27207404 |
Menninga NJ et al. | Restless Legs Syndrome Following Lung Transplantation: Prevalence and Relationship With Tacrolimus Exposure. | 2016 | Prog Transplant | pmid:27207403 |
Nankivell BJ et al. | Calcineurin Inhibitor Nephrotoxicity Through the Lens of Longitudinal Histology: Comparison of Cyclosporine and Tacrolimus Eras. | 2016 | Transplantation | pmid:27306529 |
Reeves TM et al. | Targeting Kv1.3 channels to reduce white matter pathology after traumatic brain injury. | 2016 | Exp. Neurol. | pmid:27302680 |
Matsukawa T et al. | Reduced-dose methotrexate in combination with tacrolimus was associated with rapid engraftment and recovery from oral mucositis without affecting the incidence of GVHD. | 2016 | Int. J. Hematol. | pmid:27119977 |
Peng L et al. | Comparison of different therapies in high-risk patients with idiopathic membranous nephropathy. | 2016 | J. Formos. Med. Assoc. | pmid:26315481 |
Ruangkanchanasetr P et al. | Beta Cell Function and Insulin Resistance After Conversion from Tacrolimus Twice-Daily to Extended-Release Tacrolimus Once-Daily in Stable Renal Transplant Recipients. | 2016 | Ann. Transplant. | pmid:27980321 |
Castagna L et al. | Tacrolimus compared with cyclosporine A after haploidentical T-cell replete transplantation with post-infusion cyclophosphamide. | 2016 | Bone Marrow Transplant. | pmid:26595078 |
Cai SC et al. | Topical calcineurin inhibitors in eczema and cancer association: A cohort study. | 2016 | J Dermatolog Treat | pmid:27049893 |
Aldoss I et al. | Cytogenetics Does Not Impact Outcomes in Adult Patients with Acute Lymphoblastic Leukemia Undergoing Allogeneic Hematopoietic Cell Transplantation. | 2016 | Biol. Blood Marrow Transplant. | pmid:27044907 |
Yamamoto T et al. | Editorial: tacrolimus vs. anti-tumour necrosis factor agents for moderately to severely active ulcerative colitis--authors' reply. | 2016 | Aliment. Pharmacol. Ther. | pmid:27040167 |
Taylor KM and Sparrow MP | Editorial: tacrolimus vs. anti-tumour necrosis factor agents for moderately to severely active ulcerative colitis. | 2016 | Aliment. Pharmacol. Ther. | pmid:27040166 |
Imamura CK et al. | Impact of cytochrome P450 2C19 polymorphisms on the pharmacokinetics of tacrolimus when coadministered with voriconazole. | 2016 | J Clin Pharmacol | pmid:26239045 |
Albano L et al. | Dosing of Enteric-Coated Mycophenolate Sodium Under Routine Conditions: An Observational, Multicenter Study in Kidney Transplantation. | 2016 | Ann. Transplant. | pmid:27122116 |
Gu C et al. | Triptolide Reduces the Required Dose of Tacrolimus by Attenuating Inflammation, Enhancing Immunosuppression, and Increasing Donor Chimerism in a Heterotopic Hindlimb Transplantation Model. | 2016 | Plast. Reconstr. Surg. | pmid:27879593 |