tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Gołębiewska J et al. | Tako-tsubo cardiomyopathy on the first day after renal transplantation - case report and literature review. | 2014 | Transplant. Proc. | pmid:25380951 |
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| Bakkour W et al. | Successful use of dapsone for the management of circinate balanitis. | 2014 | Clin. Exp. Dermatol. | pmid:24635073 |
| Smoter P et al. | Risk factors of acute renal failure after orthotopic liver transplantation: single-center experience. | 2014 | Transplant. Proc. | pmid:25380918 |
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| Kapoor K et al. | Lip hypertrophy due to cyclosporine therapy. | 2014 | Clin. Exp. Nephrol. | pmid:23615783 |
| Sahin S et al. | The protective effects of tacrolimus on rat uteri exposed to ischemia-reperfusion injury: a biochemical and histopathologic evaluation. | 2014 | Fertil. Steril. | pmid:24502894 |
| Ciancio G et al. | Randomized trial of three induction antibodies in kidney transplantation: long-term results. | 2014 | Transplantation | pmid:24477186 |
| Okada K et al. | [Single institution experience of HLA-haploidentical hematopoietic stem cell transplantation for children: current problems and perspective]. | 2014 | Rinsho Ketsueki | pmid:24492043 |
| Méndez A et al. | Pharmacokinetic study of conversion from tacrolimus twice-daily to tacrolimus once-daily in stable lung transplantation. | 2014 | Transplantation | pmid:24492423 |
| Moss MC et al. | Lithium use for bipolar disorder post renal transplant: is mood stabilization without toxicity possible? | 2014 | Transplantation | pmid:24492429 |
| Hinchliffe E et al. | Therapeutic drug monitoring of ciclosporin A and tacrolimus in heart lung transplant patients using dried blood spots. | 2014 | Ann. Clin. Biochem. | pmid:23939194 |
| Lankarani KB et al. | Response to: Comment on: New-onset diabetes and impaired fasting glucose after liver transplant: risk analysis and the impact of tacrolimus dose. | 2014 | Exp Clin Transplant | pmid:24471728 |
| Kabir A | Comment on: New-onset diabetes and impaired fasting glucose after a liver transplant: risk analysis and the effect of tacrolimus dosage. | 2014 | Exp Clin Transplant | pmid:24471727 |
| Kuypers DR et al. | Combined effects of CYP3A5*1, POR*28, and CYP3A4*22 single nucleotide polymorphisms on early concentration-controlled tacrolimus exposure in de-novo renal recipients. | 2014 | Pharmacogenet. Genomics | pmid:25322286 |
| Backes AN et al. | Effects of tacrolimus and insulin in a liver regeneration model in growing animals with portal vein stenosis: immunohistochemical and molecular studies. | 2014 | Pediatr. Surg. Int. | pmid:24468714 |
| Kim H et al. | Safety of reduced dose of mycophenolate mofetil combined with tacrolimus in living-donor liver transplantation. | 2014 | Clin Mol Hepatol | pmid:25320733 |
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| Curtin BF et al. | Unusually late-onset mycophenolate mofetil-related colitis. | 2014 | Am J Health Syst Pharm | pmid:25320135 |
| Zheng X et al. | Patient with neuromyelitis optica spectrum disorder combined with Sjögren's syndrome relapse free following tacrolimus treatment. | 2014 | Intern. Med. | pmid:25318807 |
| Ramachandran R et al. | Tacrolimus therapy in adult-onset steroid-resistant nephrotic syndrome due to a focal segmental glomerulosclerosis single-center experience. | 2014 | Nephrol. Dial. Transplant. | pmid:24771498 |
| Capone F et al. | Synergistic antitumor effect of Doxorubicin and tacrolimus (FK506) on hepatocellular carcinoma cell lines. | 2014 | ScientificWorldJournal | pmid:24701168 |
| Boran M et al. | Determining renal resistive and pulsatility indexes long-term after kidney transplantation in kidney transplant recipients on cyclosporine a-, tacrolimus-, or sirolimus-based regimens. | 2014 | Transplant. Proc. | pmid:24935296 |
| Tischer S and Fontana RJ | Drug-drug interactions with oral anti-HCV agents and idiosyncratic hepatotoxicity in the liver transplant setting. | 2014 | J. Hepatol. | pmid:24280292 |
| Sivakumar V et al. | Role of fludrocortisone in the management of tacrolimus-induced hyperkalemia in a renal transplant recipient. | 2014 | Saudi J Kidney Dis Transpl | pmid:24434399 |
| Motomura H et al. | Inhibitory effect of tacrolimus on progression of joint damage in patients with rheumatoid arthritis. | 2014 | Int J Rheum Dis | pmid:24251619 |
| Yargui L et al. | Metabolic status of 1088 patients after renal transplantation: assessment of twelve years monitoring in Algiers Mustapha Hospital. | 2014 | Saudi J Kidney Dis Transpl | pmid:24434409 |
| Gounden V and Soldin SJ | Tacrolimus measurement: building a better immunoassay. | 2014 | Clin. Chem. | pmid:24415738 |
| Basu B | Ofatumumab for rituximab-resistant nephrotic syndrome. | 2014 | N. Engl. J. Med. | pmid:24670185 |
| Takeuchi T et al. | Post-marketing surveillance of the safety and effectiveness of tacrolimus in 3,267 Japanese patients with rheumatoid arthritis. | 2014 | Mod Rheumatol | pmid:24261753 |
| Fukushima A et al. | Therapeutic effects of 0.1% tacrolimus eye drops for refractory allergic ocular diseases with proliferative lesion or corneal involvement. | 2014 | Br J Ophthalmol | pmid:24695688 |
| Yasukochi Y et al. | Reduction of serum TARC levels in atopic dermatitis by topical anti-inflammatory treatments. | 2014 | Asian Pac. J. Allergy Immunol. | pmid:25268342 |
| Zhang L et al. | Ambrisentan improves the outcome of rats with liver transplantation partially through reducing nephrotoxicity. | 2014 | Eur Rev Med Pharmacol Sci | pmid:25268107 |
| Donnadieu B et al. | Central retinal vein occlusion-associated tacrolimus after liver transplantation. | 2014 | Transplantation | pmid:25955343 |
| Arduino PG et al. | Pimecrolimus vs. tacrolimus for the topical treatment of unresponsive oral erosive lichen planus: a 8 week randomized double-blind controlled study. | 2014 | J Eur Acad Dermatol Venereol | pmid:23451852 |
| Wasilewski G et al. | Inadequate blood pressure control in orthotopic heart transplant: is there a role of kidney function and immunosuppressive regimen? | 2014 | Transplant. Proc. | pmid:25380929 |
| Wilusz M et al. | Effect of immunosuppressive therapy on the serum fatty acids of phospholipids fraction in patients after heart transplantation. | 2014 | Transplant. Proc. | pmid:25380928 |
| Kujawski S et al. | Calcineurin regulates coordinated outgrowth of zebrafish regenerating fins. | 2014 | Dev. Cell | pmid:24561038 |
| Eguchi R et al. | Recombinant human soluble thrombomodulin attenuates FK506-induced endothelial dysfunction through prevention of Akt inactivation. | 2014 | Exp. Cell Res. | pmid:24582967 |
| Baldo A et al. | Vitiligo, NB-UVB and tacrolimus: our experience in Naples. | 2014 | G Ital Dermatol Venereol | pmid:24566573 |
| Liu FL et al. | FKBP12 regulates the localization and processing of amyloid precursor protein in human cell lines. | 2014 | J. Biosci. | pmid:24499793 |
| Parks AC et al. | Long-term clearance of linear porokeratosis with tacrolimus, 0.1%, ointment. | 2014 | JAMA Dermatol | pmid:24553841 |
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| Dannhorn E et al. | De novo use of generic tacrolimus in liver transplantation - a single center experience with one-yr follow-up. | 2014 | Clin Transplant | pmid:25142496 |
| Noceti OM et al. | Tacrolimus pharmacodynamics and pharmacogenetics along the calcineurin pathway in human lymphocytes. | 2014 | Clin. Chem. | pmid:25142246 |
| Guy-Viterbo V et al. | Influence of donor-recipient CYP3A4/5 genotypes, age and fluconazole on tacrolimus pharmacokinetics in pediatric liver transplantation: a population approach. | 2014 | Pharmacogenomics | pmid:25141896 |
| Zhao WY et al. | Single kidneys transplanted from small pediatric donors less than 15 kilograms into pediatric recipients. | 2014 | Transplantation | pmid:25955345 |
| Feliu J et al. | Transplant-acquired food allergy (TAFA) following cord blood stem cell transplantation in two adult patients with haematological malignancies. | 2014 | Br. J. Haematol. | pmid:24962133 |
| Chen SR et al. | Calcineurin inhibitor induces pain hypersensitivity by potentiating pre- and postsynaptic NMDA receptor activity in spinal cords. | 2014 | J. Physiol. (Lond.) | pmid:24081160 |
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| Gionchetti P and Rizzello F | IBD. Sequential rescue therapy in steroid-refractory ulcerative colitis. | 2014 | Nat Rev Gastroenterol Hepatol | pmid:25023033 |
| Grafals M et al. | Immunophenotyping and efficacy of low dose ATG in non-sensitized kidney recipients undergoing early steroid withdrawal: a randomized pilot study. | 2014 | PLoS ONE | pmid:25111080 |
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| Matin M et al. | The effectiveness of excimer laser on vitiligo treatment in comparison with a combination therapy of Excimer laser and tacrolimus in an Iranian population. | 2014 | J Cosmet Laser Ther | pmid:25046236 |
| de la Fuente V et al. | Calcineurin phosphatase as a negative regulator of fear memory in hippocampus: control on nuclear factor-κB signaling in consolidation and reconsolidation. | 2014 | Hippocampus | pmid:25043904 |
| Klintmalm GB et al. | Belatacept-based immunosuppression in de novo liver transplant recipients: 1-year experience from a phase II randomized study. | 2014 | Am. J. Transplant. | pmid:25041339 |
| Ikeuchi H et al. | Efficacy and safety of multi-target therapy using a combination of tacrolimus, mycophenolate mofetil and a steroid in patients with active lupus nephritis. | 2014 | Mod Rheumatol | pmid:24252014 |
| Bax K et al. | Rapid resolution of tacrolimus intoxication-induced AKI with a corticosteroid and phenytoin. | 2014 | Ann Pharmacother | pmid:25104567 |
| Miyauchi T et al. | Evidence for the therapeutic efficacy of either mild hypothermia or oxygen radical scavengers after repetitive mild traumatic brain injury. | 2014 | J. Neurotrauma | pmid:24341607 |
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| Inaba A et al. | Cerebral toxoplasmosis after umbilical cord blood transplantation diagnosed by the detection of anti-toxoplasma specific IgM antibody in cerebrospinal fluid. | 2014 | Rinsho Ketsueki | pmid:24850458 |
| Kurzawski M et al. | Impact of PPARA and POR polymorphisms on tacrolimus pharmacokinetics and new-onset diabetes in kidney transplant recipients. | 2014 | Pharmacogenet. Genomics | pmid:24921414 |
| Marits P et al. | Evaluation of T and B lymphocyte function in clinical practice using a flow cytometry based proliferation assay. | 2014 | Clin. Immunol. | pmid:24909732 |
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| Zhao J et al. | FK506-loaded chitosan conduit promotes the regeneration of injured sciatic nerves in the rat through the upregulation of brain-derived neurotrophic factor and TrkB. | 2014 | J. Neurol. Sci. | pmid:24954089 |
| Falconer SJ et al. | Conversion from twice-daily to once-daily tacrolimus in simultaneous pancreas-kidney transplant patients. | 2014 | Transplant. Proc. | pmid:24935313 |
| Hacker C et al. | Falsely elevated cyclosporin and tacrolimus concentrations over prolonged periods of time due to reversible adsorption to central venous catheters. | 2014 | Clin. Chim. Acta | pmid:24631133 |
| Goring SM et al. | A network meta-analysis of the efficacy of belatacept, cyclosporine and tacrolimus for immunosuppression therapy in adult renal transplant recipients. | 2014 | Curr Med Res Opin | pmid:24628478 |
| Hallowell RW and Danoff SK | Interstitial lung disease associated with the idiopathic inflammatory myopathies and the antisynthetase syndrome: recent advances. | 2014 | Curr Opin Rheumatol | pmid:25203119 |
| Song L et al. | Effects of ASKP1240 combined with tacrolimus or mycophenolate mofetil on renal allograft survival in Cynomolgus monkeys. | 2014 | Transplantation | pmid:24992357 |
| Hayes D et al. | Alternative tacrolimus and sirolimus regimen associated with rapid resolution of posterior reversible encephalopathy syndrome after lung transplantation. | 2014 | Pediatr. Neurol. | pmid:24405697 |
| Hosohata K et al. | Association between CYP3A5 genotypes in graft liver and increase in tacrolimus biotransformation from steroid treatment in living-donor liver transplant patients. | 2014 | Drug Metab. Pharmacokinet. | pmid:23955548 |
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| Lalan S et al. | Effect of CYP3A5 genotype, steroids, and azoles on tacrolimus in a pediatric renal transplant population. | 2014 | Pediatr. Nephrol. | pmid:24875272 |
| Ricardo E et al. | In vivo and in vitro acquisition of resistance to voriconazole by Candida krusei. | 2014 | Antimicrob. Agents Chemother. | pmid:24867987 |
| Shihab F et al. | Focus on mTOR inhibitors and tacrolimus in renal transplantation: pharmacokinetics, exposure-response relationships, and clinical outcomes. | 2014 | Transpl. Immunol. | pmid:24861504 |
| Almeida-Paulo GN et al. | Limited sampling strategies for tacrolimus exposure (AUC0-24) prediction after Prograf(®) and Advagraf(®) administration in children and adolescents with liver or kidney transplants. | 2014 | Transpl. Int. | pmid:24861353 |
| Maeda H et al. | Disappearance of GFP-positive hepatocytes transplanted into the liver of syngeneic wild-type rats pretreated with retrorsine. | 2014 | PLoS ONE | pmid:24796859 |
| Du W et al. | Improved FK506 production by the precursors and product-tolerant mutant of Streptomyces tsukubaensis based on genome shuffling and dynamic fed-batch strategies. | 2014 | J. Ind. Microbiol. Biotechnol. | pmid:24788378 |
| Ishikawa Y and Bächinger HP | A substrate preference for the rough endoplasmic reticulum resident protein FKBP22 during collagen biosynthesis. | 2014 | J. Biol. Chem. | pmid:24821723 |
| Agrawal YP et al. | Transplant patient classification and tacrolimus assays: more evidence of the need for assay standardization. | 2014 | Ther Drug Monit | pmid:24784024 |
| Sageshima J et al. | Everolimus with low-dose tacrolimus in simultaneous pancreas and kidney transplantation. | 2014 | Clin Transplant | pmid:24779669 |
| Madian AG et al. | Case report: Inability to achieve a therapeutic dose of tacrolimus in a pediatric allogeneic stem cell transplant patient after generic substitution. | 2014 | BMC Pharmacol Toxicol | pmid:25472557 |
| Huang W et al. | Tacrolimus (FK506) suppresses TREM-1 expression at an early but not at a late stage in a murine model of fungal keratitis. | 2014 | PLoS ONE | pmid:25464008 |
| Philipone E et al. | Oral ulcerations as a sequela of tacrolimus and mycophenolate mofetil therapy. | 2014 | Oral Surg Oral Med Oral Pathol Oral Radiol | pmid:25457894 |
| Nair S and Waters B | Telaprevir in treatment of recurrent hepatitis C infection in liver transplant recipients. | 2014 | Exp Clin Transplant | pmid:24702143 |
| Chen C et al. | Rapid construction of a Bacterial Artificial Chromosomal (BAC) expression vector using designer DNA fragments. | 2014 | Plasmid | pmid:25454071 |
| Olson KA et al. | Toxic tacrolimus levels after application of topical tacrolimus and use of occlusive dressings in two bone marrow transplant recipients with cutaneous graft-versus-host disease. | 2014 | Pharmacotherapy | pmid:24700567 |
| Momohara S et al. | Recent trends in orthopedic surgery aiming to improve quality of life for those with rheumatoid arthritis: data from a large observational cohort. | 2014 | J. Rheumatol. | pmid:24692532 |
| Lee SK et al. | Overexpression of the putative extracytoplasmic function sigma (σ) factor FujE enhances FK506 production in Streptomyces sp. strain KCCM 11116P. | 2014 | Can. J. Microbiol. | pmid:24869633 |
| Navas-López VM et al. | Successful treatment for ulcerative proctitis with rectal tacrolimus in an 8-year-old girl with intolerance to mesalamine. | 2014 | Clin J Gastroenterol | pmid:26185880 |
| van der Vusse ML et al. | Helicobacter canis bacteremia in a renal transplant patient. | 2014 | Transpl Infect Dis | pmid:24372779 |
| Földes G et al. | Immunosuppressive agents modulate function, growth, and survival of cardiomyocytes and endothelial cells derived from human embryonic stem cells. | 2014 | Stem Cells Dev. | pmid:24192059 |
| Lee CH et al. | Raised tacrolimus level and acute renal injury associated with acute gastroenteritis in a child receiving local rectal tacrolimus. | 2014 | Clin J Gastroenterol | pmid:26183743 |