Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with tacrolimus
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Foster CA et al. | Pharmacological modulation of endothelial cell-associated adhesion molecule expression: implications for future treatment of dermatological diseases. | 1994 | J. Dermatol. | pmid:7531725 |
Aagaard-Tillery KM and Jelinek DF | Inhibition of human B lymphocyte cell cycle progression and differentiation by rapamycin. | 1994 | Cell. Immunol. | pmid:7517796 |
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Suzuki S and Toledo-Pereyra LH | Interleukin 1 and tumor necrosis factor production as the initial stimulants of liver ischemia and reperfusion injury. | 1994 | J. Surg. Res. | pmid:7518017 |
Nishimori H et al. | Combination therapy with FK 506 and splenectomy may induce tolerance in cardiac xenografts. | 1994 | Transplant. Proc. | pmid:7518102 |
Kawauchi M et al. | Cardiac xenotransplantation from pig to Japanese monkey with splenectomy, tacrolims, filtration plasmapheresis, and nafamstat mesilate. | 1994 | Transplant. Proc. | pmid:7518105 |
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Yasutomi M et al. | Mechanism of antibody production in hamster-to-rat concordant xenotransplantation: establishment of a simple model using intravenous injection of concordant splenocytes. | 1994 | Transplant. Proc. | pmid:7518110 |
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Reding R et al. | Conversion from cyclosporine to FK506 for salvage of immunocompromised pediatric liver allografts. Efficacy, toxicity, and dose regimen in 23 children. | 1994 | Transplantation | pmid:7507272 |
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Sabatini DM et al. | RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs. | 1994 | Cell | pmid:7518356 |
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Fealy MJ et al. | Efficacy of rapamycin and FK 506 in prolonging rat hind limb allograft survival. | 1994 | Ann. Surg. | pmid:7507657 |
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Frizell E et al. | FK506 enhances fibrogenesis in in vitro and in vivo models of liver fibrosis in rats. | 1994 | Gastroenterology | pmid:7518783 |
Yoshimura R et al. | Study of the effect of immunosuppressive agents on renal cytochrome P-450 system in the rat. | 1994 | Transplant. Proc. | pmid:7520610 |
Kitamura M et al. | Clinical experience of FK 506 for renal allograft transplantation. | 1994 | Transplant. Proc. | pmid:7520611 |
Chen CL et al. | FK 506 used as rescue therapy for refractory liver allograft rejection. | 1994 | Transplant. Proc. | pmid:7520612 |
Nakata S et al. | Immunosuppressive mechanisms of deoxymethylspergualin and FK 506 on in vitro cytotoxic T lymphocytes. | 1994 | Transplant. Proc. | pmid:7520613 |
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Imanishi M et al. | Induction of tolerance by intrathymic injection of donor bone marrow cells in the rat: simultaneous heart and skin allograft model. | 1994 | Transplant. Proc. | pmid:7520615 |
Charters AR et al. | Immunochemical analysis of FK506 binding proteins in neuronal cell lines and rat brain. | 1994 | Biochem. Soc. Trans. | pmid:7535258 |
Matsuura T et al. | Organ-specific tolerance induced by intrathymic injection of donor bone marrow cells and FK 506 or antilymphocyte serum in rat heart transplantation. | 1994 | Transplant. Proc. | pmid:7520616 |
Charters AR et al. | The subcellular distribution of FK506 binding proteins in rat brain. | 1994 | Biochem. Soc. Trans. | pmid:7535259 |
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Hirose M and Kuroda Y | Reinforcement of cyclosporin A-induced red cell destruction by superoxide. | 1994 | Tokushima J. Exp. Med. | pmid:7535479 |
Takahara S et al. | Monitoring of FK 506 blood levels in kidney transplant recipients. | 1994 | Transplant. Proc. | pmid:7520623 |
Tai PK et al. | Potentiation of progesterone receptor-mediated transcription by the immunosuppressant FK506. | 1994 | Biochemistry | pmid:7521210 |
Akita K et al. | Suppression of nitric oxide production by cyclosporin A and FK506A in rat vascular smooth muscle cells. | 1994 | Clin. Exp. Pharmacol. Physiol. | pmid:7521274 |
Woo J et al. | FK506 inhibits the differentiation of developing thymocytes but not negative selection of T cell receptor V beta 5+ and V beta 11+ T lymphocytes in vivo. | 1994 | Transpl. Immunol. | pmid:7521743 |
Kasiske BL | The effects of immunosuppressive agents on plasma lipoproteins after organ transplantation. | 1994 | J. Lab. Clin. Med. | pmid:7521894 |
Clipstone NA et al. | Molecular analysis of the interaction of calcineurin with drug-immunophilin complexes. | 1994 | J. Biol. Chem. | pmid:7523407 |
Lemster B et al. | Influence of FK 506 (tacrolimus) on circulating CD4+ T cells expressing CD25 and CD45RA antigens in 19 patients with chronic progressive multiple sclerosis participating in an open label drug safety trial. | 1994 | Autoimmunity | pmid:7539635 |
Karmann K et al. | Endothelial cell-induced resistance to cyclosporin A in human peripheral blood T cells requires contact-dependent interactions involving CD2 but not CD28. | 1994 | J. Immunol. | pmid:7523510 |
Wakabayashi H et al. | The effect of FK506 on warm ischemia and reperfusion injury in the rat liver. | 1994 | Surg. Today | pmid:7539646 |
Hiromura K et al. | FK506 inhibits renal glomerular thrombosis induced in rats by nephrotoxic serum and lipopolysaccharide. | 1994 | Kidney Int. | pmid:7523750 |
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Milan D et al. | The latch region of calcineurin B is involved in both immunosuppressant-immunophilin complex docking and phosphatase activation. | 1994 | Cell | pmid:7525078 |
Tamir H et al. | Secretogogue-induced gating of chloride channels in the secretory vesicles of parafollicular cells. | 1994 | Endocrinology | pmid:7525261 |
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Benton BM et al. | A novel FK506- and rapamycin-binding protein (FPR3 gene product) in the yeast Saccharomyces cerevisiae is a proline rotamase localized to the nucleolus. | 1994 | J. Cell Biol. | pmid:7525596 |
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Funk JO and Maibach HI | Horizons in pharmacologic intervention in allergic contact dermatitis. | 1994 | J. Am. Acad. Dermatol. | pmid:7525668 |
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Matsunami H et al. | New technique for measuring tacrolimus concentrations in blood. | 1994 | Am J Hosp Pharm | pmid:7510929 |
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Yano K et al. | Effects of intrahepatic arterial and intraportal administration of FK 506 on liver allograft survival in rats. | 1994 | Transpl. Int. | pmid:11271200 |
Devlin J et al. | Renal complications and development of hypertension in the European study of FK 506 and cyclosporin in primary liver transplant recipients. | 1994 | Transpl. Int. | pmid:11271207 |
Two-year follow-up study of the efficacy and safety of FK 506 in kidney transplant patients. Japanese FK 506 Study Group. | 1994 | Transpl. Int. | pmid:11271216 | |
Neuhaus P et al. | Neurological complications in the European multicentre study of FK 506 and cyclosporin in primary liver transplantation. | 1994 | Transpl. Int. | pmid:11271222 |
Bismuth H et al. | Focus on intractable rejection: 6-month results of the European multicentre liver study of FK 506 and cyclosporin A. | 1994 | Transpl. Int. | pmid:11271231 |
McMaster P | Patient and graft survival in the European Multicentre Liver Study--FK 506 vs cyclosporin A. | 1994 | Transpl. Int. | pmid:11271239 |
Mueller AR et al. | Neurotoxicity after orthotopic liver transplantation in cyclosporin A- and FK 506-treated patients. | 1994 | Transpl. Int. | pmid:11271254 |
Abdalla AH et al. | FK 506 as an alternative in cyclosporin-induced hemolytic uremic syndrome in a kidney transplant recipient. | 1994 | Transpl. Int. | pmid:7527640 |
Cooper MH et al. | Short-term myeloid reconstitution following TBI is not adversely affected by doses of FK506 that abrogate lethal GVHD. | 1994 | Bone Marrow Transplant. | pmid:7527689 |
Lea JP et al. | Evidence that the inhibition of Na+/K(+)-ATPase activity by FK506 involves calcineurin. | 1994 | Kidney Int. | pmid:7527873 |
Nielsen FT et al. | Nephrotoxity of FK 506: a preliminary study on comparative aspects of FK 506 and cyclosporine nephrotoxicity. | 1994 | Transplant. Proc. | pmid:7527946 |
Mor E et al. | Reversal of gastrointestinal toxicity associated with long-term FK506 immunosuppression by conversion to cyclosporine in liver transplant recipients. | 1994 | Transplantation | pmid:7513098 |
Fisher A et al. | Gastrointestinal toxicity associated with FK 506 in liver transplant recipients. | 1994 | Transplant. Proc. | pmid:7527947 |