tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Yamada H et al. | Simvastatin-tacrolimus and simvastatin-cyclosporin interactions in rats. | 1998 | Biopharm Drug Dispos | pmid:9673778 |
| Yardin C et al. | FK506 antagonizes apoptosis and c-jun protein expression in neuronal cultures. | 1998 | Neuroreport | pmid:9674596 |
| Salowe SP and Hermes JD | Competitive and slow-binding inhibition of calcineurin by drug x immunophilin complexes. | 1998 | Arch. Biochem. Biophys. | pmid:9675023 |
| Onuma H et al. | A calcineurin inhibitor, FK506, blocks voltage-gated calcium channel-dependent LTP in the hippocampus. | 1998 | Neurosci. Res. | pmid:9678635 |
| Fisher NC et al. | Chronic renal failure following liver transplantation: a retrospective analysis. | 1998 | Transplantation | pmid:9679823 |
| Sanchez-Campos S et al. | Cholestasis and alterations of glutathione metabolism induced by tacrolimus (FK506) in the rat. | 1998 | Transplantation | pmid:9679826 |
| Denesyuk AI et al. | Analogous conformations of both binding and effector regions in cyclosporin A, FK506 and rapamycin. | 1998 | Comput. Chem. | pmid:9680690 |
| Van Leent EJ et al. | Effectiveness of the ascomycin macrolactam SDZ ASM 981 in the topical treatment of atopic dermatitis. | 1998 | Arch Dermatol | pmid:9681343 |
| Hultsch T et al. | Direct evidence that FK506 inhibition of FcepsilonRI-mediated exocytosis from RBL mast cells involves calcineurin. | 1998 | Arch. Dermatol. Res. | pmid:9681677 |
| Grupp C et al. | Haemolytic uraemic syndrome (HUS) during treatment with cyclosporin A after renal transplantation--is tacrolimus the answer? | 1998 | Nephrol. Dial. Transplant. | pmid:9681701 |
| Peces R et al. | Alloimmune haemolytic anaemia resulting from anti-A and anti-B antibody induced by group O graft in renal transplant recipients. | 1998 | Nephrol. Dial. Transplant. | pmid:9681751 |
| Medh RD et al. | Agonist-specific modulation of glucocorticoid receptor-mediated transcription by immunosuppressants. | 1998 | Mol. Cell. Endocrinol. | pmid:9685211 |
| Tsuzuki S et al. | FK506 (tacrolimus) inhibits extravasation of lymphoid cells by abrogating VLA-4/VCAM-1 mediated transendothelial migration. | 1998 | FEBS Lett. | pmid:9688583 |
| Kilmartin DJ et al. | Tacrolimus (FK506) in failed cyclosporin A therapy in endogenous posterior uveitis. | 1998 | Ocul. Immunol. Inflamm. | pmid:9689640 |
| Ding JM et al. | A neuronal ryanodine receptor mediates light-induced phase delays of the circadian clock. | 1998 | Nature | pmid:9690474 |
| Moriwaki A et al. | An immunosuppressant, FK506, protects against neuronal dysfunction and death but has no effect on electrographic and behavioral activities induced by systemic kainate. | 1998 | Neuroscience | pmid:9692722 |
| Mihatsch MJ et al. | The side-effects of ciclosporine-A and tacrolimus. | 1998 | Clin. Nephrol. | pmid:9696431 |
| Rejto PA and Verkhivker GM | Molecular anchors with large stability gaps ensure linear binding free energy relationships for hydrophobic substituents. | 1998 | Pac Symp Biocomput | pmid:9697196 |
| [Tacrolimus in kidney transplantation. Bürgenstock, Switzerland, 20 March 1998]. | 1998 | Dtsch. Med. Wochenschr. | pmid:9697633 | |
| Matsumoto T et al. | Influence of FK506 on experimental atherosclerosis in cholesterol-fed rabbits. | 1998 | Atherosclerosis | pmid:9699896 |
| Duraj F et al. | [Intestinal transplantation. The first Swedish transplantation of the small intestine in an adult patient with pseudoobstruction]. | 1998 | Lakartidningen | pmid:9700261 |
| Gruessner RW et al. | Donor-specific portal blood transfusion in intestinal transplantation: a prospective, preclinical large animal study. | 1998 | Transplantation | pmid:9701258 |
| Garg UC et al. | Comparison of the Abbott IMx Tacrolimus I and Tacrolimus II assays. | 1998 | Clin. Chem. | pmid:9702984 |
| Xu M et al. | Effect of peritransplant FTY720 alone or in combination with post-transplant tacrolimus in a rat model of cardiac allotransplantation. | 1998 | Transpl. Int. | pmid:9704394 |
| Stone JH et al. | Outcome of renal transplantation in ninety-seven cyclosporine-era patients with systemic lupus erythematosus and matched controls. | 1998 | Arthritis Rheum. | pmid:9704643 |
| Ogawa T et al. | Osteoblastic differentiation is enhanced by rapamycin in rat osteoblast-like osteosarcoma (ROS 17/2.8) cells. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9705862 |
| Khattab A et al. | Cyclosporins: lack of correlation between antischistosomal properties and inhibition of cyclophilin isomerase activity. | 1998 | Exp. Parasitol. | pmid:9709036 |
| White MH et al. | Randomized, double-blind clinical trial of amphotericin B colloidal dispersion vs. amphotericin B in the empirical treatment of fever and neutropenia. | 1998 | Clin. Infect. Dis. | pmid:9709879 |
| Ruetz S | Yeast secretory vesicle system for expression and functional characterization of P-glycoproteins. | 1998 | Meth. Enzymol. | pmid:9711569 |
| Marsaud V et al. | Dexamethasone and triamcinolone acetonide accumulation in mouse fibroblasts is differently modulated by the immunosuppressants cyclosporin A, FK506, rapamycin and their analogues, as well as by other P-glycoprotein ligands. | 1998 | J. Steroid Biochem. Mol. Biol. | pmid:9712407 |
| Moreno M et al. | Monitoring of tacrolimus as rescue therapy in pediatric liver transplantation. | 1998 | Ther Drug Monit | pmid:9712459 |
| Holt DW and Johnston A | Monitoring new immunosuppressive agents. Are the methods adequate? | 1997 | Drug Metabol Drug Interact | pmid:9713574 |
| Shaw LM | Mycophenolate mofetil: pharmacokinetic strategies for optimizing immunosuppression. | 1997 | Drug Metabol Drug Interact | pmid:9713576 |
| Zini R et al. | Tacrolimus decreases in vitro oxidative phosphorylation of mitochondria from rat forebrain. | 1998 | Life Sci. | pmid:9714423 |
| Iizuka K et al. | InsP3, but not novel Ca2+ releasers, contributes to agonist-initiated contraction in rabbit airway smooth muscle. | 1998 | J. Physiol. (Lond.) | pmid:9714870 |
| Tamura F et al. | FK506 promotes liver regeneration by suppressing natural killer cell activity. | 1998 | J. Gastroenterol. Hepatol. | pmid:9715421 |
| Fukuda K et al. | cFKBP/SMAP; a novel molecule involved in the regulation of smooth muscle differentiation. | 1998 | Development | pmid:9716519 |
| Tao HR | FK506 inhibits severe graft-versus-host disease without mediating the involvement of perforin and granzyme B. | 1998 | Hokkaido Igaku Zasshi | pmid:9719949 |
| Jacobson P et al. | Tacrolimus: a new agent for the prevention of graft-versus-host disease in hematopoietic stem cell transplantation. | 1998 | Bone Marrow Transplant. | pmid:9720734 |
| Yang X et al. | Essential role of CED-4 oligomerization in CED-3 activation and apoptosis. | 1998 | Science | pmid:9721101 |
| Srivastava M et al. | Drug-associated acute-onset vanishing bile duct and Stevens-Johnson syndromes in a child. | 1998 | Gastroenterology | pmid:9721172 |
| Oellerich M et al. | Therapeutic drug monitoring of cyclosporine and tacrolimus. Update on Lake Louise Consensus Conference on cyclosporin and tacrolimus. | 1998 | Clin. Biochem. | pmid:9721427 |
| Soldin SJ | Role of immunophilins in therapeutic drug monitoring of immunosuppressive drugs. | 1998 | Clin. Biochem. | pmid:9721438 |
| Gruessner RW et al. | Mycophenolate mofetil in pancreas transplantation. | 1998 | Transplantation | pmid:9721799 |
| Terakura M et al. | Lymphoid/nonlymphoid compartmentalization of donor leukocyte chimerism in rat recipients of heart allografts, with or without adjunct bone marrow. | 1998 | Transplantation | pmid:9721804 |
| Glicklich D et al. | Chronic renal allograft rejection: no response to mycophenolate mofetil. | 1998 | Transplantation | pmid:9721811 |
| Calandra S | Sinus arrest during tacrolimus treatment: was the QT interval prolonged? | 1998 | Transplantation | pmid:9721813 |
| Kahan BD | High variability of drug exposure: a biopharmaceutic risk factor for chronic rejection. | 1998 | Transplant. Proc. | pmid:9723224 |
| Keown PA and Primmett DR | Cyclosporine: the principal immunosuppressant for renal transplantation. | 1998 | Transplant. Proc. | pmid:9723252 |
| Armenti VT et al. | Pregnancy outcomes in female renal transplant recipients. | 1998 | Transplant. Proc. | pmid:9723259 |