tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Bunnapradist S et al. | LCPT once-daily extended-release tacrolimus tablets versus twice-daily capsules: a pooled analysis of two phase 3 trials in important de novo and stable kidney transplant recipient subgroups. | 2016 | Transpl. Int. | pmid:26953629 |
| Gokhale NS | Systematic approach to managing vernal keratoconjunctivitis in clinical practice: Severity grading system and a treatment algorithm. | 2016 | Indian J Ophthalmol | pmid:27050351 |
| Parody R et al. | GvHD prophylaxis with tacrolimus plus sirolimus after reduced intensity conditioning allogeneic transplantation: results of a multicenter study. | 2016 | Bone Marrow Transplant. | pmid:27295268 |
| Rotenstein L et al. | Management of refractory autoimmune hemolytic anemia via allogeneic stem cell transplantation. | 2016 | Bone Marrow Transplant. | pmid:27272445 |
| Wen Y et al. | Tacrolimus restores podocyte injury and stabilizes the expression of Cabin1 in 5/6 nephrectomized rats. | 2016 | Ren Fail | pmid:26905810 |
| Törlén J et al. | A prospective randomized trial comparing cyclosporine/methotrexate and tacrolimus/sirolimus as graft-versus-host disease prophylaxis after allogeneic hematopoietic stem cell transplantation. | 2016 | Haematologica | pmid:27662016 |
| Martial LC et al. | A preliminary study searching for the right dose of tacrolimus in very young (≤4 years) renal transplant patients. | 2016 | J. Pharm. Pharmacol. | pmid:27669677 |
| Kim HY et al. | Tracking protein-protein interaction and localization in living cells using a high-affinity molecular binder. | 2016 | Biochem. Biophys. Res. Commun. | pmid:26820537 |
| Chang KT et al. | Tacrolimus suppresses atopic dermatitis-associated cytokines and chemokines in monocytes. | 2016 | J Microbiol Immunol Infect | pmid:25315214 |
| Zeng W et al. | Hyaluronic acid-coated niosomes facilitate tacrolimus ocular delivery: Mucoadhesion, precorneal retention, aqueous humor pharmacokinetics, and transcorneal permeability. | 2016 | Colloids Surf B Biointerfaces | pmid:26820107 |
| Nuki Y et al. | Comparison of the therapeutic efficacy and safety between tacrolimus and infliximab for moderate-to-severe ulcerative colitis: a single center experience. | 2016 | Scand. J. Gastroenterol. | pmid:26818468 |
| Joko T et al. | Therapeutic Effect of 0.1% Topical Tacrolimus for Childhood Interstitial Keratitis Refractory to Cyclosporine. | 2016 | J Nippon Med Sch | pmid:26960587 |
| Malachowski SJ et al. | Annular Lichenoid Dermatitis of Youth: A Chronic Case Managed Using Pimecrolimus. | 2016 | Pediatr Dermatol | pmid:27653808 |
| Sawada T et al. | Experimental Studies on Protective Effects of FK506 Against Hepatic Ischemia-Reperfusion Injury. | 2016 | J. Med. Invest. | pmid:27644569 |
| Cameron AM et al. | Chimeric Allografts Induced by Short-Term Treatment With Stem Cell Mobilizing Agents Result in Long-Term Kidney Transplant Survival Without Immunosuppression: II, Study in Miniature Swine. | 2016 | Am. J. Transplant. | pmid:26748958 |
| Chen CA et al. | Quantitative analysis of tissue inflammation and responses to treatment in immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome, and review of literature. | 2016 | J Microbiol Immunol Infect | pmid:26748735 |
| Karagüzel G et al. | Vitamin D status and the effects of oral vitamin D treatment in children with vitiligo: A prospective study. | 2016 | Clin Nutr ESPEN | pmid:28531780 |
| Yoshida T et al. | Oral tacrolimus oil formulations for enhanced lymphatic delivery and efficient inhibition of T-cell's interleukin-2 production. | 2016 | Eur J Pharm Biopharm | pmid:26748381 |
| Ferjani H et al. | Protective effect of mycophenolate mofetil against nephrotoxicity and hepatotoxicity induced by tacrolimus in Wistar rats. | 2016 | J. Physiol. Biochem. | pmid:26746208 |
| Abdel-Kahaar E et al. | Analytical Validation and Cross-Validation of an NFAT-Regulated Gene Expression Assay for Pharmacodynamic Monitoring of Therapy With Calcineurin Inhibitors. | 2016 | Ther Drug Monit | pmid:27661400 |
| Radziejewski K and Balicki I | Comparative clinical evaluation of tacrolimus and cyclosporine eye drops for the treatment of canine keratoconjunctivitis sicca. | 2016 | Acta Vet. Hung. | pmid:27653428 |
| Kannegieter NM et al. | Conversion to Once-Daily Tacrolimus Results in Increased p38MAPK Phosphorylation in T Lymphocytes of Kidney Transplant Recipients. | 2016 | Ther Drug Monit | pmid:26606072 |
| Wang Z et al. | Nanocomposite microparticles (nCmP) for the delivery of tacrolimus in the treatment of pulmonary arterial hypertension. | 2016 | Int J Pharm | pmid:27568494 |
| Rahnama-Moghadam S et al. | Vesicular eruption in a 2-year-old boy. | 2016 | J Fam Pract | pmid:27565104 |
| Lee C et al. | Treatment of bleomycin-induced pulmonary fibrosis by inhaled tacrolimus-loaded chitosan-coated poly(lactic-co-glycolic acid) nanoparticles. | 2016 | Biomed. Pharmacother. | pmid:26898446 |
| Zegarska J et al. | Tacrolimus Metabolite M-III May Have Nephrotoxic and Myelotoxic Effects and Increase the Incidence of Infections in Kidney Transplant Recipients. | 2016 | Transplant. Proc. | pmid:27496443 |
| Bargnoux AS et al. | Evaluation of the New Siemens Tacrolimus Assay on the Dimension EXL Integrated Chemistry System Analyzer: Comparison With an Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry Method. | 2016 | Ther Drug Monit | pmid:27494947 |
| Kociszewska-Najman B et al. | Congenital Infections in Neonates of Women With Liver or Kidney Transplants. | 2016 | Transplant. Proc. | pmid:27496446 |
| Zmonarski SC et al. | Lowering of Messenger Ribonucleic Acid Toll-Like Receptors 2-4,9 in Peripheral Blood Mononuclear Cells in Kidney Allograft Recipients, Relationships With Immunosuppressive Treatment, and Delayed Graft Function Occurrence. | 2016 | Transplant. Proc. | pmid:27496439 |
| Ashizuka S et al. | Adrenomedullin Therapy in Patients with Refractory Ulcerative Colitis: A Case Series. | 2016 | Dig. Dis. Sci. | pmid:26470867 |
| Matsui K et al. | Betamethasone, but Not Tacrolimus, Suppresses the Development of Th2 Cells Mediated by Langerhans Cell-Like Dendritic Cells. | 2016 | Biol. Pharm. Bull. | pmid:27374298 |
| Kimsa M et al. | Transforming growth factor β-related genes in human retinal pigment epithelial cells after tacrolimus treatment. | 2016 | Pharmacol Rep | pmid:27372923 |
| GarcÃa-Delgado R et al. | Systemic Absorption of Topical Tacrolimus in Metastatic Crohn Disease With Skin Ulcers. | 2016 | Actas Dermosifiliogr | pmid:27372545 |
| Gray JM and Ameduri RK | Tacrolimus-associated hemolytic uremic syndrome in a pediatric heart transplant recipient. | 2016 | Pediatr Transplant | pmid:27371345 |
| Vignali D et al. | IL-7 Mediated Homeostatic Expansion of Human CD4+CD25+FOXP3+ Regulatory T Cells After Depletion With Anti-CD25 Monoclonal Antibody. | 2016 | Transplantation | pmid:27306531 |
| Saitman A et al. | Evaluation of the Waters MassTrak LC-MS/MS Assay for Tacrolimus and a Comparison to the Abbott Architect Immunoassay. | 2016 | Ther Drug Monit | pmid:26473523 |
| Metzker M et al. | Analytical evaluation of a real-time PCR-based DNA demethylation assay to assess the frequency of naturally occurring regulatory T cells in peripheral blood. | 2016 | Clin. Biochem. | pmid:27220060 |
| Tanzi MG et al. | Pharmacokinetics of prolonged-release tacrolimus and implications for use in solid organ transplant recipients. | 2016 | Clin Transplant | pmid:27220013 |
| Yamashita T et al. | Effects of CYP3A5 polymorphism on the pharmacokinetics of a once-daily modified-release tacrolimus formulation and acute kidney injury in hematopoietic stem cell transplantation. | 2016 | Cancer Chemother. Pharmacol. | pmid:27217047 |
| Tremblay S et al. | Absence of the Effect of Pretransplant Body Mass Index on Post Kidney Transplant Outcomes. | 2016 | Prog Transplant | pmid:27207408 |
| Wen Y et al. | Effect of the knockdown of Cabin1 on p53 in glomerular podocyte. | 2016 | J. Recept. Signal Transduct. Res. | pmid:26400065 |
| Emoto C et al. | Risk Assessment of Drug-Drug Interactions of Calcineurin Inhibitors Affecting Sirolimus Pharmacokinetics in Renal Transplant Patients. | 2016 | Ther Drug Monit | pmid:27310200 |
| Badri PS et al. | Pharmacokinetics of Tacrolimus and Cyclosporine in Liver Transplant Recipients Receiving 3 Direct-Acting Antivirals as Treatment for Hepatitis C Infection. | 2016 | Ther Drug Monit | pmid:27310199 |
| RodrÃguez-AusÃn P et al. | Topical tacrolimus 0.03% for the treatment of ocular psoriasis. | 2016 | Arch Soc Esp Oftalmol | pmid:27130870 |
| Stifft F et al. | Effect of Breakfast on the Exposure of the Once-Daily Tacrolimus Formulation in Stable Kidney Transplant Recipients. | 2016 | Ther Drug Monit | pmid:27128604 |
| Pirmez R et al. | Acne keloidalis nuchae in renal transplant patients receiving tacrolimus and sirolimus. | 2016 | Australas. J. Dermatol. | pmid:27124649 |
| Khaled SK et al. | Influence of Absorption, Distribution, Metabolism, and Excretion Genomic Variants on Tacrolimus/Sirolimus Blood Levels and Graft-versus-Host Disease after Allogeneic Hematopoietic Cell Transplantation. | 2016 | Biol. Blood Marrow Transplant. | pmid:26325438 |
| Lee DR et al. | Enhanced dissolution and oral absorption of tacrolimus by supersaturable self-emulsifying drug delivery system. | 2016 | Int J Nanomedicine | pmid:27051286 |
| Cai SC et al. | Topical calcineurin inhibitors in eczema and cancer association: A cohort study. | 2016 | J Dermatolog Treat | pmid:27049893 |
| Lee WS et al. | Efficacy and safety of low-dose tacrolimus for active rheumatoid arthritis with an inadequate response to methotrexate. | 2016 | Korean J. Intern. Med. | pmid:26961485 |