tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| van den Berg JW et al. | New immunosuppressive drugs and lung transplantation: last or least? | 1999 | Thorax | pmid:10335012 |
| Henley SA et al. | Lipids increase after solitary pancreas transplantation. | 1999 | Diabetes Care | pmid:10333952 |
| Iwamoto H et al. | Inhibitory effects of FK506 on the development of experimental allergic/immune-mediated blepharoconjunctivitis in Lewis rats by systemic but not by topical administration. | 1999 | Graefes Arch. Clin. Exp. Ophthalmol. | pmid:10333108 |
| Okamoto H | The CD38-cyclic ADP-ribose signaling system in insulin secretion. | 1999 | Mol. Cell. Biochem. | pmid:10331647 |
| Dresske B et al. | Synergistic impact of "WOFIE" on the immunosuppressive potency of FK 506 in a heterotopic heart transplantation model in the rat. | 1999 | Transplant. Proc. | pmid:10331001 |
| Nakamura H et al. | Induction of autologous graft-versus-host disease after autologous peripheral blood stem cell transplantation. | 1999 | J. Allergy Clin. Immunol. | pmid:10329849 |
| Tian J and Karin M | Stimulation of Elk1 transcriptional activity by mitogen-activated protein kinases is negatively regulated by protein phosphatase 2B (calcineurin). | 1999 | J. Biol. Chem. | pmid:10329725 |
| Kohyama T et al. | A potent immunosuppressant FK506 inhibits IL-8 expression in human eosinophils. | 1999 | Mol. Cell Biol. Res. Commun. | pmid:10329481 |
| Schmidt RH et al. | Haemolytic-uraemic syndrome after tacrolimus rescue therapy for cortisone-resistant rejection. | 1999 | Nephrol. Dial. Transplant. | pmid:10328486 |
| Ruzicka T et al. | Tacrolimus: the drug for the turn of the millennium? | 1999 | Arch Dermatol | pmid:10328199 |
| Garrity ER et al. | Suggested guidelines for the use of tacrolimus in lung-transplant recipients. | 1999 | J. Heart Lung Transplant. | pmid:10328140 |
| Raofi V et al. | A prospective randomized trial comparing the efficacy of tacrolimus versus cyclosporine in black recipients of primary cadaveric renal transplants. | 1999 | Am. J. Surg. | pmid:10326847 |
| Ferlicot S et al. | [Smooth muscle mesentery associated with Epstein-Barr virus (EBV). Report of a case in a child with a liver transplant under FK506 regimen]. | 1999 | Ann Pathol | pmid:10320913 |
| Morioka M et al. | Activities of calcineurin and phosphatase 2A in the hippocampus after transient forebrain ischemia. | 1999 | Brain Res. | pmid:10320733 |
| Genazzani AA et al. | Calcineurin controls inositol 1,4,5-trisphosphate type 1 receptor expression in neurons. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10318964 |
| Remy I and Michnick SW | Clonal selection and in vivo quantitation of protein interactions with protein-fragment complementation assays. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10318894 |
| Stratta RJ et al. | Evolution in pancreas transplantation techniques: simultaneous kidney-pancreas transplantation using portal-enteric drainage without antilymphocyte induction. | 1999 | Ann. Surg. | pmid:10235529 |
| Akahane M et al. | Osteogenic phenotype expression of allogeneic rat marrow cells in porous hydroxyapatite ceramics. | 1999 | J. Bone Miner. Res. | pmid:10234577 |
| Mollison KW et al. | A macrolactam inhibitor of T helper type 1 and T helper type 2 cytokine biosynthesis for topical treatment of inflammatory skin diseases. | 1999 | J. Invest. Dermatol. | pmid:10233764 |
| Jolles S et al. | Combination oral and topical tacrolimus in therapy-resistant pyoderma gangrenosum. | 1999 | Br. J. Dermatol. | pmid:10233301 |
| Lyon CC et al. | Recalcitrant pyoderma gangrenosum treated with systemic tacrolimus. | 1999 | Br. J. Dermatol. | pmid:10233300 |
| Vente C et al. | Erosive mucosal lichen planus: response to topical treatment with tacrolimus. | 1999 | Br. J. Dermatol. | pmid:10233234 |
| Johnston A and Holt DW | Therapeutic drug monitoring of immunosuppressant drugs. | 1999 | Br J Clin Pharmacol | pmid:10233195 |
| Uno T et al. | Pharmacokinetic advantages of a newly developed tacrolimus oil-in-water-type emulsion via the enteral route. | 1999 | Lipids | pmid:10230718 |
| Göthel SF and Marahiel MA | Peptidyl-prolyl cis-trans isomerases, a superfamily of ubiquitous folding catalysts. | 1999 | Cell. Mol. Life Sci. | pmid:10228556 |
| Torocsik HV et al. | FK506-induced leukoencephalopathy in children with organ transplants. | 1999 | Neurology | pmid:10227644 |
| Taylor DO et al. | A randomized, multicenter comparison of tacrolimus and cyclosporine immunosuppressive regimens in cardiac transplantation: decreased hyperlipidemia and hypertension with tacrolimus. | 1999 | J. Heart Lung Transplant. | pmid:10226898 |
| Charco R et al. | Serum cholesterol changes in long-term survivors of liver transplantation: a comparison between cyclosporine and tacrolimus therapy. | 1999 | Liver Transpl Surg | pmid:10226111 |
| Herr I et al. | FK506 prevents stroke-induced generation of ceramide and apoptosis signaling. | 1999 | Brain Res. | pmid:10224298 |
| Ferrari D et al. | P2X7/P2Z purinoreceptor-mediated activation of transcription factor NFAT in microglial cells. | 1999 | J. Biol. Chem. | pmid:10224077 |
| Green MD and Michaels MG | Tacrolimus: effects and side effects. | 1999 | Pediatr. Infect. Dis. J. | pmid:10223694 |
| Knoll GA and Bell RC | Tacrolimus versus cyclosporin for immunosuppression in renal transplantation: meta-analysis of randomised trials. | 1999 | BMJ | pmid:10213717 |
| Jani A et al. | Modulation of cell-mediated immunity prolongs adenovirus-mediated transgene expression in sciatic nerve. | 1999 | Hum. Gene Ther. | pmid:10210146 |
| Lütkes P et al. | [Quality of life following transplantation. The impact ofa new immunosuppressive substance]. | 1999 | Zentralbl Chir | pmid:10209841 |
| Cetinkale O et al. | Modulating the functions of neutrophils and lipid peroxidation by FK506 in a rat model of thermal injury. | 1999 | Burns | pmid:10208383 |
| Hortelano S et al. | Protective effect of cyclosporin A and FK506 from nitric oxide-dependent apoptosis in activated macrophages. | 1999 | Br. J. Pharmacol. | pmid:10205001 |
| Nagasaki Y et al. | Reversal of hypopigmentation in phenylketonuria mice by adenovirus-mediated gene transfer. | 1999 | Pediatr. Res. | pmid:10203136 |
| Sloper CM et al. | Tacrolimus (FK506) in the treatment of posterior uveitis refractory to cyclosporine. | 1999 | Ophthalmology | pmid:10201592 |
| De Lima JJ et al. | Effects of FK506 in rat and human resistance arteries. | 1999 | Kidney Int. | pmid:10201018 |
| Mollison KW et al. | Discovery of ascomycin analogs with potent topical but weak systemic activity for treatment of inflammatory skin diseases. | 1998 | Curr. Pharm. Des. | pmid:10197049 |
| Azuma N et al. | Immunosuppression with FK506 in rat arterial allografts: fate of allogeneic endothelial cells. | 1999 | J. Vasc. Surg. | pmid:10194498 |
| Meiser BM et al. | Combination therapy with tacrolimus and mycophenolate mofetil following cardiac transplantation: importance of mycophenolic acid therapeutic drug monitoring. | 1999 | J. Heart Lung Transplant. | pmid:10194038 |
| Fansa H et al. | The effect of the immunosuppressant FK 506 on peripheral nerve regeneration following nerve grafting. | 1999 | J Hand Surg Br | pmid:10190602 |
| Zhang W et al. | Failure of calcineurin inhibitors to prevent pressure-overload left ventricular hypertrophy in rats. | 1999 | Circ. Res. | pmid:10189360 |
| Yasutsune T et al. | Vasorelaxation and inhibition of the voltage-operated Ca2+ channels by FK506 in the porcine coronary artery. | 1999 | Br. J. Pharmacol. | pmid:10188984 |
| Antoniou EA et al. | Immunosuppressive effect of combination schedules of brequinar with leflunomide or tacrolimus on rat cardiac allotransplantation. | 1999 | Microsurgery | pmid:10188834 |
| Holländer GA et al. | Molecular and biological actions of cyclosporin A and FK506 on T cell development and function. | 1994 | Transfus Sci | pmid:10155542 |
| Hemenway CS and Heitman J | Calcineurin. Structure, function, and inhibition. | 1999 | Cell Biochem. Biophys. | pmid:10099825 |
| Shapiro R et al. | Posttransplant diabetes in pediatric recipients on tacrolimus. | 1999 | Transplantation | pmid:10096540 |
| Nogueira JM et al. | A comparison of recipient renal outcomes with laparoscopic versus open live donor nephrectomy. | 1999 | Transplantation | pmid:10096529 |
| Pompeo A et al. | Cyclosporin A, but not FK506, increases arachidonic acid release and inhibits proliferation of pituitary corticotrope tumor cells. | 1999 | Life Sci. | pmid:10096434 |
| Kenyon NS et al. | Islet transplantation: present and future perspectives. | 1998 | Diabetes Metab Rev | pmid:10095999 |
| Nakahama H et al. | Effect of FK 506 in the treatment of autoimmune glomerulonephritis in Brown Norway rats. | 1999 | Nephron | pmid:10095178 |
| Kimura T et al. | N-glycosylation is involved in the sensitivity of Saccharomyces cerevisiae to HM-1 killer toxin secreted from Hansenula mrakii IFO 0895. | 1999 | Appl. Microbiol. Biotechnol. | pmid:10091323 |
| Crabtree GR | Generic signals and specific outcomes: signaling through Ca2+, calcineurin, and NF-AT. | 1999 | Cell | pmid:10089876 |
| Liang J et al. | Refined structure of the FKBP12-rapamycin-FRB ternary complex at 2.2 A resolution. | 1999 | Acta Crystallogr. D Biol. Crystallogr. | pmid:10089303 |
| Trimbur GM et al. | Cloning, sequencing, and nucleolar targeting of the basal-body-binding nucleolar protein BN46/51. | 1999 | J. Cell. Sci. | pmid:10085251 |
| Yura H et al. | Synthesis and pharmacokinetics of a novel macromolecular prodrug of Tacrolimus (FK506), FK506-dextran conjugate. | 1999 | J Control Release | pmid:10084872 |
| Webber SA | 15 years of pediatric heart transplantation at the University of Pittsburgh: lessons learned and future prospects. | 1997 | Pediatr Transplant | pmid:10084782 |
| Atkison P et al. | Small bowel transplantation in children. | 1997 | Pediatr Transplant | pmid:10084770 |
| Shapiro R | Tacrolimus in pediatric renal transplantation: a review. | 1998 | Pediatr Transplant | pmid:10084728 |
| Vieregge B et al. | Synergistic effects of the alkaloid sinomenine in combination with the immunosuppressive drugs tacrolimus and mycophenolic acid. | 1999 | Planta Med. | pmid:10083851 |
| Cirocco RE et al. | Kidney recipient CMV incidence in the gancyclovir era: monitoring viral DNA by a CMV-PCR assay. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083604 |
| Fu F et al. | Systemic administration of CTLA4-Ig or anti-CD40 ligand antibody inhibits second-set rejection of mouse liver allografts. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083555 |
| Chiba K et al. | FTY720, a novel immunosuppressant, induces sequestration of circulating lymphocytes by acceleration of lymphocyte homing. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083549 |
| Hoshino Y et al. | FTY720, a novel immunosuppressant, shows a synergistic effect in combination with FK 506 in rat allograft models. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083547 |
| Jiang H et al. | Inhibition of IL-10 by FK 506 may be responsible for overcoming ongoing allograft rejection in the rat. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083538 |
| Schorlemmer HU et al. | Coadministration of malononitrilamides and tacrolimus induces tolerance in a rat skin allograft model. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083529 |
| Wu MS et al. | Cyclosporine, but not FK506 and rapamycin, enhances Na(+)-K(+)-CL- cotransport activity in cultured medullary thick ascending limb cells. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083527 |
| Yamashita K et al. | Effect of a novel immunosuppressant, FTY720, on heart and liver transplantations in rats. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083526 |
| Mohamed MA et al. | The effect of cyclosporin A and tacrolimus on cultured human epithelial cells: the role of TGF-beta. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083523 |
| Zanker B et al. | Comparison of MPA trough levels in patients with severe diabetes mellitus and from non-diabetics after transplantation. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083521 |
| Zuckermann A et al. | Benefit of mycophenolate mofetil in patients with cyclosporine A-induced nephropathy after lung transplantation. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083518 |
| Kokado Y et al. | Low-dose tacrolimus (FK 506)-based immunosuppressive protocol in living donor renal transplantation. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083515 |
| Opelz G | Immunosuppression with FK 506 does not improve kidney graft survival. Collaborative Transplant Study. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083513 |
| Shapiro R et al. | A prospective, randomized trial of tacrolimus/prednisone vs tacrolimus/prednisone/mycophenolate mofetil in renal transplantation: 1-year actuarial follow-up. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083507 |
| Steinmueller T et al. | The effect of cyclosporine vs FK 506 on glucose metabolism. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083504 |
| Yang HC et al. | Tacrolimus/"low-dose" mycophenolate mofetil versus microemulsion cyclosporine/"low-dose" mycophenolate mofetil after kidney transplantation--1-year follow-up of a prospective, randomized clinical trial. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083501 |
| Klupp J et al. | Mycophenolate mofetil in combination with tacrolimus versus Neoral after liver transplantation. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083497 |
| McAlister VC et al. | Oral delivery of liposomal tacrolimus: increased efficacy and reduced toxicity. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083495 |
| Navia MA | Rational design of new immunosuppressive drugs. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083489 |
| Song Z et al. | FK 506 prevents islet xenograft rejection: a study in the pig-to-rat model. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083437 |
| Terakura M et al. | Effects of peritransplant administration of hematopoietic growth factors on the development of chronic allograft rejection. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083380 |
| Kaibori M et al. | Inhibition of iNOS induction by FK506, but not by cyclosporine, in rat hepatocytes. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083347 |
| Rao AS et al. | Immune modulation in organ allograft recipients by single or multiple donor bone marrow infusions. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083302 |
| Rastellini C et al. | Prolonged survival of islet allografts following combined therapy with tacrolimus and leflunomide. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083278 |
| Stratta RJ | Optimal immunosuppression in pancreas transplantation. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083263 |
| Kaufman DB et al. | Single-center experience of 60 consecutive simultaneous pancreas-kidney transplants using mycophenolate mofetil and tacrolimus as primary maintenance immunotherapy. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083261 |
| Humar A et al. | Surgical complications requiring early relaparotomy after pancreas transplantation: comparison of the cyclosporine and FK 506 eras. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083256 |
| Kandaswamy R et al. | Vascular graft thrombosis after pancreas transplantation: comparison of the FK 506 and cyclosporine eras. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083254 |
| Damotte D et al. | Morphologic features of large bowel biopsies in combined small and large bowel transplantations could predict clinical rejection. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083252 |
| Schulz T et al. | Mycophenolate mofetil/prednisolone/single-shot ATG with tacrolimus or cyclosporine in pancreas/kidney transplantation: first results of an ongoing prospective randomized trial. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083251 |
| Murase N et al. | Immunomodulation of intestinal transplant with allograft irradiation and simultaneous donor bone marrow infusion. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083238 |
| Fischer L et al. | Hepatitis G virus infection in liver transplant recipients. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083208 |
| Rayes N et al. | Treatment of hepatitis B-reinfection or de novo-infection after liver transplantation with famciclovir--how effective is it? | 1999 Feb-Mar | Transplant. Proc. | pmid:10083200 |
| Molmenti E et al. | Noncompliance after pediatric liver transplantation. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083164 |
| Mueller AR et al. | Is the use of marginal liver grafts justified? | 1999 Feb-Mar | Transplant. Proc. | pmid:10083160 |
| Kato T et al. | Mycophenolate mofetil rescue therapy in patients with chronic hepatic allograft rejection. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083158 |
| Lohmann R et al. | Quadruple induction therapy including antithymocyte globulin or interleukin-2 receptor antibody or FK 506-based induction therapy after liver transplantation. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083151 |
| Tacrolimus in renal transplantation: a comparison of induction vs noninduction therapy (triple therapy): three-month results. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083131 |